StarFunc result for job id O14638

User Input

>input (875 residues)
MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFD
ASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCL
QRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTL
MPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLS
SKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERIS
TLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRN
LHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNS
EEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGG
GNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLN
HLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEI
TATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPT
VPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEE
FRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHY
FVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVR
DVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	PDB:4b56A	0.811	0.868	0.000	816	0.491	0.527	4b56A.pdb.gz	Structure of Npp1, an Ectonucleotide Pyrophosphatase/Phosphodiesterase Involved in Tissue Calcification.
2	PDB:6c01A	0.935	0.999	0.000	819	0.936	1.000	6c01A.pdb.gz	Structural basis for nucleotide recognition by the ectoenzyme CD203c.
3	PDB:6g4gB	0.845	0.972	0.000	759	0.719	0.829	6g4gB.pdb.gz	Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain.
4	PDB:6g4gC	0.823	0.967	0.000	742	0.704	0.830	6g4gC.pdb.gz	Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain.
5	PDB:6g4gD	0.866	0.968	0.000	781	0.735	0.823	6g4gD.pdb.gz	Crystallization of ectonucleotide phosphodiesterase/pyrophosphatase-3 and orientation of the SMB domains in the full-length ectodomain.
6	PDB:6wevAbA	0.893	0.956	0.000	817	0.515	0.552	6wevAbA.pdb.gz	Crystal structures of human ENPP1 in apo and bound forms.
7	AFDB:B0JZL7	0.901	0.898	0.000	878	0.486	0.484	B0JZL7.pdb.gz	B0JZL7_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Danio rerio OX=7955 GN=si:ch211-142e24.2 PE=1 SV=1
8	AFDB:O14638	1.000	1.000	0.000	875	1.000	1.000	O14638.pdb.gz	ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Homo sapiens OX=9606 GN=ENPP3 PE=1 SV=2
9	AFDB:P06802	0.898	0.868	0.000	906	0.505	0.488	P06802.pdb.gz	ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Mus musculus OX=10090 GN=Enpp1 PE=1 SV=4
10	AFDB:P22413	0.895	0.848	0.000	925	0.528	0.499	P22413.pdb.gz	ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Homo sapiens OX=9606 GN=ENPP1 PE=1 SV=2
11	AFDB:P97675	0.981	0.981	0.000	875	0.814	0.814	P97675.pdb.gz	ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Rattus norvegicus OX=10116 GN=Enpp3 PE=1 SV=2
12	AFDB:Q6PGY9	0.836	0.860	0.000	850	0.450	0.464	Q6PGY9.pdb.gz	Q6PGY9_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 2 OS=Danio rerio OX=7955 GN=atx PE=2 SV=1
13	AFDB:Q13822	0.842	0.853	8.625E-104	863	0.423	0.429	Q13822.pdb.gz	ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 OS=Homo sapiens OX=9606 GN=ENPP2 PE=1 SV=3
14	AFDB:E2RUH0	0.841	0.856	1.012E-103	859	0.423	0.431	E2RUH0.pdb.gz	E2RUH0_CHICK Ectonucleotide pyrophosphatase/phosphodiesterase 2, long form OS=Gallus gallus OX=9031 GN=Enpp2 PE=2 SV=1
15	AFDB:Q64610	0.845	0.834	5.976E-103	887	0.433	0.427	Q64610.pdb.gz	ENPP2_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 OS=Rattus norvegicus OX=10116 GN=Enpp2 PE=1 SV=2
16	PDB:5s9mA	0.834	0.901	9.714E-101	809	0.429	0.464	5s9mA.pdb.gz	Crystal Structure of a rat Autotaxin complex
17	PDB:3wayA	0.828	0.919	1.599E-100	787	0.427	0.475	3wayA.pdb.gz	Screening and X-ray Crystal Structure-based Optimization of Autotaxin (ENPP2) Inhibitors, Using a Newly Developed Fluorescence Probe
18	PDB:6xkdB	0.750	0.961	3.532E-92	681	0.426	0.548	6xkdB.pdb.gz	Structure-Aided Development of Small-Molecule Inhibitors of ENPP1, the Extracellular Phosphodiesterase of the Immunotransmitter cGAMP.
19	AFDB:Q9UJA9	0.413	0.750	5.210E-39	477	0.155	0.285	Q9UJA9.pdb.gz	ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 OS=Homo sapiens OX=9606 GN=ENPP5 PE=1 SV=1
20	PDB:5venA	0.417	0.939	2.073E-38	382	0.151	0.346	5venA.pdb.gz	A key tyrosine substitution restricts nucleotide hydrolysis by the ectoenzyme NPP5.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	B0JZL7	0.0	876	878	0.472	0.470	B0JZL7_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 1 OS=Danio rerio OX=7955 GN=si:ch211-142e24.2 PE=1 SV=1
2	B2RBY8	0.0	942	873	0.527	0.528	B2RBY8_HUMAN cDNA, FLJ95771, highly similar to Homo sapiens ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), mRNA OS=Homo sapiens OX=9606 PE=2 SV=1
3	E2RUH0	0.0	792	859	0.429	0.437	E2RUH0_CHICK Ectonucleotide pyrophosphatase/phosphodiesterase 2, long form OS=Gallus gallus OX=9031 GN=Enpp2 PE=2 SV=1
4	O14638	0.0	1840	875	1.000	1.000	ENPP3_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Homo sapiens OX=9606 GN=ENPP3 PE=1 SV=2
5	P06802	0.0	924	906	0.505	0.488	ENPP1_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Mus musculus OX=10090 GN=Enpp1 PE=1 SV=4
6	P22413	0.0	946	925	0.528	0.499	ENPP1_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Homo sapiens OX=9606 GN=ENPP1 PE=1 SV=2
7	P97675	0.0	1491	875	0.815	0.815	ENPP3_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Rattus norvegicus OX=10116 GN=Enpp3 PE=1 SV=2
8	Q13822	0.0	788	863	0.432	0.438	ENPP2_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 OS=Homo sapiens OX=9606 GN=ENPP2 PE=1 SV=3
9	Q64610	0.0	798	887	0.435	0.430	ENPP2_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 OS=Rattus norvegicus OX=10116 GN=Enpp2 PE=1 SV=2
10	Q6DYE8	0.0	1472	874	0.808	0.809	ENPP3_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 OS=Mus musculus OX=10090 GN=Enpp3 PE=1 SV=2
11	Q6PGY9	0.0	819	850	0.450	0.464	Q6PGY9_DANRE Ectonucleotide pyrophosphatase/phosphodiesterase 2 OS=Danio rerio OX=7955 GN=atx PE=2 SV=1
12	Q924C3	0.0	915	906	0.503	0.486	ENPP1_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 OS=Rattus norvegicus OX=10116 GN=Enpp1 PE=1 SV=2
13	Q9R1E6	0.0	798	862	0.433	0.440	ENPP2_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 OS=Mus musculus OX=10090 GN=Enpp2 PE=1 SV=3
14	E2RUH1	3.58e-97	310	372	0.159	0.374	E2RUH1_CHICK Ectonucleotide pyrophosphatase/phosphodiesterase 2 OS=Gallus gallus OX=9031 GN=Enpp2 PE=1 SV=1
15	Q9SU83	3.28e-86	286	496	0.182	0.321	Q9SU83_ARATH Alkaline-phosphatase-like family protein OS=Arabidopsis thaliana OX=3702 GN=At4g29680 PE=1 SV=1
16	Q9SU81	6.19e-76	257	461	0.177	0.336	Q9SU81_ARATH Alkaline-phosphatase-like family protein OS=Arabidopsis thaliana OX=3702 GN=At4g29700 PE=1 SV=1
17	Q9EQG7	3.62e-71	244	477	0.158	0.289	ENPP5_MOUSE Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 OS=Mus musculus OX=10090 GN=Enpp5 PE=1 SV=3
18	Q9UJA9	3.83e-69	239	477	0.153	0.281	ENPP5_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 OS=Homo sapiens OX=9606 GN=ENPP5 PE=1 SV=1
19	P84039	4.51e-69	239	477	0.151	0.277	ENPP5_RAT Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 OS=Rattus norvegicus OX=10116 GN=Enpp5 PE=1 SV=2
20	Q9Y6X5	5.94e-67	232	453	0.158	0.305	ENPP4_HUMAN Bis(5'-adenosyl)-triphosphatase ENPP4 OS=Homo sapiens OX=9606 GN=ENPP4 PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF01223 Endonuclease_NS	0.0045	28.4	DNA/RNA non-specific endonuclease
2	PF01663 Phosphodiest	9.1e-81	283.8	Type I phosphodiesterase / nucleotide pyrophosphatase
3	PF01033 Somatomedin_B	4.2e-14	63.9	Somatomedin B domain
4	PF00884 Sulfatase	23	15.8	Sulfatase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000406261

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000301825	0.973	Ectonucleoside triphosphate diphosphohydrolase 3
2	9606.ENSP00000360561	0.961	Ectonucleoside triphosphate diphosphohydrolase 8
3	9606.ENSP00000360250	0.960	Ectonucleoside triphosphate diphosphohydrolase 1
4	9606.ENSP00000430075	0.956	AMP deaminase 1
5	9606.ENSP00000335246	0.954	Ectonucleoside triphosphate diphosphohydrolase 5
6	9606.ENSP00000256578	0.949	AMP deaminase 2
7	9606.ENSP00000365840	0.948	Ectonucleoside triphosphate diphosphohydrolase 6
8	9606.ENSP00000351520	0.929	Ectonucleoside triphosphate diphosphohydrolase 4
9	9606.ENSP00000256997	0.927	Acid phosphatase 2, lysosomal
10	9606.ENSP00000226279	0.920	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
11	9606.ENSP00000265016	0.920	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
12	9606.ENSP00000365926	0.919	Riboflavin kinase
13	9606.ENSP00000294724	0.916	Glycogen debranching enzyme
14	9606.ENSP00000379802	0.914	AMP deaminase 3
15	9606.ENSP00000468767	0.910	Tartrate-resistant acid phosphatase type 5
16	9606.ENSP00000164139	0.909	Glycogen phosphorylase, muscle form
17	9606.ENSP00000216392	0.909	Glycogen phosphorylase, liver form
18	9606.ENSP00000216962	0.909	Glycogen phosphorylase, brain form
19	9606.ENSP00000286621	0.908	Adenosine kinase
20	9606.ENSP00000340736	0.908	Glycogenin-1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0043167	0.999	ion binding
GO:0016462	0.999	pyrophosphatase activity
GO:0008081	0.999	phosphoric diester hydrolase activity
GO:0004527	0.999	exonuclease activity
GO:0047429	0.993	nucleoside triphosphate diphosphatase activity
GO:0004528	0.992	phosphodiesterase I activity
GO:0008270	0.981	zinc ion binding
GO:0005509	0.953	calcium ion binding
GO:0005515	0.567	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.997	organic substance metabolic process
GO:0044238	0.997	primary metabolic process
GO:0044237	0.997	cellular metabolic process
GO:0006807	0.996	nitrogen compound metabolic process
GO:1901564	0.993	organonitrogen compound metabolic process
GO:0019637	0.992	organophosphate metabolic process
GO:0006796	0.991	phosphate-containing compound metabolic process
GO:0055086	0.989	nucleobase-containing small molecule metabolic process
GO:1901135	0.984	carbohydrate derivative metabolic process
GO:0072521	0.982	purine-containing compound metabolic process
GO:0009117	0.975	nucleotide metabolic process
GO:0006163	0.967	purine nucleotide metabolic process
GO:0009259	0.966	ribonucleotide metabolic process
GO:0009150	0.959	purine ribonucleotide metabolic process
GO:0009141	0.863	nucleoside triphosphate metabolic process
GO:0009144	0.766	purine nucleoside triphosphate metabolic process
GO:0009199	0.743	ribonucleoside triphosphate metabolic process
GO:0009205	0.515	purine ribonucleoside triphosphate metabolic process
GO:0046434	0.468	organophosphate catabolic process
GO:0032501	0.372	multicellular organismal process
GO:0050789	0.355	regulation of biological process
GO:0050794	0.330	regulation of cellular process
GO:0046034	0.327	ATP metabolic process
GO:0050896	0.308	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0016020	0.997	membrane
GO:0009986	0.985	cell surface
GO:0005622	0.962	intracellular anatomical structure
GO:0005737	0.954	cytoplasm
GO:0005576	0.953	extracellular region
GO:0005886	0.951	plasma membrane
GO:0043226	0.917	organelle
GO:0043227	0.876	membrane-bounded organelle
GO:0043231	0.736	intracellular membrane-bounded organelle
GO:0005615	0.651	extracellular space
GO:0005829	0.503	cytosol
GO:0065010	0.307	extracellular membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.6.1.-	0.999	In phosphorus-containing anhydrides.
EC:3.1.4.-	0.999	Phosphoric diester hydrolases.
EC:3.6.1.9	0.993	nucleotide diphosphatase.
EC:3.1.4.1	0.992	phosphodiesterase I.

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