8eyk/1/1:E/1:F

Sequences
>8eyk-a1-m1-cE (length=966) [Search sequence]
SAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDV
VLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTP
NPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMS
ILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGL
HTESAPRRQQEQQVPILEKFCFTPHDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLK
AINCATSGVVGLVNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMN
VYRDGAWGAFRHFLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLC
TVYYASLNFRDIMLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLAT
SVLLSPDFLWDVPSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAA
IAIALSLGCRVFTTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLV
LNSLAEEKLQASVRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNESS
ADWREVWALVQAGIRDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAV
LKGAKPKLMSAISKTFCPAHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGY
QAKQVRRWRRQGVQVQVSTSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQT
PEFFQDVCKPKYSGTLNLDRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERI
CEKRRHEGLPGLAVQWGAIGDVGILVETMSDTIVSGTLPQRMASCLEVLDLFLNQPHMVL
SSFVLA
>8eyk-a1-m1-cF (length=1070) [Search sequence]
SAAIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKTLARALGLGVEQLPVVFEDV
VLHQATILPKTGTVSLEVRLLEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPTP
NPTEPLFLAQAEVYKELRLRGYDYGPHFQGILEASLEGDSGRLLWKDNWVSFMDTMLQMS
ILGSAKHGLYLPTRVTAIHIDPATHRQKLYTLQDKAQVADVVVSRWLRVTVAGGVHISGL
HTESAPRRQQEQQVPILEKFCFTPHTEGLLDSPALKACLDTAVENMPSLKMKVVEHLYSR
IPGLLSPHPLLQLSYTLLVCNPASALSNMVAALREGGFLLLHTLDAWESLFSRVSLRLVG
LKKLFLCRRPTPQDSPIFLPVDDTSFRWVESLKGILADEDSSRPVWLKAINCATSGVVGL
VNCLRREPGGNRLRCVLLSNLSSTSHVPEVDPGSAELQKVLQGDLVMNVYRDGAWGAFRH
FLLEEDKPEEPTAHAFVSTLTRGDLSSIRWVCSSLRHAQPTCPGAQLCTVYYASLNFRDI
MLATGKLSPDAIPGKWTSQDSLLGMEFSGRDASGKRVMGLVPAKGLATSVLLSPDFLWDV
PSNWTLEEAASVPVVYSTAYYALVVRGRVRPGETLLIHSGSGGVGQAAIAIALSLGCRVF
TTVGSAEKRAYLQARFPQLDSTSFANSRDTSFEQHVLWHTGGKGVDLVLNSLAEEKLQAS
VRCLATHGRFLEIGKFDLSQNHPLGMAIFLKNVTFHGVLLDAFFNEADWREVWALVQAGI
RDGVVRPLKCTVFHGAQVEDAFRYMAQGKHIGKVVVQVLAEEPEAVLKKLMSAISKTFCP
AHKSYIIAGGLGGFGLELAQWLIQRGVQKLVLTSRSGIRTGYQAKQVRRWRRQGVQVQVS
TSNISSLEGARGLIAEAAQLGPVGGVFNLAVVLRDGLLENQTPEFFQDVCKPKYSGTLNL
DRVTREACPELDYFVVFSSVSCGRGNAGQSNYGFANSAMERICEKRRHEGLPGLAVQWGA
IGDVGILVETMSTNDTIVSGTLPQRMASCLEVLDLFLNQPHMVLSSFVLA
Structure information
PDB ID 8eyk (database links: RCSB PDB PDBe PDBj PDBsum)
Title Atomic model of the core modifying region of human fatty acid synthase in complex with TVB-2640
Assembly ID 1
Resolution 2.7Å
Method of structure determination ELECTRON MICROSCOPY
Number of inter-chain contacts 162
Sequence identity between the two chains 0.994
PubMed citation 37308485
Chain information
Chain 1 Chain 2
Model ID 1 1
Chain ID E F
UniProt accession P49327 P49327
Species 9606 (Homo sapiens) 9606 (Homo sapiens)
Function annotation BioLiP:8eykE BioLiP:8eykF
3D structure
Switch viewer: [NGL] [JSmol]
Dimer structure: Chain 1 in red; Chain 2 in blue.
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Download: 8eyk-a1-m1-cE_8eyk-a1-m1-cF.pdb.gz
Full biological assembly
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Download: 8eyk-assembly1.cif.gz
Similar dimers
Other dimers with similar sequences and structures 4w9n/1/1:B/1:A 4w9n/2/1:D/1:C 4w9n/3/1:B/1:A 4w9n/3/1:D/1:C 8eyi/1/1:E/1:F 8gkc/1/1:A/1:D
Other dimers with similar sequences but different poses
  • 4w9n/3/1:D/1:B 4w9n/3/1:C/1:A
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