7m6l/1/1:G/1:I

Sequences

>7m6l-a1-m1-cG (length=4299) [Search sequence]

VQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFTLE QSLSVRALQEMLANGHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDAT GEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNM NPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDDQRRLVYYEGGAVCTHARSLWRL EPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEK LPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAILHQEGHMD DALFLTRCQQEESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGPALPIEAVILSL QDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAE YAGEEAAESWKEIVNLLYELLASLIRGNRANCALFSTNLDWVVSKLDRLEASSGILEVLY CVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL LPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVVPFLTAQATHLRVG WALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVVS CCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPP PGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPP HLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMS GETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLV DRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRT LLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWA RPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFTLN GEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEP FAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARMDGTVDTPPCLRLAHRTWGSQNSLVE MLFLRLSLPVQFHQHFRCTNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQH DMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVRISHTDLVIGCLVDLATGL MTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSERKN PAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQDPLTMMALHIPEENR CMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGP LRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRRHGLPGVGVTTSLR PPHHFSPPCFVAALAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFV PVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEGLLQMKLPESVKLQMCNLLEYFCDQE LQHRVESLAAFAERYVDKLQANQRSRYALLMRAFTMSAAETARRTREFRSPPQEQINMLL HFKDEADEEDCPLPEDIRQDLQDFHQDLLAHCGIPQSLQELVSHMVVRWAQEDYVQSPEL VRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEEN LMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGIRFPKMVTSCCRFLCYFCRI SRQNQRSMFDHLSYLLENSQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQ SCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPAL RGEGGSGLLAAIEEAIRISEDPARDGPNRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAG KGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFL DRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCA PLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRL VFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSL AHKKYDQELYRMAMPCLCAIAGALPPDYVDASYSSKAEKNFDPRPVETLNVIIPEKLDSF INKFAEYTHEKWAFDKIQNNWSYGENVDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLK AMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKG GGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRSSIEKRFAFGFLQQLLRWM DISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGS GGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEI VKAGLRSFFESASEDIEKMVENLRLGKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDV ILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNAC SVYTTKSPRERAILGLPNSVEEMCPDIPVLDRLMADIGGLAESGARYTEMPHVIEITLPM LCSYLPRWWERGPEAPPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMK RLAVFAQPIVSRARPELLHSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRD EFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNANAEELFRMVGEIFIYWSKSHNFKREEQ NFVVQNEINNMSFLTYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDE EVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLE QTEHPYKSVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEK KPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLVSFEEKEMEKQRLLYQQS RLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGF FQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVIEKVMADDEFTQDLFRFLQLLCE GHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSK AMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELL KELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVG SEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQ EPARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERI YFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISE FWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGY MEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVK GQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEITAHNERKP DPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAM GVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDD MMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIID AFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINK DETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS

>7m6l-a1-m1-cI (length=4299) [Search sequence]

VQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEPTSNAQNVPPDLAICCFTLE QSLSVRALQEMLANGHRTLLYGHAILLRHAHSRMYLSCLTTSRSMTDKLAFDVGLQEDAT GEACWWTMHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNM NPICSCCEEGYVTGGHVLRLFHGHMDECLTISAADSDDQRRLVYYEGGAVCTHARSLWRL EPLRISWSGSHLRWGQPLRIRHVTTGRYLALTEDQGLVVVDACKAHTKATSFCFRVSKEK LPKRDVEGMGPPEIKYGESLCFVQHVASGLWLTYAAPDPKALRLGVLKKKAILHQEGHMD DALFLTRCQQEESQAARMIHSTAGLYNQFIKGLDSFSGKPRGSGPPAGPALPIEAVILSL QDLIGYFEPPSEELQHEEKQSKLRSLRNRQSLFQEEGMLSLVLNCIDRLNVYTTAAHFAE YAGEEAAESWKEIVNLLYELLASLIRGNRANCALFSTNLDWVVSKLDRLEASSGILEVLY CVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLDVLCSLCVCNGVAVRSNQDLITENL LPGRELLLQTNLINYVTSIRPNIFVGRAEGSTQYGKWYFEVMVDEVVPFLTAQATHLRVG WALTEGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWTGHVARPVTSPGQHLLAPEDVVS CCLDLSVPSISFRINGCPVQGVFEAFNLDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPP PGYAPCHEAVLPRERLRLEPIKEYRREGPRGPHLVGPSRCLSHTDFVPCPVDTVQIVLPP HLERIREKLAENIHELWALTRIEQGWTYGPVRDDNKRLHPCLVNFHSLPEPERNYNLQMS GETLKTLLALGCHVGMADEKAEDNLKKTKLPKTYMMSNGYKPAPLDLSHVRLTPAQTTLV DRLAENGHNVWARDRVAQGWSYSAVQDIPARRNPRLVPYRLLDEATKRSNRDSLCQAVRT LLGYGYNIEPPDQEPSQVENQSRWDRVRIFRAEKSYTVQSGRWYFEFEAVTTGEMRVGWA RPELRPDVELGADELAYVFNGHRGQRWHLGSEPFGRPWQSGDVVGCMIDLTENTIIFTLN GEVLMSDSGSETAFREIEIGDGFLPVCSLGPGQVGHLNLGQDVSSLRFFAICGLQEGFEP FAINMQRPVTTWFSKSLPQFEPVPPEHPHYEVARMDGTVDTPPCLRLAHRTWGSQNSLVE MLFLRLSLPVQFHQHFRCTNRDDPEIILNTTTYYYSVRVFAGQEPSCVWVGWVTPDYHQH DMNFDLSKVRAVTVTMGDEQGNVHSSLKCSNCYMVWGGDFVRISHTDLVIGCLVDLATGL MTFTANGKESNTFFQVEPNTKLFPAVFVLPTHQNVIQFELGKQKNIMPLSAAMFLSERKN PAPQCPPRLEVQMLMPVSWSRMPNHFLQVETRRAGERLGWAVQCQDPLTMMALHIPEENR CMDILELSERLDLQRFHSHTLRLYRAVCALGNNRVAHALCSHVDQAQLLHALEDAHLPGP LRAGYYDLLISIHLESACRSRRSMLSEYIVPLTPETRAITLFPPGRRHGLPGVGVTTSLR PPHHFSPPCFVAALAPARLSPAIPLEALRDKALRMLGEAVRDGGQHARDPVGGSVEFQFV PVLKLVSTLLVMGIFGDEDVKQILKMIEPEVFTEGLLQMKLPESVKLQMCNLLEYFCDQE LQHRVESLAAFAERYVDKLQANQRSRYALLMRAFTMSAAETARRTREFRSPPQEQINMLL HFKDEADEEDCPLPEDIRQDLQDFHQDLLAHCGIPQSLQELVSHMVVRWAQEDYVQSPEL VRAMFSLLHRQYDGLGELLRALPRAYTISPSSVEDTMSLLECLGQIRSLLIVQMGPQEEN LMIQSIGNIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGIRFPKMVTSCCRFLCYFCRI SRQNQRSMFDHLSYLLENSQGSTPLDVAAASVIDNNELALALQEQDLEKVVSYLAGCGLQ SCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRKPECFGPAL RGEGGSGLLAAIEEAIRISEDPARDGPNRVHLGHAIMSFYAALIDLLGRCAPEMHLIQAG KGEALRIRAILRSLVPLDDLVGIISLPLQIPTLGKDGALVQPKMSASFVPDHKASMVLFL DRVYGIENQDFLLHVLDVGFLPDMRAAASLDTATFSTTEMALALNRYLCLAVLPLITKCA PLFAGTEHRAIMVDSMLHTVYRLSRGRSLTKAQRDVIEDCLMALCRYIRPSMLQHLLRRL VFDVPILNEFAKMPLKLLTNHYERCWKYYCLPTGWANFGVTSEEELHLTRKLFWGIFDSL AHKKYDQELYRMAMPCLCAIAGALPPDYVDASYSSKAEKNFDPRPVETLNVIIPEKLDSF INKFAEYTHEKWAFDKIQNNWSYGENVDEELKTHPMLRPYKTFSEKDKEIYRWPIKESLK AMIAWEWTIEKAREGEYNPQPPDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQELEAKG GGTHPLLVPYDTLTAKEKARDREKAQELLKFLQMNGYAVTRSSIEKRFAFGFLQQLLRWM DISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFTNHCLYFLSTPAKVLGS GGHASNKEKEMITSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEI VKAGLRSFFESASEDIEKMVENLRLGKGVGQNLTYTTVALLPVLTTLFQHIAQHQFGDDV ILDDVQVSCYRTLCSIYSLGTTKNTYVEKLRPALGECLARLAAAMPVAFLEPQLNEYNAC SVYTTKSPRERAILGLPNSVEEMCPDIPVLDRLMADIGGLAESGARYTEMPHVIEITLPM LCSYLPRWWERGPEAPPPALPAGAPPPCTAVTSDHLNSLLGNILRIIVNNLGIDEATWMK RLAVFAQPIVSRARPELLHSHFIPTIGRLRKRAGKVVAEEEQLRLEAKAEAEEGELLVRD EFSVLCRDLYALYPLLIRYVDNNRAHWLTEPNANAEELFRMVGEIFIYWSKSHNFKREEQ NFVVQNEINNMSFLTYSVQTSLIVATLKKMLPIGLNMCAPTDQDLIMLAKTRYALKDTDE EVREFLQNNLHLQGKVEGSPSLRWQMALYRGLPGREEDADDPEKIVRRVQEVSAVLYHLE QTEHPYKSVVACFRMTPLYNLPTHRACNMFLESYKAAWILTEDHSFEDRMIDDLSKAGEK KPDPLHQLVLHFSRTALTEKSKLDEDYLYMAYADIMAKSCHLVSFEEKEMEKQRLLYQQS RLHTRGAAEMVLQMISACKGETGAMVSSTLKLGISILNGGNAEVQQKMLDYLKDKKEVGF FQSIQALMQTCSVLDLNAFERQNKAEGLGMVNEDGTVIEKVMADDEFTQDLFRFLQLLCE GHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIEEQGKRNFSK AMSVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMMKLAQDSSQIELL KELLDLQKDMVVMLLSLLEGNVVNGMIARQMVDMLVESSSNVEMILKFFDMFLKLKDIVG SEAFQDYVTDPRGLISKKDFQKAMDSQKQFTGPEIQFLLSCSEADENEMINFEEFANRFQ EPARDIGFNVAVLLTNLSEHVPHDPRLRNFLELAESILEYFRPYLGRIEIMGASRRIERI YFEISETNRAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIAAQISE FWGELEVQRVKFLNYLSRNFYTLRFLALFLAFAINFILLFYKVSDSPPMVYYFLEESTGY MEPALWCLSLLHTLVAFLCIIGYNCLKVPLVIFKREKELARKLEFDGLYITEQPGDDDVK GQWDRLVLNTPSFPSNYWDKFVKRKVLDKHGDIFGRERIAELLGMDLASLEITAHNERKP DPPPGLLTWLMSIDVKYQIWKFGVIFTDNSFLYLGWYMVMSLLGHYNNFFFAAHLLDIAM GVKTLRTILSSVTHNGKQLVMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDD MMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIID AFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINK DETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLS

Structure information

PDB ID	7m6l (database links: RCSB PDB PDBe PDBj PDBsum)
Title	High resolution structure of the membrane embedded skeletal muscle ryanodine receptor
Assembly ID	1
Resolution	3.98Å
Method of structure determination	ELECTRON MICROSCOPY
Number of inter-chain contacts	163
Sequence identity between the two chains	1.0
PubMed citation	34469755

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	G	I
UniProt accession	P11716	P11716
Species	9986 (Oryctolagus cuniculus)	9986 (Oryctolagus cuniculus)
Function annotation	BioLiP:7m6lG	BioLiP:7m6lI

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black]   [White]   Download: 7m6l-a1-m1-cG_7m6l-a1-m1-cI.pdb.gz

Full biological assembly Color: [By chain]   [By residue index]   Spin: [Spin off]   [Spin on]   [Reset] Render: [Low quality]   [High quality]   Background: [Black quality]   [White quality]   Download: 7m6l-assembly1.cif.gz

Similar dimers

Other dimers with similar sequences and structures

7m6l/1/1:A/1:B 7m6l/1/1:A/1:G 7m6l/1/1:B/1:I