StarFunc result for job id O15392

User Input

>input (142 residues)
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:E7CU85	0.988	0.988	2.553E-25	142	1.000	1.000	E7CU85.pdb.gz	E7CU85_HUMAN Baculoviral IAP repeat-containing 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=1
2	AFDB:E3SCZ8	0.976	0.976	1.550E-23	142	0.866	0.866	E3SCZ8.pdb.gz	BIRC5_CAVPO Baculoviral IAP repeat-containing protein 5 OS=Cavia porcellus OX=10141 GN=BIRC5 PE=1 SV=1
3	AFDB:Q9JHY7	0.974	0.974	6.484E-23	142	0.824	0.824	Q9JHY7.pdb.gz	BIRC5_RAT Baculoviral IAP repeat-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Birc5 PE=2 SV=1
4	PDB:3uedC	0.964	0.985	8.515E-23	139	0.979	1.000	3uedC.pdb.gz	Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres.
5	AFDB:Q50L39	0.885	0.805	2.543E-18	157	0.549	0.497	Q50L39.pdb.gz	BI52A_XENLA Baculoviral IAP repeat-containing protein 5.2-A OS=Xenopus laevis OX=8355 GN=birc5.2-a PE=1 SV=1
6	PDB:1m4mA	0.740	0.928	3.137E-17	112	0.669	0.848	1m4mA.pdb.gz	CRYSTAL STRUCTURE AND MUTAGENIC ANALYSIS OF THE INHIBITOR-OF-APOPTOSIS PROTEIN SURVIVIN
7	AFDB:F1QTF4	0.872	0.659	2.243E-16	190	0.493	0.368	F1QTF4.pdb.gz
8	AFDB:F1R810	0.889	0.877	1.363E-15	144	0.437	0.431	F1R810.pdb.gz
9	AFDB:Q8JGN5	0.747	0.665	3.925E-15	160	0.430	0.381	Q8JGN5.pdb.gz	BI51A_XENLA Baculoviral IAP repeat-containing protein 5.1-A OS=Xenopus laevis OX=8355 GN=birc5.1-a PE=1 SV=1
10	AFDB:Q9VEM2	0.628	0.588	1.744E-10	153	0.331	0.307	Q9VEM2.pdb.gz	Q9VEM2_DROME Deterin OS=Drosophila melanogaster OX=7227 GN=Det PE=1 SV=1
11	AFDB:O14064	0.496	0.082	1.853E-8	997	0.246	0.035	O14064.pdb.gz	BIR1_SCHPO Protein bir1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=bir1 PE=1 SV=1
12	AFDB:G5EFA2	0.618	0.573	3.673E-7	155	0.246	0.226	G5EFA2.pdb.gz	BIR1_CAEEL Chromosomal passenger complex protein bir-1 OS=Caenorhabditis elegans OX=6239 GN=bir-1 PE=1 SV=1
13	PDB:5yudA	0.445	0.057	7.448E-5	1238	0.211	0.024	5yudA.pdb.gz	Structural basis for specific flagellin recognition by the NLR protein NAIP5.
14	PDB:6b5bA	0.425	0.057	2.585E-4	1199	0.190	0.023	6b5bA.pdb.gz
15	PDB:4gskB	0.111	0.039	1.890	572	0.063	0.016	4gskB.pdb.gz	Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.
16	PDB:4v6wCp	0.148	0.221	3.521	91	0.028	0.044	4v6wCp.pdb.gz	Structures of the human and Drosophila 80S ribosome.
17	PDB:4g85A	0.190	0.076	4.806	427	0.056	0.019	4g85A.pdb.gz
18	PDB:1ecfB	0.216	0.065	5.114	500	0.085	0.024	1ecfB.pdb.gz	Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli.
19	PDB:2bskD	0.238	0.331	5.114	90	0.106	0.167	2bskD.pdb.gz
20	PDB:4gslA	0.116	0.044	5.792	598	0.070	0.017	4gslA.pdb.gz	Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	E7CU85	1.09e-102	291	142	1.000	1.000	E7CU85_HUMAN Baculoviral IAP repeat-containing 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=1
2	O15392	1.09e-102	291	142	1.000	1.000	BIRC5_HUMAN Baculoviral IAP repeat-containing protein 5 OS=Homo sapiens OX=9606 GN=BIRC5 PE=1 SV=3
3	E3SCZ8	2.54e-91	263	142	0.866	0.866	BIRC5_CAVPO Baculoviral IAP repeat-containing protein 5 OS=Cavia porcellus OX=10141 GN=BIRC5 PE=1 SV=1
4	Q9JHY7	7.93e-87	251	142	0.824	0.824	BIRC5_RAT Baculoviral IAP repeat-containing protein 5 OS=Rattus norvegicus OX=10116 GN=Birc5 PE=2 SV=1
5	O70201	1.09e-86	251	140	0.831	0.843	BIRC5_MOUSE Baculoviral IAP repeat-containing protein 5 OS=Mus musculus OX=10090 GN=Birc5 PE=1 SV=1
6	Q50L39	8.99e-56	173	157	0.549	0.497	BI52A_XENLA Baculoviral IAP repeat-containing protein 5.2-A OS=Xenopus laevis OX=8355 GN=birc5.2-a PE=1 SV=1
7	Q804H7	1.68e-55	172	157	0.549	0.497	BI52B_XENLA Baculoviral IAP repeat-containing protein 5.2-B OS=Xenopus laevis OX=8355 GN=birc5.2-b PE=1 SV=2
8	Q90WU9	7.43e-46	147	142	0.493	0.493	Q90WU9_DANRE Baculoviral IAP repeat-containing 5a OS=Danio rerio OX=7955 GN=bir5a PE=1 SV=1
9	Q90WU8	9.36e-42	137	128	0.458	0.508	Q90WU8_DANRE Baculoviral IAP repeat-containing 5b OS=Danio rerio OX=7955 GN=bir5b PE=2 SV=1
10	Q8JGN5	1.69e-41	137	160	0.465	0.412	BI51A_XENLA Baculoviral IAP repeat-containing protein 5.1-A OS=Xenopus laevis OX=8355 GN=birc5.1-a PE=1 SV=1
11	Q9VEM2	1.87e-24	94.0	153	0.324	0.301	Q9VEM2_DROME Deterin OS=Drosophila melanogaster OX=7227 GN=Det PE=1 SV=1
12	Q9NR09	4.38e-13	67.4	4857	0.211	0.006	BIRC6_HUMAN Baculoviral IAP repeat-containing protein 6 OS=Homo sapiens OX=9606 GN=BIRC6 PE=1 SV=3
13	Q8MS47	4.39e-13	67.4	1151	0.204	0.025	Q8MS47_DROME RE07981p (Fragment) OS=Drosophila melanogaster OX=7227 GN=Bruce PE=2 SV=1
14	O88738	4.87e-13	67.4	4882	0.211	0.006	BIRC6_MOUSE Baculoviral IAP repeat-containing protein 6 OS=Mus musculus OX=10090 GN=Birc6 PE=1 SV=2
15	O14064	6.32e-13	67.0	997	0.197	0.028	BIR1_SCHPO Protein bir1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=bir1 PE=1 SV=1
16	A0A0B4KGR9	8.53e-13	66.6	4875	0.204	0.006	A0A0B4KGR9_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform D OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
17	A0A0B4KH36	8.53e-13	66.6	4852	0.204	0.006	A0A0B4KH36_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform C OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
18	A0A0B4KFQ0	8.62e-13	66.6	4865	0.204	0.006	A0A0B4KFQ0_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform E OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1
19	Q9VH01	8.70e-13	66.6	4876	0.204	0.006	Q9VH01_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform A OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=3
20	A0A0B4KG50	9.87e-13	66.2	4976	0.204	0.006	A0A0B4KG50_DROME BIR repeat containing ubiquitin-conjugating enzyme, isoform B OS=Drosophila melanogaster OX=7227 GN=Bruce PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00653 BIR	3.2e-21	87.1	Inhibitor of Apoptosis domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9483.ENSCJAP00000036200

Rank	PPI partner	STRING score	Description
1	9483.ENSCJAP00000003627	0.996	Cell division cycle associated 8
2	9483.ENSCJAP00000028920	0.991	Aurora kinase B
3	9483.ENSCJAP00000035422	0.990	Inner centromere protein antigens 135/155kDa
4	9483.ENSCJAP00000037861	0.986	Diablo, IAP-binding mitochondrial protein
5	9483.ENSCJAP00000020758	0.982	Aurora kinase A
6	9483.ENSCJAP00000000030	0.942	Aurora kinase C
7	9483.ENSCJAP00000035621	0.941	Caspase 7, apoptosis-related cysteine peptidase
8	9483.ENSCJAP00000024828	0.939	BUB1 mitotic checkpoint serine/threonine kinase
9	9483.ENSCJAP00000048034	0.939	Baculoviral IAP repeat-containing 4 (Predicted)
10	9483.ENSCJAP00000010532	0.936	Caspase 3, apoptosis-related cysteine peptidase
11	9483.ENSCJAP00000007601	0.931	Kinesin-like protein
12	9483.ENSCJAP00000039199	0.917	Rac GTPase activating protein 1
13	9483.ENSCJAP00000011810	0.915	Kinesin-like protein
14	9483.ENSCJAP00000031798	0.909	HtrA serine peptidase 2
15	9483.ENSCJAP00000006902	0.906	Baculoviral IAP repeat containing 2
16	9483.ENSCJAP00000038885	0.904	BUB1 mitotic checkpoint serine/threonine kinase B
17	9483.ENSCJAP00000013177	0.902	Kinesin-like protein
18	9483.ENSCJAP00000006814	0.900	Shugoshin-like 1 (S. pombe)
19	9483.ENSCJAP00000006284	0.884	Cell division cycle 20
20	9483.ENSCJAP00000013531	0.882	Uncharacterized protein

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0019899	0.565	enzyme binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050794	0.992	regulation of cellular process
GO:0048518	0.981	positive regulation of biological process
GO:0022402	0.978	cell cycle process
GO:1901990	0.935	regulation of mitotic cell cycle phase transition
GO:0010941	0.934	regulation of cell death
GO:0007088	0.930	regulation of mitotic nuclear division
GO:0033044	0.929	regulation of chromosome organization
GO:0010948	0.928	negative regulation of cell cycle process
GO:0051983	0.925	regulation of chromosome segregation
GO:0000075	0.923	cell cycle checkpoint signaling
GO:0043069	0.920	negative regulation of programmed cell death
GO:0042981	0.911	regulation of apoptotic process
GO:0045930	0.911	negative regulation of mitotic cell cycle
GO:0030071	0.907	regulation of mitotic metaphase/anaphase transition
GO:0033047	0.905	regulation of mitotic sister chromatid segregation
GO:0043066	0.903	negative regulation of apoptotic process
GO:0010639	0.902	negative regulation of organelle organization
GO:1903047	0.901	mitotic cell cycle process
GO:1905818	0.887	regulation of chromosome separation
GO:0045839	0.886	negative regulation of mitotic nuclear division
GO:0033048	0.885	negative regulation of mitotic sister chromatid segregation
GO:1901991	0.863	negative regulation of mitotic cell cycle phase transition
GO:0007093	0.862	mitotic cell cycle checkpoint signaling
GO:0080090	0.846	regulation of primary metabolic process
GO:0007094	0.825	mitotic spindle assembly checkpoint signaling
GO:0060255	0.820	regulation of macromolecule metabolic process
GO:0051246	0.795	regulation of protein metabolic process
GO:0071704	0.790	organic substance metabolic process
GO:0065009	0.780	regulation of molecular function
GO:0032501	0.721	multicellular organismal process
GO:0010605	0.707	negative regulation of macromolecule metabolic process
GO:0050790	0.703	regulation of catalytic activity
GO:0045861	0.668	negative regulation of proteolysis
GO:0048522	0.659	positive regulation of cellular process
GO:0043086	0.646	negative regulation of catalytic activity
GO:0051346	0.598	negative regulation of hydrolase activity
GO:0031323	0.576	regulation of cellular metabolic process
GO:0044238	0.572	primary metabolic process
GO:0044770	0.567	cell cycle phase transition
GO:0052547	0.530	regulation of peptidase activity
GO:0006807	0.527	nitrogen compound metabolic process
GO:0043170	0.513	macromolecule metabolic process
GO:0044839	0.504	cell cycle G2/M phase transition
GO:0071840	0.491	cellular component organization or biogenesis
GO:0052548	0.474	regulation of endopeptidase activity
GO:0010466	0.441	negative regulation of peptidase activity
GO:0003008	0.437	system process
GO:0016043	0.437	cellular component organization
GO:0044237	0.431	cellular metabolic process
GO:0007605	0.420	sensory perception of sound
GO:0010951	0.406	negative regulation of endopeptidase activity
GO:0045787	0.399	positive regulation of cell cycle
GO:0051179	0.345	localization
GO:0050000	0.337	chromosome localization
GO:0006996	0.302	organelle organization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005737	1.000	cytoplasm
GO:0015630	0.997	microtubule cytoskeleton
GO:0098687	0.995	chromosomal region
GO:0005654	0.995	nucleoplasm
GO:0032991	0.989	protein-containing complex
GO:0000775	0.988	chromosome, centromeric region
GO:0030496	0.985	midbody
GO:0005829	0.971	cytosol
GO:0005819	0.962	spindle
GO:0016020	0.453	membrane
GO:0005815	0.376	microtubule organizing center
GO:0000793	0.346	condensed chromosome
GO:0005875	0.331	microtubule associated complex
GO:0000776	0.321	kinetochore

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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