Programs and source code

• SSIPe standalone program and source code

Libraries and databases

• NIL library
• STRING sequence and linkscore database with confidence score ≥ 0.7

Training and independent test sets

• Training Set, compiled from SKEMPI 2.0, consists of 1470 mutations from 118 dimer structures.
• Test Set 1, compiled from SKEMPI 2.0, consists of 734 mutations from 59 dimer structures.
• Test Set 2, compiled from SKEMPI 2.0, consists of 888 mutations from 153 dimer structures split from 86 complexes having three or more chains.
• Test set 3 (Target T55 of 26^th CAPRI), consists of 190 mutations from 2 dimer structures split from 1 complex with three or more chains.
• Test set 4 (Target T56 of 26^th CAPRI), consists of 152 mutations from 2 dimer structures split from 1 complex with three or more chains.

Results

• SSIPe Results
• SSIPe versus other methods on Test Set 1

Reference

• Xiaoqiang Huang, Wei Zheng, Robin Pearce, Yang Zhang. SSIPe: accurately estimating protein-protein binding affinity change upon mutations using evolutionary profiles in combination with an optimized physical energy function. Bioinformatics (2019) https://doi.org/10.1093/bioinformatics/btz926