StarFunc result for job id O43272

User Input

>input (600 residues)
MALRRALPALRPCIPRFVQLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQE
AYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAG
EDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQ
YQAHRAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGR
PQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDW
FTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRML
QRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAY
DNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDY
VLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHQVYFGQLLGMCDQISFPLGQ
AGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A087WWM6	0.933	0.933	3.319E-91	600	0.995	0.995	A0A087WWM6.pdb.gz	A0A087WWM6_HUMAN Proline dehydrogenase OS=Homo sapiens OX=9606 GN=PRODH PE=1 SV=1
2	AFDB:F1MAR6	0.930	0.932	4.762E-80	599	0.813	0.815	F1MAR6.pdb.gz	F1MAR6_RAT Proline dehydrogenase OS=Rattus norvegicus OX=10116 GN=Prodh PE=1 SV=3
3	AFDB:Q04499	0.824	0.729	7.628E-51	681	0.460	0.405	Q04499.pdb.gz	PROD_DROME Proline dehydrogenase 1, mitochondrial OS=Drosophila melanogaster OX=7227 GN=slgA PE=1 SV=2
4	AFDB:Q9UF12	0.618	0.688	5.432E-31	536	0.312	0.349	Q9UF12.pdb.gz	HYPDH_HUMAN Hydroxyproline dehydrogenase OS=Homo sapiens OX=9606 GN=PRODH2 PE=1 SV=2
5	AFDB:Q8VCZ9	0.623	0.811	1.944E-30	456	0.303	0.399	Q8VCZ9.pdb.gz	HYPDH_MOUSE Hydroxyproline dehydrogenase OS=Mus musculus OX=10090 GN=Prodh2 PE=1 SV=1
6	AFDB:Q57U33	0.715	0.768	7.294E-30	556	0.275	0.297	Q57U33.pdb.gz	Q57U33_TRYB2 Proline dehydrogenase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.8P12.290 PE=3 SV=1
7	AFDB:P92983	0.633	0.754	3.465E-29	499	0.273	0.329	P92983.pdb.gz	PROD1_ARATH Proline dehydrogenase 1, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=POX1 PE=1 SV=2
8	AFDB:Q6NKX1	0.614	0.765	2.935E-27	476	0.253	0.319	Q6NKX1.pdb.gz	PROD2_ARATH Proline dehydrogenase 2, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=POX2 PE=1 SV=1
9	AFDB:Q5BCJ9	0.519	0.643	2.101E-19	478	0.223	0.280	Q5BCJ9.pdb.gz	Q5BCJ9_EMENI Proline dehydrogenase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=prnD PE=3 SV=1
10	AFDB:A0A1D8PNH4	0.469	0.566	1.340E-17	489	0.173	0.213	A0A1D8PNH4.pdb.gz	A0A1D8PNH4_CANAL Proline dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=PUT1 PE=3 SV=1
11	PDB:4h6qA	0.412	0.849	1.130E-10	281	0.127	0.270	4h6qA.pdb.gz	Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release.
12	PDB:2g37B	0.400	0.769	4.494E-9	300	0.127	0.253	2g37B.pdb.gz	Structure and Kinetics of Monofunctional Proline Dehydrogenase from Thermus thermophilus.
13	PDB:3hazA	0.404	0.261	5.428E-9	983	0.152	0.093	3hazA.pdb.gz	Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum
14	PDB:5zfsB	0.120	0.183	6.092E-3	294	0.063	0.129	5zfsB.pdb.gz	X-ray structure of Arthrobacter globiformis M30 ketose 3-epimerase for the production of D-allulose from D-fructose.
15	PDB:1f05A	0.151	0.241	9.318E-3	322	0.067	0.124	1f05A.pdb.gz
16	PDB:3vnlA	0.174	0.297	1.566E-2	291	0.062	0.127	3vnlA.pdb.gz	Crystal structures of D-psicose 3-epimerase from Clostridium cellulolyticum H10 and its complex with ketohexose sugars.
17	PDB:7v6gB	0.188	0.302	2.633E-2	338	0.053	0.095	7v6gB.pdb.gz	Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis.
18	PDB:1ea9C	0.148	0.151	2.894E-2	583	0.052	0.053	1ea9C.pdb.gz
19	PDB:2e3zA	0.140	0.173	3.335E-2	460	0.032	0.041	2e3zA.pdb.gz
20	PDB:6ap6A	0.091	0.157	3.496E-2	264	0.032	0.072	6ap6A.pdb.gz	Inhibition of strigolactone receptors byN-phenylanthranilic acid derivatives: Structural and functional insights.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A0A087WWM6	0.0	1235	600	0.995	0.995	A0A087WWM6_HUMAN Proline dehydrogenase OS=Homo sapiens OX=9606 GN=PRODH PE=1 SV=1
2	A0A0G2K2S1	0.0	903	538	0.713	0.796	A0A0G2K2S1_RAT Proline dehydrogenase OS=Rattus norvegicus OX=10116 GN=Prodh PE=1 SV=2
3	E7EQL6	0.0	1021	492	0.817	0.996	E7EQL6_HUMAN Proline dehydrogenase OS=Homo sapiens OX=9606 GN=PRODH PE=1 SV=1
4	F1MAR6	0.0	1019	599	0.815	0.816	F1MAR6_RAT Proline dehydrogenase OS=Rattus norvegicus OX=10116 GN=Prodh PE=1 SV=3
5	O43272	0.0	1244	600	1.000	1.000	PROD_HUMAN Proline dehydrogenase 1, mitochondrial OS=Homo sapiens OX=9606 GN=PRODH PE=1 SV=3
6	Q04499	0.0	536	681	0.468	0.413	PROD_DROME Proline dehydrogenase 1, mitochondrial OS=Drosophila melanogaster OX=7227 GN=slgA PE=1 SV=2
7	Q9WU79	0.0	1005	599	0.818	0.820	PROD_MOUSE Proline dehydrogenase 1, mitochondrial OS=Mus musculus OX=10090 GN=Prodh PE=1 SV=2
8	Q57U33	2.98e-72	244	556	0.293	0.317	Q57U33_TRYB2 Proline dehydrogenase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.8P12.290 PE=3 SV=1
9	Q9UF12	1.25e-62	218	536	0.205	0.229	HYPDH_HUMAN Hydroxyproline dehydrogenase OS=Homo sapiens OX=9606 GN=PRODH2 PE=1 SV=2
10	Q8VCZ9	2.37e-61	212	456	0.200	0.263	HYPDH_MOUSE Hydroxyproline dehydrogenase OS=Mus musculus OX=10090 GN=Prodh2 PE=1 SV=1
11	P92983	3.01e-50	183	499	0.152	0.182	PROD1_ARATH Proline dehydrogenase 1, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=POX1 PE=1 SV=2
12	Q6NKX1	3.52e-49	179	476	0.158	0.200	PROD2_ARATH Proline dehydrogenase 2, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=POX2 PE=1 SV=1
13	Q5BCJ9	6.15e-23	104	478	0.135	0.169	Q5BCJ9_EMENI Proline dehydrogenase OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=prnD PE=3 SV=1
14	A0A1D8PNH4	6.48e-19	92.4	489	0.115	0.141	A0A1D8PNH4_CANAL Proline dehydrogenase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=PUT1 PE=3 SV=1
15	P09368	2.35e-17	87.4	476	0.140	0.176	PUT1_YEAST Proline dehydrogenase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=PUT1 PE=1 SV=2
16	Q9I5F6	4.92e-05	48.9	1060	0.102	0.058	Q9I5F6_PSEAE Bifunctional protein PutA OS=Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) OX=208964 GN=putA PE=3 SV=1
17	Q4KES9	0.044	39.7	4901	0.043	0.005	Q4KES9_PSEF5 Non-ribosomal peptide synthetase OfaC OS=Pseudomonas fluorescens (strain ATCC BAA-477 / NRRL B-23932 / Pf-5) OX=220664 GN=ofaC PE=4 SV=3
18	Q9BYX2	0.050	39.3	928	0.052	0.033	TBD2A_HUMAN TBC1 domain family member 2A OS=Homo sapiens OX=9606 GN=TBC1D2 PE=1 SV=3
19	Q89E26	0.11	38.1	999	0.107	0.064	Q89E26_BRADU Bifunctional protein PutA OS=Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) OX=224911 GN=putA PE=1 SV=1
20	P10503	0.12	38.1	1320	0.105	0.048	PUTA_SALTY Bifunctional protein PutA OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) OX=99287 GN=putA PE=2 SV=4

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF09487 HrpB2	1.3e+02	14.4	Bacterial type III secretion protein (HrpB2)
2	PF01619 Pro_dh	1.4e-76	269.3	Proline dehydrogenase

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000481127

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000364490	0.995	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial
2	9606.ENSP00000384949	0.962	Pyrroline-5-carboxylate reductase 1, mitochondrial
3	9606.ENSP00000360268	0.948	Delta-1-pyrroline-5-carboxylate synthase
4	9606.ENSP00000220966	0.936	Pyrroline-5-carboxylate reductase 3
5	9606.ENSP00000342502	0.936	Pyrroline-5-carboxylate reductase 2
6	9606.ENSP00000226299	0.903	Cytosol aminopeptidase
7	9606.ENSP00000263556	0.900	Prolyl 4-hydroxylase subunit alpha-1
8	9606.ENSP00000384999	0.900	Prolyl 4-hydroxylase subunit alpha-2
9	9606.ENSP00000357838	0.842	Ornithine aminotransferase, mitochondrial
10	9606.ENSP00000384716	0.803	Probable palmitoyltransferase ZDHHC8
11	9606.ENSP00000354511	0.802	Catechol O-methyltransferase
12	9606.ENSP00000349577	0.801	Proline dehydrogenase
13	9606.ENSP00000333401	0.748	Mitochondrial ribosomal protein L40
14	9606.ENSP00000331313	0.733	G protein subunit beta 1 like
15	9606.ENSP00000356468	0.729	Influenza virus NS1A-binding protein
16	9606.ENSP00000331681	0.727	DiGeorge syndrome critical region gene 6
17	9606.ENSP00000482514	0.727	Protein DGCR6
18	9606.ENSP00000216714	0.718	DNA-(apurinic or apyrimidinic site) lyase
19	9606.ENSP00000248879	0.705	Protein DGCR6L
20	9606.ENSP00000403645	0.695	Transport and golgi organization 2 homolog

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0036094	1.000	small molecule binding
GO:0043168	1.000	anion binding
GO:0004657	1.000	proline dehydrogenase activity
GO:0097159	0.995	organic cyclic compound binding
GO:0016597	0.942	amino acid binding
GO:1901363	0.888	heterocyclic compound binding
GO:0005515	0.862	protein binding
GO:1901265	0.827	nucleoside phosphate binding
GO:0050660	0.799	flavin adenine dinucleotide binding
GO:0071949	0.724	FAD binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071704	0.997	organic substance metabolic process
GO:0044237	0.997	cellular metabolic process
GO:0044238	0.994	primary metabolic process
GO:0006807	0.991	nitrogen compound metabolic process
GO:0050789	0.982	regulation of biological process
GO:1901605	0.980	alpha-amino acid metabolic process
GO:0009063	0.976	amino acid catabolic process
GO:0009064	0.973	glutamine family amino acid metabolic process
GO:1901606	0.973	alpha-amino acid catabolic process
GO:0050794	0.972	regulation of cellular process
GO:0006560	0.952	proline metabolic process
GO:0006575	0.949	cellular modified amino acid metabolic process
GO:0009065	0.947	glutamine family amino acid catabolic process
GO:0048518	0.939	positive regulation of biological process
GO:0048522	0.856	positive regulation of cellular process
GO:0010941	0.763	regulation of cell death
GO:0042219	0.754	cellular modified amino acid catabolic process
GO:1901360	0.736	organic cyclic compound metabolic process
GO:0010942	0.533	positive regulation of cell death
GO:0046700	0.524	heterocycle catabolic process
GO:1901361	0.467	organic cyclic compound catabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.999	mitochondrion
GO:0005654	0.985	nucleoplasm
GO:0016020	0.969	membrane
GO:0005829	0.301	cytosol

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:23784	1.000	a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)
EC:1.5.5.2	1.000	proline dehydrogenase.

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