8ewi/1/1:B/1:D |
| >8ewi-a1-m1-cB (length=1775) [Search sequence] |
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ
WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLS
SVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAK
NKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSC
RFQLRSPESLKNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSS
GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKG
VHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDG
NGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQT
LMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN
KVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILE
TAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIF
ECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDL
LYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDSDMPDHDLEPPRF
AQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFT
HCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMA
SSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSI
DAMQGSEELFSVEPLPPRPSSMLDEPLERTTNSSHANGAAQAPRSMQWAVRNNASSYLTS
ASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWN
WMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRMSARGDFLNYALSLMRSHN
DEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTETGQNHPFFRRSDSMTFLGCIPP
NPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEV
LPTKMSPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGG
FEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRV
KVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNDNAPLFYQPGKRGFYTPRPG
KNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESL
RQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYA
EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE
SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDD
QHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTK |
| >8ewi-a1-m1-cD (length=1775) [Search sequence] |
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLSPVSLGEDLQWWPDKDGTKFICIGALYSELLAVSSKGELYQ
WKWSESEPYRNAQNPSLHHPRATFLGLTNEKIVLLSANSIRATVATENNKVATWVDETLS
SVASKLEHTAQTYSELQGERIVSLHCCALYTCAQLENSLYWWGVVPFSQRKKMLEKARAK
NKKPKSSAGISSMPNITVGTQVCLRNNPLYHAGAVAFSISAGIPKVGVLMESVWNMNDSC
RFQLRSPESLKNEEQWSLREVVFVEDVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSS
GPDADPSSLLQDCRLLRIDELQVVKTGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKG
VHAVLKTGNWVRYCIFDLATGKAEQENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDG
NGTIYPMAKDCMGGIRDPDWLDLPPISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQT
LMQHILRCDYEACRQYLMNLEQAVVLEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSN
KVESKDRKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILE
TAQKIAKAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIF
ECRTCGLLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDL
LYRLLTATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDSDMPDHDLEPPRF
AQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRLDCFT
HCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILSVEMA
SSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLASTSI
DAMQGSEELFSVEPLPPRPSSMLDEPLERTTNSSHANGAAQAPRSMQWAVRNNASSYLTS
ASSLARAYSIVIRQISDLMGLIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWN
WMVSIMDSTEAQLRYGSALASAGDPGHPNHPLHASQNSARRMSARGDFLNYALSLMRSHN
DEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTETGQNHPFFRRSDSMTFLGCIPP
NPFEVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEV
LPTKMSPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGG
FEVKESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRV
KVTFKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNDNAPLFYQPGKRGFYTPRPG
KNTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESL
RQLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYA
EHRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDE
SGENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDD
QHLPTANTCISRLYVPLYSSKQILKQKLLLAIKTK |
|
| PDB ID |
8ewi (database links:
RCSB PDB
PDBe
PDBj
PDBsum) |
| Title |
Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form |
| Assembly ID |
1 |
| Resolution |
3.5Å |
| Method of structure determination |
ELECTRON MICROSCOPY |
| Number of inter-chain contacts |
42 |
| Sequence identity between the two chains |
1.0 |
| PubMed citation |
37040767 |
|
|
Chain 1 |
Chain 2 |
| Model ID |
1 |
1 |
| Chain ID |
B |
D |
| UniProt accession |
O95071 |
O95071 |
| Species |
9606 (Homo sapiens) |
9606 (Homo sapiens) |
| Function annotation |
BioLiP:8ewiB |
BioLiP:8ewiD |
|
Switch viewer: [NGL] [JSmol]
|
Dimer structure:
Chain 1 in red;
Chain 2 in blue.
|
Full biological assembly
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|
| Other dimers with similar sequences but different poses |
8e0q/1/1:A/1:B 8d4x/1/1:B/1:A 8ewi/1/1:A/1:B 8ewi/1/1:C/1:D |
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