6pf8/3/1:E/2:E

Sequences

>6pf8-a3-m1-cE (length=506) [Search sequence]

EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNNKCDSNKKNALIMGRKTWDSI
GRRPLKNRIIVVISSSLPQDEADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDA
LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQTFCTKNISYDFMIFEKQELKS
IDDTVDLLGEIFGIRKMGNRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAYRE
NRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFEELIWFIKGDTNGNHLIEKKVYI
WSGNGSKEYLERIGLGHREENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIETL
KNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTNDNCLSCNLYQRSCDLGLGSPFNI
ASYAILTMMLAQVCGYEPGELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKVEN
IEDFKWEDIELIGYYPYPTIKMDMAV

>6pf8-a3-m2-cE (length=506) [Search sequence]

Structure information

PDB ID	6pf8 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)-4-chlorobenzoic acid
Assembly ID	3
Resolution	2.533Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	221
Sequence identity between the two chains	1.0
PubMed citation	31536894

Chain information

	Chain 1	Chain 2
Model ID	1	2
Chain ID	E	E
UniProt accession	A0A0S4TER9	A0A0S4TER9
Species	237895 (Cryptosporidium hominis)	237895 (Cryptosporidium hominis)
Function annotation	BioLiP:6pf8E	BioLiP:6pf8E

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

6pf8-a3-m1-cE_6pf8-a3-m2-cE.pdb.gz

Full biological assembly

Download:

6pf8-assembly3.cif.gz

Similar dimers

Other dimers with similar sequences and structures

1qzf/1/1:A/1:B 1qzf/2/1:C/1:D 1qzf/3/1:E/2:E 1sej/1/1:A/1:B 1sej/2/1:C/1:D 1sej/3/1:E/2:E 2oip/1/1:A/1:B 2oip/2/1:C/1:D 2oip/3/1:E/2:E 3dl5/1/1:D/1:C 3dl5/2/1:A/1:B 3dl5/3/1:E/2:E 3dl6/1/1:C/1:D 3dl6/2/1:A/1:B 3dl6/3/1:E/2:E 3hj3/1/1:A/1:B 3hj3/2/1:D/1:C 4ky8/1/1:A/1:B 4ky8/2/1:C/1:D 4q0d/1/1:A/1:E 4q0d/2/1:B/1:C 4q0d/3/1:D/2:D 4q0e/1/1:A/1:C 4q0e/2/1:B/1:D 6ojs/1/1:A/1:C 6ojs/2/1:B/1:E 6ojs/3/1:D/2:D 6pf7/1/1:A/1:B 6pf7/2/1:D/1:C 6pf7/3/1:E/2:E 6pf8/1/1:A/1:B 6pf8/2/1:C/1:D 6pf9/1/1:A/2:A 6pf9/2/1:B/1:C 6pf9/3/3:E/1:D 6pfa/1/1:A/1:B 6pfa/2/1:C/1:D 6pfa/3/1:E/2:E 6pfb/1/1:A/1:B 6pfb/2/1:C/1:D 6pfb/3/1:E/2:E 6pfc/1/1:A/2:A 6pfc/2/1:B/1:D 6pfc/3/1:C/3:E 6pfd/1/1:A/1:B 6pfd/2/1:C/1:D 6pfd/3/1:E/2:E 6pfe/1/1:A/1:B 6pfe/2/1:E/1:C 6pfe/3/1:D/2:D 6pff/1/1:A/1:B 6pff/2/1:C/1:D 6pff/3/1:E/2:E 6pfg/1/1:A/1:B 6pfg/2/1:E/3:C 6pfg/3/1:D/2:D 6pfh/1/1:B/1:A 6pfh/2/1:C/2:C 6pfh/3/1:E/1:D 6pfi/1/1:A/1:B 6pfi/2/1:C/1:D 6pfi/3/1:E/2:E 6wep/1/1:A/1:B