7b48/1/1:D/1:C

Sequences
>7b48-a1-m1-cD (length=189) [Search sequence]
VPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTR
VRAMAIYKQSQHMTEVVRRCPHHERSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVP
YEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVHVCACPG
RDRRTEEEN
>7b48-a1-m1-cC (length=192) [Search sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGT
RVRAMAIYKQSQHMTEVVRRCPHHERCSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVV
VPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVHVCAC
PGRDRRTEEENL
Structure information
PDB ID 7b48 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ). Human p53DBD-R273H mutant bound to MQ: R273H-MQ (II)
Assembly ID 1
Resolution 2.05Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 10
Sequence identity between the two chains 1.0
PubMed citation 34862374
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID D C
UniProt accession P04637 P04637
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:7b48D BioLiP:7b48C
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 7b48-a1-m1-cD_7b48-a1-m1-cC.pdb.gz
Full biological assembly
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Download: 7b48-assembly1.cif.gz

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