StarFunc result for job id B3EWG5

User Input

>input (89 residues)
MLGGLGKLAAEGLAHRTEKATEGAIHAVEEVVKEVVGHAKETGEKAIAEAIKKAQESGDK
KMKEITETVTNTVTNAITHAAESLDKLGQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:B3EWG5	1.000	1.000	8.324E-11	89	1.000	1.000	B3EWG5.pdb.gz	FM25C_HUMAN Protein FAM25C OS=Homo sapiens OX=9606 GN=FAM25C PE=1 SV=1
2	AFDB:I3L3T1	0.505	0.430	9.055	107	0.101	0.084	I3L3T1.pdb.gz	I3L3T1_HUMAN 14-3-3 protein epsilon OS=Homo sapiens OX=9606 GN=YWHAE PE=1 SV=1
3	AFDB:P61981	0.433	0.172	9.055	247	0.090	0.032	P61981.pdb.gz	1433G_HUMAN 14-3-3 protein gamma OS=Homo sapiens OX=9606 GN=YWHAG PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B3EWG5	1.87e-55	167	89	1.000	1.000	FM25C_HUMAN Protein FAM25C OS=Homo sapiens OX=9606 GN=FAM25C PE=1 SV=1
2	P53694	2.3	28.9	308	0.135	0.039	RTN1_SCHPO Reticulon-like protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=rtn1 PE=1 SV=1
3	W6RTA4	3.6	28.5	8922	0.247	0.002	CLA1_CAEEL Protein clarinet OS=Caenorhabditis elegans OX=6239 GN=cla-1 PE=1 SV=2
4	Q9LF41	3.7	28.1	1038	0.225	0.019	UBE4_ARATH Probable ubiquitin conjugation factor E4 OS=Arabidopsis thaliana OX=3702 GN=PUB1 PE=2 SV=1
5	P77872	4.6	28.1	505	0.225	0.040	CATA_HELPY Catalase OS=Helicobacter pylori (strain ATCC 700392 / 26695) OX=85962 GN=katA PE=1 SV=2
6	A0A0G2JWX2	4.9	28.1	3121	0.146	0.004	A0A0G2JWX2_RAT Laminin subunit alpha 2 OS=Rattus norvegicus OX=10116 GN=Lama2 PE=1 SV=1
7	A0A8I5ZPP7	4.9	28.1	3137	0.146	0.004	A0A8I5ZPP7_RAT Laminin subunit alpha 2 OS=Rattus norvegicus OX=10116 GN=Lama2 PE=1 SV=1
8	F1M614	5.0	28.1	3117	0.146	0.004	F1M614_RAT Laminin subunit alpha 2 OS=Rattus norvegicus OX=10116 GN=Lama2 PE=4 SV=4
9	Q80UP3	5.2	27.7	929	0.247	0.024	DGKZ_MOUSE Diacylglycerol kinase zeta OS=Mus musculus OX=10090 GN=Dgkz PE=1 SV=2
10	A6QGC0	5.6	27.7	664	0.213	0.029	PRKC_STAAE Serine/threonine-protein kinase PrkC OS=Staphylococcus aureus (strain Newman) OX=426430 GN=prkC PE=1 SV=1
11	Q9SPG1	5.6	27.7	286	0.180	0.056	Q9SPG1_ARATH Myb domain protein 42 OS=Arabidopsis thaliana OX=3702 GN=MYB42 PE=2 SV=1
12	Q9UTL9	5.9	27.7	1375	0.146	0.009	YIV5_SCHPO Uncharacterized ATP-dependent helicase C144.05 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC144.05 PE=3 SV=1
13	O96111	6.2	27.7	304	0.225	0.066	O96111_PLAF7 Stevor OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0200400 PE=4 SV=1
14	Q04228	6.3	27.7	584	0.247	0.038	UBX2_YEAST UBX domain-containing protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=UBX2 PE=1 SV=1
15	Q13574	6.7	27.7	928	0.247	0.024	DGKZ_HUMAN Diacylglycerol kinase zeta OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=4
16	Q9UPQ4	7.8	27.3	493	0.202	0.037	TRI35_HUMAN E3 ubiquitin-protein ligase TRIM35 OS=Homo sapiens OX=9606 GN=TRIM35 PE=1 SV=2
17	E9PNL8	7.9	27.3	707	0.247	0.031	E9PNL8_HUMAN Diacylglycerol kinase OS=Homo sapiens OX=9606 GN=DGKZ PE=1 SV=1
18	B7WN66	9.7	26.9	5085	0.225	0.004	B7WN66_CAEEL Ryanodine receptor 44F OS=Caenorhabditis elegans OX=6239 GN=unc-68 PE=1 SV=5
19	O08560	9.9	26.9	929	0.247	0.024	DGKZ_RAT Diacylglycerol kinase zeta OS=Rattus norvegicus OX=10116 GN=Dgkz PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF12862 ANAPC5	2e+02	13.4	Anaphase-promoting complex subunit 5
2	PF01442 Apolipoprotein	2.3e+02	13.0	Apolipoprotein A1/A4/E domain
3	PF03477 ATP-cone	4.4e+02	12.9	ATP cone domain
4	PF13690 CheX	9.3e+02	11.4	Chemotaxis phosphatase CheX
5	PF01610 DDE_Tnp_ISL3	13	16.9	Transposase
6	PF07311 Dodecin	4.2	19.1	Dodecin
7	PF11157 DUF2937	1.3e+02	13.8	Protein of unknown function (DUF2937)
8	PF20117 DUF6507	29	16.5	Family of unknown function (DUF6507)
9	PF15825 FAM25	2.5e-31	119.1	FAM25 family
10	PF02108 FliH	32	16.0	Flagellar assembly protein FliH
11	PF17681 GCP_N_terminal	3.1e+02	12.4	Gamma tubulin complex component N-terminal
12	PF00745 GlutR_dimer	12	17.7	Glutamyl-tRNAGlu reductase, dimerisation domain
13	PF09509 Hypoth_Ymh	1e+02	14.2	Protein of unknown function (Hypoth_ymh)
14	PF12998 ING	2.4e+02	13.7	Inhibitor of growth proteins N-terminal histone-binding
15	PF03036 Perilipin	59	14.1	Perilipin family
16	PF05597 Phasin	3.6e+02	12.6	Poly(hydroxyalcanoate) granule associated protein (phasin)
17	PF05480 PSMbeta	8.4e+02	11.2	Phenol-soluble modulin beta protein
18	PF01158 Ribosomal_L36e	30	16.3	Ribosomal protein L36e
19	PF19352 TetR_C_38	19	16.7	Tetracyclin repressor-like, C-terminal domain
20	PF20155 TMP_3	27	16.0	Tape measure protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9593.ENSGGOP00000015378

Rank	PPI partner	STRING score	Description
1	9593.ENSGGOP00000008879	0.646	Multimerin 2
2	9593.ENSGGOP00000016942	0.575	Adipogenesis regulatory factor

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0065007	0.999	biological regulation
GO:0050789	0.973	regulation of biological process
GO:0050794	0.953	regulation of cellular process
GO:0009987	0.614	cellular process
GO:0071704	0.548	organic substance metabolic process
GO:0048518	0.470	positive regulation of biological process
GO:0023051	0.387	regulation of signaling
GO:0010646	0.387	regulation of cell communication
GO:0048519	0.369	negative regulation of biological process
GO:0048523	0.320	negative regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043231	0.996	intracellular membrane-bounded organelle
GO:0070013	0.988	intracellular organelle lumen
GO:0005576	0.985	extracellular region
GO:0005615	0.972	extracellular space
GO:0005634	0.969	nucleus
GO:0005737	0.965	cytoplasm
GO:0005829	0.952	cytosol
GO:1903561	0.945	extracellular vesicle
GO:0070062	0.939	extracellular exosome
GO:0005654	0.899	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]