5hs3/3/1:C/1:E

Sequences
>5hs3-a3-m1-cC (length=281) [Search sequence]
MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGV
LEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGA
EYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVV
NSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEP
LKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHP
>5hs3-a3-m1-cE (length=282) [Search sequence]
MPPHGELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGV
LEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGA
EYRDMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVV
NSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEP
LKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPT
Structure information
PDB ID 5hs3 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol
Assembly ID 3
Resolution 3.103Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 27
Sequence identity between the two chains 1.0
PubMed citation 27010513
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID C E
UniProt accession P04818 P04818
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:5hs3C BioLiP:5hs3E
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 5hs3-a3-m1-cC_5hs3-a3-m1-cE.pdb.gz
Full biological assembly
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Download: 5hs3-assembly3.cif.gz
Similar dimers
Other dimers with similar sequences and structures 5hs3/2/1:F/1:B 6ojv/1/1:B/1:C
Other dimers with similar sequences but different poses
  • 6gyj/1/1:B/1:A 1hzw/1/1:B/1:A 1i00/1/1:A/1:B 1ju6/1/1:A/1:B 1ju6/2/1:C/1:D 1juj/1/1:A/1:B 1juj/2/1:C/1:D 1rts/1/1:A/1:B 2rd8/1/1:B/1:A 2rda/1/1:B/1:A 2rda/2/1:C/2:C 2rda/3/1:D/3:D 2rda/4/1:E/1:F 2tsr/1/1:A/1:B 2tsr/2/1:C/1:D 3ed7/1/1:A/2:A 3ehi/1/1:X/2:X 3ejl/1/1:A/1:B 3ejl/2/1:C/1:D 3gg5/1/1:B/1:A 3gg5/2/1:C/1:D 3gh0/1/1:A/2:A 3h9k/1/1:A/1:B 3h9k/2/1:C/2:C 3h9k/3/1:D/1:E 3hb8/1/1:A/1:B 3hb8/2/1:C/2:C 3hb8/3/1:D/1:E 3ihi/1/1:A/1:B 3n5e/1/1:A/1:B 3n5e/1/1:D/1:A 3ob7/1/1:A/1:B 3ob7/2/1:C/2:C 3ob7/3/1:E/1:D 4e5o/1/1:A/1:B 4e5o/2/1:C/1:D 4e5o/3/1:F/1:E 4eb4/1/1:A/1:B 4eb4/2/1:C/1:D 4eb4/3/1:A/1:B 4eb4/3/2:C/2:D 4ein/1/1:A/1:B 4ez8/1/1:A/2:A 4g2o/2/1:X/2:X 4g6w/2/1:X/2:X 4gd7/2/1:A/2:A 4h1i/1/1:A/1:C 4h1i/2/1:B/1:D 4o1x/1/1:C/1:A 4o1x/2/1:D/1:B 5fct/1/1:A/1:B 5wrn/1/1:B/1:A 5wrn/2/1:C/1:D 5wrn/3/1:F/1:E 5x4x/1/1:A/2:A 5x4y/1/1:A/2:A 5x5a/1/1:D/1:A 5x5a/2/1:E/1:B 5x5a/3/1:F/1:C 5x5d/1/1:D/1:A 5x5d/2/1:E/1:B 5x5d/3/1:F/1:C 5x5q/1/1:D/1:A 5x5q/2/1:E/1:B 5x5q/3/1:F/1:C 5x66/1/1:A/1:D 5x66/2/1:E/1:B 5x66/3/1:C/1:F 5x67/1/1:A/1:B 5x69/1/1:D/1:A 5x69/2/1:E/1:B 6f6z/1/1:A/1:B 6gko/1/1:B/1:A 6ojv/2/1:A/1:D 6pf3/1/1:A/1:C 6pf3/2/1:B/2:B 6pf3/3/1:D/3:D 6pf4/1/1:B/1:D 6pf4/2/1:A/2:C 6pf5/1/1:A/4:D 6pf5/2/1:B/2:B 6pf5/3/1:C/3:C 6pf6/1/1:A/1:B 6pf6/2/2:D/1:C 6qxg/1/1:B/1:A 6qxg/2/1:C/2:C 6r2e/1/1:A/1:B 6r2e/2/1:C/1:D 6r2e/3/1:E/1:F 6r2e/4/1:G/1:H 6y08/1/1:B/1:A 6zxo/1/1:A/1:B 6zxo/2/1:C/1:D 6zxo/3/1:F/1:E
  • 4eb4/3/2:D/1:B 4eb4/3/2:C/1:A
  • 6oju/2/1:A/1:C 6oju/1/1:B/1:D
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