4qq5/2/2:A/3:A

Sequences

>4qq5-a2-m2-cA (length=275) [Search sequence]

QDPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDQASTVAVKMLK
DNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVILECAAKGNLREFLRARR
PPGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLALPVKW
MAPEALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCP
PELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV

>4qq5-a2-m3-cA (length=275) [Search sequence]

Structure information

PDB ID	4qq5 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal Structure of FGF Receptor (FGFR) 4 Kinase Harboring the V550L Gate-Keeper Mutation in Complex With FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
Assembly ID	2
Resolution	2.203Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	24
Sequence identity between the two chains	1.0
PubMed citation	25317566

Chain information

	Chain 1	Chain 2
Model ID	2	3
Chain ID	A	A
UniProt accession	P22455	P22455
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:4qq5A	BioLiP:4qq5A

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

4qq5-a2-m2-cA_4qq5-a2-m3-cA.pdb.gz

Full biological assembly

Download:

4qq5-assembly2.cif.gz

Similar dimers

Other dimers with similar sequences and structures

4qq5/2/1:A/2:A 4qq5/2/1:A/3:A