5j87/1/1:C/1:B

Sequences

>5j87-a1-m1-cC (length=261) [Search sequence]

EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWH EKADERPTFKILLSNILDVMD

>5j87-a1-m1-cB (length=274) [Search sequence]

PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE KVYTIMYSCWHEKADERPTFKILLSNILDVMDEE

Structure information

PDB ID	5j87 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
Assembly ID	1
Resolution	1.59Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	17
Sequence identity between the two chains	1.0
PubMed citation	28315597

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	C	B
UniProt accession	Q06187	Q06187
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:5j87C	BioLiP:5j87B

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Download: 5j87-a1-m1-cC_5j87-a1-m1-cB.pdb.gz

Full biological assembly Download: 5j87-assembly1.cif.gz

Similar dimers

Other dimers with similar sequences but different poses

1k2p/1/1:A/1:B 3p08/3/1:A/1:B