StarFunc result for job id O00329

User Input

>input (1044 residues)
MPPGVDCPMEFWTKEENQSVVVDFLLPTGVYLNFPVSRNANLSTIKQLLWHRAQYEPLFH
MLSGPEAYVFTCINQTAEQQELEDEQRRLCDVQPFLPVLRLVAREGDRVKKLINSQISLL
IGKGLHEFDSLCDPEVNDFRAKMCQFCEEAAARRQQLGWEAWLQYSFPLQLEPSAQTWGP
GTLRLPNRALLVNVKFEGSEESFTFQVSTKDVPLALMACALRKKATVFRQPLVEQPEDYT
LQVNGRHEYLYGSYPLCQFQYICSCLHSGLTPHLTMVHSSSILAMRDEQSNPAPQVQKPR
AKPPPIPAKKPSSVSLWSLEQPFRIELIQGSKVNADERMKLVVQAGLFHGNEMLCKTVSS
SEVSVCSEPVWKQRLEFDINICDLPRMARLCFALYAVIEKAKKARSTKKKSKKADCPIAW
ANLMLFDYKDQLKTGERCLYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAP
HPVYYPALEKILELGRHSECVHVTEEEQLQLREILERRGSGELYEHEKDLVWKLRHEVQE
HFPEALARLLLVTKWNKHEDVAQMLYLLCSWPELPVLSALELLDFSFPDCHVGSFAIKSL
RKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSV
ALRFGLILEAYCRGSTHHMKVLMKQGEALSKLKALNDFVKLSSQKTPKPQTKELMHLCMR
QEAYLEALSHLQSPLDPSTLLAEVCVEQCTFMDSKMKPLWIMYSNEEAGSGGSVGIIFKN
GDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLRSDTIANIQLN
KSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAGYCVATYVLGIGDRHSDNIM
IRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGYC
ERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKFN
EALRESWKTKVNWLAHNVSKDNRQ

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:6gy0A	0.773	0.980	0.000	822	0.745	0.946	6gy0A.pdb.gz	A class of highly selective inhibitors bind to an active state of PI3K gamma.
2	PDB:6pyuA	0.872	0.978	0.000	930	0.887	0.996	6pyuA.pdb.gz	Design of selective PI3K delta inhibitors using an iterative scaffold-hopping workflow.
3	PDB:7lq1A	0.890	0.977	0.000	950	0.908	0.998	7lq1A.pdb.gz	Discovery of a new series of PI3K-delta inhibitors from Virtual Screening.
4	AFDB:D4A5Q1	0.892	0.986	0.000	944	0.839	0.928	D4A5Q1.pdb.gz	D4A5Q1_RAT phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Rattus norvegicus OX=10116 GN=Pik3cd PE=3 SV=2
5	AFDB:F1NHX1	0.973	0.971	0.000	1046	0.825	0.823	F1NHX1.pdb.gz	F1NHX1_CHICK phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Gallus gallus OX=9031 GN=PIK3CD PE=3 SV=1
6	AFDB:F1RB17	0.973	0.977	0.000	1039	0.696	0.700	F1RB17.pdb.gz
7	AFDB:O00329	1.000	1.000	0.000	1044	1.000	1.000	O00329.pdb.gz	PK3CD_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2
8	AFDB:P42338	0.946	0.923	0.000	1070	0.580	0.565	P42338.pdb.gz	PK3CB_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1
9	PDB:4ajwB	0.744	0.979	1.088E-102	792	0.712	0.938	4ajwB.pdb.gz	Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
10	PDB:4ajwA	0.721	0.982	2.141E-96	765	0.690	0.941	4ajwA.pdb.gz	Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective Pi3Kbeta Inhibitors for the Treatment of Phosphatase and Tensin Homologue (Pten)-Deficient Cancers.
11	PDB:2y3aA	0.859	0.916	1.385E-88	976	0.553	0.591	2y3aA.pdb.gz	Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
12	AFDB:P91634	0.907	0.872	1.776E-88	1088	0.398	0.381	P91634.pdb.gz	P91634_DROME PI-3 kinase OS=Drosophila melanogaster OX=7227 GN=Pi3K92E PE=1 SV=1
13	AFDB:F1QAD7	0.909	0.889	4.711E-87	1069	0.400	0.391	F1QAD7.pdb.gz	F1QAD7_DANRE phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Danio rerio OX=7955 GN=pik3ca PE=3 SV=2
14	PDB:4yknA	0.859	0.748	7.472E-83	1205	0.394	0.341	4yknA.pdb.gz	Discovery of a Potent Class of PI3K alpha Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
15	PDB:5dxhD	0.836	0.887	8.225E-81	981	0.386	0.411	5dxhD.pdb.gz	The Rational Design of Selective Benzoxazepin Inhibitors of the alpha-Isoform of Phosphoinositide 3-Kinase Culminating in the Identification of (S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide (GDC-0326).
16	PDB:5itdA	0.854	0.894	1.161E-80	995	0.395	0.414	5itdA.pdb.gz	Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors.
17	PDB:5swpA	0.873	0.860	4.586E-77	1060	0.391	0.385	5swpA.pdb.gz	Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
18	AFDB:F1QVE6	0.798	0.761	6.323E-71	1098	0.325	0.309	F1QVE6.pdb.gz
19	AFDB:P54673	0.764	0.515	7.513E-71	1571	0.301	0.200	P54673.pdb.gz	PI3K1_DICDI Phosphatidylinositol 3-kinase 1 OS=Dictyostelium discoideum OX=44689 GN=pikA PE=2 SV=2
20	AFDB:A0A024R720	0.787	0.747	1.941E-70	1102	0.330	0.312	A0A024R720.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0G2K344	0.0	755	1068	0.412	0.403	PK3CA_RAT Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Rattus norvegicus OX=10116 GN=Pik3ca PE=1 SV=1
2	D4A5Q1	0.0	1622	944	0.782	0.864	D4A5Q1_RAT phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Rattus norvegicus OX=10116 GN=Pik3cd PE=3 SV=2
3	F1NHX1	0.0	1788	1046	0.824	0.822	F1NHX1_CHICK phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Gallus gallus OX=9031 GN=PIK3CD PE=3 SV=1
4	F1QAD7	0.0	763	1069	0.413	0.403	F1QAD7_DANRE phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Danio rerio OX=7955 GN=pik3ca PE=3 SV=2
5	H0Y871	0.0	917	702	0.436	0.648	H0Y871_HUMAN Phosphatidylinositol 3-kinase catalytic subunit type 3 (Fragment) OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1
6	O00329	0.0	2170	1044	1.000	1.000	PK3CD_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Homo sapiens OX=9606 GN=PIK3CD PE=1 SV=2
7	O35904	0.0	2029	1043	0.945	0.946	PK3CD_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus OX=10090 GN=Pik3cd PE=1 SV=2
8	O42391	0.0	754	1068	0.412	0.403	O42391_CHICK phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Gallus gallus OX=9031 GN=PIK3CA PE=1 SV=1
9	P32871	0.0	752	1068	0.411	0.402	PK3CA_BOVIN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Bos taurus OX=9913 GN=PIK3CA PE=1 SV=1
10	P42336	0.0	750	1068	0.410	0.401	PK3CA_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Homo sapiens OX=9606 GN=PIK3CA PE=1 SV=2
11	P42337	0.0	756	1068	0.413	0.404	PK3CA_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Mus musculus OX=10090 GN=Pik3ca PE=1 SV=2
12	P42338	0.0	1192	1070	0.580	0.565	PK3CB_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Homo sapiens OX=9606 GN=PIK3CB PE=1 SV=1
13	P91634	0.0	737	1088	0.399	0.383	P91634_DROME PI-3 kinase OS=Drosophila melanogaster OX=7227 GN=Pi3K92E PE=1 SV=1
14	Q7SYE7	0.0	1488	1039	0.696	0.700	Q7SYE7_DANRE phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Danio rerio OX=7955 GN=zgc:63473 PE=2 SV=1
15	Q8BTI9	0.0	1198	1064	0.575	0.564	PK3CB_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Mus musculus OX=10090 GN=Pik3cb PE=1 SV=2
16	Q9Z1L0	0.0	1192	1070	0.576	0.562	PK3CB_RAT Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform OS=Rattus norvegicus OX=10116 GN=Pik3cb PE=2 SV=1
17	Q9JHG7	9.86e-161	505	1102	0.317	0.300	PK3CG_MOUSE Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Mus musculus OX=10090 GN=Pik3cg PE=1 SV=2
18	P48736	4.53e-160	504	1102	0.300	0.284	PK3CG_HUMAN Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform OS=Homo sapiens OX=9606 GN=PIK3CG PE=1 SV=3
19	D3ZFJ0	4.78e-160	503	1102	0.297	0.281	D3ZFJ0_RAT phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Rattus norvegicus OX=10116 GN=Pik3cg PE=1 SV=1
20	Q6NTI2	1.65e-153	486	1098	0.343	0.326	Q6NTI2_DANRE phosphatidylinositol-4,5-bisphosphate 3-kinase OS=Danio rerio OX=7955 GN=zgc:77033 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13575 DUF4135	3.9e+02	11.6	Domain of unknown function (DUF4135)
2	PF00613 PI3Ka	6.6e-51	183.9	Phosphoinositide 3-kinase family, accessory domain (PIK domain)
3	PF00792 PI3K_C2	6.7e-20	82.9	Phosphoinositide 3-kinase C2
4	PF02192 PI3K_p85B	1.1e-27	106.9	PI3-kinase family, p85-binding domain
5	PF00794 PI3K_rbd	2.2e-27	106.7	PI3-kinase family, ras-binding domain
6	PF00454 PI3_PI4_kinase	5.5e-57	205.0	Phosphatidylinositol 3- and 4-kinase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000366563

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000428056	0.999	Phosphatidylinositol 3-kinase regulatory subunit alpha
2	9606.ENSP00000222254	0.995	Phosphatidylinositol 3-kinase regulatory subunit beta
3	9606.ENSP00000392812	0.988	Phosphoinositide 3-kinase regulatory subunit 5
4	9606.ENSP00000361021	0.986	Phosphatase and tensin homolog
5	9606.ENSP00000262741	0.984	Phosphatidylinositol 3-kinase regulatory subunit gamma
6	9606.ENSP00000407586	0.975	GTPase HRas
7	9606.ENSP00000373399	0.970	Phosphatidylinositol 4-phosphate 5-kinase-like protein 1
8	9606.ENSP00000265382	0.968	Phosphatidylinositol 4-phosphate 5-kinase type-1 beta
9	9606.ENSP00000483570	0.964	Tyrosine-protein kinase BTK
10	9606.ENSP00000357883	0.958	Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha
11	9606.ENSP00000466363	0.955	Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
12	9606.ENSP00000256196	0.954	Ras-related protein R-Ras2
13	9606.ENSP00000437940	0.954	B-lymphocyte antigen CD19
14	9606.ENSP00000405338	0.943	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
15	9606.ENSP00000304895	0.942	Insulin receptor substrate 1
16	9606.ENSP00000298229	0.939	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
17	9606.ENSP00000451828	0.939	RAC-alpha serine/threonine-protein kinase
18	9606.ENSP00000480157	0.935	Phosphoinositide 3-kinase regulatory subunit 6
19	9606.ENSP00000344220	0.932	3-phosphoinositide-dependent protein kinase 1
20	9606.ENSP00000482548	0.932	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0016773	1.000	phosphotransferase activity, alcohol group as acceptor
GO:0035004	1.000	phosphatidylinositol 3-kinase activity
GO:0052742	0.985	phosphatidylinositol kinase activity
GO:0016303	0.977	1-phosphatidylinositol-3-kinase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.994	regulation of cellular process
GO:0048518	0.993	positive regulation of biological process
GO:0023052	0.989	signaling
GO:0051716	0.985	cellular response to stimulus
GO:0048583	0.985	regulation of response to stimulus
GO:0019222	0.980	regulation of metabolic process
GO:0048522	0.980	positive regulation of cellular process
GO:0002376	0.977	immune system process
GO:0007165	0.977	signal transduction
GO:0001775	0.960	cell activation
GO:0060255	0.951	regulation of macromolecule metabolic process
GO:0009966	0.947	regulation of signal transduction
GO:0051896	0.944	regulation of protein kinase B signaling
GO:0022603	0.934	regulation of anatomical structure morphogenesis
GO:0048584	0.925	positive regulation of response to stimulus
GO:1902533	0.917	positive regulation of intracellular signal transduction
GO:0051239	0.898	regulation of multicellular organismal process
GO:0007166	0.885	cell surface receptor signaling pathway
GO:0010468	0.883	regulation of gene expression
GO:0051897	0.878	positive regulation of protein kinase B signaling
GO:0045321	0.875	leukocyte activation
GO:0032502	0.869	developmental process
GO:0048856	0.864	anatomical structure development
GO:0046649	0.849	lymphocyte activation
GO:0009605	0.846	response to external stimulus
GO:0048519	0.838	negative regulation of biological process
GO:0006950	0.823	response to stress
GO:0008152	0.796	metabolic process
GO:0031323	0.768	regulation of cellular metabolic process
GO:0051240	0.763	positive regulation of multicellular organismal process
GO:0035556	0.760	intracellular signal transduction
GO:0051179	0.750	localization
GO:0042127	0.745	regulation of cell population proliferation
GO:0071704	0.739	organic substance metabolic process
GO:0002684	0.739	positive regulation of immune system process
GO:0009893	0.736	positive regulation of metabolic process
GO:0050778	0.733	positive regulation of immune response
GO:0042221	0.725	response to chemical
GO:0010628	0.718	positive regulation of gene expression
GO:0016477	0.711	cell migration
GO:0070887	0.690	cellular response to chemical stimulus
GO:0051094	0.674	positive regulation of developmental process
GO:0044237	0.669	cellular metabolic process
GO:0044238	0.662	primary metabolic process
GO:0040011	0.659	locomotion
GO:0002253	0.649	activation of immune response
GO:0045765	0.647	regulation of angiogenesis
GO:0002764	0.630	immune response-regulating signaling pathway
GO:0030154	0.623	cell differentiation
GO:0002757	0.623	immune response-activating signaling pathway
GO:0051234	0.614	establishment of localization
GO:0048468	0.604	cell development
GO:0048872	0.597	homeostasis of number of cells
GO:0080090	0.595	regulation of primary metabolic process
GO:0050900	0.545	leukocyte migration
GO:0006935	0.544	chemotaxis
GO:0042113	0.541	B cell activation
GO:0060326	0.522	cell chemotaxis
GO:0006810	0.498	transport
GO:0002252	0.491	immune effector process
GO:0002521	0.488	leukocyte differentiation
GO:2000145	0.478	regulation of cell motility
GO:0009719	0.474	response to endogenous stimulus
GO:0030334	0.472	regulation of cell migration
GO:0051641	0.464	cellular localization
GO:0048523	0.451	negative regulation of cellular process
GO:0030595	0.448	leukocyte chemotaxis
GO:0006796	0.439	phosphate-containing compound metabolic process
GO:0002768	0.430	immune response-regulating cell surface receptor signaling pathway
GO:0051171	0.429	regulation of nitrogen compound metabolic process
GO:0009892	0.429	negative regulation of metabolic process
GO:0071495	0.424	cellular response to endogenous stimulus
GO:0006955	0.420	immune response
GO:0044419	0.418	biological process involved in interspecies interaction between organisms
GO:0002429	0.416	immune response-activating cell surface receptor signaling pathway
GO:0007167	0.414	enzyme-linked receptor protein signaling pathway
GO:0030335	0.412	positive regulation of cell migration
GO:0010605	0.407	negative regulation of macromolecule metabolic process
GO:0009607	0.401	response to biotic stimulus
GO:0016192	0.398	vesicle-mediated transport
GO:0006952	0.374	defense response
GO:0065009	0.368	regulation of molecular function
GO:0071840	0.365	cellular component organization or biogenesis
GO:0051707	0.361	response to other organism
GO:0051649	0.357	establishment of localization in cell
GO:0007169	0.354	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0002274	0.344	myeloid leukocyte activation
GO:0042981	0.343	regulation of apoptotic process
GO:0031325	0.341	positive regulation of cellular metabolic process
GO:0010033	0.326	response to organic substance
GO:0016043	0.319	cellular component organization
GO:0010632	0.303	regulation of epithelial cell migration

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0016020	0.979	membrane
GO:0071944	0.931	cell periphery
GO:0032991	0.926	protein-containing complex
GO:0005886	0.922	plasma membrane
GO:1990234	0.679	transferase complex
GO:0019898	0.643	extrinsic component of membrane
GO:0098796	0.622	membrane protein complex
GO:0061695	0.532	transferase complex, transferring phosphorus-containing groups
GO:0005942	0.339	phosphatidylinositol 3-kinase complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.1.-	1.000	Phosphotransferases with an alcohol group as acceptor.
RHEA:12709	0.977	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)
EC:2.7.1.137	0.977	phosphatidylinositol 3-kinase.

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