7la9/3/1:C/1:E

Sequences
>7la9-a3-m1-cC (length=105) [Search sequence]
TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
>7la9-a3-m1-cE (length=105) [Search sequence]
TNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
WNAQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKINEL
Structure information
PDB ID 7la9 (database links: RCSB PDB PDBe PDBj PDBsum)
Title Crystal structure of the first bromodomain (BD1) of human BRD4 (BRD4-1) in complex with bivalent inhibitor NC-III-49-1
Assembly ID 3
Resolution 2.2Å
Method of structure determination X-RAY DIFFRACTION
Number of inter-chain contacts 12
Sequence identity between the two chains 1.0
PubMed citation 35867655
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID C E
UniProt accession O60885 O60885
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:7la9C BioLiP:7la9E
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
Color: [By chain]   [By residue index]  
Spin: [Spin off]   [Spin on]   [Reset]
Render: [Low quality]   [High quality]  
Background: [Black]   [White]  
Download: 7la9-a3-m1-cC_7la9-a3-m1-cE.pdb.gz
Full biological assembly
Color: [By chain]   [By residue index]  
Spin: [Spin off]   [Spin on]   [Reset]
Render: [Low quality]   [High quality]  
Background: [Black quality]   [White quality]  
Download: 7la9-assembly3.cif.gz
Similar dimers
Other dimers with similar sequences and structures 7la9/1/1:A/1:D 7la9/2/1:B/1:F
Other dimers with similar sequences but different poses
  • 6u8g/1/2:C/1:A 6u72/1/1:B/2:A 6u74/1/2:C/1:A 6u74/2/1:D/3:B 6u8g/2/3:D/1:B
  • 7l9m/1/1:A/1:B 7mr5/1/1:A/1:B 7mr6/1/1:A/1:B 7mr7/1/1:B/1:A
    		•

    [Back to Home]