MetaGO server

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MetaGO is an algorithm for predicting Gene Ontology (GO) of proteins. It consists of three pipelines to detect functional homologs through (1) local and global structure alignments, (2) sequence and sequence profile comparison, and (3) partner-homology based protein-protein interaction mapping. The final function insights are a combination of the three pipelines through logistic regression. (view an example of MetaGO prediction)

MetaGO On-Line

Structure of Query Protein (Mandatory, [30,1500] residues in PDB format)
Copy and paste your structure file here Sample input

Or upload the stucture file from your local computer

Sequence of Query Protein (Optional, [30,1500] residues in FASTA format)
Copy and paste your sequence file here Sample input

Or upload the sequence file from your local computer

Email: (Mandatory, where results will be sent to)

Job ID: (Optional, your given name to this protein)

Advanced options

MetaGO Download

Reference:

Chengxin Zhang, Wei Zheng, Peter L. Freddolino, and Yang Zhang. MetaGO: Predicting Gene Ontology of non-homologous proteins through low-resolution protein structure prediction and protein-protein network mapping. Journal of Molecular Biology, 430: 2256-2265 (2018). [PDF] [Support Information] [Server]

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