StarFunc result for job id O15056

User Input

>input (1496 residues)
MALSKGLRLLGRLGAEGDCSVLLEARGRDDCLLFEAGTVATLAPEEKEVIKGQYGKLTDA
YGCLGELRLKSGGTSLSFLVLVTGCTSVGRIPDAEIYKITATDFYPLQEEAKEEERLIAL
KKILSSGVFYFSWPNDGSRFDLTVRTQKQGDDSSEWGNSFFWNQLLHVPLRQHQVSCCDW
LLKIICGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY
MDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVV
VNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGGKLEKLETLLRPQLKLH
WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGLSSKPIV
DRFVESFKAMWSLNGHSLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEA
IKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKRIRIAMGTWNVN
GGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMVELSAGNIVNAS
TTNKKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGG
KAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQKLCFPMGRNVFSHDY
VFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTY
KYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPG
ALQYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSFQGPLDATVVVNLQSPT
LEEKNEFPEDLRTELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA
VKIRPKTKDWLKGLREEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDILEDDED
YLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDADLVELKRE
LEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQ
TARLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGASEEALSAVAP
RDLEASSEPEPTPGAAKPETPQAPPLLPRRPPPRVPAIKKPTLRRTGKPLSPEEQFEQQT
VHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAERPSHRKPASDEAPPGAGASVP
PPLEAPPLVPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTYNSSDSPSGHPPAAGTVFPQ
GDFLSTSSATSPDSDGTKAMKPEAAPLLGDYQDPFWNLLHHPKLLNNTWLSKSSDPLDSG
TRSPKRDPIDPVSAGASAAKAELPPDHEHKTLGHWVTISDQEKRTALQVFDPLAKT

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O15056	1.000	1.000	0.000	1496	1.000	1.000	O15056.pdb.gz	SYNJ2_HUMAN Synaptojanin-2 OS=Homo sapiens OX=9606 GN=SYNJ2 PE=1 SV=3
2	AFDB:O43426	0.657	0.625	0.000	1573	0.438	0.416	O43426.pdb.gz	SYNJ1_HUMAN Synaptojanin-1 OS=Homo sapiens OX=9606 GN=SYNJ1 PE=1 SV=2
3	AFDB:O55207	0.689	0.689	0.000	1496	0.842	0.842	O55207.pdb.gz	SYNJ2_RAT Synaptojanin-2 OS=Rattus norvegicus OX=10116 GN=Synj2 PE=1 SV=2
4	AFDB:Q62910	0.659	0.627	0.000	1574	0.436	0.415	Q62910.pdb.gz	SYNJ1_RAT Synaptojanin-1 OS=Rattus norvegicus OX=10116 GN=Synj1 PE=1 SV=3
5	AFDB:Q9D2G5	0.682	0.712	0.000	1434	0.809	0.844	Q9D2G5.pdb.gz	SYNJ2_MOUSE Synaptojanin-2 OS=Mus musculus OX=10090 GN=Synj2 PE=1 SV=2
6	AFDB:Q54PV1	0.200	0.168	3.713E-28	1800	0.153	0.127	Q54PV1.pdb.gz	Q54PV1_DICDI Inositol 5-phosphatase OS=Dictyostelium discoideum OX=44689 GN=Dd5P2 PE=4 SV=1
7	PDB:4tu3X	0.218	0.742	2.988E-21	400	0.071	0.265	4tu3X.pdb.gz
8	PDB:7k1wF	0.244	0.724	7.921E-21	462	0.072	0.232	7k1wF.pdb.gz
9	PDB:2imqX	0.166	0.794	6.964E-17	280	0.043	0.229	2imqX.pdb.gz	Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein
10	PDB:4f1iA	0.124	0.448	2.264E-8	328	0.031	0.143	4f1iA.pdb.gz
11	PDB:1akoA	0.122	0.512	9.645E-6	268	0.027	0.153	1akoA.pdb.gz
12	PDB:7oqcF	0.053	0.241	1.550E-3	267	0.019	0.105	7oqcF.pdb.gz	Structural insights into how Prp5 proofreads the pre-mRNA branch site.
13	AFDB:A8DYK5	0.048	0.054	2.118E-3	1306	0.088	0.101	A8DYK5.pdb.gz	A8DYK5_DROME Uncharacterized protein, isoform B OS=Drosophila melanogaster OX=7227 GN=Isha PE=1 SV=1
14	PDB:5vsuA	0.050	0.173	2.220E-3	387	0.019	0.072	5vsuA.pdb.gz	Architecture of the U6 snRNP reveals specific recognition of 3'-end processed U6 snRNA.
15	PDB:7ohxo	0.045	0.496	3.179E-3	112	0.011	0.143	7ohxo.pdb.gz	Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.
16	PDB:3pgwP	0.051	0.515	3.522E-3	113	0.015	0.195	3pgwP.pdb.gz
17	PDB:3lqvB	0.045	0.491	5.044E-3	115	0.013	0.165	3lqvB.pdb.gz	Branch Recognition by SF3b14
18	AFDB:G5EGK6	0.043	0.029	5.068E-3	2407	0.094	0.058	G5EGK6.pdb.gz	DIN1_CAEEL Daf-12-interacting protein 1 OS=Caenorhabditis elegans OX=6239 GN=din-1 PE=1 SV=1
19	AFDB:Q71RC2	0.050	0.089	1.736E-2	724	0.057	0.117	Q71RC2.pdb.gz	LARP4_HUMAN La-related protein 4 OS=Homo sapiens OX=9606 GN=LARP4 PE=1 SV=3
20	AFDB:Q5T481	0.042	0.051	1.924E-2	1227	0.066	0.080	Q5T481.pdb.gz	RBM20_HUMAN RNA-binding protein 20 OS=Homo sapiens OX=9606 GN=RBM20 PE=1 SV=4

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E9QHF3	0.0	1155	1308	0.378	0.433	E9QHF3_DANRE phosphoinositide 5-phosphatase OS=Danio rerio OX=7955 GN=fb02f11 PE=1 SV=2
2	G5ECL2	0.0	696	1119	0.265	0.354	SYNJ_CAEEL Synaptojanin OS=Caenorhabditis elegans OX=6239 GN=unc-26 PE=1 SV=1
3	O15056	0.0	3087	1496	1.000	1.000	SYNJ2_HUMAN Synaptojanin-2 OS=Homo sapiens OX=9606 GN=SYNJ2 PE=1 SV=3
4	O18964	0.0	1177	1324	0.374	0.422	SYNJ1_BOVIN Synaptojanin-1 (Fragment) OS=Bos taurus OX=9913 GN=SYNJ1 PE=1 SV=2
5	O43426	0.0	1184	1573	0.376	0.357	SYNJ1_HUMAN Synaptojanin-1 OS=Homo sapiens OX=9606 GN=SYNJ1 PE=1 SV=2
6	O55207	0.0	2433	1496	0.840	0.840	SYNJ2_RAT Synaptojanin-2 OS=Rattus norvegicus OX=10116 GN=Synj2 PE=1 SV=2
7	Q5U0V7	0.0	931	1218	0.317	0.389	Q5U0V7_DROME phosphoinositide 5-phosphatase OS=Drosophila melanogaster OX=7227 GN=Synj PE=1 SV=1
8	Q62910	0.0	1182	1574	0.376	0.358	SYNJ1_RAT Synaptojanin-1 OS=Rattus norvegicus OX=10116 GN=Synj1 PE=1 SV=3
9	Q8CHC4	0.0	1176	1574	0.374	0.355	SYNJ1_MOUSE Synaptojanin-1 OS=Mus musculus OX=10090 GN=Synj1 PE=1 SV=3
10	Q8MR94	0.0	676	959	0.233	0.364	Q8MR94_DROME phosphoinositide 5-phosphatase (Fragment) OS=Drosophila melanogaster OX=7227 GN=Synj PE=2 SV=1
11	Q9D2G5	0.0	2392	1434	0.806	0.841	SYNJ2_MOUSE Synaptojanin-2 OS=Mus musculus OX=10090 GN=Synj2 PE=1 SV=2
12	O43001	6.43e-129	430	1076	0.191	0.265	SYJ1_SCHPO Inositol-1,4,5-trisphosphate 5-phosphatase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=syj1 PE=1 SV=1
13	P50942	9.11e-127	427	1183	0.181	0.229	INP52_YEAST Polyphosphatidylinositol phosphatase INP52 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=INP52 PE=1 SV=1
14	Q12271	2.18e-121	410	1107	0.196	0.265	INP53_YEAST Polyphosphatidylinositol phosphatase INP53 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=INP53 PE=1 SV=1
15	Q54D97	1.70e-114	396	1379	0.198	0.215	Q54D97_DICDI Inositol 5-phosphatase OS=Dictyostelium discoideum OX=44689 GN=Dd5P3 PE=4 SV=1
16	A0A1D8PIH6	1.38e-90	319	986	0.165	0.251	A0A1D8PIH6_CANAL phosphoinositide 5-phosphatase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=INP51 PE=3 SV=1
17	P40559	2.41e-80	288	946	0.151	0.239	INP51_YEAST Phosphatidylinositol 4,5-bisphosphate 5-phosphatase INP51 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=INP51 PE=1 SV=1
18	Q9USQ6	1.41e-76	276	889	0.134	0.226	SYJ2_SCHPO Inositol-1,4,5-trisphosphate 5-phosphatase 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=syj2 PE=2 SV=1
19	Q8I7P3	5.87e-65	239	787	0.094	0.179	Q8I7P3_DICDI Inositol 5-phosphatase 4 OS=Dictyostelium discoideum OX=44689 GN=Dd5P4 PE=3 SV=1
20	Q6NVF0	3.49e-64	239	900	0.090	0.150	OCRL_MOUSE Inositol polyphosphate 5-phosphatase OCRL OS=Mus musculus OX=10090 GN=Ocrl PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF08952 DUF1866	1.2e-57	205.3	Domain of unknown function (DUF1866)
2	PF03372 Exo_endo_phos	1.5e-09	49.4	Endonuclease/Exonuclease/phosphatase family
3	PF02383 Syja_N	3.9e-61	218.7	SacI homology domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000347792

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000360798	0.955	Epidermal growth factor receptor substrate 15
2	9606.ENSP00000362014	0.955	Dynamin-1
3	9606.ENSP00000316779	0.952	Myc box-dependent-interacting protein 1
4	9606.ENSP00000351926	0.950	AP-2 complex subunit alpha-1
5	9606.ENSP00000377015	0.945	Phosphatidylinositol-binding clathrin assembly protein
6	9606.ENSP00000292807	0.939	AP-2 complex subunit mu
7	9606.ENSP00000373713	0.939	Phosphatidylinositide phosphatase SAC1
8	9606.ENSP00000406209	0.937	Epsin-1
9	9606.ENSP00000074304	0.935	Type I inositol 3,4-bisphosphate 4-phosphatase
10	9606.ENSP00000361064	0.935	Multiple inositol polyphosphate phosphatase 1
11	9606.ENSP00000361021	0.934	Phosphatase and tensin homolog
12	9606.ENSP00000363046	0.929	Inositol polyphosphate multikinase
13	9606.ENSP00000260386	0.926	Inositol-trisphosphate 3-kinase A
14	9606.ENSP00000411152	0.924	Inositol-trisphosphate 3-kinase B
15	9606.ENSP00000425487	0.924	Type II inositol 3,4-bisphosphate 4-phosphatase
16	9606.ENSP00000267615	0.922	Inositol-tetrakisphosphate 1-kinase
17	9606.ENSP00000376142	0.920	Inositol polyphosphate-1-phosphatase
18	9606.ENSP00000380878	0.919	Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform
19	9606.ENSP00000267012	0.918	Bridging integrator 2
20	9606.ENSP00000383089	0.917	Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0004439	1.000	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0005515	0.999	protein binding
GO:0034596	0.994	phosphatidylinositol phosphate 4-phosphatase activity
GO:0052744	0.991	phosphatidylinositol monophosphate phosphatase activity
GO:0004438	0.874	phosphatidylinositol-3-phosphate phosphatase activity
GO:0106018	0.857	phosphatidylinositol-3,5-bisphosphate phosphatase activity
GO:0052745	0.433	inositol phosphate phosphatase activity
GO:0046030	0.402	inositol trisphosphate phosphatase activity
GO:0043813	0.382	phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.988	cellular process
GO:0046474	0.897	glycerophospholipid biosynthetic process
GO:0016043	0.877	cellular component organization
GO:0046488	0.864	phosphatidylinositol metabolic process
GO:0065007	0.799	biological regulation
GO:0050789	0.774	regulation of biological process
GO:0050794	0.728	regulation of cellular process
GO:0006661	0.536	phosphatidylinositol biosynthetic process
GO:0050896	0.513	response to stimulus
GO:0032501	0.506	multicellular organismal process
GO:0061024	0.423	membrane organization
GO:0051179	0.387	localization
GO:0032502	0.346	developmental process
GO:0048856	0.337	anatomical structure development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.998	cytosol
GO:0016020	0.991	membrane
GO:0043229	0.959	intracellular organelle
GO:0005886	0.953	plasma membrane
GO:0043227	0.906	membrane-bounded organelle
GO:0043231	0.768	intracellular membrane-bounded organelle
GO:0030054	0.571	cell junction
GO:0045202	0.495	synapse
GO:0043228	0.357	non-membrane-bounded organelle
GO:0043232	0.353	intracellular non-membrane-bounded organelle
GO:0032991	0.301	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:22764	1.000	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + phosphate
EC:3.1.3.36	1.000	phosphoinositide 5-phosphatase.
RHEA:12316	0.874	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + phosphate
EC:3.1.3.64	0.874	phosphatidylinositol-3-phosphatase.

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