6rsh/1/1:B/1:A

Sequences
>6rsh-a1-m1-cB (length=279) [Search sequence]
VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPHIADLKKEIEIL
RNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDY
LGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKETVKDDRDSPVFWYAPECLMQ
SKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLP
CPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
>6rsh-a1-m1-cA (length=284) [Search sequence]
VDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKK
EIEILRNLYHENIVKYKGICTEGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQIC
KGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKETVKDDRDSPVFWYAP
ECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKE
GKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
Structure information
PDB ID 6rsh (database links: RCSB PDB PDBe PDBj PDBsum)
Title Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Assembly ID 1
Resolution 1.71Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 48
Sequence identity between the two chains 1.0
PubMed citation
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID B A
UniProt accession P23458 P23458
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:6rshB BioLiP:6rshA
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 6rsh-a1-m1-cB_6rsh-a1-m1-cA.pdb.gz
Full biological assembly
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Download: 6rsh-assembly1.cif.gz
Similar dimers
Other dimers with similar sequences and structures 4e5w/1/1:B/1:A 6rsb/1/1:B/1:A 6rsc/1/1:B/1:A
Other dimers with similar sequences but different poses
  • 4l00/3/1:A/1:B 4l01/3/1:A/1:B
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