StarFunc result for job id O00330

User Input

>input (501 residues)
MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSK
NIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTL
RFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTAT
PTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPH
AYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF
IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDD
ELATRFLKSFKANLENPIRLA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O00330	1.000	1.000	1.728E-98	501	1.000	1.000	O00330.pdb.gz	ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3
2	AFDB:Q8BKZ9	0.679	0.679	2.134E-87	501	0.850	0.850	Q8BKZ9.pdb.gz	ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial OS=Mus musculus OX=10090 GN=Pdhx PE=1 SV=1
3	AFDB:H0YDD4	0.600	0.579	9.093E-53	520	0.401	0.387	H0YDD4.pdb.gz	H0YDD4_HUMAN Acetyltransferase component of pyruvate dehydrogenase complex OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=2
4	AFDB:Q804C3	0.594	0.465	1.383E-52	652	0.371	0.285	Q804C3.pdb.gz	Q804C3_DANRE Acetyltransferase component of pyruvate dehydrogenase complex OS=Danio rerio OX=7955 GN=wu:fc21f08 PE=1 SV=1
5	AFDB:Q0WQF7	0.463	0.365	1.522E-51	637	0.383	0.301	Q0WQF7.pdb.gz	ODP21_ARATH Dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=LTA3 PE=1 SV=2
6	AFDB:Q8BMF4	0.604	0.475	1.522E-51	642	0.377	0.294	Q8BMF4.pdb.gz	ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dlat PE=1 SV=2
7	AFDB:F4J5T2	0.456	0.322	5.361E-51	713	0.387	0.272	F4J5T2.pdb.gz	F4J5T2_ARATH Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Arabidopsis thaliana OX=3702 GN=LTA3 PE=1 SV=1
8	AFDB:P10515	0.591	0.461	6.814E-51	647	0.375	0.291	P10515.pdb.gz	ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3
9	AFDB:E9PEJ4	0.575	0.535	8.157E-51	542	0.403	0.373	E9PEJ4.pdb.gz	E9PEJ4_HUMAN Acetyltransferase component of pyruvate dehydrogenase complex OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=1
10	AFDB:Q19749	0.594	0.588	3.239E-50	507	0.367	0.363	Q19749.pdb.gz	ODP2_CAEEL Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=dlat-1 PE=1 SV=1
11	PDB:6h60A	0.449	0.944	1.202E-39	233	0.465	1.000	6h60A.pdb.gz
12	PDB:7b9kA	0.441	0.678	2.548E-28	320	0.196	0.306	7b9kA.pdb.gz
13	PDB:6h55A	0.430	0.900	1.539E-27	233	0.222	0.476	6h55A.pdb.gz
14	PDB:5ja2A	0.232	0.106	7.984E-6	1238	0.062	0.025	5ja2A.pdb.gz	Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture.
15	PDB:4eywB	0.236	0.192	8.274E-5	634	0.098	0.077	4eywB.pdb.gz	Isothermal titration calorimetry with micelles: Thermodynamics of inhibitor binding to carnitine palmitoyltransferase 2 membrane protein.
16	PDB:3bg5B	0.127	0.061	1.052E-4	1074	0.040	0.019	3bg5B.pdb.gz	Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction.
17	PDB:3n6rG	0.137	0.107	1.052E-4	646	0.046	0.036	3n6rG.pdb.gz	Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
18	PDB:2xr7A	0.247	0.270	1.117E-4	452	0.052	0.058	2xr7A.pdb.gz	Structural Basis for Modification of Flavonol and Naphthol Glucoconjugates by Nicotiana Tabacum Malonyltransferase (Ntmat1).
19	PDB:3n6rA	0.137	0.117	1.600E-4	591	0.046	0.039	3n6rA.pdb.gz	Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
20	PDB:3bg5A	0.129	0.059	2.585E-4	1137	0.040	0.018	3bg5A.pdb.gz	Crystal structures of human and Staphylococcus aureus pyruvate carboxylase and molecular insights into the carboxyltransfer reaction.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O00330	0.0	1009	501	1.000	1.000	ODPX_HUMAN Pyruvate dehydrogenase protein X component, mitochondrial OS=Homo sapiens OX=9606 GN=PDHX PE=1 SV=3
2	Q8BKZ9	0.0	841	501	0.852	0.852	ODPX_MOUSE Pyruvate dehydrogenase protein X component, mitochondrial OS=Mus musculus OX=10090 GN=Pdhx PE=1 SV=1
3	H0YDD4	1.77e-94	298	520	0.401	0.387	H0YDD4_HUMAN Acetyltransferase component of pyruvate dehydrogenase complex OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=2
4	E9PEJ4	4.71e-92	292	542	0.395	0.365	E9PEJ4_HUMAN Acetyltransferase component of pyruvate dehydrogenase complex OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=1
5	P10515	1.95e-90	291	647	0.369	0.286	ODP2_HUMAN Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Homo sapiens OX=9606 GN=DLAT PE=1 SV=3
6	Q86YI5	1.95e-90	291	647	0.369	0.286	Q86YI5_HUMAN Acetyltransferase component of pyruvate dehydrogenase complex OS=Homo sapiens OX=9606 GN=DLAT PE=2 SV=1
7	Q8BMF4	1.21e-88	286	642	0.357	0.279	ODP2_MOUSE Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Mus musculus OX=10090 GN=Dlat PE=1 SV=2
8	Q804C3	1.67e-87	283	652	0.357	0.275	Q804C3_DANRE Acetyltransferase component of pyruvate dehydrogenase complex OS=Danio rerio OX=7955 GN=wu:fc21f08 PE=1 SV=1
9	Q19749	2.26e-87	279	507	0.369	0.365	ODP2_CAEEL Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=dlat-1 PE=1 SV=1
10	O59816	3.49e-87	278	483	0.347	0.360	ODP2_SCHPO Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=lat1 PE=3 SV=1
11	P08461	6.53e-87	281	632	0.355	0.282	ODP2_RAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Rattus norvegicus OX=10116 GN=Dlat PE=1 SV=3
12	Q5M729	2.51e-86	277	539	0.357	0.332	ODP23_ARATH Dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At1g54220 PE=1 SV=1
13	Q0WQF7	1.15e-85	278	637	0.345	0.272	ODP21_ARATH Dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=LTA3 PE=1 SV=2
14	Q8RWN9	4.79e-85	274	539	0.343	0.319	ODP22_ARATH Dihydrolipoyllysine-residue acetyltransferase component 2 of pyruvate dehydrogenase complex, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=At3g13930 PE=1 SV=2
15	F4J5T2	4.82e-85	278	713	0.345	0.243	F4J5T2_ARATH Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Arabidopsis thaliana OX=3702 GN=LTA3 PE=1 SV=1
16	Q5AYC2	5.39e-78	254	488	0.367	0.377	Q5AYC2_EMENI Acetyltransferase component of pyruvate dehydrogenase complex OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=ANIA_06708 PE=3 SV=1
17	Q38AK7	8.42e-77	250	451	0.339	0.377	Q38AK7_TRYB2 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.6k15.3080 PE=3 SV=1
18	Q7KTK9	2.04e-63	214	421	0.214	0.254	Q7KTK9_DROME dihydrolipoyllysine-residue acetyltransferase OS=Drosophila melanogaster OX=7227 GN=muc PE=1 SV=1
19	M9PCA2	3.26e-63	215	473	0.214	0.226	M9PCA2_DROME Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex OS=Drosophila melanogaster OX=7227 GN=muc PE=1 SV=1
20	M9PCU4	4.95e-63	215	489	0.214	0.219	M9PCU4_DROME dihydrolipoyllysine-residue acetyltransferase OS=Drosophila melanogaster OX=7227 GN=muc PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00198 2-oxoacid_dh	1.5e-67	239.1	2-oxoacid dehydrogenases acyltransferase (catalytic domain)
2	PF00364 Biotin_lipoyl	1.5e-15	68.1	Biotin-requiring enzyme
3	PF13533 Biotin_lipoyl_2	8.7	17.5	Biotin-lipoyl like
4	PF02817 E3_binding	0.00073	31.1	e3 binding domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000227868

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000205402	0.999	Dihydrolipoyl dehydrogenase, mitochondrial
2	9606.ENSP00000307241	0.999	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
3	9606.ENSP00000369134	0.998	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
4	9606.ENSP00000376352	0.993	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
5	9606.ENSP00000280346	0.991	Dihydrolipoamide S-acetyltransferase
6	9606.ENSP00000295266	0.986	Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial
7	9606.ENSP00000387536	0.981	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
8	9606.ENSP00000377115	0.979	Lipoyltransferase 1, mitochondrial
9	9606.ENSP00000222673	0.978	2-oxoglutarate dehydrogenase, mitochondrial
10	9606.ENSP00000420927	0.976	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
11	9606.ENSP00000319531	0.971	Glycine cleavage system H protein, mitochondrial
12	9606.ENSP00000309548	0.969	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial
13	9606.ENSP00000379503	0.965	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
14	9606.ENSP00000288050	0.950	Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
15	9606.ENSP00000005178	0.948	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
16	9606.ENSP00000335304	0.944	Dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
17	9606.ENSP00000310928	0.909	Peroxisome proliferator-activated receptor delta
18	9606.ENSP00000419692	0.901	Retinoic acid receptor RXR-alpha
19	9606.ENSP00000318351	0.898	2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
20	9606.ENSP00000269980	0.869	2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0016620	0.999	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004738	0.999	pyruvate dehydrogenase activity
GO:0016740	0.790	transferase activity
GO:0016746	0.446	acyltransferase activity
GO:0016747	0.432	acyltransferase activity, transferring groups other than amino-acyl groups
GO:0043167	0.334	ion binding
GO:0140096	0.325	catalytic activity, acting on a protein

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0044237	0.982	cellular metabolic process
GO:0071704	0.979	organic substance metabolic process
GO:0044238	0.979	primary metabolic process
GO:0044281	0.976	small molecule metabolic process
GO:0006807	0.958	nitrogen compound metabolic process
GO:0006090	0.925	pyruvate metabolic process
GO:0006085	0.920	acetyl-CoA biosynthetic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0070013	0.991	intracellular organelle lumen
GO:0032991	0.933	protein-containing complex
GO:0005759	0.823	mitochondrial matrix
GO:1902494	0.804	catalytic complex
GO:0098798	0.779	mitochondrial protein-containing complex
GO:1990204	0.735	oxidoreductase complex
GO:0045254	0.414	pyruvate dehydrogenase complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:1.2.1.-	0.999	With NAD(+) or NADP(+) as acceptor.
EC:2.-.-.-	0.790	Transferases.
EC:2.3.-.-	0.446	Acyltransferases.
EC:2.3.1.-	0.432	Transferring groups other than amino-acyl groups.

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