StarFunc result for job id O00763

User Input

>input (2458 residues)
MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPSQEPFPASDNSGETPQR
NGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRNPLSSSDAAPSPELQANGT
GTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQLMTNFILGSFDDYSSDEDSV
AGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMRPSMSGLHLVKRGREHKKLDLHR
DFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCMRSIRRWAYEMFRNERAIRFVVMVT
PEDLKANAEYIKMADHYVPVPGGPNNNNYANVELIVDIAKRIPVQAVWAGWGHASENPKL
PELLCKNGVAFLGPPSEAMWALGDKIASTVVAQTLQVPTLPWSGSGLTVEWTEDDLQQGK
RISVPEDVYDKGCVKDVDEGLEAAERIGFPLMIKASEGGGGKGIRKAESAEDFPILFRQV
QSEIPGSPIFLMKLAQHARHLEVQILADQYGNAVSLFGRDCSIQRRHQKIVEEAPATIAP
LAIFEFMEQCAIRLAKTVGYVSAGTVEYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNL
PAAQLQIAMGVPLHRLKDIRLLYGESPWGVTPISFETPSNPPLARGHVIAARITSENPDE
GFKPSSGTVQELNFRSSKNVWGYFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVA
LKELSIRGDFRTTVEYLINLLETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGAL
NVADAMFRTCMTDFLHSLERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIM
NGCHIEIDAHRLNDGGLLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSP
SAGKLTQYTVEDGGHVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVAR
LELDDPSKVHPAEPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIK
LKEWVQKLMMTLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFP
SQQIATILDCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRV
EHHFQQAHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSD
ELISILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCP
ENLKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCV
VEFQFMLPSSHPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDFTR
NFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDEALVP
ILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEPALAFQL
ELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLITKEASFEY
LQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEESVRYMVMRYGS
RLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVTDSRSGNIMFHSF
GNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQALFKLWGSPDKYPK
DILTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPEGRDVIVIGNDITFRIG
SFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIKHMFHVAWVDPEDPHKGFK
YLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDIIGKDDGLGVENLRGSGMIAGESSL
AYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHIILTGASALNKVLGREVYTSNNQL
GGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKDNHSPVPIITPTDPIDREIEFLPSR
APYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEIMAPWAQTVVTGRARLGGIPVGVIAVE
TRTVEVAVPADPANLDSEAKIIQQAGQVWFPDSAYKTAQAVKDFNREKLPLMIFANWRGF
SGGMKDMYDQVLKFGAYIVDGLRQYKQPILIYIPPYAELRGGSWVVIDATINPLCIEMYA
DKESRGGVLEPEGTVEIKFRKKDLIKSMRRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLK
AREDLLLPIYHQVAVQFADFHDTPGRMLEKGVISDILEWKTARTFLYWRLRRLLLEDQVK
QEILQASGELSHVHIQSMLRRWFVETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRSTIR
ENITYLKHDSVLKTIRGLVEENPEVAVDCVIYLSQHISPAERAQVVHLLSTMDSPAST

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:5cskA	0.748	0.915	0.000	1996	0.391	0.481	5cskA.pdb.gz
2	PDB:5cskB	0.733	0.884	0.000	2017	0.393	0.479	5cskB.pdb.gz
3	PDB:5cslA	0.768	0.915	0.000	2050	0.406	0.486	5cslA.pdb.gz	Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
4	PDB:5cslB	0.755	0.887	0.000	2072	0.402	0.477	5cslB.pdb.gz	Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer.
5	PDB:6g2dC	0.816	0.941	0.000	2121	0.675	0.782	6g2dC.pdb.gz
6	PDB:6g2iA	0.340	0.389	0.000	2080	0.661	0.781	6g2iA.pdb.gz
7	AFDB:E9PSQ0	0.926	0.925	0.000	2460	0.855	0.854	E9PSQ0.pdb.gz	E9PSQ0_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=2
8	AFDB:O00763	1.000	1.000	0.000	2458	1.000	1.000	O00763.pdb.gz	ACACB_HUMAN Acetyl-CoA carboxylase 2 OS=Homo sapiens OX=9606 GN=ACACB PE=1 SV=3
9	AFDB:P78820	0.834	0.898	0.000	2280	0.424	0.457	P78820.pdb.gz	ACAC_SCHPO Acetyl-CoA carboxylase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cut6 PE=1 SV=2
10	AFDB:Q13085	0.902	0.944	0.000	2346	0.712	0.746	Q13085.pdb.gz	ACACA_HUMAN Acetyl-CoA carboxylase 1 OS=Homo sapiens OX=9606 GN=ACACA PE=1 SV=2
11	PDB:6g2hA	0.267	0.748	4.899E-75	761	0.242	0.783	6g2hA.pdb.gz
12	PDB:3n6rG	0.180	0.599	3.206E-45	646	0.079	0.300	3n6rG.pdb.gz	Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
13	PDB:3u9sA	0.189	0.683	1.416E-41	621	0.075	0.296	3u9sA.pdb.gz	An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
14	PDB:4rcnB	0.175	0.401	2.740E-41	1000	0.107	0.262	4rcnB.pdb.gz
15	AFDB:Q8IPB2	0.078	0.151	4.568E-2	1071	0.040	0.092	Q8IPB2.pdb.gz	Q8IPB2_DROME Tubulin tyrosine ligase-like 4A, isoform D OS=Drosophila melanogaster OX=7227 GN=TTLL4A PE=4 SV=2
16	AFDB:A0A2R8QBA1	0.038	0.069	1.644	1200	0.024	0.049	A0A2R8QBA1.pdb.gz
17	AFDB:O88935	0.096	0.303	1.894	706	0.024	0.085	O88935.pdb.gz	SYN1_MOUSE Synapsin-1 OS=Mus musculus OX=10090 GN=Syn1 PE=1 SV=2
18	AFDB:Q2UY11	0.038	0.075	2.398	1141	0.024	0.053	Q2UY11.pdb.gz	COSA1_MOUSE Collagen alpha-1(XXVIII) chain OS=Mus musculus OX=10090 GN=Col28a1 PE=2 SV=1
19	AFDB:Q54DW4	0.036	0.051	3.336	1350	0.049	0.089	Q54DW4.pdb.gz	Q54DW4_DICDI Pleckstrin domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=xacA PE=4 SV=1
20	AFDB:Q9TXR6	0.037	0.075	4.426	1094	0.020	0.046	Q9TXR6.pdb.gz	Q9TXR6_CAEEL VWFA domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=dpy-1 PE=1 SV=2

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0G2K1F2	4529	2476	0.876	0.870	A0A0G2K1F2_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=2
2	A0A0G2K5L6	4535	2462	0.876	0.874	A0A0G2K5L6_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=2
3	A0A2R8QJA0	3657	2375	0.705	0.729	A0A2R8QJA0_DANRE acetyl-CoA carboxylase OS=Danio rerio OX=7955 GN=acc PE=1 SV=1
4	A0A8I6ART3	4271	2277	0.821	0.887	A0A8I6ART3_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=1
5	A1Z784	2883	2482	0.571	0.565	A1Z784_DROME acetyl-CoA carboxylase OS=Drosophila melanogaster OX=7227 GN=ACC PE=1 SV=1
6	A8DY67	2878	2348	0.570	0.597	A8DY67_DROME acetyl-CoA carboxylase OS=Drosophila melanogaster OX=7227 GN=ACC PE=1 SV=2
7	B7G7S4	701	2092	0.148	0.174	B7G7S4_PHATC acetyl-CoA carboxylase OS=Phaeodactylum tricornutum (strain CCAP 1055/1) OX=556484 GN=ACC1 PE=4 SV=1
8	D3ZBE2	4365	2459	0.852	0.851	D3ZBE2_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=4
9	E9PSQ0	4403	2460	0.856	0.856	E9PSQ0_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=1 SV=2
10	E9Q4Z2	4554	2448	0.884	0.888	ACACB_MOUSE Acetyl-CoA carboxylase 2 OS=Mus musculus OX=10090 GN=Acacb PE=1 SV=1
11	F4I1L3	1553	2355	0.360	0.376	ACC2_ARATH Acetyl-CoA carboxylase 2 OS=Arabidopsis thaliana OX=3702 GN=ACC2 PE=2 SV=1
12	F6P055	3653	2383	0.705	0.727	F6P055_DANRE acetyl-CoA carboxylase OS=Danio rerio OX=7955 GN=acc PE=1 SV=1
13	G3H9D1	2451	1579	0.479	0.745	G3H9D1_CRIGR Acetyl-CoA carboxylase 1 OS=Cricetulus griseus OX=10029 GN=I79_006999 PE=1 SV=1
14	H2L0M0	650	2165	0.136	0.155	H2L0M0_CAEEL acetyl-CoA carboxylase OS=Caenorhabditis elegans OX=6239 GN=pod-2 PE=1 SV=1
15	O00763	5118	2458	1.000	1.000	ACACB_HUMAN Acetyl-CoA carboxylase 2 OS=Homo sapiens OX=9606 GN=ACACB PE=1 SV=3
16	O70151	4360	2456	0.851	0.851	O70151_RAT acetyl-CoA carboxylase OS=Rattus norvegicus OX=10116 GN=Acacb PE=2 SV=1
17	P11029	3708	2324	0.712	0.753	ACAC_CHICK Acetyl-CoA carboxylase OS=Gallus gallus OX=9031 GN=ACAC PE=1 SV=1
18	P11497	3642	2345	0.715	0.749	ACACA_RAT Acetyl-CoA carboxylase 1 OS=Rattus norvegicus OX=10116 GN=Acaca PE=1 SV=1
19	P32874	1742	2273	0.386	0.418	HFA1_YEAST Acetyl-CoA carboxylase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=HFA1 PE=1 SV=2
20	P78820	1965	2280	0.423	0.456	ACAC_SCHPO Acetyl-CoA carboxylase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cut6 PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08326 ACC_central	7.3e-271	912.3	Acetyl-CoA carboxylase, central region
2	PF02222 ATP-grasp	0.82	20.8	ATP-grasp domain
3	PF02655 ATP-grasp_3	2.5e+02	13.1	ATP-grasp domain
4	PF02785 Biotin_carb_C	3e-20	83.7	Biotin carboxylase C-terminal domain
5	PF00289 Biotin_carb_N	4.9e-28	109.2	Biotin carboxylase, N-terminal domain
6	PF00364 Biotin_lipoyl	2.5e-12	57.8	Biotin-requiring enzyme
7	PF01039 Carboxyl_trans	1.8e-184	625.7	Carboxyl transferase domain
8	PF02786 CPSase_L_D2	1.5e-45	166.9	Carbamoyl-phosphate synthase L chain, ATP binding domain
9	PF07478 Dala_Dala_lig_C	67	14.4	D-ala D-ala ligase C-terminus
10	PF16216 GxGYxYP_N	2.4e+02	13.2	GxGYxY sequence motif in domain of unknown function N-terminal

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000341044

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000304592	0.988	Fatty acid synthase
2	9606.ENSP00000382071	0.988	Biotin--protein ligase
3	9606.ENSP00000253792	0.978	ATP-citrate synthase
4	9606.ENSP00000348069	0.971	Sterol regulatory element-binding protein 1
5	9606.ENSP00000253382	0.965	Acetyl-coenzyme A synthetase, cytoplasmic
6	9606.ENSP00000290429	0.961	Malonyl-CoA-acyl carrier protein transacylase, mitochondrial
7	9606.ENSP00000316924	0.950	Acetyl-coenzyme A synthetase 2-like, mitochondrial
8	9606.ENSP00000265641	0.948	Carnitine O-palmitoyltransferase 1, liver isoform
9	9606.ENSP00000360290	0.937	5'-AMP-activated protein kinase catalytic subunit alpha-2
10	9606.ENSP00000450436	0.931	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
11	9606.ENSP00000280346	0.927	Dihydrolipoamide S-acetyltransferase
12	9606.ENSP00000479130	0.926	Acyl-CoA synthetase family member 3, mitochondrial
13	9606.ENSP00000379011	0.920	Carnitine O-palmitoyltransferase 1, muscle isoform
14	9606.ENSP00000265838	0.917	Acetyl-CoA acetyltransferase, mitochondrial
15	9606.ENSP00000356015	0.917	Acetyl-CoA acetyltransferase, cytosolic
16	9606.ENSP00000346148	0.914	5'-AMP-activated protein kinase catalytic subunit alpha-1
17	9606.ENSP00000303246	0.904	Acyl-coenzyme A thioesterase 12
18	9606.ENSP00000376303	0.903	Carnitine O-palmitoyltransferase 1, brain isoform
19	9606.ENSP00000262430	0.901	Malonyl-CoA decarboxylase, mitochondrial
20	9606.ENSP00000329357	0.901	Transcription factor Sp1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:1901681	1.000	sulfur compound binding
GO:0033218	1.000	amide binding
GO:0019842	1.000	vitamin binding
GO:0033293	1.000	monocarboxylic acid binding
GO:1901363	0.999	heterocyclic compound binding
GO:0097159	0.999	organic cyclic compound binding
GO:0003989	0.999	acetyl-CoA carboxylase activity
GO:0005515	0.996	protein binding
GO:0042802	0.925	identical protein binding
GO:0009374	0.370	biotin binding
GO:0016740	0.348	transferase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.935	organic substance metabolic process
GO:0044238	0.929	primary metabolic process
GO:0044237	0.924	cellular metabolic process
GO:0044281	0.795	small molecule metabolic process
GO:0006807	0.712	nitrogen compound metabolic process
GO:0050896	0.678	response to stimulus
GO:1901564	0.601	organonitrogen compound metabolic process
GO:1901576	0.559	organic substance biosynthetic process
GO:0006796	0.548	phosphate-containing compound metabolic process
GO:0006082	0.547	organic acid metabolic process
GO:0044249	0.535	cellular biosynthetic process
GO:0006629	0.523	lipid metabolic process
GO:1901360	0.520	organic cyclic compound metabolic process
GO:0010033	0.506	response to organic substance
GO:0043436	0.497	oxoacid metabolic process
GO:0019752	0.489	carboxylic acid metabolic process
GO:0006163	0.484	purine nucleotide metabolic process
GO:0044255	0.414	cellular lipid metabolic process
GO:0019693	0.387	ribose phosphate metabolic process
GO:0009150	0.368	purine ribonucleotide metabolic process
GO:0032787	0.358	monocarboxylic acid metabolic process
GO:0090407	0.329	organophosphate biosynthetic process
GO:0006790	0.307	sulfur compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0016020	0.736	membrane
GO:0005829	0.478	cytosol
GO:0031090	0.349	organelle membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:11308	0.999	acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate
EC:6.4.1.2	0.999	acetyl-CoA carboxylase.
EC:2.-.-.-	0.348	Transferases.

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