StarFunc result for job id O00622

User Input

>input (381 residues)
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL
NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ
CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG
KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS
KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP
HANEAAFPFYRLFNDIHKFRD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O00622	1.000	1.000	8.460E-74	381	1.000	1.000	O00622.pdb.gz	CCN1_HUMAN CCN family member 1 OS=Homo sapiens OX=9606 GN=CCN1 PE=1 SV=1
2	AFDB:Q6PFL2	0.400	0.382	1.094E-48	400	0.627	0.598	Q6PFL2.pdb.gz
3	AFDB:Q98TQ8	0.399	0.437	4.667E-40	344	0.438	0.485	Q98TQ8.pdb.gz	Q98TQ8_CHICK Cellular communication network factor 2 OS=Gallus gallus OX=9031 GN=CCN2 PE=2 SV=1
4	AFDB:P29279	0.405	0.434	5.799E-40	349	0.451	0.493	P29279.pdb.gz	CCN2_HUMAN CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2
5	AFDB:Q5RI33	0.406	0.444	7.608E-40	345	0.430	0.475	Q5RI33.pdb.gz	Q5RI33_DANRE Cellular communication network factor 2a (Fragment) OS=Danio rerio OX=7955 GN=ctgf PE=2 SV=1
6	AFDB:A0A024R9J4	0.365	0.389	2.891E-38	357	0.409	0.437	A0A024R9J4.pdb.gz
7	AFDB:Q64299	0.348	0.374	5.856E-38	354	0.412	0.444	Q64299.pdb.gz	CCN3_MOUSE CCN family member 3 OS=Mus musculus OX=10090 GN=Ccn3 PE=1 SV=1
8	AFDB:O95388	0.374	0.386	8.647E-36	367	0.365	0.379	O95388.pdb.gz	CCN4_HUMAN CCN family member 4 OS=Homo sapiens OX=9606 GN=CCN4 PE=1 SV=1
9	AFDB:O54775	0.345	0.357	1.849E-35	367	0.367	0.381	O54775.pdb.gz	CCN4_MOUSE CCN family member 4 OS=Mus musculus OX=10090 GN=Ccn4 PE=2 SV=1
10	AFDB:D0E2W2	0.352	0.394	4.641E-30	338	0.307	0.346	D0E2W2.pdb.gz	D0E2W2_DANRE Cellular communication network factor 6 OS=Danio rerio OX=7955 GN=si:dkey-119m7.6 PE=2 SV=1
11	PDB:2k8pA	0.154	0.269	8.253E-3	189	0.050	0.101	2k8pA.pdb.gz
12	PDB:5nxsA	0.130	0.165	9.713E-3	290	0.068	0.090	5nxsA.pdb.gz
13	PDB:4my2A	0.098	0.080	6.858E-2	474	0.073	0.059	4my2A.pdb.gz	Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex.
14	PDB:5ffoG	0.136	0.166	8.071E-2	297	0.037	0.047	5ffoG.pdb.gz	Force interacts with macromolecular structure in activation of TGF-beta.
15	PDB:7jg2J	0.099	0.214	1.118E-1	132	0.073	0.212	7jg2J.pdb.gz
16	PDB:4v6xCA	0.072	0.094	1.246E-1	255	0.050	0.075	4v6xCA.pdb.gz	Structures of the human and Drosophila 80S ribosome.
17	PDB:1wq8A	0.111	0.347	1.316E-1	100	0.024	0.090	1wq8A.pdb.gz
18	PDB:7ag0A	0.116	0.283	1.548E-1	140	0.031	0.086	7ag0A.pdb.gz
19	PDB:5nxsB	0.120	0.175	1.822E-1	251	0.039	0.060	5nxsB.pdb.gz
20	PDB:1m4uA	0.115	0.205	2.264E-1	199	0.029	0.055	1m4uA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	F1QL10	0.0	520	369	0.659	0.680	F1QL10_DANRE Cellular communication network factor 1 OS=Danio rerio OX=7955 GN=cyr61 PE=3 SV=1
2	O00622	0.0	780	381	1.000	1.000	CCN1_HUMAN CCN family member 1 OS=Homo sapiens OX=9606 GN=CCN1 PE=1 SV=1
3	P18406	0.0	664	379	0.916	0.921	CCN1_MOUSE CCN family member 1 OS=Mus musculus OX=10090 GN=Ccn1 PE=1 SV=1
4	Q9ES72	0.0	662	379	0.916	0.921	CCN1_RAT CCN family member 1 OS=Rattus norvegicus OX=10116 GN=Ccn1 PE=2 SV=1
5	P29279	1.60e-108	324	349	0.459	0.501	CCN2_HUMAN CCN family member 2 OS=Homo sapiens OX=9606 GN=CCN2 PE=1 SV=2
6	Q5RI33	2.01e-107	321	345	0.433	0.478	Q5RI33_DANRE Cellular communication network factor 2a (Fragment) OS=Danio rerio OX=7955 GN=ctgf PE=2 SV=1
7	P29268	8.10e-106	317	348	0.457	0.500	CCN2_MOUSE CCN family member 2 OS=Mus musculus OX=10090 GN=Ccn2 PE=1 SV=3
8	Q9R1E9	1.52e-105	316	347	0.451	0.496	CCN2_RAT CCN family member 2 OS=Rattus norvegicus OX=10116 GN=Ccn2 PE=2 SV=1
9	Q98TQ8	4.09e-105	315	344	0.425	0.471	Q98TQ8_CHICK Cellular communication network factor 2 OS=Gallus gallus OX=9031 GN=CCN2 PE=2 SV=1
10	Q64299	2.08e-89	275	354	0.420	0.452	CCN3_MOUSE CCN family member 3 OS=Mus musculus OX=10090 GN=Ccn3 PE=1 SV=1
11	P48745	2.81e-88	272	357	0.402	0.429	CCN3_HUMAN CCN family member 3 OS=Homo sapiens OX=9606 GN=CCN3 PE=1 SV=1
12	Q9QZQ5	2.82e-86	267	351	0.399	0.433	CCN3_RAT CCN family member 3 OS=Rattus norvegicus OX=10116 GN=Ccn3 PE=1 SV=1
13	O95388	2.01e-82	258	367	0.388	0.403	CCN4_HUMAN CCN family member 4 OS=Homo sapiens OX=9606 GN=CCN4 PE=1 SV=1
14	Q99PP0	3.74e-81	254	367	0.373	0.387	CCN4_RAT CCN family member 4 OS=Rattus norvegicus OX=10116 GN=Ccn4 PE=2 SV=1
15	O54775	7.00e-81	254	367	0.373	0.387	CCN4_MOUSE CCN family member 4 OS=Mus musculus OX=10090 GN=Ccn4 PE=2 SV=1
16	A0A384NYW3	4.48e-60	199	354	0.318	0.342	A0A384NYW3_HUMAN Epididymis secretory sperm binding protein OS=Homo sapiens OX=9606 PE=2 SV=1
17	O95389	4.48e-60	199	354	0.318	0.342	CCN6_HUMAN Cellular communication network factor 6 OS=Homo sapiens OX=9606 GN=CCN6 PE=1 SV=1
18	D0E2W2	4.62e-56	189	338	0.312	0.352	D0E2W2_DANRE Cellular communication network factor 6 OS=Danio rerio OX=7955 GN=si:dkey-119m7.6 PE=2 SV=1
19	Q9Z0G4	3.81e-51	173	251	0.255	0.386	CCN5_MOUSE CCN family member 5 OS=Mus musculus OX=10090 GN=Ccn5 PE=2 SV=1
20	Q9JHC6	1.74e-44	155	250	0.249	0.380	CCN5_RAT CCN family member 5 OS=Rattus norvegicus OX=10116 GN=Ccn5 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00007 Cys_knot	8.3e-13	59.9	Cystine-knot domain
2	PF00219 IGFBP	9.8e-07	40.6	Insulin-like growth factor binding protein
3	PF19035 TSP1_CCN	5.7e-15	66.7	CCN3 Nov like TSP1 domain
4	PF00090 TSP_1	1.4	20.4	Thrombospondin type 1 domain
5	PF00093 VWC	1.7e-06	39.6	von Willebrand factor type C domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000398736

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000296181	0.979	Integrin beta-5
2	9606.ENSP00000452786	0.968	Integrin beta-3
3	9606.ENSP00000441691	0.965	Integrin alpha-M
4	9606.ENSP00000261023	0.960	Integrin alpha-V
5	9606.ENSP00000380948	0.920	Integrin beta-2
6	9606.ENSP00000295666	0.825	Insulin-like growth factor-binding protein 7
7	9606.ENSP00000356954	0.825	Connective tissue growth factor
8	9606.ENSP00000478927	0.781	Transcriptional coactivator YAP1
9	9606.ENSP00000360762	0.776	Ankyrin repeat domain-containing protein 1
10	9606.ENSP00000363055	0.766	ZW10 interactor
11	9606.ENSP00000437550	0.766	Serine/threonine-protein kinase LATS1
12	9606.ENSP00000424765	0.759	Angiomotin-like protein 2
13	9606.ENSP00000435233	0.759	Transcriptional enhancer factor TEF-1
14	9606.ENSP00000419465	0.723	WW domain-containing transcription regulator protein 1
15	9606.ENSP00000231061	0.719	SPARC
16	9606.ENSP00000361818	0.701	Syndecan-4
17	9606.ENSP00000352926	0.663	Transcriptional enhancer factor TEF-3
18	9606.ENSP00000346839	0.646	Fibronectin type III domain containing
19	9606.ENSP00000284523	0.645	Protein Wnt-3a
20	9606.ENSP00000354733	0.643	Protein strawberry notch homolog 2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0005102	0.858	signaling receptor binding
GO:0097367	0.551	carbohydrate derivative binding
GO:0044877	0.382	protein-containing complex binding
GO:0140677	0.378	molecular function activator activity
GO:0050839	0.306	cell adhesion molecule binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050789	0.996	regulation of biological process
GO:0009987	0.990	cellular process
GO:0048856	0.990	anatomical structure development
GO:0060255	0.986	regulation of macromolecule metabolic process
GO:0048522	0.985	positive regulation of cellular process
GO:0051239	0.980	regulation of multicellular organismal process
GO:0050896	0.977	response to stimulus
GO:0040012	0.965	regulation of locomotion
GO:0032501	0.957	multicellular organismal process
GO:0009893	0.939	positive regulation of metabolic process
GO:2000145	0.936	regulation of cell motility
GO:0040017	0.932	positive regulation of locomotion
GO:0030334	0.932	regulation of cell migration
GO:0010468	0.930	regulation of gene expression
GO:0010604	0.920	positive regulation of macromolecule metabolic process
GO:0051240	0.912	positive regulation of multicellular organismal process
GO:2000147	0.908	positive regulation of cell motility
GO:0030335	0.903	positive regulation of cell migration
GO:0061035	0.898	regulation of cartilage development
GO:0051094	0.893	positive regulation of developmental process
GO:0007275	0.889	multicellular organism development
GO:0007155	0.882	cell adhesion
GO:0048519	0.867	negative regulation of biological process
GO:0080090	0.867	regulation of primary metabolic process
GO:0009888	0.846	tissue development
GO:0045595	0.844	regulation of cell differentiation
GO:0048523	0.840	negative regulation of cellular process
GO:0031323	0.831	regulation of cellular metabolic process
GO:0051171	0.822	regulation of nitrogen compound metabolic process
GO:0048583	0.796	regulation of response to stimulus
GO:0045765	0.795	regulation of angiogenesis
GO:0048731	0.792	system development
GO:0045597	0.789	positive regulation of cell differentiation
GO:0071840	0.786	cellular component organization or biogenesis
GO:0043085	0.785	positive regulation of catalytic activity
GO:0031325	0.784	positive regulation of cellular metabolic process
GO:0016043	0.780	cellular component organization
GO:0023051	0.775	regulation of signaling
GO:0051247	0.768	positive regulation of protein metabolic process
GO:0010646	0.760	regulation of cell communication
GO:0051716	0.749	cellular response to stimulus
GO:0048513	0.749	animal organ development
GO:0010628	0.747	positive regulation of gene expression
GO:0043408	0.745	regulation of MAPK cascade
GO:0009889	0.740	regulation of biosynthetic process
GO:0042127	0.738	regulation of cell population proliferation
GO:0045766	0.732	positive regulation of angiogenesis
GO:0009653	0.714	anatomical structure morphogenesis
GO:0006950	0.705	response to stress
GO:0048584	0.698	positive regulation of response to stimulus
GO:1902533	0.688	positive regulation of intracellular signal transduction
GO:0072359	0.686	circulatory system development
GO:0009611	0.684	response to wounding
GO:0007154	0.632	cell communication
GO:0023052	0.624	signaling
GO:0009891	0.606	positive regulation of biosynthetic process
GO:0007165	0.581	signal transduction
GO:0042221	0.558	response to chemical
GO:0010556	0.516	regulation of macromolecule biosynthetic process
GO:0001817	0.510	regulation of cytokine production
GO:2001141	0.509	regulation of RNA biosynthetic process
GO:0006355	0.503	regulation of DNA-templated transcription
GO:0048869	0.495	cellular developmental process
GO:0008284	0.468	positive regulation of cell population proliferation
GO:0010557	0.465	positive regulation of macromolecule biosynthetic process
GO:0048870	0.464	cell motility
GO:0042325	0.464	regulation of phosphorylation
GO:0045935	0.456	positive regulation of nucleobase-containing compound metabolic process
GO:0031328	0.452	positive regulation of cellular biosynthetic process
GO:0031399	0.449	regulation of protein modification process
GO:0030154	0.430	cell differentiation
GO:0001932	0.424	regulation of protein phosphorylation
GO:1902680	0.416	positive regulation of RNA biosynthetic process
GO:1903508	0.408	positive regulation of nucleic acid-templated transcription
GO:0045893	0.391	positive regulation of DNA-templated transcription
GO:0006357	0.364	regulation of transcription by RNA polymerase II
GO:0008152	0.355	metabolic process
GO:0051128	0.342	regulation of cellular component organization
GO:0045944	0.332	positive regulation of transcription by RNA polymerase II
GO:0009892	0.326	negative regulation of metabolic process
GO:0010605	0.307	negative regulation of macromolecule metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0031012	0.995	extracellular matrix
GO:0062023	0.972	collagen-containing extracellular matrix
GO:0043231	0.971	intracellular membrane-bounded organelle
GO:0005737	0.965	cytoplasm
GO:0005576	0.928	extracellular region
GO:0070013	0.809	intracellular organelle lumen
GO:0012505	0.666	endomembrane system
GO:0005615	0.449	extracellular space
GO:0005783	0.417	endoplasmic reticulum
GO:0016020	0.364	membrane
GO:0031981	0.336	nuclear lumen
GO:0005654	0.311	nucleoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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