4uxl/1/1:A/2:A

Sequences

>4uxl-a1-m1-cA (length=288) [Search sequence]

IENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIE
FLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTL
VDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKEG
LLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLE
PPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKS

>4uxl-a1-m2-cA (length=288) [Search sequence]

Structure information

PDB ID	4uxl (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Structure of Human ROS1 Kinase Domain in Complex with PF-06463922
Assembly ID	1
Resolution	2.4Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	76
Sequence identity between the two chains	1.0
PubMed citation	25733882

Chain information

	Chain 1	Chain 2
Model ID	1	2
Chain ID	A	A
UniProt accession	P08922	P08922
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:4uxlA	BioLiP:4uxlA

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

4uxl-a1-m1-cA_4uxl-a1-m2-cA.pdb.gz

Full biological assembly

Download:

4uxl-assembly1.cif.gz