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# LOMETS results for example-D2

#### [Click result.zip to download all results on this page]

Input Sequence in FASTA format

>example-D2 (57 residues) RIDREFAKQAEKIFPGVKYIEETNVVLIGDKVRVSEIGVEGVGPVAERAKRLFEEFL

Predicted Secondary Structure

Sequence

20 40
| |
RIDREFAKQAEKIFPGVKYIEETNVVLIGDKVRVSEIGVEGVGPVAERAKRLFEEFL
Prediction
CCCHHHHHHHHHHCCCCSSSSSCCSSSSSSSSSSSSCCCCCCCHHHHHHHHHHHHHC
Conf.Score 964999999999889968997678899986789866566577789999999999769
H:Helix; S:Strand; C:Coil
Predicted Solvent Accessibility

Sequence | 20 40 | | RIDREFAKQAEKIFPGVKYIEETNVVLIGDKVRVSEIGVEGVGPVAERAKRLFEEFL
Prediction | 845551153056314404325534103124414135442634232253036126636
| Values range from 0 (buried residue) to 8 (highly exposed residue)

Predicted Contact and Distance Map Used in LOMETS

Contact Map | Distance Map

LOMETS threading is guided by the consensus contact map (left figure) and distance map (right figure) derived based on confidence scores of DeepPotential. In the contact and distance maps, the axes mark the residue index along the sequence. For the contact map, each dot represents a residue pair with predicted contact, while for the distance map a color scale represents a distance of 1-20+ angstroms. No dot is close to the diagonal in the contact map, because LOMETS does not consider contacts for residue pairs separated by <4 residues.

Top 10 Templates Identified by LOMETS

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | DownloadAlignment |  | 20 40 | |
| Sec.Str. Sol.Acc. Seq | CCCHHHHHHHHHHCCCCSSSSSCCSSSSSSSSSSSSCCCCCCCHHHHHHHHHHHHHC 845551153056314404325534103124414135442634232253036126636 RIDREFAKQAEKIFPGVKYIEETNVVLIGDKVRVSEIGVEGVGPVAERAKRLFEEFL
1 | 7mj0A | 7mj0 | 0.358 | 3.823 | 0.25 | 0.25 | 1.00 | 0.35 | HHpred |  | RLSAEKFAALQPALPTAVYHATAQCMTVGEQPAPKTPG VTAGTP V A EEAAVTAETFG
2 | 6y2qA1 | 6y2q | 0.540 | 2.119 | 0.12 | 0.12 | 1.00 | 0.90 | Hybrid-CEthreader |  | NIETESRQFIENKNYSIQSIGPMLRVVFTRLATVDQYLTGANRSLGQELADHLFETI
3 | 6y2qA1 | 6y2q | 0.540 | 2.119 | 0.12 | 0.12 | 1.00 | 0.85 | CEthreader |  | NIETESRQFIENKNYSIQSIGPMLRVVFTRLATVDQYLTGANRSLGQELADHLFETI
4 | 5v8wA | 5v8w | 0.423 | 2.052 | 0.21 | 0.21 | 1.00 | 0.83 | SparksX |  | IPVEQFVQTLE KHFSDIKVEDTGHIV LLQELIQIEEDSCDNDEMLRVRLRDLVLKF L
5 | 6y2qA1 | 6y2q | 0.606 | 1.899 | 0.04 | 0.04 | 0.98 | 0.97 | MapAlign |  | LVRANIETESRQFIQSIGPMGSRAGLRVVFTVDIFYTTIQYNRSLGQELADHLFET-
6 | 7mj0A | 7mj0 | 0.299 | 4.051 | 0.23 | 0.21 | 0.93 | 0.60 | MRFsearch |  | ---AEKFAALQPALPTAVYHATAQCMTVGGYIAVVTA-GTSDQP V A EEAAVTAETFG
7 | 7mj0A | 7mj0 | 0.358 | 3.823 | 0.25 | 0.25 | 1.00 | 0.34 | HHsearch |  | RLSAEKFAALQPALPTAVYHATAQCMTVGEQPAPKTPG VTAGTP V A EEAAVTAETFG
8 | 5v8wA | 5v8w | 0.416 | 2.148 | 0.18 | 0.18 | 1.00 | 0.67 | MUSTER |  | SIPEQFVQTLE KHFSDIKVEDTAKGHIVLLETLIQIEECDNDEMLRVRLRDLVLKF L
9 | 2hg7A | 2hg7 | 0.255 | 3.628 | 0.10 | 0.09 | 0.89 | 0.38 | FFAS3D |  | -----LYDAIMYKYPNAVSRKDFELRNDGNGSYIEKWNLRAPLPTQAELETWWE EL-
10 | 7agvA1 | 7agv | 0.423 | 3.351 | 0.06 | 0.05 | 0.93 | 0.78 | EigenThreader |  | SGLN--IKENDLGIGKKFIETHEKMTIIIGRREIFNESLDDS--EARQIAAILGPQA
(a) | Templates are ranked in descending order of the following score: score(i,j)=conf(i)·Z(i,j)/Z0(i)+seqid(i,j), where Z(i,j) is the Z-score of j-th template of i-th server; Z0(i) is the Z-score cutoff for defining good/bad templates for the i-th server; conf(i) is the confidence of i-th server which is defined as the average TM-score to the natives of all predictions calculated from a large-scale benchmark test; and seqid(i,j) is the sequence identity to query of j-th template of i-th server. (See here for details)
(b) | PDB Hit is the PDB of the specific domain/chain aligned to the query.
(c) | RCSB Link is the RCSB PDB link of the full-length protein.
(d) | CMO is the contact map overlap score, calculated from the number of overlapping contacts between the predicted contact map and the contact map derived from the aligned template, then normalized by the number of predicted contacts.
(e) | MAE is the mean absolute error between the predicted distance map and the distance map derived from the aligned template.
(f) | ID1 is the number of template residues identical to query divided by the number of aligned residues.
(g) | ID2 is the number of template residues identical to query divided by the query sequence length.
(h) | Cov is equal to the number of aligned template residues divided by the query sequence length.
(i) | Norm. Zscore is the normalized Z-score of the threading alignments. A normalized Z-score ≥1 means a good alignment.
(j) | Download Alignment list the threading program used to identify the template provide the 3D structure of aligned regions of threading templates.
(k) | Sec.Str. is predicted secondary structure, with H, S and C representing helix, strand, and coil, respectively.
(l) | Sol.Acc. is predicted solvent accessibility, where values range from 0 (buried residue) to 8 (highly exposed residue)
(m) | Images of the top 10 PDB hits are listed below, together with the threading programs used to detect them:
7mj0 HHpred,MRFsearch, HHsearch | 6y2q Hybrid-CEthreader,CEthreader, MapAlign | 5v8w SparksX,MUSTER | 2hg7 FFAS3D | 7agv EigenThreader

Full-Length Models

LOMETS uses L-BFGS to construct full-length models guided by the distance restraints predicted by DeepPotential and calculated from top detected templates.
By dragging your mouse on the images, you can rotate and zoom the structure.

Download Model 1 | Download Model 2 | Download Model 3 | Download Model 4 | Download Model 5

Proteins with similar structure

LOMETS uses the TM-align structural alignment program to match the first model to all structures in the PDB library.
This section reports the top 10 proteins from the PDB that have the closest structural similarity, i.e., the highest TM-score, to the predicted model.
Due to the structural similarity, these proteins often have similar functions to the target.

| Top 10 structural analogues in PDB (as identified by TM-align)
Click to view | Rank | RCSB Link | TM-score | RMSDa | IDENa | Cov. | Download PDB | Download FASTA
--- | --- | --- | --- | --- | --- | --- | --- | ---
| 1 | 1m5q | 0.78 | 1.78 | 1.0 | 1.0 | 1m5qY2 | 1m5qY2
| 2 | 1m5q | 0.78 | 1.78 | 1.0 | 1.0 | 1m5qY | 1m5qY
| 3 | 1k0e | 0.722 | 1.88 | 0.073 | 0.96 | 1k0eA | 1k0eA
| 4 | 5v8w | 0.703 | 1.9 | 0.109 | 0.96 | 5v8wB | 5v8wB
| 5 | 5v8w | 0.688 | 2.09 | 0.214 | 0.98 | 5v8wA | 5v8wA
| 6 | 7lht | 0.682 | 2.12 | 0.055 | 0.96 | 7lhtA2 | 7lhtA2
| 7 | 3osm | 0.681 | 2.29 | 0.035 | 1.0 | 3osmA | 3osmA
| 8 | 1wqa | 0.681 | 2.28 | 0.185 | 0.94 | 1wqaA | 1wqaA
| 9 | 1wqa | 0.681 | 2.28 | 0.185 | 0.94 | 1wqaA4 | 1wqaA4
| 10 | 7bfq | 0.675 | 2.05 | 0.109 | 0.96 | 7bfqB | 7bfqB

(a) | Query structure is shown in cartoon, while the structural analog is displayed using backbone trace.
(b) | Ranking of proteins is based on TM-score of the structural alignment between the query structure and known structures in the PDB library.
(c) | RMSDa is the RMSD between residues that are structurally aligned by TM-align.
(d) | IDENa is the percentage sequence identity in the structurally aligned region.
(e) | Cov. represents the coverage of the alignment by TM-align and is equal to the number of structurally aligned residues divided by the length of the query protein.
(f) | Download PDB provides the structure of the aligned model and template.
(g) | Download FASTA provides the fasta format and full-length alignment of model and template. Shows alignment for potential ligand binding pockets and GO/EC terms.

Function and Ligand Binding Annotation for Proteins with Similar Structure

(a) | PDB Hit is the PDB of the specific domain/chain aligned to Model 1
(b) | RCSB Link is the RCSB PDB link of the full-length protein.
(c) | Gene Ontology (GO) term and Enzyme Commission (EC) number list the function annotations for structurally aligned proteins, as collected by BioLiP database.
(d) | Ligand lists known binding ligands for each aligned protein, as collected by BioLiP database.
| (e) | Binding Site Residues lists the known binding residues for each ligand as collected by BioLiP database. The residue numbering is based on the specfic domain/chain numbering and highlighted residues means they are present in the alignment with Model 1. Note: Listed binding residues may not be representative of the full ligand binding pocket and may be part of a complex with another protein chain/domain. Also, for a single ligand, one template may have multiple binding sites.

Rank | PDB Hit | RCSB Link | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 1m5qY2 | 1m5q |  | GO:0000398 | GO:0005732 |  |  |
2 | 1m5qY | 1m5q |  | GO:0000398 | GO:0005732 |  |  |
3 | 1k0eA | 1k0e | GO:0046820,GO:0016740,GO:0000287 | GO:0009058,GO:0009396,GO:0046654,GO:0046656 |  | 2.6.1.85 | TRP | L32 H33 S34 Y41 S42 R43 F44 P238 F239 S240 I378 S390
4 | 5v8wB | 5v8w |  |  |  | 3.1.27.- |  |
5 | 5v8wA | 5v8w |  |  |  |  |  |
6 | 7lhtA2 | 7lht |  |  |  |  |  |
7 | 3osmA | 3osm |  |  |  | 2.7.11.1 |  |
8 | 1wqaA | 1wqa | GO:0016868,GO:0008966,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.8 | MG | S101 D243 D245 D247 R248
9 | 1wqaA4 | 1wqa | GO:0016868,GO:0008966,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.8 |  |
10 | 7bfqB | 7bfq |  |  |  |  |  |

Top Templates and Function Annotation from Component Threading Programs

LOMETS combines templates from multiple individual threading programs, as listed in the following tables.

(a) | Templates are ranked in descending order of normalized Z-score, as explained by (i) below.
(b) | PDB Hit is the PDB of the specific domain/chain aligned to the query.
(c) | RCSB Link is the RCSB PDB link of the full-length protein.
(d) | CMO is the contact map overlap score, calculated from the number of overlapping contacts between the predicted contact map and the contact map derived from the aligned template, then normalized by the number of predicted contacts.
(e) | MAE is the mean absolute error between the predicted distance map and the distance map derived from the aligned template.
(f) | ID1 is the number of template residues identical to query divided by the number of aligned residues.
(g) | ID2 is the number of template residues identical to query divided by the query sequence length.
(h) | Cov is equal to the number of aligned template residues divided by the query sequence length.
(i) | Norm. Zscore is the normalized Z-score of the threading alignments. A normalized Z-score ≥1 means a good alignment.
(j) | Download PDB provides the structure of the aligned region for each template.
(k) | Download FASTA provides the fasta format and full-length alignment of model and template. Shows alignment for potential ligand binding pockets and GO/EC terms.
(l) | Gene Ontology (GO) term and Enzyme Commission (EC) number list the function annotations for template proteins, as collected by BioLiP database.
(m) | Ligand lists known binding ligands for each template protein, as collected by BioLiP database.
(n) | Binding Site Residues lists the known binding residues for each ligand as collected by BioLiP database. The residue numbering is based on the template PDB numbering and highlighted residues means they are aligned with the query sequence. Note: Listed binding residues may not be representative of the full ligand binding pocket and may be part of a complex with another protein chain/domain. Also, for a single ligand, one template may have multiple binding sites.

Templates from Hybrid-CEthreader

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 6y2qA1 | 6y2q | 0.540 | 2.119 | 0.12 | 0.12 | 1.68 | 0.90 | template_1 | template_1 |  |  |  |  |  |
2 | 7cunI2 | 7cun | 0.504 | 1.791 | 0.19 | 0.19 | 1.35 | 0.85 | template_2 | template_2 |  |  |  |  |  |
3 | 2f7lA3 | 2f7l | 0.489 | 2.003 | 0.21 | 0.21 | 1.53 | 0.82 | template_3 | template_3 | GO:0016868,GO:0000287,GO:0008966,GO:0016853,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.2,5.4.2.8 |  |
4 | 7bfqB2 | 7bfq | 0.460 | 2.041 | 0.07 | 0.07 | 1.58 | 0.72 | template_4 | template_4 |  |  |  |  |  |
5 | 1wqaA4 | 1wqa | 0.423 | 2.395 | 0.16 | 0.16 | 1.53 | 0.64 | template_5 | template_5 | GO:0016868,GO:0008966,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.8 |  |
6 | 6gykO2 | 6gyk | 0.416 | 2.641 | 0.16 | 0.16 | 1.42 | 0.62 | template_6 | template_6 | GO:0000978,GO:0008134,GO:0003700,GO:0000979,GO:0000995,GO:0016251,GO:0001016,GO:0001186,GO:0001179,GO:0001102,GO:0003677,GO:0097718,GO:0005515,GO:0001092,GO:0003682,GO:0008301 | GO:0006366,GO:0001188,GO:0006355,GO:0070898,GO:0070893,GO:0042790,GO:0051123 | GO:0005667,GO:0005669,GO:0000126,GO:0005634,GO:0005672,GO:0032991,GO:0005654 |  |  |
7 | 4b0aA1 | 4b0a | 0.416 | 2.895 | 0.14 | 0.14 | 2.74 | 0.62 | template_7 | template_7 | GO:0003677 | GO:0006352 |  | 2.3.1.48 | CA CA | G29 D31 D31 D38 Y39 N92
8 | 1e6yE1 | 1e6y | 0.416 | 2.680 | 0.11 | 0.11 | 2.54 | 0.61 | template_8 | template_8 | GO:0050524,GO:0016740 | GO:0015948 |  | 2.8.4.1 |  |
9 | 3vn5A1 | 3vn5 | 0.431 | 2.283 | 0.18 | 0.18 | 1.18 | 0.59 | template_9 | template_9 | GO:0004523,GO:0003723,GO:0003676,GO:0004519,GO:0016787,GO:0046872,GO:0004518,GO:0000287 | GO:0090305,GO:0090502,GO:0016070,GO:0006298,GO:0043137,GO:0006401 | GO:0005737,GO:0032299 | 3.1.26.4 |  |
10 | 5wq7A5 | 5wq7 | 0.394 | 2.169 | 0.13 | 0.11 | 1.09 | 0.59 | template_10 | template_10 | GO:0008565 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |

Templates from SparksX

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 5v8wA | 5v8w | 0.423 | 2.052 | 0.21 | 0.21 | 1.35 | 0.83 | template_1 | template_1 |  |  |  |  |  |
2 | 5wq8A4 | 5wq8 | 0.372 | 2.177 | 0.04 | 0.04 | 1.11 | 0.81 | template_2 | template_2 | GO:0008565,GO:0042802 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |
3 | 7cunI2 | 7cun | 0.387 | 2.248 | 0.21 | 0.21 | 1.35 | 0.79 | template_3 | template_3 |  |  |  |  |  |
4 | 5wq7A1 | 5wq7 | 0.343 | 2.740 | 0.13 | 0.11 | 1.19 | 0.79 | template_4 | template_4 | GO:0008565 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |
5 | 3ezjG2 | 3ezj | 0.387 | 2.324 | 0.20 | 0.16 | 0.96 | 0.78 | template_5 | template_5 |  |  |  |  |  |
6 | 2n2uA | 2n2u | 0.263 | 2.799 | 0.06 | 0.05 | 1.35 | 0.77 | template_6 | template_6 |  |  |  |  |  |
7 | 4e9jA2 | 4e9j | 0.372 | 2.272 | 0.13 | 0.11 | 1.14 | 0.77 | template_7 | template_7 |  |  |  |  |  |
8 | 1dq3A3 | 1dq3 | 0.321 | 2.803 | 0.13 | 0.12 | 1.42 | 0.74 | template_8 | template_8 | GO:0004519,GO:0016788 | GO:0016539 |  | 1.17.4.1 |  |
9 | 4e9jA3 | 4e9j | 0.358 | 2.283 | 0.13 | 0.11 | 1.21 | 0.73 | template_9 | template_9 |  |  |  |  |  |
10 | 5ho1A | 5ho1 | 0.197 | 3.535 | 0.18 | 0.18 | 1.51 | 0.73 | template_10 | template_10 |  |  |  |  | ZN | H40 D42 H78

Templates from CEthreader

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 6y2qA1 | 6y2q | 0.540 | 2.119 | 0.12 | 0.12 | 1.68 | 0.85 | template_1 | template_1 |  |  |  |  |  |
2 | 7bfqB2 | 7bfq | 0.460 | 2.041 | 0.07 | 0.07 | 1.58 | 0.67 | template_2 | template_2 |  |  |  |  |  |
3 | 3sqgB2 | 3sqg | 0.445 | 2.708 | 0.14 | 0.14 | 2.67 | 0.66 | template_3 | template_3 | GO:0050524,GO:0016740 | GO:0015948 |  | 2.8.4.1 | SO4 | A29 K88 R89
4 | 1wqaA4 | 1wqa | 0.431 | 2.610 | 0.14 | 0.14 | 1.53 | 0.61 | template_4 | template_4 | GO:0016868,GO:0008966,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.8 |  |
5 | 4b0aA1 | 4b0a | 0.438 | 2.564 | 0.12 | 0.12 | 2.74 | 0.59 | template_5 | template_5 | GO:0003677 | GO:0006352 |  | 2.3.1.48 | CA CA | G29 D31 D31 D38 Y39 N92
6 | 5wq7A5 | 5wq7 | 0.409 | 2.100 | 0.13 | 0.11 | 1.09 | 0.57 | template_6 | template_6 | GO:0008565 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |
7 | 3vn5A1 | 3vn5 | 0.431 | 2.283 | 0.18 | 0.18 | 1.18 | 0.52 | template_7 | template_7 | GO:0004523,GO:0003723,GO:0003676,GO:0004519,GO:0016787,GO:0046872,GO:0004518,GO:0000287 | GO:0090305,GO:0090502,GO:0016070,GO:0006298,GO:0043137,GO:0006401 | GO:0005737,GO:0032299 | 3.1.26.4 |  |
8 | 5a8rB1 | 5a8r | 0.401 | 2.792 | 0.07 | 0.07 | 2.33 | 0.52 | template_8 | template_8 | GO:0050524,GO:0016740 | GO:0015948 |  |  |  |
9 | 4b0aA2 | 4b0a | 0.387 | 2.746 | 0.12 | 0.12 | 1.42 | 0.51 | template_9 | template_9 | GO:0003677 | GO:0006352 |  | 2.3.1.48 | CA | G21 S24
10 | 5wq8A4 | 5wq8 | 0.387 | 2.123 | 0.04 | 0.04 | 1.11 | 0.51 | template_10 | template_10 | GO:0008565,GO:0042802 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |

Templates from HHsearch

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 7mj0A | 7mj0 | 0.358 | 3.823 | 0.25 | 0.25 | 3.54 | 0.34 | template_1 | template_1 |  |  |  |  |  |
2 | 4i5sA | 4i5s | 0.182 | 4.048 | 0.19 | 0.18 | 6.67 | 0.28 | template_2 | template_2 | GO:0004673,GO:0000155,GO:0016772,GO:0005524,GO:0016301,GO:0000166,GO:0016740 | GO:0000160,GO:0023014,GO:0018106,GO:0007165,GO:0016310,GO:0006355 | GO:0016020,GO:0016021 | 2.7.13.1 |  |
3 | 3hrgA1 | 3hrg | 0.088 | 7.381 | 0.14 | 0.05 | 2.44 | 0.25 | template_3 | template_3 |  |  |  |  |  |
4 | 4f67A1 | 4f67 | 0.124 | 4.213 | 0.18 | 0.14 | 1.98 | 0.25 | template_4 | template_4 |  |  |  |  |  |
5 | 3d2rB | 3d2r | 0.139 | 4.278 | 0.15 | 0.14 | 6.35 | 0.25 | template_5 | template_5 | GO:0004672,GO:0004740,GO:0005524,GO:0016301,GO:0000166,GO:0016740 | GO:0006468,GO:0005975,GO:0006006,GO:0016310,GO:0006885,GO:0010565,GO:0042593,GO:0042594,GO:0046320,GO:0008286,GO:0010510,GO:0010906,GO:0042304,GO:0045124,GO:0009267,GO:0071398,GO:0072593,GO:2000811 | GO:0005739,GO:0005759 | 2.7.11.2 | ADP | N238 R241 A242 D273 V278 L286 Y291 S292 T293 A300 G301 F302 G303 G305 L306 T330
6 | 3crlB2 | 3crl | 0.161 | 4.332 | 0.17 | 0.16 | 3.77 | 0.25 | template_6 | template_6 | GO:0004740,GO:0004672,GO:0005524,GO:0016301,GO:0000166,GO:0016740,GO:0004674,GO:0042803,GO:0044877,GO:0046982 | GO:0005975,GO:0006006,GO:0016310,GO:0006111,GO:0006885,GO:0008286,GO:0010510,GO:0010565,GO:0010906,GO:0031670,GO:0042593,GO:0006468,GO:0018105 | GO:0005739,GO:0005759,GO:0005967,GO:0045254 | 2.7.11.2 | ANP MG | E72 N76 R79 A80 D111 V116 L124 G136 F137 G138 Y139 G140 L141 P142 E72 N76
7 | 4rkiA2 | 4rki | 0.226 | 3.980 | 0.10 | 0.09 | 2.32 | 0.21 | template_7 | template_7 | GO:0003677,GO:0003887,GO:0008408,GO:0016779,GO:0016740,GO:0005515 | GO:0006260,GO:0006271,GO:0071897,GO:0090305 | GO:0009360,GO:0005737 | 2.7.7.7 |  |
8 | 6linA2 | 6lin | 0.146 | 4.313 | 0.15 | 0.14 | 3.11 | 0.21 | template_8 | template_8 |  |  |  |  | EH0 | L61 N64 R67 A68 D99 G103 V104 K108 L112 Y117 G119 L122 L138 E142 T146
9 | 6blkC | 6blk | 0.161 | 4.003 | 0.13 | 0.12 | 2.77 | 0.21 | template_9 | template_9 | GO:0016772 | GO:0016310 |  | 3.1.3.- | ATP | N57 A58 K60 W61 D86 P89 I91 F104 R105 S106 A109 G114 G116 L117 G118 L119 T147
10 | 2q8gA2 | 2q8g | 0.139 | 4.285 | 0.17 | 0.16 | 3.02 | 0.21 | template_10 | template_10 | GO:0004672,GO:0004740,GO:0005524,GO:0016301,GO:0000166,GO:0016740,GO:0005515 | GO:0006468,GO:0005975,GO:0006006,GO:0016310,GO:0010510,GO:0008283,GO:0008631,GO:0010906,GO:0097411 | GO:0005739,GO:0005759,GO:0005967,GO:0005634,GO:0005730 | 2.7.11.2 |  |

Templates from MapAlign

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 6y2qA1 | 6y2q | 0.606 | 1.899 | 0.04 | 0.04 | 1.68 | 0.97 | template_1 | template_1 |  |  |  |  |  |
2 | 1sgoA | 1sgo | 0.584 | 2.689 | 0.04 | 0.04 | 2.44 | 0.97 | template_2 | template_2 | GO:0051018,GO:0034237,GO:0005515,GO:0019901,GO:0004860,GO:0008013 | GO:0060828,GO:0090263,GO:0006469,GO:0008631,GO:0030111 | GO:0005634,GO:0005737 |  |  |
3 | 1wqaA4 | 1wqa | 0.620 | 1.898 | 0.21 | 0.19 | 1.53 | 0.95 | template_3 | template_3 | GO:0016868,GO:0008966,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.8 |  |
4 | 7bfqB2 | 7bfq | 0.584 | 1.889 | 0.11 | 0.11 | 1.58 | 0.87 | template_4 | template_4 |  |  |  |  |  |
5 | 4b0aA1 | 4b0a | 0.555 | 1.992 | 0.10 | 0.09 | 2.74 | 0.82 | template_5 | template_5 | GO:0003677 | GO:0006352 |  | 2.3.1.48 | CA CA | G29 D31 D31 D38 Y39 N92
6 | 5a1uG10 | 5a1u | 0.591 | 2.182 | 0.05 | 0.05 | 2.30 | 0.76 | template_6 | template_6 | GO:0005198 | GO:0006886,GO:0016192,GO:0006891,GO:0006888,GO:0015031 | GO:0030117,GO:0030126,GO:0005737,GO:0005794,GO:0005798,GO:0016020,GO:0031410,GO:0005886,GO:0030663,GO:0005793,GO:0000139,GO:0005829,GO:0043231,GO:0030137 |  |  |
7 | 4b0aA2 | 4b0a | 0.504 | 2.529 | 0.09 | 0.09 | 1.42 | 0.66 | template_7 | template_7 | GO:0003677 | GO:0006352 |  | 2.3.1.48 | CA | G21 S24
8 | 6gykO2 | 6gyk | 0.504 | 2.410 | 0.08 | 0.07 | 1.42 | 0.66 | template_8 | template_8 | GO:0000978,GO:0008134,GO:0003700,GO:0000979,GO:0000995,GO:0016251,GO:0001016,GO:0001186,GO:0001179,GO:0001102,GO:0003677,GO:0097718,GO:0005515,GO:0001092,GO:0003682,GO:0008301 | GO:0006366,GO:0001188,GO:0006355,GO:0070898,GO:0070893,GO:0042790,GO:0051123 | GO:0005667,GO:0005669,GO:0000126,GO:0005634,GO:0005672,GO:0032991,GO:0005654 |  |  |
9 | 6gykO1 | 6gyk | 0.518 | 2.045 | 0.10 | 0.09 | 1.74 | 0.66 | template_9 | template_9 | GO:0000978,GO:0008134,GO:0003700,GO:0000979,GO:0000995,GO:0016251,GO:0001016,GO:0001186,GO:0001179,GO:0001102,GO:0003677,GO:0097718,GO:0005515,GO:0001092,GO:0003682,GO:0008301 | GO:0006366,GO:0001188,GO:0006355,GO:0070898,GO:0070893,GO:0042790,GO:0051123 | GO:0005667,GO:0005669,GO:0000126,GO:0005634,GO:0005672,GO:0032991,GO:0005654 |  |  |
10 | 3vn5A1 | 3vn5 | 0.569 | 1.955 | 0.12 | 0.11 | 1.18 | 0.63 | template_10 | template_10 | GO:0004523,GO:0003723,GO:0003676,GO:0004519,GO:0016787,GO:0046872,GO:0004518,GO:0000287 | GO:0090305,GO:0090502,GO:0016070,GO:0006298,GO:0043137,GO:0006401 | GO:0005737,GO:0032299 | 3.1.26.4 |  |

Templates from MUSTER

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 5v8wA | 5v8w | 0.416 | 2.148 | 0.18 | 0.18 | 1.35 | 0.67 | template_1 | template_1 |  |  |  |  |  |
2 | 2nrvA2 | 2nrv | 0.197 | 3.461 | 0.22 | 0.19 | 1.11 | 0.61 | template_2 | template_2 |  |  |  |  |  |
3 | 3ezjG2 | 3ezj | 0.358 | 2.147 | 0.20 | 0.16 | 0.96 | 0.61 | template_3 | template_3 |  |  |  |  |  |
4 | 1x2iA | 1x2i | 0.168 | 3.237 | 0.20 | 0.19 | 1.19 | 0.59 | template_4 | template_4 | GO:0003677 | GO:0006281 |  |  |  |
5 | 1xu4A1 | 1xu4 | 0.226 | 3.881 | 0.10 | 0.09 | 1.07 | 0.58 | template_5 | template_5 | GO:0003677,GO:0000166,GO:0003684,GO:0005524,GO:0008094,GO:0042802 | GO:0006281,GO:0006310,GO:0006259,GO:0006974 |  |  |  |
6 | 6i1xA3 | 6i1x | 0.299 | 3.248 | 0.14 | 0.14 | 1.28 | 0.58 | template_6 | template_6 |  |  |  |  |  |
7 | 4ys2A | 4ys2 | 0.190 | 3.617 | 0.16 | 0.16 | 1.25 | 0.58 | template_7 | template_7 | GO:0008324 | GO:0006813 |  |  | 2BA | L17 R18 F22 I27 F28 P40 H41 G42
8 | 3w5xA | 3w5x | 0.168 | 3.584 | 0.13 | 0.12 | 1.40 | 0.58 | template_8 | template_8 |  |  |  |  |  |
9 | 5wq8A4 | 5wq8 | 0.372 | 2.168 | 0.04 | 0.04 | 1.11 | 0.56 | template_9 | template_9 | GO:0008565,GO:0042802 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |
10 | 3vn5A1 | 3vn5 | 0.307 | 2.653 | 0.20 | 0.19 | 1.18 | 0.56 | template_10 | template_10 | GO:0004523,GO:0003723,GO:0003676,GO:0004519,GO:0016787,GO:0046872,GO:0004518,GO:0000287 | GO:0090305,GO:0090502,GO:0016070,GO:0006298,GO:0043137,GO:0006401 | GO:0005737,GO:0032299 | 3.1.26.4 |  |

Templates from MRFsearch

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 7mj0A | 7mj0 | 0.299 | 4.051 | 0.23 | 0.21 | 3.54 | 0.60 | template_1 | template_1 |  |  |  |  |  |
2 | 2nxuA | 2nxu | 0.219 | 3.771 | 0.13 | 0.11 | 2.35 | 0.47 | template_2 | template_2 | GO:0003743 | GO:0006413,GO:0006412 |  |  |  |
3 | 3jc8Qa5 | 3jc8 | 0.328 | 2.997 | 0.23 | 0.18 | 1.12 | 0.47 | template_3 | template_3 |  |  | GO:0009279 |  |  |
4 | 2ljkA | 2ljk | 0.248 | 3.224 | 0.15 | 0.14 | 2.05 | 0.47 | template_4 | template_4 | GO:0005515 | GO:0010269,GO:0043066,GO:0051491,GO:0006915,GO:0030335 | GO:0005829,GO:0016020,GO:0005737,GO:0005886,GO:0031235 |  |  |
5 | 7ofhA | 7ofh | 0.431 | 2.454 | 0.07 | 0.05 | 4.05 | 0.47 | template_5 | template_5 |  |  |  |  |  |
6 | 6ybvs | 6ybv | 0.263 | 2.658 | 0.11 | 0.09 | 2.42 | 0.45 | template_6 | template_6 |  |  |  |  | NUC | S72 S74 K84 K118 R121 Y123
7 | 5w68A | 5w68 | 0.401 | 2.198 | 0.05 | 0.04 | 6.14 | 0.43 | template_7 | template_7 |  | GO:0009306 |  |  |  |
8 | 6ve2A1 | 6ve2 | 0.394 | 2.653 | 0.12 | 0.09 | 1.05 | 0.42 | template_8 | template_8 |  |  |  |  |  |
9 | 5wq7A1 | 5wq7 | 0.365 | 2.955 | 0.14 | 0.11 | 1.19 | 0.42 | template_9 | template_9 | GO:0008565 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |
10 | 4e9jA3 | 4e9j | 0.380 | 2.641 | 0.12 | 0.09 | 1.21 | 0.42 | template_10 | template_10 |  |  |  |  |  |

Templates from DisCovER

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 5v8wA | 5v8w | 0.591 | 1.512 | 0.20 | 0.19 | 1.35 | 0.87 | template_1 | template_1 |  |  |  |  |  |
2 | 7cunI2 | 7cun | 0.438 | 2.609 | 0.07 | 0.07 | 1.35 | 0.80 | template_2 | template_2 |  |  |  |  |  |
3 | 4dsdA1 | 4dsd | 0.350 | 3.410 | 0.09 | 0.05 | 1.04 | 0.70 | template_3 | template_3 |  |  |  |  |  |
4 | 1wqaA4 | 1wqa | 0.635 | 1.905 | 0.18 | 0.16 | 1.53 | 0.67 | template_4 | template_4 | GO:0016868,GO:0008966,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.8 |  |
5 | 1vokA1 | 1vok | 0.526 | 2.135 | 0.12 | 0.11 | 1.58 | 0.64 | template_5 | template_5 | GO:0000978,GO:0008134,GO:0003700,GO:0000979,GO:0003677,GO:0005515 | GO:0006366,GO:0006355,GO:0006352 | GO:0005667,GO:0005669,GO:0005634 |  |  |
6 | 2z8uB2 | 2z8u | 0.453 | 2.612 | 0.14 | 0.12 | 1.35 | 0.61 | template_6 | template_6 | GO:0003677,GO:0000978,GO:0008134,GO:0003700,GO:0000979 | GO:0006352,GO:0006366,GO:0006355 | GO:0005667 |  |  |
7 | 6gykO2 | 6gyk | 0.460 | 2.936 | 0.10 | 0.09 | 1.42 | 0.59 | template_7 | template_7 | GO:0000978,GO:0008134,GO:0003700,GO:0000979,GO:0000995,GO:0016251,GO:0001016,GO:0001186,GO:0001179,GO:0001102,GO:0003677,GO:0097718,GO:0005515,GO:0001092,GO:0003682,GO:0008301 | GO:0006366,GO:0001188,GO:0006355,GO:0070898,GO:0070893,GO:0042790,GO:0051123 | GO:0005667,GO:0005669,GO:0000126,GO:0005634,GO:0005672,GO:0032991,GO:0005654 |  |  |
8 | 3vn5A1 | 3vn5 | 0.474 | 2.347 | 0.16 | 0.14 | 1.18 | 0.59 | template_8 | template_8 | GO:0004523,GO:0003723,GO:0003676,GO:0004519,GO:0016787,GO:0046872,GO:0004518,GO:0000287 | GO:0090305,GO:0090502,GO:0016070,GO:0006298,GO:0043137,GO:0006401 | GO:0005737,GO:0032299 | 3.1.26.4 |  |
9 | 7bfqB2 | 7bfq | 0.540 | 1.801 | 0.10 | 0.09 | 1.58 | 0.58 | template_9 | template_9 |  |  |  |  |  |
10 | 4b0aA2 | 4b0a | 0.474 | 2.608 | 0.11 | 0.11 | 1.42 | 0.57 | template_10 | template_10 | GO:0003677 | GO:0006352 |  | 2.3.1.48 | CA | G21 S24

Templates from FFAS3D

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 2hg7A | 2hg7 | 0.255 | 3.628 | 0.10 | 0.09 | 1.05 | 0.38 | template_1 | template_1 |  |  |  |  |  |
2 | 1oltA2 | 1olt | 0.226 | 3.513 | 0.15 | 0.14 | 1.42 | 0.35 | template_2 | template_2 | GO:0004109,GO:0003824,GO:0051536,GO:0051539,GO:0046872,GO:0016491,GO:0051989 | GO:0006779,GO:0055114,GO:0006782 | GO:0005737 | 1.3.98.3 |  |
3 | 2ebbA | 2ebb | 0.175 | 3.657 | 0.14 | 0.12 | 1.68 | 0.35 | template_3 | template_3 | GO:0008124,GO:0016829 | GO:0006729 |  | 4.2.1.96 |  |
4 | 2v6uA | 2v6u | 0.146 | 3.775 | 0.20 | 0.18 | 1.81 | 0.35 | template_4 | template_4 | GO:0008124,GO:0016829 | GO:0006729 |  | 4.2.1.96 |  |
5 | 3j21k2 | 3j21 | 0.292 | 3.726 | 0.20 | 0.16 | 1.33 | 0.33 | template_5 | template_5 |  |  |  |  |  |
6 | 4ftfA | 4ftf | 0.248 | 3.763 | 0.12 | 0.11 | 1.91 | 0.32 | template_6 | template_6 |  |  |  |  |  |
7 | 5wq8A4 | 5wq8 | 0.343 | 2.393 | 0.05 | 0.04 | 1.11 | 0.31 | template_7 | template_7 | GO:0008565,GO:0042802 | GO:0009306,GO:0015628,GO:0015031 | GO:0015627,GO:0019867,GO:0016020,GO:0009279 |  |  |
8 | 1usoB | 1uso | 0.263 | 3.210 | 0.20 | 0.18 | 1.37 | 0.31 | template_8 | template_8 | GO:0008124,GO:0016829 | GO:0006729 |  |  |  |
9 | 2npbA | 2npb | 0.182 | 3.406 | 0.17 | 0.16 | 1.54 | 0.31 | template_9 | template_9 | GO:0016209,GO:0016491 | GO:0098869,GO:0055114,GO:0010269 | GO:0005829,GO:0005737,GO:0005886 |  |  |
10 | 1y30A | 1y30 | 0.226 | 4.109 | 0.07 | 0.07 | 2.51 | 0.31 | template_10 | template_10 | GO:0048037,GO:0070967,GO:0016627,GO:0016491,GO:0042803,GO:0010181,GO:0030170,GO:0070402,GO:0071949 | GO:0055114,GO:0042816 | GO:0005829 |  | FMN | Q28 S30 N31 V32 Q33 S46 R51 A52 K53

Templates from EigenThreader

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 7agvA1 | 7agv | 0.423 | 3.351 | 0.06 | 0.05 | 1.37 | 0.78 | template_1 | template_1 |  |  |  |  |  |
2 | 3qmfA1 | 3qmf | 0.401 | 3.015 | 0.08 | 0.07 | 2.33 | 0.75 | template_2 | template_2 |  | GO:0046854 |  | 3.1.3.25 |  |
3 | 7cunI2 | 7cun | 0.438 | 2.078 | 0.16 | 0.16 | 1.35 | 0.73 | template_3 | template_3 |  |  |  |  |  |
4 | 5v8wA | 5v8w | 0.518 | 1.882 | 0.18 | 0.18 | 1.35 | 0.73 | template_4 | template_4 |  |  |  |  |  |
5 | 7bfqB2 | 7bfq | 0.496 | 1.983 | 0.05 | 0.05 | 1.58 | 0.68 | template_5 | template_5 |  |  |  |  |  |
6 | 6gykO1 | 6gyk | 0.394 | 2.882 | 0.10 | 0.09 | 1.74 | 0.63 | template_6 | template_6 | GO:0000978,GO:0008134,GO:0003700,GO:0000979,GO:0000995,GO:0016251,GO:0001016,GO:0001186,GO:0001179,GO:0001102,GO:0003677,GO:0097718,GO:0005515,GO:0001092,GO:0003682,GO:0008301 | GO:0006366,GO:0001188,GO:0006355,GO:0070898,GO:0070893,GO:0042790,GO:0051123 | GO:0005667,GO:0005669,GO:0000126,GO:0005634,GO:0005672,GO:0032991,GO:0005654 |  |  |
7 | 5lhxA | 5lhx | 0.380 | 2.912 | 0.08 | 0.07 | 1.53 | 0.63 | template_7 | template_7 | GO:0004674 | GO:0006468,GO:0007099 | GO:0005814 | 2.7.11.21 |  |
8 | 2f7lA3 | 2f7l | 0.453 | 2.132 | 0.21 | 0.21 | 1.53 | 0.62 | template_8 | template_8 | GO:0016868,GO:0000287,GO:0008966,GO:0016853,GO:0046872 | GO:0005975,GO:0071704 |  | 5.4.2.2,5.4.2.8 |  |
9 | 6ewjA | 6ewj | 0.234 | 3.919 | 0.04 | 0.04 | 7.00 | 0.62 | template_9 | template_9 | GO:0003824 |  |  |  |  |
10 | 2iy0A | 2iy0 | 0.387 | 3.138 | 0.04 | 0.04 | 3.96 | 0.62 | template_10 | template_10 | GO:0008234 | GO:0006508 |  | 3.4.22.- |  |

Templates from HHpred

Rank | PDB Hit | RCSB Link | CMO | MAE | ID1 | ID2 | Cov | Norm. Zscore | Download PDB | Download FASTA | Gene_Ontology_(GO)_term (Molecular_Function) | Gene_Ontology_(GO)_term (Biological_Process) | Gene_Ontology_(GO)_term (Cellular_Componenet) | Enzyme_Commission (EC)_number | Ligand | Binding site residues
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
1 | 7mj0A | 7mj0 | 0.358 | 3.823 | 0.25 | 0.25 | 3.54 | 0.35 | template_1 | template_1 |  |  |  |  |  |

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References:
1. | W Zheng, Q Wuyun, X Zhou, Y Li, P Freddolino, Y Zhang. LOMETS3: Integrating deep-learning and profile-alignment for advanced protein template recognition and function annotation. Nucleic Acids Research, 50: W454-W464 (2022)
2. | W Zheng, C Zhang, Q Wuyun, R Pearce, Y Li, Y Zhang. LOMETS2: improved meta-threading server for fold-recognition and structure-based function annotation for distant-homology proteins. Nucleic Acids Research, 47: W429-W436 (2019).
3. | S Wu, Y Zhang. LOMETS: A local meta-threading-server for protein structure prediction. Nucleic Acids Research, 35: 3375-3382 (2007).