4tpt/1/1:B/1:A

Sequences

>4tpt-a1-m1-cB (length=277) [Search sequence]

DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVL
KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIH
RDLNSHNCLIKLDKTVVVADFGLSRLIVYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIV
LCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFS
KLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYGL

>4tpt-a1-m1-cA (length=279) [Search sequence]

DLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVL
KFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMAYLHSMCIIH
RDLNSHNCLIKLDKTVVVADFGLSRLIVKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSF
GIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRP
AFSKLEDSFEALSLYLGELGIPLPAELEELDHTVSMQYG

Structure information

PDB ID	4tpt (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal Structure of the Human LIMK2 Kinase Domain In Complex With a Non-ATP Competitive Inhibitor
Assembly ID	1
Resolution	2.6Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	156
Sequence identity between the two chains	0.996
PubMed citation	25589930

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	B	A
UniProt accession	P53671	P53671
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:4tptB	BioLiP:4tptA

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

4tpt-a1-m1-cB_4tpt-a1-m1-cA.pdb.gz

Full biological assembly

Download:

4tpt-assembly1.cif.gz