StarFunc result for job id A6NMY6

User Input

>input (339 residues)
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNIV
TNRDNAQRQDIVFSYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKG
LGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRA
EDGSVIDYELIDQDAQDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDM
LESIRKEVKGDLENAFLNLVQRIQNKPLYFADQLYDSMKGKGTRDKVLIRIMVSRSEVDM
LKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A6NMY6	1.000	1.000	1.058E-47	339	1.000	1.000	A6NMY6.pdb.gz	AXA2L_HUMAN Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2
2	PDB:7p70A	0.945	0.787	5.041E-43	407	0.914	0.762	7p70A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
3	PDB:7p73A	0.936	0.756	1.612E-42	420	0.914	0.738	7p73A.pdb.gz	Quantitative fragmentomics allow affinity mapping of interactomes.
4	AFDB:P17785	0.940	0.940	1.981E-42	339	0.876	0.876	P17785.pdb.gz	ANXA2_CHICK Annexin A2 OS=Gallus gallus OX=9031 GN=ANXA2 PE=1 SV=2
5	PDB:5n7dA	0.941	0.754	6.674E-42	423	0.914	0.733	5n7dA.pdb.gz	Dynamic control of RSK complexes by phosphoswitch-based regulation.
6	PDB:7qqnC	0.917	0.753	8.835E-41	414	0.917	0.751	7qqnC.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
7	PDB:7pc3A	0.901	0.755	3.658E-40	405	0.894	0.748	7pc3A.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
8	PDB:7nmiB	0.905	0.629	5.626E-40	488	0.885	0.615	7nmiB.pdb.gz	Transactivation domain of p53 in complex with S100P using annexin A2 as a crystallization chaperone
9	PDB:6t58A	0.911	0.590	6.977E-40	524	0.906	0.586	6t58A.pdb.gz	Structure Determination of the Transactivation Domain of p53 in Complex with S100A4 Using Annexin A2 as a Crystallization Chaperone.
10	PDB:7pcbA	0.904	0.739	7.284E-40	415	0.891	0.728	7pcbA.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
11	PDB:7pc5A	0.906	0.759	1.389E-39	405	0.891	0.746	7pc5A.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
12	PDB:7qqmA	0.904	0.743	4.256E-39	413	0.914	0.751	7qqmA.pdb.gz	A scalable strategy to solve structures of PDZ domains and their complexes.
13	AFDB:Q7T3A8	0.916	0.913	2.641E-31	340	0.519	0.518	Q7T3A8.pdb.gz
14	AFDB:P14669	0.921	0.963	1.118E-29	324	0.448	0.469	P14669.pdb.gz	ANXA3_RAT Annexin A3 OS=Rattus norvegicus OX=10116 GN=Anxa3 PE=1 SV=4
15	AFDB:P12429	0.918	0.962	1.578E-29	323	0.442	0.464	P12429.pdb.gz	ANXA3_HUMAN Annexin A3 OS=Homo sapiens OX=9606 GN=ANXA3 PE=1 SV=3
16	AFDB:P09525	0.911	0.967	2.427E-29	319	0.454	0.483	P09525.pdb.gz	ANXA4_HUMAN Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4
17	AFDB:P81287	0.919	0.969	8.457E-29	321	0.428	0.452	P81287.pdb.gz	ANXA5_BOVIN Annexin A5 OS=Bos taurus OX=9913 GN=ANXA5 PE=1 SV=3
18	AFDB:P50995	0.916	0.618	9.623E-29	505	0.442	0.297	P50995.pdb.gz	ANX11_HUMAN Annexin A11 OS=Homo sapiens OX=9606 GN=ANXA11 PE=1 SV=1
19	AFDB:P07150	0.901	0.883	1.005E-28	346	0.499	0.488	P07150.pdb.gz	ANXA1_RAT Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2
20	AFDB:B5XAE0	0.905	0.967	1.143E-28	317	0.422	0.451	B5XAE0.pdb.gz	B5XAE0_SALSA Annexin OS=Salmo salar OX=8030 GN=ANXA5 PE=2 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A6NMY6	0.0	693	339	1.000	1.000	AXA2L_HUMAN Putative annexin A2-like protein OS=Homo sapiens OX=9606 GN=ANXA2P2 PE=5 SV=2
2	P04272	0.0	669	339	0.962	0.962	ANXA2_BOVIN Annexin A2 OS=Bos taurus OX=9913 GN=ANXA2 PE=1 SV=2
3	P07355	0.0	680	339	0.979	0.979	ANXA2_HUMAN Annexin A2 OS=Homo sapiens OX=9606 GN=ANXA2 PE=1 SV=2
4	P07356	0.0	664	339	0.956	0.956	ANXA2_MOUSE Annexin A2 OS=Mus musculus OX=10090 GN=Anxa2 PE=1 SV=2
5	P17785	0.0	619	339	0.876	0.876	ANXA2_CHICK Annexin A2 OS=Gallus gallus OX=9031 GN=ANXA2 PE=1 SV=2
6	P19620	0.0	662	339	0.959	0.959	ANXA2_PIG Annexin A2 OS=Sus scrofa OX=9823 GN=ANXA2 PE=1 SV=4
7	Q07936	0.0	661	339	0.947	0.947	ANXA2_RAT Annexin A2 OS=Rattus norvegicus OX=10116 GN=Anxa2 PE=1 SV=2
8	Q6TEQ7	0.0	671	339	0.968	0.968	ANXA2_CANLF Annexin A2 OS=Canis lupus familiaris OX=9615 GN=ANXA2 PE=1 SV=1
9	P07150	2.81e-115	339	346	0.499	0.488	ANXA1_RAT Annexin A1 OS=Rattus norvegicus OX=10116 GN=Anxa1 PE=1 SV=2
10	P10107	1.72e-114	337	346	0.499	0.488	ANXA1_MOUSE Annexin A1 OS=Mus musculus OX=10090 GN=Anxa1 PE=1 SV=2
11	Q804H2	2.45e-114	337	340	0.528	0.526	Q804H2_DANRE Annexin OS=Danio rerio OX=7955 GN=anx1a PE=1 SV=1
12	P04083	4.77e-113	333	346	0.504	0.494	ANXA1_HUMAN Annexin A1 OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=2
13	Q5TZZ9	4.77e-113	333	346	0.504	0.494	Q5TZZ9_HUMAN Annexin OS=Homo sapiens OX=9606 GN=ANXA1 PE=1 SV=1
14	P19619	1.09e-112	333	346	0.513	0.503	ANXA1_PIG Annexin A1 OS=Sus scrofa OX=9823 GN=ANXA1 PE=1 SV=3
15	P46193	1.37e-111	330	346	0.504	0.494	ANXA1_BOVIN Annexin A1 OS=Bos taurus OX=9913 GN=ANXA1 PE=1 SV=2
16	P97429	1.16e-101	303	319	0.466	0.495	ANXA4_MOUSE Annexin A4 OS=Mus musculus OX=10090 GN=Anxa4 PE=1 SV=4
17	P09525	4.54e-100	300	319	0.454	0.483	ANXA4_HUMAN Annexin A4 OS=Homo sapiens OX=9606 GN=ANXA4 PE=1 SV=4
18	P13214	1.05e-99	298	319	0.457	0.486	ANXA4_BOVIN Annexin A4 OS=Bos taurus OX=9913 GN=ANXA4 PE=1 SV=2
19	P17153	1.33e-97	293	321	0.442	0.467	ANXA5_CHICK Annexin A5 OS=Gallus gallus OX=9031 GN=ANXA5 PE=1 SV=2
20	P14669	2.37e-97	293	324	0.451	0.472	ANXA3_RAT Annexin A3 OS=Rattus norvegicus OX=10116 GN=Anxa3 PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00191 Annexin	1.6e-88	302.0	Annexin
2	PF18947 HAMP_2	1.4e+02	13.9	HAMP domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61853.ENSNLEP00000014373

Rank	PPI partner	STRING score	Description
1	61853.ENSNLEP00000015913	0.999	S100 calcium binding protein A10
2	61853.ENSNLEP00000012660	0.938	S100 calcium binding protein A4
3	61853.ENSNLEP00000015584	0.917	Plasminogen activator, tissue
4	61853.ENSNLEP00000013885	0.888	Plasminogen
5	61853.ENSNLEP00000004250	0.884	AHNAK nucleoprotein
6	61853.ENSNLEP00000012569	0.868	Belongs to the S-100 family.
7	61853.ENSNLEP00000022618	0.868	Belongs to the S-100 family.
8	61853.ENSNLEP00000012592	0.863	Dysferlin
9	61853.ENSNLEP00000017752	0.862	Proprotein convertase subtilisin/kexin type 9
10	61853.ENSNLEP00000018335	0.837	Cathepsin B
11	61853.ENSNLEP00000019881	0.816	annotation not available
12	61853.ENSNLEP00000012667	0.814	S100 calcium binding protein A2
13	61853.ENSNLEP00000001633	0.813	Annexin A1
14	61853.ENSNLEP00000012655	0.809	S100 calcium binding protein A6
15	61853.ENSNLEP00000023611	0.747	Prohibitin
16	61853.ENSNLEP00000015544	0.739	Galectin
17	61853.ENSNLEP00000008139	0.738	Secretory leukocyte peptidase inhibitor
18	61853.ENSNLEP00000005416	0.713	Synaptosomal-associated protein, 23kDa
19	61853.ENSNLEP00000010020	0.708	Cell division cycle 42
20	61853.ENSNLEP00000014017	0.703	May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By [...]

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.998	protein binding
GO:0005543	0.998	phospholipid binding
GO:0005544	0.889	calcium-dependent phospholipid binding
GO:0043167	0.836	ion binding
GO:0098772	0.410	molecular function regulator activity
GO:0035091	0.317	phosphatidylinositol binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050789	0.993	regulation of biological process
GO:0009987	0.990	cellular process
GO:0050794	0.983	regulation of cellular process
GO:0048518	0.960	positive regulation of biological process
GO:0019222	0.957	regulation of metabolic process
GO:0050896	0.956	response to stimulus
GO:0060255	0.945	regulation of macromolecule metabolic process
GO:0048856	0.938	anatomical structure development
GO:0080090	0.937	regulation of primary metabolic process
GO:0051171	0.935	regulation of nitrogen compound metabolic process
GO:0032501	0.886	multicellular organismal process
GO:0051246	0.853	regulation of protein metabolic process
GO:1900046	0.843	regulation of hemostasis
GO:0048522	0.822	positive regulation of cellular process
GO:0048583	0.810	regulation of response to stimulus
GO:0032879	0.805	regulation of localization
GO:0048519	0.802	negative regulation of biological process
GO:0061041	0.791	regulation of wound healing
GO:0051173	0.772	positive regulation of nitrogen compound metabolic process
GO:0007275	0.754	multicellular organism development
GO:0050818	0.740	regulation of coagulation
GO:0010604	0.733	positive regulation of macromolecule metabolic process
GO:0051179	0.727	localization
GO:0010468	0.721	regulation of gene expression
GO:0065009	0.704	regulation of molecular function
GO:0051234	0.698	establishment of localization
GO:0051716	0.684	cellular response to stimulus
GO:0006810	0.670	transport
GO:0051247	0.661	positive regulation of protein metabolic process
GO:0031323	0.643	regulation of cellular metabolic process
GO:0031214	0.641	biomineral tissue development
GO:0071704	0.638	organic substance metabolic process
GO:0048731	0.613	system development
GO:0030154	0.609	cell differentiation
GO:0009653	0.573	anatomical structure morphogenesis
GO:0044419	0.568	biological process involved in interspecies interaction between organisms
GO:0051049	0.549	regulation of transport
GO:0042221	0.523	response to chemical
GO:0071840	0.513	cellular component organization or biogenesis
GO:0010605	0.508	negative regulation of macromolecule metabolic process
GO:0044238	0.499	primary metabolic process
GO:0048523	0.487	negative regulation of cellular process
GO:0051172	0.479	negative regulation of nitrogen compound metabolic process
GO:0007154	0.472	cell communication
GO:0023052	0.470	signaling
GO:0006807	0.470	nitrogen compound metabolic process
GO:0016043	0.467	cellular component organization
GO:0007165	0.458	signal transduction
GO:0043170	0.451	macromolecule metabolic process
GO:0044403	0.450	biological process involved in symbiotic interaction
GO:0051641	0.423	cellular localization
GO:0051128	0.419	regulation of cellular component organization
GO:0006950	0.407	response to stress
GO:0051050	0.391	positive regulation of transport
GO:1903317	0.391	regulation of protein maturation
GO:0031325	0.381	positive regulation of cellular metabolic process
GO:0051248	0.367	negative regulation of protein metabolic process
GO:0044093	0.328	positive regulation of molecular function
GO:0023051	0.323	regulation of signaling
GO:0072359	0.318	circulatory system development
GO:0044237	0.315	cellular metabolic process
GO:0032101	0.301	regulation of response to external stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071944	1.000	cell periphery
GO:0016020	1.000	membrane
GO:0031982	1.000	vesicle
GO:0012505	0.998	endomembrane system
GO:0005737	0.998	cytoplasm
GO:0005576	0.977	extracellular region
GO:0043231	0.974	intracellular membrane-bounded organelle
GO:0032991	0.969	protein-containing complex
GO:0005886	0.966	plasma membrane
GO:0005829	0.950	cytosol
GO:0070062	0.881	extracellular exosome
GO:0043233	0.855	organelle lumen
GO:0070013	0.850	intracellular organelle lumen
GO:0031410	0.825	cytoplasmic vesicle
GO:0005634	0.815	nucleus
GO:0031012	0.636	extracellular matrix
GO:0062023	0.593	collagen-containing extracellular matrix
GO:0099503	0.401	secretory vesicle
GO:0031090	0.370	organelle membrane
GO:0098588	0.315	bounding membrane of organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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