7nfc/1/1:F/1:A

Sequences
>7nfc-a1-m1-cF (length=3557) [Search sequence]
CSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFV
RKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALD
LLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEM
INNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIF
NFVLQIDLKRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALS
ALESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIINKELSIAIRGYGLFAGPCKVINAKD
VDFMYVELIQRCKQMFLTQDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDS
FPQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPWKVPTYK
DYVDLFRHLLSSDQMMDSILADSLNHLLYDEFVKSVLKIVEKLDLTLEIQANLHPAKPKD
FSAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKK
IKYFEGDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVP
ALQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSFNKVVLK
HLKKTKNLSLEEIRIRVVQMLGSLGGQINKNLLMMKSYVAWDREKRLSFAVPFREMKPVI
FLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQLYKRT
FPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDPVDSTL
RDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASLAFNNI
YREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEKKHVSL
NKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPGNRSPN
LWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTSLQATLCWLDLLLAALECYNTFIGE
RTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFTSPQEGERYNYSKCTVVVRI
MEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLPDVCVN
LMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACKQLHRA
GLLHNILPSQSTDLHHSVGTELLSLVYKGIASLDLSCKQLASGLLELAFAFGGLCERLVS
LLLNPAVLSTSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMVSAVLN
GMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKILQIDSS
VSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFLEELRRVLEQLIVAHFPMQ
SREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQSSFRRI
ARRGSCVTQVGLLESVYEMFRTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAIDVLKT
FDTQITKKMGYYKILDVMYSRLPNELTKTLIKLCYDAFTENLERRRLYHCAAYNCAISVI
CCVFNELKFYQRHECMAPLTALVKHMHRSLRDLPSWMKFLHGKLGNPIVPLNIRLFLAKL
VINTEEVFRPYAKHWLSPLLQLAASENGEGIHYMVVEIVATILSWTGLATPTGVPKDEVL
ANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPNSKDNS
VGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLILRYVM
ERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLLPKFHG
VLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKLKPVEL
RELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDTDNDSQEIFKLAKDVLIQGLIDENP
GLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSPDYPNP
MFEHPLSECEFQEYTIDSDWRFRSTVLTGRTDLLRLRRRFMRDQEKLSLMYARKGVAEQK
REKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQLFSSL
FSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAALLSLD
PAAVSAGCLASLQQPVGIRLLEEALLRLLLPPDVLRWVELAKLYRSIGEYDVLRGIFTSE
IGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDCYNHLA
EWKSLEYCSTASIDSEKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDKAMHGE
LQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLTKLQSV
QALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRCFFLSK
IEEKLDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVSWVQSY
CRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYRIIANA
LSSEPACLAEIEEDKARRILELSGEDSEKVIAGLYQRAFQHLSEAVQAAEEEAGVIDAYM
TLADFCDQQLRKEEEAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTK
EISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESTSTGHK
NKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAVNKKNIEKMYERM
YAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGSDFNDITNMLLLKMNKDSKPPGNLKE
CSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKRIIIRG
HDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMTSRLGL
IEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLDVGAYMLMYKGANRTETVT
SFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRHLNNFM
VAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIMVHALR
AFRSDPGLLTNTMDVFVKEPSFDWKNWYPRQKICYAKRKLAGANPAVITCDELLLGHEKA
PAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEPWMXXX
XXXXXXXXXXXXXXXXX
>7nfc-a1-m1-cA (length=3562) [Search sequence]
CSLLRLQETLSAADRCGAALAGHQLIRGLGQECVLSSSPAVLALQTSLVFSRDFGLLVFV
RKSLNSIEFRECREEILKFLCIFLEKMGQKIAPYSVEIKNTCTSVYTKDRAAKCKIPALD
LLIKLLQTFRSSRLMDEFKIGELFSKFYGELALKKKIPDTVLEKVYELLGLLGEVHPSEM
INNAENLFRAFLGELKTQMTSAVREPKLPVLAGCLKGLSSLLCNFTKSMEEDPQTSREIF
NFVLKAIRRYAVPSAGLRLFALHASQFSTCLLDNYVSLFEVLLKWCAHTNVELKKAALSA
LESFLKQVSNMVAKNAEMHKNKLQYFMEQFYGIINKELSIAIRGYGLFAGPCKVINAKDV
DFMYVELIQRCKQMFLTQDRVYQMPSFLQSVASVLLYLDTVPEVYTPVLEHLVVMQIDSF
PQYSPKMQLVCCRAIVKVFLALAAKGPVLRNCISTVVHQGLIRICSKPVVLPWKVPTYKD
YVDLFRHLLSSDQMMDSILADSLNHLLYDEFVKSVLKIVEKLDLTLEIQANLHPAKPKDF
SAFINLVEFCREILPEKQAEFFEPWVYSFSYELILQSTRLPLISGFYKLLSITVRNAKKI
KYFEGDPEKYSCFALFVKFGKEVAVKMKQYKDELLASCLTFLLSLPHNIIELDVRAYVPA
LQMAFKLGLSYTPLAEVGLNALEEWSIYIDRHVMQPYYKDILPCLDGYLKTSFNKVVLKH
LKKTKNLSSNEAISLEEIRIRVVQMLGSLGGQINKNLLMMKSYVAWDREKRLSFAVPFRE
MKPVIFLDVFLPRVTELALTASDRQTKVAACELLHSMVMFMLGKATQMPEGGQGAPPMYQ
LYKRTFPVLLRLACDVDQVTRQLYEPLVMQLIHWFTNNKKFESQDTVALLEAILDGIVDP
VDSTLRDFCGRCIREFLKWSIKQITPQQQEKSPVNTKSLFKRLYSLALHPNAFKRLGASL
AFNNIYREFREEESLVEQFVFEALVIYMESLALAHADEKSLGTIQQCCDAIDHLCRIIEK
KHVSLNKAKKRRLPRGFPPSASLCLLDLVKWLLAHCGRPQTECRHKSIELFYKFVPLLPG
NRSPNLWLKDVLKEEGVSFLINTFEGGGCGQPSGILAQPTSLQATLCWLDLLLAALECYN
TFIGERTVGALQVLGTEAQSSLLKAVAFFLESIAMHDIIAAEKCFTSPQEGERYNYSKCT
VVVRIMEFTTTLLNTSPEGWKLLKKDLCNTHLMRVLVQTLCEPASIGFNIGDVQVMAHLP
DVCVNLMKALKMSPYKDILETHLREKITAQSIEELCAVNLYGPDAQVDRSRLAAVVSACK
QLHRAGLLHNILPSQSTDLHHSVGTELLSLVYKGIASLDLSCKQLASGLLELAFAFGGLC
ERLVSLLLNPAVLSTSVIHFSHGEYFYSLFSETINTELLKNLDLAVLELMQSSVDNTKMV
SAVLNGMLDQSFRERANQKHQGLKLATTILQHWKKCDSWWAKDSPLETKMAVLALLAKIL
QIDSSVSFNTSHGSFPEVFTTYISLLADTKLDLHLKGQAVTLLPFFLEELRRVLEQLIVA
HFPMQSREFPPGTPRFNNYVDCMKKFLDALELSQSPMLLELMTEVLCREQQHVMEELFQS
SFRRIARRGSCVTQVGLLESVYEMFRTRQSFVDRSLLTLLWHCSLDALREFFSTIVVDAI
DVLKTFDTQITKKMGYYKILDVMYSRLPNELTKTLIKLCYDAFTENLERRRLYHCAAYNC
AISVICCVFNELKFYQRHECMAPLTALVKHMHRSLRDLPSWMKFLHGKLGNPIVPLNIRL
FLAKLVINTEEVFRPYAKHWLSPLLQLAASENGEGIHYMVVEIVATILSWTGLATPTGVP
KDEVLANRLLNFLMKHVFHPKRAVFRHNLEIIKTLVECWKDCLSIPYRLIFEKFSGKDPN
SKDNSVGIQLLGIVMANDLPPYDPQCGIQSSEYFQALVNNMSFVRYKEVYAAAAEVLGLI
LRYVMERKNILEESLCELVAKQLKQHQNTMEDKFIVCLNKVTKSFPPLADRFMNAVFFLL
PKFHGVLKTLCLEVVLCRVEGMTELYFQLKSKDFVQVMRHRDDERQKVCLDIIYKMMPKL
KPVELRELLNPVVEFVSHPSTTCREQMYNILMWIHDNYRDTDNDSQEIFKLAKDVLIQGL
IDENPGLQLIIRNFWSHETRLPSNTLDRLLALNSLYSPKIEVHFLSLATNFLLEMTSMSP
DYPNPMFEHPLSECEFQEYTIDSDWRFRSTVLTGRTDLLRLRRRFMRDQEKLSLMYARKG
VAEQKREKEIKSELKMKQDAQVVLYRSYRHGDLPDIQIKHSSLITPLQAVAQRDPIIAKQ
LFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDISCQHAA
LLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLLPPDVLRWVELAKLYRSIGEYDVLRG
IFTSEIGTKQITQSALLAEARSDYSEAAKQYDEALNKQDWVDGEPTEAEKDFWELASLDC
YNHLAEWKSLEYCSTASIDSEKIWSEPFYQETYLPYMIRSKLKLLLQGEADQSLLTFIDK
AMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSFMQNYSSIDVLLHQSRLT
KLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDPMNIWDDIITNRC
FFLSKIEEKLDISSLIRSCKFSMKMKMIDSARKQNNFSLAMKLLKELHKESKTRDDWLVS
WVQSYCRLSHCRSRSQGCSEQVLTVLKTVSLLDENNVSSYLSKNILAFRDQNILLGTTYR
IIANALSSEPACLAEIEEDKARRILELSGEDSEKVIAGLYQRAFQHLSEAVQAAEEEAGV
IDAYMTLADFCDQQLRKEEEAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETL
SLMTKEISSVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSEST
STGHKNKEFVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAVNKKNIEK
MYERMYAALGDPKAPGLGAFRRKFIQTFGKEFDKHFGKGSDFNDITNMLLLKMNKDSKPP
GNLKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASLRRPKR
IIIRGHDEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQLRTYSVVPMT
SRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLDVGAYMLMYKGANR
TETVTSFRKRESKVPADLLKRAFVRMSTSPEAFLALRSHFASSHALICISHWILGIGDRH
LNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLMLPMKETGLMYSIM
VHALRAFRSDPGLLTNTMDVFVKEPSFDWKNWYPRQKICYAKRKLAGANPAVITCDELLL
GHEKAPAFRDYVAVARGSKDHNIRAQEPESGLSEETQVKCLMDQATDPNILGRTWEGWEP
WMXXXXXXXXXXXXXXXXXXXX
Structure information
PDB ID 7nfc (database links: RCSB PDB PDBe PDBj PDBsum)
Title Cryo-EM structure of NHEJ super-complex (dimer)
Assembly ID 1
Resolution 4.14Å
Method of structure determination ELECTRON MICROSCOPY
Number of inter-chain contacts 45
Sequence identity between the two chains 0.999
PubMed citation 34352203
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID F A
UniProt accession P78527 P78527
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:7nfcF BioLiP:7nfcA
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 7nfc-a1-m1-cF_7nfc-a1-m1-cA.pdb.gz
Full biological assembly
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Download: 7nfc-assembly1.cif.gz
Similar dimers

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