7jxi/1/1:C/2:D

Sequences

>7jxi-a1-m1-cC (length=283) [Search sequence]

NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREPKANKEILDE
AYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIA
KGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDLPSPTDSNFYRALMDEEDM

>7jxi-a1-m2-cD (length=289) [Search sequence]

ALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATANKEILDEAY
VMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKG
MNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLVPIKWMALESILHRIYTHQSDV
WSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADS
RPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEED

Structure information

PDB ID	7jxi (database links: RCSB PDB PDBe PDBj PDBsum)
Title	EGFR kinase (T790M/V948R) in complex with PF-06747775
Assembly ID	1
Resolution	3Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	58
Sequence identity between the two chains	0.982
PubMed citation

Chain information

	Chain 1	Chain 2
Model ID	1	2
Chain ID	C	D
UniProt accession	P00533	P00533
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:7jxiC	BioLiP:7jxiD

3D structure

Switch viewer: [NGL] [JSmol]

Dimer structure: Chain 1 in red; Chain 2 in blue.

Download:

7jxi-a1-m1-cC_7jxi-a1-m2-cD.pdb.gz

Full biological assembly

Download:

7jxi-assembly1.cif.gz