5j87/1/1:A/1:B

Sequences
>5j87-a1-m1-cA (length=263) [Search sequence]
EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE
KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK
QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS
SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWH
EKADERPTFKILLSNILDVMDEE
>5j87-a1-m1-cB (length=274) [Search sequence]
PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE
EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD
VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS
PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE
KVYTIMYSCWHEKADERPTFKILLSNILDVMDEE
Structure information
PDB ID 5j87 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
Assembly ID 1
Resolution 1.59Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 26
Sequence identity between the two chains 1.0
PubMed citation 28315597
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID A B
UniProt accession Q06187 Q06187
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:5j87A BioLiP:5j87B
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 5j87-a1-m1-cA_5j87-a1-m1-cB.pdb.gz
Full biological assembly
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Download: 5j87-assembly1.cif.gz

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