4q6r/1/1:A/1:B |
| >4q6r-a1-m1-cA (length=442) [Search sequence] |
EYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAWS
NPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKGI
KTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQF
PHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISAD
THYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMHF
GENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAKG
WNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQT
TVDRNMVAELSSVFLDSLYSTD |
| >4q6r-a1-m1-cB (length=443) [Search sequence] |
KEYVKALPSQGLSSSAVLEKLKEYSSMDAFWQEGRASGTVYSGEEKLTELLVKAYGDFAW
SNPLHPDIFPGLRKIEAEIVRIACSLFNGGPDSCGCVTSGGTESILMACKAYRDLAFEKG
IKTPEIVAPQSAHAAFNKAASYFGMKIVRVPLTKMMEVDVRAMRRAISRNTAMLVCSTPQ
FPHGVIDPVPEVAKLAVKYKIPLHVDACLGGFLIVFMEKAGYPLEHPFDFRVKGVTSISA
DTHYGYAPKGSSLVLYSDKKYRNYQFFVDTDWQGGIYASPTIAGSRPGGISAACWAALMH
FGENGYVEATKQIIKTARFLKSELENIKGIFVFGNPQLSVIALGSRDFDIYRLSNLMTAK
GWNLNQLQFPPSIHFCITLLHARKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQ
TTVDRNMVAELSSVFLDSLYSTD |
|
| PDB ID |
4q6r (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Crystal structure of human sphingosine-1-phosphate lyase in complex with inhibitor 6-[(2R)-4-(4-benzyl-7-chlorophthalazin-1-yl)-2-methylpiperazin-1-yl]pyridine-3-carbonitrile |
| Assembly ID |
1 |
| Resolution |
2.4Å |
| Method of structure determination |
X-RAY DIFFRACTION |
| Number of inter-chain contacts |
459 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
24809814 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
1 |
1 |
| Chain ID |
A |
B |
| UniProt accession |
O95470 |
O95470 |
| Species |
9606 (Homo sapiens) |
9606 (Homo sapiens) |
| Function annotation |
BioLiP:4q6rA |
BioLiP:4q6rB |
|
Switch viewer: [NGL] [JSmol]
|
Dimer structure:
Chain 1 in red;
Chain 2 in blue.
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Full biological assembly
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