StarFunc result for job id O15357

User Input

>input (1258 residues)
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:D7PF45	0.567	0.566	0.000	1260	0.954	0.952	D7PF45.pdb.gz	SHIP2_PIG Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Sus scrofa OX=9823 GN=INPPL1 PE=1 SV=2
2	AFDB:Q2I6J1	0.652	0.648	0.000	1266	0.678	0.674	Q2I6J1.pdb.gz	SHP2A_DANRE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A OS=Danio rerio OX=7955 GN=inppl1a PE=2 SV=2
3	AFDB:Q92835	0.480	0.507	0.000	1189	0.391	0.414	Q92835.pdb.gz	SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2
4	AFDB:Q9ES52	0.485	0.510	0.000	1191	0.389	0.411	Q9ES52.pdb.gz	SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Mus musculus OX=10090 GN=Inpp5d PE=1 SV=2
5	AFDB:W5U6G9	0.613	0.614	0.000	1256	0.683	0.684	W5U6G9.pdb.gz	W5U6G9_ICTPU phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase OS=Ictalurus punctatus OX=7998 GN=inppl1a PE=2 SV=1
6	AFDB:O43426	0.225	0.181	2.980E-26	1573	0.149	0.119	O43426.pdb.gz	SYNJ1_HUMAN Synaptojanin-1 OS=Homo sapiens OX=9606 GN=SYNJ1 PE=1 SV=2
7	PDB:2imqX	0.197	0.810	9.568E-18	280	0.052	0.236	2imqX.pdb.gz	Heme-assisted S-nitrosation of a proximal thiolate in a nitric oxide transport protein
8	PDB:4f1iA	0.152	0.479	7.015E-9	328	0.037	0.140	4f1iA.pdb.gz
9	PDB:1ka6A	0.083	0.884	8.182E-9	107	0.034	0.402	1ka6A.pdb.gz	A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome.
10	AFDB:Q57WH0	0.087	0.088	2.202E-6	1241	0.050	0.051	Q57WH0.pdb.gz	Q57WH0_TRYB2 C2 domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.28B13.500 PE=4 SV=1
11	PDB:1akoA	0.139	0.502	4.730E-6	268	0.037	0.172	1akoA.pdb.gz
12	PDB:7kiuA	0.143	0.550	8.315E-6	263	0.035	0.167	7kiuA.pdb.gz	Structural features of Dnase1L3 responsible for serum antigen clearance.
13	PDB:2j63A	0.147	0.428	9.213E-6	333	0.033	0.126	2j63A.pdb.gz
14	PDB:4fl2A	0.073	0.164	1.539E-5	555	0.023	0.052	4fl2A.pdb.gz	Structural and biophysical characterization of the syk activation switch.
15	PDB:4k2rA	0.075	0.168	4.077E-5	551	0.024	0.054	4k2rA.pdb.gz	Structural Basis for Activation of ZAP-70 by Phosphorylation of the SH2-Kinase Linker.
16	PDB:1griA	0.075	0.412	7.545E-5	211	0.024	0.142	1griA.pdb.gz
17	PDB:4gwfA	0.071	0.176	9.751E-5	497	0.025	0.062	4gwfA.pdb.gz
18	AFDB:I2HAJ6	0.059	0.050	1.031E-4	1725	0.091	0.066	I2HAJ6.pdb.gz	I2HAJ6_CAEEL Neurexin-3-beta OS=Caenorhabditis elegans OX=6239 GN=nrx-1 PE=4 SV=1
19	AFDB:O75038	0.081	0.073	1.636E-4	1416	0.074	0.066	O75038.pdb.gz	PLCH2_HUMAN 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Homo sapiens OX=9606 GN=PLCH2 PE=1 SV=3
20	AFDB:Q9BXF6	0.081	0.139	7.623E-4	653	0.056	0.107	Q9BXF6.pdb.gz	RFIP5_HUMAN Rab11 family-interacting protein 5 OS=Homo sapiens OX=9606 GN=RAB11FIP5 PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A0C5A9Q6	0.0	1590	1283	0.676	0.663	A0A0C5A9Q6_ICTPU phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (Fragment) OS=Ictalurus punctatus OX=7998 PE=2 SV=1
2	A0A0C5AMM3	0.0	794	1116	0.339	0.383	A0A0C5AMM3_ICTPU phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase OS=Ictalurus punctatus OX=7998 PE=2 SV=1
3	D7PF45	0.0	2233	1260	0.944	0.942	SHIP2_PIG Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Sus scrofa OX=9823 GN=INPPL1 PE=1 SV=2
4	H0Y5Q9	0.0	608	810	0.227	0.352	H0Y5Q9_HUMAN Inositol polyphosphate-5-phosphatase D (Fragment) OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=1
5	O15357	0.0	2568	1258	1.000	1.000	SHIP2_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Homo sapiens OX=9606 GN=INPPL1 PE=1 SV=2
6	P97573	0.0	825	1190	0.344	0.364	SHIP1_RAT Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Rattus norvegicus OX=10116 GN=Inpp5d PE=1 SV=1
7	Q2I6J1	0.0	1578	1266	0.676	0.672	SHP2A_DANRE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A OS=Danio rerio OX=7955 GN=inppl1a PE=2 SV=2
8	Q6P549	0.0	2302	1257	0.959	0.959	SHIP2_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Mus musculus OX=10090 GN=Inppl1 PE=1 SV=1
9	Q92835	0.0	813	1189	0.347	0.368	SHIP1_HUMAN Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Homo sapiens OX=9606 GN=INPP5D PE=1 SV=2
10	Q9ES52	0.0	819	1191	0.347	0.367	SHIP1_MOUSE Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 OS=Mus musculus OX=10090 GN=Inpp5d PE=1 SV=2
11	Q9WVR3	0.0	2319	1257	0.955	0.956	SHIP2_RAT Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 OS=Rattus norvegicus OX=10116 GN=Inppl1 PE=1 SV=1
12	W5U6G9	0.0	1588	1256	0.673	0.674	W5U6G9_ICTPU phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase OS=Ictalurus punctatus OX=7998 GN=inppl1a PE=2 SV=1
13	W5UIG7	0.0	793	1118	0.340	0.383	W5UIG7_ICTPU phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase OS=Ictalurus punctatus OX=7998 GN=Inpp5d PE=2 SV=1
14	Q54W40	5.86e-59	223	940	0.136	0.182	Q54W40_DICDI Inositol 5-phosphatase OS=Dictyostelium discoideum OX=44689 GN=Dd5P1 PE=4 SV=1
15	A0A0R4IPY6	1.47e-44	178	961	0.088	0.116	A0A0R4IPY6_DANRE phosphoinositide 5-phosphatase OS=Danio rerio OX=7955 GN=wu:fi09g03 PE=1 SV=1
16	F1QIY4	2.09e-44	177	953	0.088	0.116	F1QIY4_DANRE phosphoinositide 5-phosphatase OS=Danio rerio OX=7955 GN=wu:fi09g03 PE=1 SV=2
17	D3ZGS3	1.21e-43	174	902	0.084	0.118	OCRL_RAT Inositol polyphosphate 5-phosphatase OCRL OS=Rattus norvegicus OX=10116 GN=Ocrl PE=1 SV=1
18	Q01968	1.57e-43	174	901	0.084	0.118	OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL OS=Homo sapiens OX=9606 GN=OCRL PE=1 SV=3
19	Q6NVF0	1.14e-41	168	900	0.083	0.116	OCRL_MOUSE Inositol polyphosphate 5-phosphatase OCRL OS=Mus musculus OX=10090 GN=Ocrl PE=1 SV=1
20	E7ESY0	3.79e-41	165	748	0.088	0.148	E7ESY0_HUMAN phosphoinositide 5-phosphatase OS=Homo sapiens OX=9606 GN=INPP5B PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03372 Exo_endo_phos	1.6e-08	46.0	Endonuclease/Exonuclease/phosphatase family
2	PF00536 SAM_1	3.5e-05	35.5	SAM domain (Sterile alpha motif)
3	PF07647 SAM_2	1.6e-05	36.2	SAM domain (Sterile alpha motif)
4	PF00017 SH2	8.4e-13	59.5	SH2 domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000298229

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000351209	0.998	Ephrin type-A receptor 2
2	9606.ENSP00000401303	0.998	SHC-transforming protein 1
3	9606.ENSP00000264033	0.984	E3 ubiquitin-protein ligase CBL
4	9606.ENSP00000317272	0.972	Hepatocyte growth factor receptor
5	9606.ENSP00000351497	0.972	Low affinity immunoglobulin gamma Fc region receptor II-b
6	9606.ENSP00000451828	0.965	RAC-alpha serine/threonine-protein kinase
7	9606.ENSP00000074304	0.963	Type I inositol 3,4-bisphosphate 4-phosphatase
8	9606.ENSP00000361021	0.963	Phosphatase and tensin homolog
9	9606.ENSP00000425487	0.959	Type II inositol 3,4-bisphosphate 4-phosphatase
10	9606.ENSP00000239440	0.946	Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3
11	9606.ENSP00000265970	0.941	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha
12	9606.ENSP00000289153	0.941	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
13	9606.ENSP00000366563	0.939	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
14	9606.ENSP00000356155	0.936	Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
15	9606.ENSP00000363046	0.934	Inositol polyphosphate multikinase
16	9606.ENSP00000260386	0.933	Inositol-trisphosphate 3-kinase A
17	9606.ENSP00000263967	0.933	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
18	9606.ENSP00000352121	0.933	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
19	9606.ENSP00000411152	0.933	Inositol-trisphosphate 3-kinase B
20	9606.ENSP00000263370	0.926	Inositol-trisphosphate 3-kinase C

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0016791	0.999	phosphatase activity
GO:0052866	0.956	phosphatidylinositol phosphate phosphatase activity
GO:0034595	0.937	phosphatidylinositol phosphate 5-phosphatase activity
GO:0052745	0.882	inositol phosphate phosphatase activity
GO:0034594	0.819	phosphatidylinositol trisphosphate phosphatase activity
GO:0046030	0.794	inositol trisphosphate phosphatase activity
GO:0034485	0.382	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
GO:0004445	0.365	inositol-polyphosphate 5-phosphatase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0006793	0.995	phosphorus metabolic process
GO:0046486	0.990	glycerolipid metabolic process
GO:0046488	0.983	phosphatidylinositol metabolic process
GO:0050794	0.981	regulation of cellular process
GO:0050896	0.976	response to stimulus
GO:0016043	0.970	cellular component organization
GO:0032501	0.965	multicellular organismal process
GO:0048856	0.965	anatomical structure development
GO:0045017	0.945	glycerolipid biosynthetic process
GO:0006661	0.941	phosphatidylinositol biosynthetic process
GO:0048523	0.850	negative regulation of cellular process
GO:0007275	0.819	multicellular organism development
GO:0051716	0.801	cellular response to stimulus
GO:0023052	0.729	signaling
GO:0007154	0.722	cell communication
GO:0048583	0.696	regulation of response to stimulus
GO:0007165	0.690	signal transduction
GO:0019222	0.627	regulation of metabolic process
GO:0009966	0.615	regulation of signal transduction
GO:0060255	0.594	regulation of macromolecule metabolic process
GO:0007166	0.485	cell surface receptor signaling pathway
GO:0048518	0.449	positive regulation of biological process
GO:0042221	0.434	response to chemical
GO:0031323	0.424	regulation of cellular metabolic process
GO:0048522	0.410	positive regulation of cellular process
GO:0080090	0.394	regulation of primary metabolic process
GO:0048731	0.349	system development

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005829	0.999	cytosol
GO:0043231	0.996	intracellular membrane-bounded organelle
GO:0012505	0.989	endomembrane system
GO:0005886	0.989	plasma membrane
GO:0031981	0.987	nuclear lumen
GO:0005654	0.951	nucleoplasm
GO:0005794	0.321	Golgi apparatus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:3.1.3.-	0.999	Phosphoric monoester hydrolases.
RHEA:25528	0.382	a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + phosphate
EC:3.1.3.56	0.365	inositol-polyphosphate 5-phosphatase.

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