StarFunc result for job id A0A1W2PP81

User Input

>input (198 residues)
METGRQTGVSAEMLAMPRGLKGSKKDGIPEDLDGNLEAPRDQEGELRSEDVMDLTEGDSE
ASASAPPAAKRRKTHTKGKKESKPTVDAEEAQRMTTLLSAMSEEQLSRYEVCRRSAFPRA
RVAGLMRAITGSSVSENAAIAMAGIAKLFVGEVVEEALDVCEMWGETPPLQPKHLREAVR
RLKPKGLFPNSNCKRIMF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:Q15544	0.555	0.524	4.098E-15	211	0.535	0.502	Q15544.pdb.gz	TAF11_HUMAN Transcription initiation factor TFIID subunit 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1
2	AFDB:Q99JX1	0.598	0.564	5.925E-15	211	0.540	0.507	Q99JX1.pdb.gz	TAF11_MOUSE Transcription initiation factor TFIID subunit 11 OS=Mus musculus OX=10090 GN=Taf11 PE=1 SV=1
3	AFDB:P49906	0.550	0.556	1.407E-12	196	0.379	0.383	P49906.pdb.gz	TAF11_DROME Transcription initiation factor TFIID subunit 11 OS=Drosophila melanogaster OX=7227 GN=Taf11 PE=1 SV=1
4	AFDB:Q9US54	0.494	0.492	4.541E-10	199	0.298	0.296	Q9US54.pdb.gz	TAF11_SCHPO Transcription initiation factor TFIID subunit 11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=taf11 PE=3 SV=1
5	AFDB:A0A3B3ITY8	0.361	0.359	6.566E-10	200	0.439	0.435	A0A3B3ITY8.pdb.gz	A0A3B3ITY8_HUMAN TATA-box binding protein associated factor 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1
6	PDB:7edxk	0.450	0.878	1.024E-9	98	0.348	0.704	7edxk.pdb.gz	Structural insights into preinitiation complex assembly on core promoters.
7	AFDB:Q9M565	0.523	0.494	7.215E-9	210	0.308	0.290	Q9M565.pdb.gz	TAF11_ARATH Transcription initiation factor TFIID subunit 11 OS=Arabidopsis thaliana OX=3702 GN=TAF11 PE=1 SV=1
8	PDB:1bfmA	0.323	0.857	6.972E-3	69	0.076	0.217	1bfmA.pdb.gz
9	PDB:2rvqD	0.316	0.466	1.072E-2	129	0.101	0.155	2rvqD.pdb.gz
10	PDB:5y27A	0.338	0.652	1.371E-2	98	0.086	0.173	5y27A.pdb.gz
11	PDB:2rvqC	0.325	0.459	1.753E-2	133	0.131	0.195	2rvqC.pdb.gz
12	PDB:5z30G	0.301	0.513	1.753E-2	110	0.106	0.191	5z30G.pdb.gz	Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.
13	PDB:7egdF	0.327	0.159	1.753E-2	412	0.040	0.019	7egdF.pdb.gz	Structural insights into preinitiation complex assembly on core promoters.
14	PDB:4draH	0.315	0.758	1.864E-2	76	0.071	0.184	4draH.pdb.gz
15	PDB:1jfiB	0.333	0.479	3.048E-2	135	0.066	0.096	1jfiB.pdb.gz	Crystal structure of negative cofactor 2 recognizing the TBP-DNA transcription complex.
16	PDB:5y26B	0.304	0.624	3.048E-2	92	0.061	0.130	5y26B.pdb.gz
17	AFDB:Q8IHQ2	0.333	0.058	5.222E-2	1301	0.111	0.017	Q8IHQ2.pdb.gz	Q8IHQ2_PLAF7 Oocyst rupture protein 1, putative OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1146600 PE=3 SV=1
18	AFDB:Q9U226	0.321	0.190	1.235E-1	342	0.111	0.064	Q9U226.pdb.gz	TAF12_CAEEL Transcription initiation factor TFIID subunit 12 OS=Caenorhabditis elegans OX=6239 GN=taf-12 PE=1 SV=2
19	AFDB:Q9W3V9	0.321	0.111	1.785E-1	601	0.152	0.050	Q9W3V9.pdb.gz	Q9W3V9_DROME Nuclear factor Y-box C OS=Drosophila melanogaster OX=7227 GN=Nf-YC PE=1 SV=1
20	AFDB:Q54F38	0.339	0.117	2.283E-1	619	0.167	0.053	Q54F38.pdb.gz	H3V1_DICDI Histone H3.v1 OS=Dictyostelium discoideum OX=44689 GN=H3v1 PE=3 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	Q15544	1.77e-65	202	211	0.576	0.540	TAF11_HUMAN Transcription initiation factor TFIID subunit 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1
2	Q99JX1	1.34e-62	195	211	0.561	0.526	TAF11_MOUSE Transcription initiation factor TFIID subunit 11 OS=Mus musculus OX=10090 GN=Taf11 PE=1 SV=1
3	A0A3B3ITY8	1.26e-37	130	200	0.419	0.415	A0A3B3ITY8_HUMAN TATA-box binding protein associated factor 11 OS=Homo sapiens OX=9606 GN=TAF11 PE=1 SV=1
4	P49906	5.68e-36	126	196	0.318	0.321	TAF11_DROME Transcription initiation factor TFIID subunit 11 OS=Drosophila melanogaster OX=7227 GN=Taf11 PE=1 SV=1
5	Q9US54	5.14e-23	93.2	199	0.237	0.236	TAF11_SCHPO Transcription initiation factor TFIID subunit 11 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=taf11 PE=3 SV=1
6	Q9M565	6.31e-19	82.8	210	0.232	0.219	TAF11_ARATH Transcription initiation factor TFIID subunit 11 OS=Arabidopsis thaliana OX=3702 GN=TAF11 PE=1 SV=1
7	Q04226	1.38e-07	52.8	346	0.111	0.064	TAF11_YEAST Transcription initiation factor TFIID subunit 11 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=TAF11 PE=1 SV=1
8	Q8TF80	0.42	33.1	269	0.126	0.093	WTF5_SCHPO Meiotic drive suppressor wtf5 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=wtf5 PE=3 SV=1
9	Q86XD5	1.0	32.3	332	0.056	0.033	F131B_HUMAN Protein FAM131B OS=Homo sapiens OX=9606 GN=FAM131B PE=1 SV=3
10	O50064	4.8	30.4	654	0.136	0.041	FIMB2_ARATH Fimbrin-2 OS=Arabidopsis thaliana OX=3702 GN=FIM2 PE=2 SV=1
11	U3H0P2	5.6	30.0	249	0.111	0.088	WTF25_SCHPO Meiotic drive suppressor wtf25 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=wtf25 PE=3 SV=1
12	O74474	9.1	29.3	329	0.106	0.064	WTF21_SCHPO Meiotic drive suppressor wtf21 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=wtf21 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00808 CBFD_NFYB_HMF	0.058	25.0	Histone-like transcription factor (CBF/NF-Y) and archaeal histone
2	PF00125 Histone	88	14.8	Core histone H2A/H2B/H3/H4
3	PF14695 LINES_C	1.9e+02	12.9	Lines C-terminus
4	PF04719 TAFII28	6.6e-28	107.9	hTAFII28-like protein conserved region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9593.ENSGGOP00000027441

Rank	PPI partner	STRING score	Description
1	9593.ENSGGOP00000002710	0.924	TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
2	9593.ENSGGOP00000007336	0.924	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
3	9593.ENSGGOP00000000388	0.921	Transcription initiation factor TFIID subunit 10
4	9593.ENSGGOP00000008371	0.914	TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
5	9593.ENSGGOP00000008899	0.913	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
6	9593.ENSGGOP00000005330	0.889	TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
7	9593.ENSGGOP00000027533	0.888	TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
8	9593.ENSGGOP00000016296	0.883	TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
9	9593.ENSGGOP00000002080	0.859	Uncharacterized protein
10	9593.ENSGGOP00000003902	0.859	TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
11	9593.ENSGGOP00000009307	0.855	Uncharacterized protein
12	9593.ENSGGOP00000023578	0.855	Uncharacterized protein
13	9593.ENSGGOP00000001038	0.851	TATA box binding protein like 2
14	9593.ENSGGOP00000002430	0.851	TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
15	9593.ENSGGOP00000004050	0.851	TATA-box binding protein associated factor 9
16	9593.ENSGGOP00000011550	0.851	TATA box binding protein
17	9593.ENSGGOP00000015303	0.851	Transcription initiation factor TFIID subunit
18	9593.ENSGGOP00000026097	0.851	Transcription initiation factor TFIID subunit
19	9593.ENSGGOP00000018571	0.846	TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
20	9593.ENSGGOP00000011524	0.836	TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0140223	0.955	general transcription initiation factor activity
GO:0003676	0.948	nucleic acid binding
GO:0016251	0.947	RNA polymerase II general transcription initiation factor activity
GO:0003677	0.897	DNA binding
GO:0140110	0.339	transcription regulator activity
GO:0008134	0.334	transcription factor binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0060255	0.985	regulation of macromolecule metabolic process
GO:0010468	0.978	regulation of gene expression
GO:0009987	0.973	cellular process
GO:0048518	0.973	positive regulation of biological process
GO:0071704	0.917	organic substance metabolic process
GO:0044237	0.915	cellular metabolic process
GO:0044238	0.912	primary metabolic process
GO:0050794	0.902	regulation of cellular process
GO:0006807	0.899	nitrogen compound metabolic process
GO:0009058	0.896	biosynthetic process
GO:1901576	0.891	organic substance biosynthetic process
GO:0044249	0.891	cellular biosynthetic process
GO:1901360	0.888	organic cyclic compound metabolic process
GO:0046483	0.888	heterocycle metabolic process
GO:0043170	0.884	macromolecule metabolic process
GO:0034654	0.879	nucleobase-containing compound biosynthetic process
GO:0097659	0.865	nucleic acid-templated transcription
GO:0006351	0.864	DNA-templated transcription
GO:0006366	0.825	transcription by RNA polymerase II
GO:0010604	0.709	positive regulation of macromolecule metabolic process
GO:0080090	0.677	regulation of primary metabolic process
GO:0051171	0.677	regulation of nitrogen compound metabolic process
GO:0031323	0.676	regulation of cellular metabolic process
GO:0019219	0.674	regulation of nucleobase-containing compound metabolic process
GO:0006352	0.651	DNA-templated transcription initiation
GO:0051252	0.639	regulation of RNA metabolic process
GO:0006367	0.639	transcription initiation at RNA polymerase II promoter
GO:0071840	0.629	cellular component organization or biogenesis
GO:0016043	0.618	cellular component organization
GO:0048522	0.539	positive regulation of cellular process
GO:0010556	0.533	regulation of macromolecule biosynthetic process
GO:0031326	0.533	regulation of cellular biosynthetic process
GO:1903506	0.516	regulation of nucleic acid-templated transcription
GO:0006355	0.514	regulation of DNA-templated transcription
GO:0031325	0.492	positive regulation of cellular metabolic process
GO:0051173	0.491	positive regulation of nitrogen compound metabolic process
GO:0051254	0.466	positive regulation of RNA metabolic process
GO:0031328	0.462	positive regulation of cellular biosynthetic process
GO:0010557	0.460	positive regulation of macromolecule biosynthetic process
GO:1903508	0.426	positive regulation of nucleic acid-templated transcription
GO:0045893	0.419	positive regulation of DNA-templated transcription
GO:0006357	0.360	regulation of transcription by RNA polymerase II
GO:0045944	0.315	positive regulation of transcription by RNA polymerase II

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005634	0.998	nucleus
GO:0005654	0.986	nucleoplasm
GO:0005737	0.752	cytoplasm
GO:0032991	0.568	protein-containing complex
GO:1902494	0.306	catalytic complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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