StarFunc result for job id O75390

User Input

>input (466 residues)
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVV
GQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLF
WLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESN
FARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNF
TNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPL
HGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQ
REFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYY
TVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024RB75	0.967	0.967	1.560E-63	466	0.981	0.981	A0A024RB75.pdb.gz
2	AFDB:Q80X68	0.971	0.971	5.381E-61	466	0.899	0.899	Q80X68.pdb.gz	Q80X68_MOUSE Citrate synthase OS=Mus musculus OX=10090 GN=Csl PE=1 SV=1
3	AFDB:A0A060VYW9	0.963	0.951	2.053E-59	472	0.852	0.841	A0A060VYW9.pdb.gz	A0A060VYW9_ONCMY Citrate synthase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00080933001 PE=3 SV=1
4	PDB:2ctsA	0.887	0.944	2.397E-53	437	0.899	0.959	2ctsA.pdb.gz	Crystallographic refinement and atomic models of two different forms of citrate synthase at 2.7 and 1.7 A resolution.
5	AFDB:P34575	0.952	0.948	5.608E-53	468	0.674	0.671	P34575.pdb.gz	CISY_CAEEL Probable citrate synthase, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=cts-1 PE=3 SV=1
6	AFDB:Q9W401	0.949	0.953	1.660E-51	464	0.702	0.705	Q9W401.pdb.gz	CISY_DROME Probable citrate synthase, mitochondrial OS=Drosophila melanogaster OX=7227 GN=kdn PE=2 SV=1
7	AFDB:A0A060WFK8	0.854	0.822	2.862E-48	484	0.719	0.692	A0A060WFK8.pdb.gz	A0A060WFK8_ONCMY Citrate synthase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00073853001 PE=3 SV=1
8	AFDB:O00098	0.923	0.907	3.114E-48	474	0.627	0.616	O00098.pdb.gz	CISY_EMENI Citrate synthase, mitochondrial OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=citA PE=2 SV=3
9	AFDB:Q10306	0.927	0.894	6.397E-48	483	0.605	0.584	Q10306.pdb.gz	CISY_SCHPO Probable citrate synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cit1 PE=3 SV=3
10	AFDB:A0A1D8PSH3	0.932	0.930	1.624E-47	467	0.592	0.591	A0A1D8PSH3.pdb.gz	A0A1D8PSH3_CANAL Citrate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CIT1 PE=3 SV=1
11	AFDB:Q553V1	0.932	0.944	4.301E-47	460	0.599	0.607	Q553V1.pdb.gz	CISYM_DICDI Citrate synthase, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=cs PE=3 SV=1
12	PDB:6k5vA	0.918	0.988	7.837E-45	433	0.577	0.621	6k5vA.pdb.gz
13	PDB:5uqrA	0.880	0.933	2.646E-38	439	0.483	0.513	5uqrA.pdb.gz	Comparative studies of Aspergillus fumigatus 2-methylcitrate synthase and human citrate synthase.
14	PDB:6zu0C	0.680	0.739	2.502E-16	426	0.217	0.237	6zu0C.pdb.gz
15	PDB:1a59A	0.676	0.822	5.140E-16	377	0.204	0.252	1a59A.pdb.gz	Structural adaptations of the cold-active citrate synthase from an Antarctic bacterium.
16	PDB:6s6fB	0.677	0.840	1.546E-15	370	0.178	0.224	6s6fB.pdb.gz
17	PDB:4jaeA	0.638	0.693	2.134E-14	426	0.210	0.230	4jaeA.pdb.gz	Enzyme-substrate complexes of allosteric citrate synthase: Evidence for a novel intermediate in substrate binding.
18	PDB:3hwkE	0.651	0.812	2.424E-14	367	0.176	0.223	3hwkE.pdb.gz
19	PDB:3o8jA	0.666	0.839	3.125E-14	364	0.170	0.217	3o8jA.pdb.gz
20	PDB:4tvmA	0.594	0.717	9.802E-14	380	0.210	0.258	4tvmA.pdb.gz	Structures of citrate synthase and malate dehydrogenase of Mycobacterium tuberculosis.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A060VYW9	843	472	0.856	0.845	A0A060VYW9_ONCMY Citrate synthase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00080933001 PE=3 SV=1
2	A0A060WFK8	707	484	0.725	0.698	A0A060WFK8_ONCMY Citrate synthase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00073853001 PE=3 SV=1
3	A0A060WKC7	842	472	0.856	0.845	A0A060WKC7_ONCMY Citrate synthase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00073739001 PE=3 SV=1
4	A0A060XAB1	827	470	0.843	0.836	A0A060XAB1_ONCMY Citrate synthase OS=Oncorhynchus mykiss OX=8022 GN=GSONMT00032804001 PE=3 SV=1
5	A0A0C4DGI3	837	400	0.858	1.000	A0A0C4DGI3_HUMAN Citrate synthase OS=Homo sapiens OX=9606 GN=CS PE=1 SV=1
6	A0A1D8PSH3	595	467	0.594	0.593	A0A1D8PSH3_CANAL Citrate synthase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CIT1 PE=3 SV=1
7	B4DJV2	943	453	0.970	0.998	B4DJV2_HUMAN Citrate synthase OS=Homo sapiens OX=9606 GN=CS PE=1 SV=1
8	O00098	623	474	0.620	0.610	CISY_EMENI Citrate synthase, mitochondrial OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=citA PE=2 SV=3
9	O75390	969	466	1.000	1.000	CISY_HUMAN Citrate synthase, mitochondrial OS=Homo sapiens OX=9606 GN=CS PE=1 SV=2
10	P00889	932	464	0.957	0.961	CISY_PIG Citrate synthase, mitochondrial OS=Sus scrofa OX=9823 GN=CS PE=1 SV=2
11	P00890	602	479	0.603	0.587	CISY1_YEAST Citrate synthase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CIT1 PE=1 SV=2
12	P08679	568	460	0.567	0.574	CISY2_YEAST Citrate synthase, peroxisomal OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CIT2 PE=1 SV=1
13	P20115	587	474	0.579	0.570	CISY4_ARATH Citrate synthase 4, mitochondrial OS=Arabidopsis thaliana OX=3702 GN=CSY4 PE=1 SV=3
14	P23007	815	433	0.837	0.901	CISY_CHICK Citrate synthase, mitochondrial OS=Gallus gallus OX=9031 GN=CS PE=1 SV=1
15	P34575	676	468	0.676	0.673	CISY_CAEEL Probable citrate synthase, mitochondrial OS=Caenorhabditis elegans OX=6239 GN=cts-1 PE=3 SV=1
16	Q10306	602	483	0.599	0.578	CISY_SCHPO Probable citrate synthase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=cit1 PE=3 SV=3
17	Q2U9X4	607	474	0.605	0.595	Q2U9X4_ASPOR Citrate synthase OS=Aspergillus oryzae (strain ATCC 42149 / RIB 40) OX=510516 GN=AO090102000627 PE=3 SV=1
18	Q553V1	597	460	0.603	0.611	CISYM_DICDI Citrate synthase, mitochondrial OS=Dictyostelium discoideum OX=44689 GN=cs PE=3 SV=1
19	Q7ZVY5	872	468	0.876	0.872	CISY_DANRE Citrate synthase, mitochondrial OS=Danio rerio OX=7955 GN=cs PE=2 SV=1
20	Q80X68	883	466	0.899	0.899	Q80X68_MOUSE Citrate synthase OS=Mus musculus OX=10090 GN=Csl PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00285 Citrate_synt	4.5e-98	340.2	Citrate synthase, C-terminal domain
2	PF08447 PAS_3	1.1e+02	14.5	PAS fold
3	PF02547 Queuosine_synth	3.2e+02	11.8	Queuosine biosynthesis protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000342056

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000327070	0.999	Malate dehydrogenase, mitochondrial
2	9606.ENSP00000216254	0.998	Aconitate hydratase, mitochondrial
3	9606.ENSP00000438144	0.997	Malate dehydrogenase, cytoplasmic
4	9606.ENSP00000217901	0.996	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial
5	9606.ENSP00000280346	0.994	Dihydrolipoamide S-acetyltransferase
6	9606.ENSP00000299518	0.994	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
7	9606.ENSP00000262030	0.992	ATP synthase subunit beta, mitochondrial
8	9606.ENSP00000355518	0.992	Fumarate hydratase, mitochondrial
9	9606.ENSP00000253792	0.990	ATP-citrate synthase
10	9606.ENSP00000381736	0.989	ATP synthase subunit alpha, mitochondrial
11	9606.ENSP00000377532	0.986	Pyruvate carboxylase, mitochondrial
12	9606.ENSP00000309477	0.979	Cytoplasmic aconitate hydratase
13	9606.ENSP00000307241	0.978	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
14	9606.ENSP00000373620	0.977	60 kDa heat shock protein, mitochondrial
15	9606.ENSP00000377446	0.976	Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
16	9606.ENSP00000253382	0.972	Acetyl-coenzyme A synthetase, cytoplasmic
17	9606.ENSP00000317159	0.971	Cytochrome c1, heme protein, mitochondrial
18	9606.ENSP00000364649	0.964	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
19	9606.ENSP00000316924	0.959	Acetyl-coenzyme A synthetase 2-like, mitochondrial
20	9606.ENSP00000264932	0.956	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0036440	0.999	citrate synthase activity
GO:0004108	0.958	citrate (Si)-synthase activity
GO:0097159	0.741	organic cyclic compound binding
GO:1901363	0.739	heterocyclic compound binding
GO:0005515	0.350	protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0044238	0.999	primary metabolic process
GO:0071704	0.997	organic substance metabolic process
GO:0044237	0.994	cellular metabolic process
GO:0044281	0.911	small molecule metabolic process
GO:0006091	0.894	generation of precursor metabolites and energy
GO:0019752	0.885	carboxylic acid metabolic process
GO:0006807	0.879	nitrogen compound metabolic process
GO:0045333	0.851	cellular respiration
GO:0009060	0.786	aerobic respiration
GO:0006099	0.654	tricarboxylic acid cycle
GO:1901564	0.574	organonitrogen compound metabolic process
GO:0034641	0.474	cellular nitrogen compound metabolic process
GO:1901360	0.340	organic cyclic compound metabolic process
GO:0046483	0.334	heterocycle metabolic process
GO:0006725	0.328	cellular aromatic compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	0.998	mitochondrion
GO:0070013	0.950	intracellular organelle lumen
GO:0016020	0.472	membrane

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
RHEA:16845	0.999	acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+)
EC:2.3.3.16	0.999	citrate synthase (unknown stereospecificity).
EC:2.3.3.1	0.958	citrate (Si)-synthase.

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