7md4/1/1:A/1:B |
| >7md4-a1-m1-cA (length=724) [Search sequence] |
VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRV
YGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELC
YLATIDWSRILDSVEDNYIVLCKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLD
GRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLL
CTPCEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRS
YALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPK
LCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYW
PPDFRDLLGFMLFYKEAPYQNVVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKT
LVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHY
LVFWERQAEDSELFELDYCLKGLKLPSREEHRPFEKVVNKESLVISGLRHFTGYRIELQA
CNQDTPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLY
EVSYRRYGDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYV
TDYL |
| >7md4-a1-m1-cB (length=778) [Search sequence] |
HLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDY
LLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIE
KNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTQFVERCWTHSHCQKVCPT
ICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCV
NFSFCQDLHHKCKCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKT
IDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS
FFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIH
KMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDL
LGFMLFYKEAPYQNVVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDE
RRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQ
AEDSELFELDYCLKGLKLPSREEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPE
ERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRY
GDEELHLCVSRKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLD |
|
| PDB ID |
7md4 (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Insulin receptor ectodomain dimer complexed with two IRPA-3 partial agonists |
| Assembly ID |
1 |
| Resolution |
4.5Å |
| Method of structure determination |
ELECTRON MICROSCOPY |
| Number of inter-chain contacts |
39 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
35177603 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
1 |
1 |
| Chain ID |
A |
B |
| UniProt accession |
P06213 |
P06213 |
| Species |
9606 (Homo sapiens) |
9606 (Homo sapiens) |
| Function annotation |
BioLiP:7md4A |
BioLiP:7md4B |
|
Switch viewer: [NGL] [JSmol]
|
Dimer structure:
Chain 1 in red;
Chain 2 in blue.
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Full biological assembly
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