5j87/1/1:D/1:B

Sequences

>5j87-a1-m1-cD (length=263) [Search sequence]

EIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHE
KLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESK
QFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFS
SKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIMYSCWH
EKADERPTFKILLSNILDVMDEE

>5j87-a1-m1-cB (length=274) [Search sequence]

PSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIE
EAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKD
VCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWS
PPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASE
KVYTIMYSCWHEKADERPTFKILLSNILDVMDEE

Structure information

PDB ID	5j87 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
Assembly ID	1
Resolution	1.59Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	21
Sequence identity between the two chains	1.0
PubMed citation	28315597

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	D	B
UniProt accession	Q06187	Q06187
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:5j87D	BioLiP:5j87B

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

5j87-a1-m1-cD_5j87-a1-m1-cB.pdb.gz

Full biological assembly

Download:

5j87-assembly1.cif.gz