StarFunc result for job id O60248

User Input

>input (233 residues)
MALPGSSQDQAWSLEPPAATAAASSSSGPQEREGAGSPAAPGTLPLEKVKRPMNAFMVWS
SAQRRQMAQQNPKMHNSEISKRLGAQWKLLDEDEKRPFVEEAKRLRARHLRDYPDYKYRP
RRKAKSSGAGPSRCGQGRGNLASGGPLWGPGYATTQPSRGFGYRPPSYSTAYLPGSYGSS
HCKLEAPSPCSLPQSDPRLQGELLPTYTHYLPPGSPTPYNPPLAGAPMPLTHL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O60248	0.999	0.999	8.071E-34	233	1.000	1.000	O60248.pdb.gz	SOX15_HUMAN Protein SOX-15 OS=Homo sapiens OX=9606 GN=SOX15 PE=1 SV=1
2	AFDB:P43267	0.601	0.605	9.294E-26	231	0.747	0.753	P43267.pdb.gz	SOX15_MOUSE Protein SOX-15 OS=Mus musculus OX=10090 GN=Sox15 PE=1 SV=3
3	AFDB:O95416	0.351	0.341	1.065E-11	240	0.326	0.317	O95416.pdb.gz	SOX14_HUMAN Transcription factor SOX-14 OS=Homo sapiens OX=9606 GN=SOX14 PE=1 SV=1
4	AFDB:Q6RVD7	0.345	0.328	1.372E-11	245	0.356	0.339	Q6RVD7.pdb.gz	SX21B_DANRE Transcription factor Sox-21-B OS=Danio rerio OX=7955 GN=sox21b PE=2 SV=1
5	AFDB:P47792	0.353	0.281	2.585E-11	297	0.382	0.300	P47792.pdb.gz	SX19A_DANRE Transcription factor Sox-19a OS=Danio rerio OX=7955 GN=sox19a PE=1 SV=2
6	AFDB:B0ZTE1	0.341	0.304	3.330E-11	262	0.369	0.328	B0ZTE1.pdb.gz	SOX21_XENLA Transcription factor Sox-21 OS=Xenopus laevis OX=8355 GN=sox21 PE=2 SV=1
7	AFDB:Q20201	0.352	0.387	4.870E-11	212	0.296	0.325	Q20201.pdb.gz	SOX3_CAEEL Transcription factor sox-3 OS=Caenorhabditis elegans OX=6239 GN=sox-3 PE=2 SV=1
8	AFDB:B0ZTE2	0.340	0.332	5.528E-11	239	0.318	0.310	B0ZTE2.pdb.gz	SOX14_XENLA Transcription factor Sox-14 OS=Xenopus laevis OX=8355 GN=sox14 PE=2 SV=1
9	AFDB:P43680	0.362	0.228	1.110E-10	377	0.373	0.231	P43680.pdb.gz	SOX18_MOUSE Transcription factor SOX-18 OS=Mus musculus OX=10090 GN=Sox18 PE=1 SV=3
10	AFDB:P48433	0.357	0.271	1.110E-10	312	0.386	0.288	P48433.pdb.gz	SOX3_CHICK Transcription factor SOX-3 OS=Gallus gallus OX=9031 GN=SOX3 PE=2 SV=1
11	PDB:1j5nA	0.261	0.610	8.703E-4	93	0.090	0.226	1j5nA.pdb.gz	The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding
12	PDB:7ploI	0.191	0.102	7.648E-1	451	0.039	0.020	7ploI.pdb.gz	A conserved mechanism for regulating replisome disassembly in eukaryotes.
13	PDB:7fbyA	0.107	0.160	1.353	153	0.060	0.092	7fbyA.pdb.gz	Crystal Structure of PH0140 from Pyrococcus horikosii OT3
14	PDB:7n9sA	0.135	0.018	2.893	2365	0.039	0.004	7n9sA.pdb.gz
15	PDB:6zm7CE	0.150	0.278	4.230	124	0.047	0.089	6zm7CE.pdb.gz	Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2.
16	PDB:1vfiA	0.163	0.306	5.116	95	0.034	0.084	1vfiA.pdb.gz
17	PDB:3dufA	0.119	0.080	6.187	365	0.039	0.025	3dufA.pdb.gz	Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multienzyme complex
18	PDB:8escE	0.122	0.058	6.591	440	0.039	0.020	8escE.pdb.gz	Structure and flexibility of the yeast NuA4 histone acetyltransferase complex.
19	PDB:2cyyA	0.104	0.157	7.022	151	0.064	0.099	2cyyA.pdb.gz	Crystal structure of PH1519 from Pyrococcus horikosii OT3
20	PDB:4ob3B	0.099	0.100	7.022	229	0.060	0.061	4ob3B.pdb.gz	The active site sulfenic acid ligand in nitrile hydratases can function as a nucleophile.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O60248	6.11e-169	466	233	1.000	1.000	SOX15_HUMAN Protein SOX-15 OS=Homo sapiens OX=9606 GN=SOX15 PE=1 SV=1
2	P43267	2.28e-114	328	231	0.747	0.753	SOX15_MOUSE Protein SOX-15 OS=Mus musculus OX=10090 GN=Sox15 PE=1 SV=3
3	Q9DDD7	3.61e-43	149	292	0.313	0.250	SX19B_DANRE Transcription factor Sox-19b OS=Danio rerio OX=7955 GN=sox19b PE=1 SV=1
4	B0ZTE1	1.19e-42	147	262	0.283	0.252	SOX21_XENLA Transcription factor Sox-21 OS=Xenopus laevis OX=8355 GN=sox21 PE=2 SV=1
5	P55863	1.19e-42	148	309	0.335	0.252	SOX3A_XENLA Transcription factor Sox-3-A OS=Xenopus laevis OX=8355 GN=sox3-a PE=1 SV=1
6	Q6RVD7	3.27e-42	145	245	0.275	0.261	SX21B_DANRE Transcription factor Sox-21-B OS=Danio rerio OX=7955 GN=sox21b PE=2 SV=1
7	P47792	6.90e-42	145	297	0.270	0.212	SX19A_DANRE Transcription factor Sox-19a OS=Danio rerio OX=7955 GN=sox19a PE=1 SV=2
8	Q20201	8.04e-42	143	212	0.309	0.340	SOX3_CAEEL Transcription factor sox-3 OS=Caenorhabditis elegans OX=6239 GN=sox-3 PE=2 SV=1
9	Q811W0	2.40e-41	144	276	0.275	0.232	SOX21_MOUSE Transcription factor SOX-21 OS=Mus musculus OX=10090 GN=Sox21 PE=2 SV=1
10	Q9Y651	3.10e-41	143	276	0.275	0.232	SOX21_HUMAN Transcription factor SOX-21 OS=Homo sapiens OX=9606 GN=SOX21 PE=2 SV=1
11	P48430	3.29e-41	144	315	0.292	0.216	SOX2_CHICK Transcription factor SOX-2 OS=Gallus gallus OX=9031 GN=SOX2 PE=1 SV=1
12	B0ZTE2	4.62e-41	142	239	0.262	0.255	SOX14_XENLA Transcription factor Sox-14 OS=Xenopus laevis OX=8355 GN=sox14 PE=2 SV=1
13	Q6P0E1	1.13e-40	143	315	0.262	0.194	SOX2_DANRE Transcription factor Sox-2 OS=Danio rerio OX=7955 GN=sox2 PE=2 SV=1
14	Q7SZS1	1.16e-40	141	239	0.283	0.276	SX21A_DANRE Transcription factor Sox-21-A OS=Danio rerio OX=7955 GN=sox21a PE=2 SV=1
15	Q32PP9	1.17e-40	141	238	0.262	0.256	SOX14_DANRE Transcription factor Sox-14 OS=Danio rerio OX=7955 GN=sox14 PE=2 SV=1
16	O42569	1.24e-40	143	311	0.266	0.199	SOX2_XENLA Transcription factor Sox-2 OS=Xenopus laevis OX=8355 GN=sox2 PE=1 SV=1
17	Q9W7R5	1.24e-40	142	280	0.275	0.229	SOX21_CHICK Transcription factor SOX-21 OS=Gallus gallus OX=9031 GN=SOX21 PE=2 SV=1
18	P48432	1.52e-40	143	319	0.266	0.194	SOX2_MOUSE Transcription factor SOX-2 OS=Mus musculus OX=10090 GN=Sox2 PE=1 SV=2
19	D4A543	1.54e-40	143	319	0.266	0.194	D4A543_RAT SRY-box transcription factor 2 OS=Rattus norvegicus OX=10116 GN=Sox2 PE=4 SV=1
20	Q60I23	1.54e-40	143	319	0.266	0.194	Q60I23_MOUSE SRY (sex determining region Y)-box 2 OS=Mus musculus OX=10090 GN=Sox2 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00505 HMG_box	1e-23	94.8	HMG (high mobility group) box
2	PF09011 HMG_box_2	1.4e-08	46.5	HMG-box domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000355354

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000259915	0.769	POU domain, class 5, transcription factor 1
2	9606.ENSP00000367203	0.656	Lysine-specific demethylase 6A
3	9606.ENSP00000229307	0.623	Homeobox protein NANOG
4	9606.ENSP00000421169	0.607	BEN domain containing 4
5	9606.ENSP00000246229	0.573	Zinc finger protein PLAGL2
6	9606.ENSP00000325546	0.573	Zinc finger protein PLAG1
7	9606.ENSP00000264193	0.566	Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial
8	9606.ENSP00000472109	0.516	Transcriptional enhancer factor TEF-4
9	9606.ENSP00000371728	0.507	Neurensin-2
10	9606.ENSP00000217086	0.503	Sal-like protein 4
11	9606.ENSP00000419298	0.502	Putative POU domain, class 5, transcription factor 1B

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0043565	0.997	sequence-specific DNA binding
GO:0003690	0.984	double-stranded DNA binding
GO:0140110	0.980	transcription regulator activity
GO:1990837	0.974	sequence-specific double-stranded DNA binding
GO:0003700	0.968	DNA-binding transcription factor activity
GO:0000981	0.882	DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000976	0.879	transcription cis-regulatory region binding
GO:0000977	0.503	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000987	0.432	cis-regulatory region sequence-specific DNA binding
GO:0000978	0.389	RNA polymerase II cis-regulatory region sequence-specific DNA binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

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[0.6,0.7)

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[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.995	regulation of cellular process
GO:0006355	0.990	regulation of DNA-templated transcription
GO:0032502	0.987	developmental process
GO:0048856	0.984	anatomical structure development
GO:0032501	0.981	multicellular organismal process
GO:0006357	0.962	regulation of transcription by RNA polymerase II
GO:0007275	0.922	multicellular organism development
GO:0048513	0.906	animal organ development
GO:0048731	0.865	system development
GO:0048518	0.856	positive regulation of biological process
GO:0048522	0.816	positive regulation of cellular process
GO:0010604	0.789	positive regulation of macromolecule metabolic process
GO:0051173	0.787	positive regulation of nitrogen compound metabolic process
GO:0031325	0.786	positive regulation of cellular metabolic process
GO:0007548	0.770	sex differentiation
GO:0051254	0.636	positive regulation of RNA metabolic process
GO:0045893	0.625	positive regulation of DNA-templated transcription
GO:0009987	0.603	cellular process
GO:0045944	0.490	positive regulation of transcription by RNA polymerase II
GO:0048519	0.467	negative regulation of biological process
GO:0045137	0.443	development of primary sexual characteristics
GO:0048523	0.438	negative regulation of cellular process
GO:0031324	0.415	negative regulation of cellular metabolic process
GO:0051172	0.359	negative regulation of nitrogen compound metabolic process
GO:0010558	0.340	negative regulation of macromolecule biosynthetic process
GO:0031327	0.340	negative regulation of cellular biosynthetic process
GO:0050896	0.322	response to stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

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[0.4,0.5)

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GO term	C-score	Name
GO:0005654	0.997	nucleoplasm
GO:0032991	0.979	protein-containing complex
GO:0005737	0.848	cytoplasm
GO:0005667	0.356	transcription regulator complex
GO:0043232	0.356	intracellular non-membrane-bounded organelle

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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