5j87/1/1:C/1:D

Sequences

>5j87-a1-m1-cC (length=261) [Search sequence]

EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE
KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK
QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS
SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWH
EKADERPTFKILLSNILDVMD

>5j87-a1-m1-cD (length=263) [Search sequence]

Structure information

PDB ID	5j87 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
Assembly ID	1
Resolution	1.59Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	44
Sequence identity between the two chains	1.0
PubMed citation	28315597

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	C	D
UniProt accession	Q06187	Q06187
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:5j87C	BioLiP:5j87D

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

5j87-a1-m1-cC_5j87-a1-m1-cD.pdb.gz

Full biological assembly

Download:

5j87-assembly1.cif.gz