7k7o/1/1:A/1:B

Sequences
>7k7o-a1-m1-cA (length=257) [Search sequence]
SFHRVDQKEITQLSHLGQGTRTNVYEGRLRELRVVLKVLDPSHHDIALAFYETASLMSQV
SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL
ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLP
LSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLT
YEPTQRPSFRTILRDLT
>7k7o-a1-m1-cB (length=257) [Search sequence]
SFHRVDQKEITQLSHLGQGTRTNVYEGRLRELRVVLKVLDPSHHDIALAFYETASLMSQV
SHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYL
ENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLP
STAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTY
EPTQRPSFRTILRDLTR
Structure information
PDB ID 7k7o (database links: RCSB PDB PDBe PDBj PDBsum)
Title CRYSTAL STRUCTURE OF TYROSINE KINASE 2 JH2 (PSEUDO KINASE DOMAIN) COMPLEXED WITH COMPOUND-12 AKA:6-[(cyclopropanecarbonyl)amino]-4-{[2-methoxy-3-(pyrimidin-2-yl)phenyl]amino}-N-methylpyridazine-3-carboxamide
Assembly ID 1
Resolution 2.82Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 17
Sequence identity between the two chains 0.996
PubMed citation 33370104
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID A B
UniProt accession P29597 P29597
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:7k7oA BioLiP:7k7oB
3D structure
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Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 7k7o-a1-m1-cA_7k7o-a1-m1-cB.pdb.gz
Full biological assembly
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Download: 7k7o-assembly1.cif.gz
Similar dimers
Other dimers with similar sequences and structures 6nze/1/1:A/1:B 6nzh/1/1:A/1:B 6nzp/1/1:A/1:B 6nzq/1/1:A/1:B 6nzr/1/1:B/1:A 7k7q/1/1:B/1:A
Other dimers with similar sequences but different poses
  • 4wov/3/1:B/1:A 5tkd/3/1:B/2:A
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