StarFunc result for job id O15061

User Input

>input (1565 residues)
MLSWRLQTGPEKAELQELNARLYDYVCRVRELERENLLLEEELRGRRGREGLWAEGQARC
AEEARSLRQQLDELSWATALAEGERDALRRELRELQRLDAEERAARGRLDAELGAQQREL
QEALGARAALEALLGRLQAERRGLDAAHERDVRELRARAASLTMHFRARATGPAAPPPRL
REVHDSYALLVAESWRETVQLYEDEVRELEEALRRGQESRLQAEEETRLCAQEAEALRRE
ALGLEQLRARLEDALLRMREEYGIQAEERQRAIDCLEDEKATLTLAMADWLRDYQDLLQV
KTGLSLEVATYRALLEGESNPEIVIWAEHVENMPSEFRNKSYHYTDSLLQRENERNLFSR
QKAPLASFNHSSALYSNLSGHRGSQTGTSIGGDARRGFLGSGYSSSATTQQENSYGKAVS
SQTNVRTFSPTYGLLRNTEAQVKTFPDRPKAGDTREVPVYIGEDSTIARESYRDRRDKVA
AGASESTRSNERTVILGKKTEVKATREQERNRPETIRTKPEEKMFDSKEKASEERNLRWE
ELTKLDKEARQRESQQMKEKAKEKDSPKEKSVREREVPISLEVSQDRRAEVSPKGLQTPV
KDAGGGTGREAEARELRFRLGTSDATGSLQGDSMTETVAENIVTSILKQFTQSPETEASA
DSFPDTKVTYVDRKELPGERKTKTEIVVESKLTEDVDVSDEAGLDYLLSKDIKEVGLKGK
SAEQMIGDIINLGLKGREGRAKVVNVEIVEEPVSYVSGEKPEEFSVPFKVEEVEDVSPGP
WGLVKEEEGYGESDVTFSVNQHRRTKQPQENTTHVEEVTEAGDSEGEQSYFVSTPDEHPG
GHDRDDGSVYGQIHIEEESTIRYSWQDEIVQGTRRRTQKDGAVGEKVVKPLDVPAPSLEG
DLGSTHWKEQARSGEFHAEPTVIEKEIKIPHEFHTSMKGISSKEPRQQLVEVIGQLEETL
PERMREELSALTREGQGGPGSVSVDVKKVQGAGGSSVTLVAEVNVSQTVDADRLDLEELS
KDEASEMEKAVESVVRESLSRQRSPAPGSPDEEGGAEAPAAGIRFRRWATRELYIPSGES
EVAGGASHSSGQRTPQGPVSATVEVSSPTGFAQSQVLEDVSQAARHIKLGPSEVWRTERM
SYEGPTAEVVEVSAGGDLSQAASPTGASRSVRHVTLGPGQSPLSREVIFLGPAPACPEAW
GSPEPGPAESSADMDGSGRHSTFGCRQFHAEKEIIFQGPISAAGKVGDYFATEESVGTQT
SVRQLQLGPKEGFSGQIQFTAPLSDKVELGVIGDSVHMEGLPGSSTSIRHISIGPQRHQT
TQQIVYHGLVPQLGESGDSESTVHGEGSADVHQATHSHTSGRQTVMTEKSTFQSVVSESP
QEDSAGDTSGAEMTSGVSRSFRHIRLGPTETETSEHIAIRGPVSRTFVLAGSADSPELGK
LADSSRTLRHIAPGPKETSFTFQMDVSNVEAIRSRTQEAGALGVSDRGSWRDADSRNDQA
VGVSFKASAGEGDQAHREQGKEQAMFDKKVQLQRMVDQRSVISDEKKVALLYLDNEEEEN
DGHWF

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:G3V9G5	0.149	0.149	0.000	1557	0.688	0.691	G3V9G5.pdb.gz	G3V9G5_RAT Synemin OS=Rattus norvegicus OX=10116 GN=Synm PE=1 SV=2
2	AFDB:O15061	1.000	1.000	0.000	1565	1.000	1.000	O15061.pdb.gz	SYNEM_HUMAN Synemin OS=Homo sapiens OX=9606 GN=SYNM PE=1 SV=3
3	AFDB:Q70IV5	0.184	0.185	0.000	1561	0.693	0.694	Q70IV5.pdb.gz	SYNEM_MOUSE Synemin OS=Mus musculus OX=10090 GN=Synm PE=1 SV=2
4	AFDB:P48681	0.143	0.139	6.601E-17	1621	0.194	0.188	P48681.pdb.gz	NEST_HUMAN Nestin OS=Homo sapiens OX=9606 GN=NES PE=1 SV=2
5	AFDB:Q6P5H2	0.117	0.102	3.248E-12	1864	0.192	0.161	Q6P5H2.pdb.gz	NEST_MOUSE Nestin OS=Mus musculus OX=10090 GN=Nes PE=1 SV=1
6	AFDB:P21263	0.138	0.118	2.114E-11	1893	0.191	0.158	P21263.pdb.gz	NEST_RAT Nestin OS=Rattus norvegicus OX=10116 GN=Nes PE=1 SV=2
7	AFDB:P86839	0.167	0.200	4.762E-11	1265	0.157	0.194	P86839.pdb.gz	NEST_DANRE Nestin OS=Danio rerio OX=7955 GN=nes PE=2 SV=1
8	AFDB:P12036	0.114	0.140	2.803E-7	1026	0.127	0.193	P12036.pdb.gz	NFH_HUMAN Neurofilament heavy polypeptide OS=Homo sapiens OX=9606 GN=NEFH PE=1 SV=4
9	AFDB:Q99700	0.036	0.041	1.943E-6	1313	0.114	0.136	Q99700.pdb.gz	ATX2_HUMAN Ataxin-2 OS=Homo sapiens OX=9606 GN=ATXN2 PE=1 SV=2
10	AFDB:P19246	0.101	0.136	2.343E-6	1090	0.132	0.189	P19246.pdb.gz	NFH_MOUSE Neurofilament heavy polypeptide OS=Mus musculus OX=10090 GN=Nefh PE=1 SV=3
11	PDB:6pwnA	0.031	0.110	2.665E-1	280	0.011	0.061	6pwnA.pdb.gz
12	PDB:4djbA	0.035	0.295	8.202E-1	118	0.006	0.085	4djbA.pdb.gz
13	PDB:6zyeA	0.033	0.165	9.293E-1	222	0.009	0.063	6zyeA.pdb.gz
14	PDB:7acj5	0.029	0.168	1.193	150	0.009	0.093	7acj5.pdb.gz	Structures of tmRNA and SmpB as they transit through the ribosome.
15	PDB:7sn8K	0.038	0.089	1.270	588	0.010	0.027	7sn8K.pdb.gz	Inositol hexakisphosphate is required for Integrator function.
16	PDB:6zydA	0.032	0.117	1.439	323	0.009	0.043	6zydA.pdb.gz
17	PDB:6lypA	0.034	0.141	1.735	287	0.010	0.052	6lypA.pdb.gz
18	PDB:1g9qA	0.019	0.107	1.847	205	0.004	0.034	1g9qA.pdb.gz	The structure of ADP-ribose pyrophosphatase reveals the structural basis for the versatility of the Nudix family.
19	PDB:3o61D	0.015	0.115	1.847	190	0.003	0.026	3o61D.pdb.gz	Structural studies of the Nudix GDP-mannose hydrolase from E. coli reveals a new motif for mannose recognition.
20	PDB:4il8A	0.030	0.077	1.847	459	0.010	0.035	4il8A.pdb.gz	Identification of an essential active-site residue in the alpha-D-phosphohexomutase enzyme superfamily.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A096MK54	0.0	1587	1255	0.541	0.674	A0A096MK54_RAT Synemin OS=Rattus norvegicus OX=10116 GN=Synm PE=1 SV=1
2	G3V9G5	0.0	1948	1557	0.690	0.694	G3V9G5_RAT Synemin OS=Rattus norvegicus OX=10116 GN=Synm PE=1 SV=2
3	O15061	0.0	3157	1565	0.999	0.999	SYNEM_HUMAN Synemin OS=Homo sapiens OX=9606 GN=SYNM PE=1 SV=3
4	Q70IV5	0.0	1976	1561	0.692	0.694	SYNEM_MOUSE Synemin OS=Mus musculus OX=10090 GN=Synm PE=1 SV=2
5	P02543	5.67e-31	130	466	0.066	0.223	VIME_PIG Vimentin OS=Sus scrofa OX=9823 GN=VIM PE=1 SV=2
6	P08670	5.94e-31	130	466	0.067	0.225	VIME_HUMAN Vimentin OS=Homo sapiens OX=9606 GN=VIM PE=1 SV=4
7	V9HWE1	5.94e-31	130	466	0.067	0.225	V9HWE1_HUMAN Epididymis luminal protein 113 OS=Homo sapiens OX=9606 GN=HEL113 PE=2 SV=1
8	P48616	1.12e-30	130	466	0.066	0.223	VIME_BOVIN Vimentin OS=Bos taurus OX=9913 GN=VIM PE=1 SV=3
9	P20152	1.40e-30	129	466	0.066	0.223	VIME_MOUSE Vimentin OS=Mus musculus OX=10090 GN=Vim PE=1 SV=3
10	P02544	1.50e-30	129	465	0.066	0.224	VIME_MESAU Vimentin OS=Mesocricetus auratus OX=10036 GN=VIM PE=1 SV=2
11	P31000	1.55e-30	129	466	0.066	0.223	VIME_RAT Vimentin OS=Rattus norvegicus OX=10116 GN=Vim PE=1 SV=2
12	P48670	1.63e-30	129	448	0.067	0.234	VIME_CRIGR Vimentin (Fragment) OS=Cricetulus griseus OX=10029 GN=VIM PE=2 SV=1
13	P09654	2.49e-29	125	460	0.066	0.224	VIME_CHICK Vimentin OS=Gallus gallus OX=9031 GN=VIM PE=3 SV=2
14	Q58EE9	1.23e-27	120	444	0.073	0.259	GFAP_DANRE Glial fibrillary acidic protein OS=Danio rerio OX=7955 GN=gfap PE=1 SV=2
15	P48674	8.91e-27	118	461	0.063	0.213	VIME_ONCMY Vimentin OS=Oncorhynchus mykiss OX=8022 GN=vim PE=2 SV=1
16	A0A060XL43	1.36e-26	117	449	0.063	0.218	A0A060XL43_ONCMY IF rod domain-containing protein OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00043362001 PE=3 SV=1
17	O73665	1.50e-26	117	448	0.069	0.241	O73665_CHICK Desmin (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
18	P02542	1.53e-26	117	464	0.069	0.233	DESM_CHICK Desmin OS=Gallus gallus OX=9031 GN=DES PE=1 SV=2
19	Q05AI8	1.12e-25	115	474	0.066	0.217	Q05AI8_DANRE Desmin OS=Danio rerio OX=7955 GN=zgc:154009 PE=2 SV=1
20	P03995	1.88e-25	113	430	0.077	0.279	GFAP_MOUSE Glial fibrillary acidic protein OS=Mus musculus OX=10090 GN=Gfap PE=1 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00038 Filament	1.5e-31	121.8	Intermediate filament protein
2	PF18679 HTH_57	7.4e+02	11.8	ThcOx helix turn helix domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000336775

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000470152	0.984	Dystrobrevin alpha
2	9606.ENSP00000211998	0.972	Vinculin
3	9606.ENSP00000354923	0.875	Dystrophin
4	9606.ENSP00000386439	0.869	Syncoilin
5	9606.ENSP00000323856	0.819	Plectin
6	9606.ENSP00000263726	0.766	LIM/homeobox protein Lhx4
7	9606.ENSP00000360811	0.740	LIM/homeobox protein Lhx3
8	9606.ENSP00000348602	0.731	Amphiphysin
9	9606.ENSP00000394770	0.705	Cardiomyopathy-associated protein 5
10	9606.ENSP00000324422	0.679	Zyxin
11	9606.ENSP00000368199	0.673	Pyroglutamyl-peptidase 1-like protein
12	9606.ENSP00000467141	0.649	Titin
13	9606.ENSP00000476795	0.644	Gigaxonin
14	9606.ENSP00000304987	0.621	Phakinin
15	9606.ENSP00000354718	0.571	A-kinase anchor protein 13
16	9606.ENSP00000361060	0.551	Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
17	9606.ENSP00000239926	0.540	Myotilin
18	9606.ENSP00000280979	0.528	A-kinase anchor protein 6
19	9606.ENSP00000355166	0.525	Leucine-rich repeat-containing protein 10
20	9606.ENSP00000369981	0.518	Endophilin-A1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005200	0.998	structural constituent of cytoskeleton
GO:0008307	0.994	structural constituent of muscle
GO:0008092	0.990	cytoskeletal protein binding
GO:0017166	0.959	vinculin binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.990	cellular process
GO:0071840	0.886	cellular component organization or biogenesis
GO:0016043	0.878	cellular component organization
GO:0006996	0.846	organelle organization
GO:0007010	0.719	cytoskeleton organization
GO:0065007	0.630	biological regulation
GO:0045104	0.627	intermediate filament cytoskeleton organization
GO:0050789	0.560	regulation of biological process
GO:0050794	0.554	regulation of cellular process
GO:0032501	0.346	multicellular organismal process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0045111	0.999	intermediate filament cytoskeleton
GO:0099512	0.994	supramolecular fiber
GO:0005737	0.991	cytoplasm
GO:0005882	0.950	intermediate filament
GO:0043292	0.945	contractile fiber
GO:0030016	0.944	myofibril
GO:0016020	0.937	membrane
GO:0071944	0.862	cell periphery
GO:0043227	0.773	membrane-bounded organelle
GO:0043231	0.723	intracellular membrane-bounded organelle
GO:0005886	0.686	plasma membrane
GO:0043034	0.649	costamere
GO:0005829	0.456	cytosol
GO:0060053	0.364	neurofilament cytoskeleton

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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