8ig0/2/1:C/1:D

Sequences

>8ig0-a2-m1-cC (length=483) [Search sequence]

GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPEL TFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDH AWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVC AINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTL YHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIY KEFFEVANDVIPNLLKEAASLSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFL VQSLGRFEGQVRQKVRIVSGTVAGTARGPVLTFQSEKMKGMKELLVATKINSSAIKLQLT AQS

>8ig0-a2-m1-cD (length=485) [Search sequence]

GLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPEL TFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKV SDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDH AWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVC AINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTL YHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIY KEFFEVANDVIPNLLKEAASLLEASALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWA TFLVQSLGRFEGQVRQKVRIVSGTVAGTARGGPVLTFQSEKMKGMKELLVATKINSSAIK LQLTA

Structure information

PDB ID	8ig0 (database links: RCSB PDB PDBe PDBj PDBsum)
Title	Crystal structure of menin in complex with DS-1594b
Assembly ID	2
Resolution	2.6Å
Method of structure determination	X-RAY DIFFRACTION
Number of inter-chain contacts	47
Sequence identity between the two chains	0.996
PubMed citation	36841758

Chain information

	Chain 1	Chain 2
Model ID	1	1
Chain ID	C	D
UniProt accession	O00255	O00255
Species	9606 (Homo sapiens)	9606 (Homo sapiens)
Function annotation	BioLiP:8ig0C	BioLiP:8ig0D

3D structure

Dimer structure: Chain 1 in red; Chain 2 in blue. Download: 8ig0-a2-m1-cC_8ig0-a2-m1-cD.pdb.gz

Full biological assembly Download: 8ig0-assembly2.cif.gz

Similar dimers

Other dimers with similar sequences and structures	3u84/3/2:B/1:A 8ig0/1/1:A/1:B
Other dimers with similar sequences but different poses	3u85/2/1:A/2:A 4i80/1/1:A/2:A