8ewy/1/1:A/1:B

Sequences

>8ewy-a1-m1-cA (length=1049) [Search sequence]

PEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAP NRIITVDDKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKEATPLLDASSLEYLFAQGQ YDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPE TLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGA EIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNEEWNNFSYFPEITH IVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVH NIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTKQFKNFQIEVQKGR YSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQP VYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYEKKIKVILKVLDPSHRDISLA FFEAASMMRQVSHKHIVYLYGVCFRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKV AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIE RIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVT PSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVTHFEKRFLKRIRDLGEGH FGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICM EDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLA ARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVW SFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVY QLMRKCWEFQPSNRTTFQNLIEGFEALLK

>8ewy-a1-m1-cB (length=1049) [Search sequence]

PEPGVEVTFYLLDREPLRLGSGEYTAEELCIRAAQECSISPLCHNLFALYDESTKLWYAP NRIITVDDKTSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKEATPLLDASSLEYLFAQGQ YDLIKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPE TLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGA EIFETSMLLISSENELSRCHSNDSGNVLYEVMVTGNLGIQWRQKPNEEWNNFSYFPEITH IVIKESVVSINKQDNKNMELKLSSREEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVH NIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTKQFKNFQIEVQKGR YSLHGSMDHFPSLRDLMNHLKKQILRTDNISFVLKRCCQPKPREISNLLVATKKAQEWQP VYSMSQLSFDRILKKDIIQGEHLGRGTRTHIYSGTLLDYEKKIKVILKVLDPSHRDISLA FFEAASMMRQVSHKHIVYLYGVCFRDVENIMVEEFVEGGPLDLFMHRKSDALTTPWKFKV AKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSDIGPFIKLSDPGIPVSVLTRQECIE RIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVT PSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVTHFEKRFLKRIRDLGEGH FGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICM EDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAIQICKGMDYLGSRQYVHRDLA ARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVW SFGVTLHELLTYCDSDFSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVY QLMRKCWEFQPSNRTTFQNLIEGFEALLK

Structure information

PDB ID	8ewy (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Structure of Janus Kinase (JAK) dimer complexed with cytokine receptor intracellular domain
Assembly ID	1
Resolution	5.5Å
Method of structure determination	ELECTRON MICROSCOPY
Number of inter-chain contacts	71
Sequence identity between the two chains	1.0
PubMed citation	36867534

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	A	B
UniProt accession	B1ASP2	B1ASP2
Species	10090 (Mus musculus)	10090 (Mus musculus)
Function annotation	BioLiP:8ewyA	BioLiP:8ewyB

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Download: 8ewy-a1-m1-cA_8ewy-a1-m1-cB.pdb.gz

Full biological assembly Download: 8ewy-assembly1.cif.gz