7dl2/1/1:B/1:A

Sequences

>7dl2-a1-m1-cB (length=1042) [Search sequence]

FKVIKDYPSNEDLHERLELADFVLQWMDVGLSSKFNSCYLDEYIARMVQSSVDIEVSLQV LDAVPAESLPLFIVTLCRTINVKNLLGTHLGHSAIYNMEDRAYMEDAPLLRGAVFFVGMA LWGPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKWDILLNIIERLLQQLQTLDSPELR TIVHDLLTTVEELCDQNEFYFELVERCADQRPESSLLNLISYRAQSIHPAKDGWIQNLQA LMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSHIPEDKDHQVRKL ATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSASLEDVKTAVLGL LVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAFDFLLLLRAPYSL LFRVLLQCLKQESDWKVLKLVLGRLPESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLE SRTDLHLAVVPVLTALISYHNYLDKTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPD IIIKALPVLVVKLTHISATASMAVPLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTN PSKFNQYIVCLAHHVIAMWFIRCRLPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARS LKNLHLELTETCLDMMARYVFSNFTAVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVG TGTRSLLGKTNLAAYVPLLTQGWAEILVRRPTGNTSWLMSLENPLSPFSSDINNMPLQEL SNALMAAERFKKVPGINPSFVFLQLYHSPFFGDESNKPILLPNESQSFERSVQLLDQIPS YDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEFLTGLGRLIELKDCQPDKVYLGGLDV QFTYCWHDDIMQAVFHIATLMPDKKRHLGNDFVSIVYNDSGEDFKLGTIKGQFNFVHVIV TPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNLPFVARQMALHANMASQVHHSRSNPT DIYPSKWIARLRHIKRLRQRIC

>7dl2-a1-m1-cA (length=1127) [Search sequence]

IKDYPSNEDLHERLEVFKALTDNGRHITYLEEELADFVLQWMDVGLSSEFLLVLVNLVKF NSCYLDEYIARMVQMICLLCVRTASSVDIEVSLQVLDAVVCYNCLPAESLPLFIVTLCRT INVKELCEPCWKLMRNLLGTHLGHSAIYNMCHLMEDRAYMEDAPLLRGAVFFVGMALWGA HRLYSLRNSPTSVLPSFYQAMACPNEVVSYEIVLSITRLIKKWDILLNIIERLLQQLQTL DSPELRTIVHDLLTTVEELCDQNEFHGSQERYFELVERCADQRPESSLLNLISYRAQSIH PAKDGWIQNLQALMERFFRSESRGAVRIKVLDVLSFVLLINRQFYEEELINSVVISQLSH IPEDKDHQVRKLATQLLVDLAEGCHTHHFNSLLDIIEKVMARSLSPPPELEERDVAAYSA SLEDVKTAVLGLLVILQTKLYTLPASHATRVYEMLVSHIQLHYKHSYTLPIASSIRLQAF DFLLLLRADSLHRLGLPNKDGVVRFSPYSVPYSLLFRVLLQCLKQESDWKVLKLVLGRLP ESLRYKVLIFTSPCSVDQLCSALCSMLSGPKTLERLSRTDLHLAVVPVLTALISYHNYLD KTKQREMVYCLEQGLIHRCASQCVVALSICSVEMPDIIIKALPVLVVKLTHISATASMAV PLLEFLSTLARLPHLYRNFAAEQYASVFAISLPYTNPSKFNQYIVCLAHHVIAMWFIRCR LPFRKDFVPFITKGLRSNVLLSFDDTPEKDSFRARLKNLHLELTETCLDMMARYVFSNFT AVPKRSPVGEFLLAGGRTKTWLVGNKLVTVTTSVGTGTRSLLGNLAAYVPLLTQGWAEIL VRRPTGNTSWLMSLENPLSPFSSELSNALMAAERFKEHRGINPSFVFLQLYHSPFFGDES NKPILLPNESQSFERSVQLLDQIPSYDTHKIAVLYVGEGQSNSELAILSNEHGSYRYTEF LTGLGRLIELKDCQPDKVYLGGLDVQFTYCWHDDIMQAVFHIATLMPDKKRHLGNDFVSI VYNDSGEDFKLGTIKGQFNFVHVIVTPLDYECNLVSLQCRKDMEGLVDTSVAKIVSDRNL PFVARQMALHANMASQVHHSRSNPTDIYPSKWIARLRHIKRLRQRIC

Structure information

PDB ID	7dl2 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Cryo-EM structure of human TSC complex
Assembly ID	1
Resolution	4.4Å
Method of structure determination	ELECTRON MICROSCOPY
Number of inter-chain contacts	225
Sequence identity between the two chains	0.984

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	B	A
UniProt accession	P49815	P49815
Species	9606 (Homo sapiens)	9606 (Homo sapiens)

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black]   [White]   Download: 7dl2-a1-m1-cB_7dl2-a1-m1-cA.pdb.gz

Full biological assembly Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black quality]   [White quality]   Download: 7dl2-assembly1.cif.gz