StarFunc result for job id O60602

User Input

>input (858 residues)
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRT
VTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFH
LFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSN
QIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTV
DITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFV
FSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLP
KVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPK
INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFL
GENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTV
LSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVT
IAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTV
TKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYS
DQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCL
SDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDFQDVGWFLHKLSQQILKKE
KEKKKDNNIPLQTVATIS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:G3V6F8	0.810	0.798	0.000	871	0.700	0.690	G3V6F8.pdb.gz	G3V6F8_RAT Toll-like receptor 5 OS=Rattus norvegicus OX=10116 GN=Tlr5 PE=3 SV=1
2	AFDB:O60602	1.000	1.000	0.000	858	1.000	1.000	O60602.pdb.gz	TLR5_HUMAN Toll-like receptor 5 OS=Homo sapiens OX=9606 GN=TLR5 PE=1 SV=4
3	AFDB:Q9JLF7	0.750	0.750	0.000	859	0.723	0.722	Q9JLF7.pdb.gz	TLR5_MOUSE Toll-like receptor 5 OS=Mus musculus OX=10090 GN=Tlr5 PE=1 SV=1
4	AFDB:Q5GR02	0.699	0.696	8.702E-82	862	0.507	0.505	Q5GR02.pdb.gz	Q5GR02_CHICK Toll-like receptor 5 OS=Gallus gallus OX=9031 GN=TLR5 PE=3 SV=1
5	PDB:3j0aA	0.581	0.621	2.547E-73	797	0.928	0.999	3j0aA.pdb.gz	Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.
6	AFDB:A0A286Y971	0.663	0.643	6.716E-63	886	0.374	0.362	A0A286Y971.pdb.gz
7	AFDB:A0A2R3VHL5	0.662	0.646	4.432E-62	881	0.368	0.359	A0A2R3VHL5.pdb.gz
8	AFDB:A0A2R8RTN4	0.382	0.348	1.864E-33	955	0.255	0.229	A0A2R8RTN4.pdb.gz	A0A2R8RTN4_DANRE Toll-like receptor 22 OS=Danio rerio OX=7955 GN=TLR21.2 PE=3 SV=1
9	AFDB:F1LN63	0.506	0.483	5.732E-33	905	0.251	0.238	F1LN63.pdb.gz	F1LN63_RAT Toll-like receptor 3 OS=Rattus norvegicus OX=10116 GN=Tlr3 PE=3 SV=1
10	AFDB:Q0PQ88	0.492	0.474	8.588E-33	896	0.237	0.227	Q0PQ88.pdb.gz	Q0PQ88_CHICK Toll-like receptor 3 OS=Gallus gallus OX=9031 GN=TLR3 PE=2 SV=2
11	AFDB:B8JIL3	0.523	0.501	1.176E-32	903	0.230	0.218	B8JIL3.pdb.gz
12	PDB:7wv3A	0.532	0.660	4.930E-20	668	0.190	0.244	7wv3A.pdb.gz	TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand.
13	PDB:3t6qA	0.467	0.631	7.640E-19	601	0.152	0.216	3t6qA.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
14	PDB:3b2dA	0.439	0.591	5.156E-16	601	0.161	0.230	3b2dA.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
15	PDB:7wrqA	0.351	0.508	1.023E-12	566	0.171	0.260	7wrqA.pdb.gz
16	PDB:7tvfD	0.288	0.418	9.670E-12	515	0.140	0.233	7tvfD.pdb.gz	Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
17	PDB:6gffI	0.361	0.516	1.385E-11	551	0.154	0.240	6gffI.pdb.gz
18	PDB:5yq5B	0.266	0.696	1.324E-7	306	0.084	0.235	5yq5B.pdb.gz
19	PDB:6hkwA	0.201	0.473	1.385E-7	306	0.087	0.245	6hkwA.pdb.gz
20	PDB:1xcdA	0.211	0.504	9.999E-7	305	0.070	0.197	1xcdA.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	C0LP03	0.0	1219	859	0.702	0.701	C0LP03_RAT Toll-like receptor 5 OS=Rattus norvegicus OX=10116 GN=Tlr5 PE=2 SV=1
2	G3V6F8	0.0	1218	871	0.702	0.691	G3V6F8_RAT Toll-like receptor 5 OS=Rattus norvegicus OX=10116 GN=Tlr5 PE=3 SV=1
3	O60602	0.0	1757	858	1.000	1.000	TLR5_HUMAN Toll-like receptor 5 OS=Homo sapiens OX=9606 GN=TLR5 PE=1 SV=4
4	Q5GR02	0.0	875	862	0.513	0.510	Q5GR02_CHICK Toll-like receptor 5 OS=Gallus gallus OX=9031 GN=TLR5 PE=3 SV=1
5	Q9JLF7	0.0	1250	859	0.725	0.724	TLR5_MOUSE Toll-like receptor 5 OS=Mus musculus OX=10090 GN=Tlr5 PE=1 SV=1
6	F8W3J5	3.80e-178	538	881	0.378	0.368	F8W3J5_DANRE Toll-like receptor 5b OS=Danio rerio OX=7955 GN=tlr5 PE=1 SV=1
7	B3DIN1	2.61e-177	536	875	0.380	0.373	B3DIN1_DANRE Tlr5b protein OS=Danio rerio OX=7955 GN=tlr5b PE=1 SV=1
8	F8W4F1	3.65e-168	512	881	0.369	0.360	F8W4F1_DANRE Toll-like receptor 5 OS=Danio rerio OX=7955 GN=tlr5a PE=3 SV=2
9	A0A2R8RTN4	4.07e-51	196	955	0.277	0.249	A0A2R8RTN4_DANRE Toll-like receptor 22 OS=Danio rerio OX=7955 GN=TLR21.2 PE=3 SV=1
10	Q0PQ88	1.72e-47	184	896	0.259	0.248	Q0PQ88_CHICK Toll-like receptor 3 OS=Gallus gallus OX=9031 GN=TLR3 PE=2 SV=2
11	P58681	7.83e-46	180	1050	0.253	0.207	TLR7_MOUSE Toll-like receptor 7 OS=Mus musculus OX=10090 GN=Tlr7 PE=1 SV=1
12	Q9NYK1	1.48e-43	173	1049	0.256	0.210	TLR7_HUMAN Toll-like receptor 7 OS=Homo sapiens OX=9606 GN=TLR7 PE=1 SV=1
13	Q99MB1	1.14e-42	170	905	0.265	0.251	TLR3_MOUSE Toll-like receptor 3 OS=Mus musculus OX=10090 GN=Tlr3 PE=1 SV=2
14	Q7TNI8	1.39e-42	169	905	0.267	0.253	Q7TNI8_RAT Toll-like receptor 3 OS=Rattus norvegicus OX=10116 GN=Tlr3 PE=2 SV=1
15	F1LN63	1.90e-42	169	905	0.267	0.253	F1LN63_RAT Toll-like receptor 3 OS=Rattus norvegicus OX=10116 GN=Tlr3 PE=3 SV=1
16	A0A0G2JXV2	2.24e-42	169	927	0.267	0.247	A0A0G2JXV2_RAT Toll-like receptor 3 OS=Rattus norvegicus OX=10116 GN=Tlr3 PE=1 SV=1
17	Q5ZJ34	4.24e-42	168	972	0.177	0.156	Q5ZJ34_CHICK TIR domain-containing protein OS=Gallus gallus OX=9031 GN=RCJMB04_21a21 PE=2 SV=1
18	O15455	5.61e-40	161	904	0.190	0.180	TLR3_HUMAN Toll-like receptor 3 OS=Homo sapiens OX=9606 GN=TLR3 PE=1 SV=1
19	Q5ZJD0	1.15e-38	157	1059	0.241	0.195	Q5ZJD0_CHICK Toll-like receptor 7-long OS=Gallus gallus OX=9031 GN=RCJMB04_19d10 PE=2 SV=1
20	Q5GQ97	1.17e-38	157	1046	0.241	0.198	Q5GQ97_CHICK Toll-like receptor 7 (Fragment) OS=Gallus gallus OX=9031 GN=TLR7 PE=3 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF02723 CoV_E	4.8e+02	12.3	Coronavirus small envelope protein E
2	PF01463 LRRCT	40	16.1	Leucine rich repeat C-terminal domain
3	PF00560 LRR_1	1.9e-05	35.3	Leucine Rich Repeat
4	PF12799 LRR_4	4.7e-22	88.9	Leucine Rich repeats (2 copies)
5	PF13306 LRR_5	1.6e-09	49.2	BspA type Leucine rich repeat region (6 copies)
6	PF13516 LRR_6	0.44	21.8	Leucine Rich repeat
7	PF13855 LRR_8	6.9e-57	200.4	Leucine rich repeat
8	PF14580 LRR_9	0.00029	31.9	Leucine-rich repeat
9	PF01582 TIR	9.7e-34	128.2	TIR domain
10	PF13676 TIR_2	5.3e-07	41.7	TIR domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000440643

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000401399	0.998	Myeloid differentiation primary response protein MyD88
2	9606.ENSP00000433623	0.920	TNF receptor-associated factor 6
3	9606.ENSP00000363089	0.903	Toll-like receptor 4
4	9606.ENSP00000260010	0.886	Toll-like receptor 2
5	9606.ENSP00000384273	0.871	Transcription factor p65
6	9606.ENSP00000226574	0.867	Nuclear factor NF-kappa-B p105 subunit
7	9606.ENSP00000300589	0.846	Nucleotide-binding oligomerization domain-containing protein 2
8	9606.ENSP00000385090	0.839	NLR family CARD domain-containing protein 4
9	9606.ENSP00000376445	0.811	Toll/interleukin-1 receptor domain-containing adapter protein
10	9606.ENSP00000484824	0.799	Mucin-1
11	9606.ENSP00000284818	0.752	Lymphocyte antigen 96
12	9606.ENSP00000385675	0.737	Interleukin-6
13	9606.ENSP00000306512	0.734	Interleukin-8
14	9606.ENSP00000222823	0.727	Nucleotide-binding oligomerization domain-containing protein 1
15	9606.ENSP00000398698	0.724	Tumor necrosis factor
16	9606.ENSP00000263341	0.722	Interleukin-1 beta
17	9606.ENSP00000412237	0.712	Interleukin-10
18	9606.ENSP00000358997	0.696	Interleukin-1 receptor-associated kinase 1
19	9606.ENSP00000011653	0.675	T-cell surface glycoprotein CD4
20	9606.ENSP00000263087	0.666	Integrin alpha-E

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	1.000	protein binding
GO:0005102	0.983	signaling receptor binding
GO:0005126	0.594	cytokine receptor binding
GO:0038023	0.589	signaling receptor activity
GO:0070851	0.519	growth factor receptor binding
GO:0042802	0.404	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0048518	0.991	positive regulation of biological process
GO:0019222	0.988	regulation of metabolic process
GO:0050896	0.987	response to stimulus
GO:0050794	0.986	regulation of cellular process
GO:0009987	0.985	cellular process
GO:0051716	0.977	cellular response to stimulus
GO:0010468	0.974	regulation of gene expression
GO:0051239	0.973	regulation of multicellular organismal process
GO:0009605	0.965	response to external stimulus
GO:0010604	0.964	positive regulation of macromolecule metabolic process
GO:0001817	0.957	regulation of cytokine production
GO:0001819	0.939	positive regulation of cytokine production
GO:0042221	0.930	response to chemical
GO:0002833	0.920	positive regulation of response to biotic stimulus
GO:0048522	0.887	positive regulation of cellular process
GO:0009966	0.887	regulation of signal transduction
GO:0010033	0.885	response to organic substance
GO:0045089	0.878	positive regulation of innate immune response
GO:0031323	0.842	regulation of cellular metabolic process
GO:0051171	0.814	regulation of nitrogen compound metabolic process
GO:0002376	0.797	immune system process
GO:0007154	0.783	cell communication
GO:0023052	0.777	signaling
GO:0007165	0.773	signal transduction
GO:0032757	0.764	positive regulation of interleukin-8 production
GO:0044419	0.626	biological process involved in interspecies interaction between organisms
GO:0009607	0.615	response to biotic stimulus
GO:0009967	0.598	positive regulation of signal transduction
GO:0009628	0.581	response to abiotic stimulus
GO:0080090	0.581	regulation of primary metabolic process
GO:0006950	0.577	response to stress
GO:0009889	0.562	regulation of biosynthetic process
GO:0032501	0.561	multicellular organismal process
GO:0070887	0.557	cellular response to chemical stimulus
GO:0031326	0.531	regulation of cellular biosynthetic process
GO:0051707	0.507	response to other organism
GO:0104004	0.493	cellular response to environmental stimulus
GO:0051173	0.487	positive regulation of nitrogen compound metabolic process
GO:0071310	0.469	cellular response to organic substance
GO:0031325	0.463	positive regulation of cellular metabolic process
GO:0071214	0.438	cellular response to abiotic stimulus
GO:0006952	0.427	defense response
GO:0048519	0.416	negative regulation of biological process
GO:0032502	0.372	developmental process
GO:0048856	0.363	anatomical structure development
GO:0010556	0.348	regulation of macromolecule biosynthetic process
GO:0051252	0.347	regulation of RNA metabolic process
GO:1903506	0.337	regulation of nucleic acid-templated transcription
GO:0009612	0.334	response to mechanical stimulus
GO:0006355	0.332	regulation of DNA-templated transcription
GO:0009617	0.326	response to bacterium
GO:0006955	0.317	immune response
GO:0065009	0.315	regulation of molecular function
GO:0002757	0.310	immune response-activating signaling pathway
GO:0044093	0.304	positive regulation of molecular function

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	0.998	plasma membrane
GO:0043231	0.530	intracellular membrane-bounded organelle
GO:0005737	0.523	cytoplasm

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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