StarFunc result for job id O75417

User Input

>input (2590 residues)
MNLLRRSGKRRRSESGSDSFSGSGGDSSASPQFLSGSVLSPPPGLGRCLKAAAAGECKPT
VPDYERDKLLLANWGLPKAVLEKYHSFGVKKMFEWQAECLLLGQVLEGKNLVYSAPTSAG
KTLVAELLILKRVLEMRKKALFILPFVSVAKEKKYYLQSLFQEVGIKVDGYMGSTSPSRH
FSSLDIAVCTIERANGLINRLIEENKMDLLGMVVVDELHMLGDSHRGYLLELLLTKICYI
TRKSASCQADLASSLSNAVQIVGMSATLPNLELVASWLNAELYHTDFRPVPLLESVKVGN
SIYDSSMKLVREFEPMLQVKGDEDHVVSLCYETICDNHSVLLFCPSKKWCEKLADIIARE
FYNLHHQAEGLVKPSECPPVILEQKELLEVMDQLRRLPSGLDSVLQKTVPWGVAFHHAGL
TFEERDIIEGAFRQGLIRVLAATSTLSSGVNLPARRVIIRTPIFGGRPLDILTYKQMVGR
AGRKGVDTVGESILICKNSEKSKGIALLQGSLKPVRSCLQRREGEEVTGSMIRAILEIIV
GGVASTSQDMHTYAACTFLAASMKEGKQGIQRNQESVQLGAIEACVMWLLENEFIQSTEA
SDGTEGKVYHPTHLGSATLSSSLSPADTLDIFADLQRAMKGFVLENDLHILYLVTPMFED
WTTIDWYRFFCLWEKLPTSMKRVAELVGVEEGFLARCVKGKVVARTERQHRQMAIHKRFF
TSLVLLDLISEVPLREINQKYGCNRGQIQSLQQSAAVYAGMITVFSNRLGWHNMELLLSQ
FQKRLTFGIQRELCDLVRVSLLNAQRARVLYASGFHTVADLARANIVEVEVILKNAVPFK
SARKAVDEEEEAVEERRNMRTIWVTGRKGLTEREAAALIVEEARMILQQDLVEMGVQWNP
CALLHSSTCSLTHSESEVKEHTFISQTKSSYKKLTSKNKSNTIFSDSYIKHSPNIVQDLN
KSREHTSSFNCNFQNGNQEHQTCSIFRARKRASLDINKEKPGASQNEGKTSDKKVVQTFS
QKTKKAPLNFNSEKMSRSFRSWKRRKHLKRSRDSSPLKDSGACRIHLQGQTLSNPSLCED
PFTLDEKKTEFRNSGPFAKNVSLSGKEKDNKTSFPLQIKQNCSWNITLTNDNFVEHIVTG
SQSKNVTCQATSVVSEKGRGVAVEAEKINEVLIQNGSKNQNVYMKHHDIHPINQYLRKQS
HEQTSTITKQKNIIERQMPCEAVSSYINRDSNVTINCERIKLNTEENKPSHFQALGDDIS
RTVIPSEVLPSAGAFSKSEGQHENFLNISRLQEKTGTYTTNKTKNNHVSDLGLVLCDFED
SFYLDTQSEKIIQQMATENAKLGAKDTNLAAGIMQKSLVQQNSMNSFQKECHIPFPAEQH
PLGATKIDHLDLKTVGTMKQSSDSHGVDILTPESPIFHSPILLEENGLFLKKNEVSVTDS
QLNSFLQGYQTQETVKPVILLIPQKRTPTGVEGECLPVPETSLNMSDSLLFDSFSDDYLV
KEQLPDMQMKEPLPSEVTSNHFSDSLCLQEDLIKKSNVNENQDTHQQLTCSNDESIIFSE
MDSVQMVEALDNVDIFPVQEKNHTVVSPRALELSDPVLDEHHQGDQDGGDQDERAEKSKL
TGTRQNHSFIWSGASFDLSPGLQRILDKVSSPLENEKLKSMTINFSSLNRKNTELNEEQE
VISNLETKQVQGISFSSNNEVKSKIEMLENNANHDETSSLLPRKESNIVDDNGLIPPTPI
PTSASKLTFPGILETPVNPWKTNNVLQPGESYLFGSPSDIKNHDLSPGSRNGFKDNSPIS
DTSFSLQLSQDGLQLTPASSSSESLSIIDVASDQNLFQTFIKEWRCKKRFSISLACEKIR
SLTSSKTATIGSRFKQASSPQEIPIRDDGFPIKGCDDTLVVGLAVCWGGRDAYYFSLQKE
QKHSEISASLVPPSLDPSLTLKDRMWYLQSCLRKESDKECSVVIYDFIQSYKILLLSCGI
SLEQSYEDPKVACWLLDPDSQEPTLHSIVTSFLPHELPLLEGMETSQGIQSLGLNAGSEH
SGRYRASVESILIFNSMNQLNSLLQKENLQDVFRKVEMPSQYCLALLELNGIGFSTAECE
SQKHIMQAKLDAIETQAYQLAGHSFSFTSSDDIAEVLFLELKLPPNREMKNQGSKKTLGS
TRRGIDNGRKLRLGRQFSTSKDVLNKLKALHPLPGLILEWRRITNAITKVVFPLQREKCL
NPFLGMERIYPVSQSHTATGRITFTEPNIQNVPRDFEIKMPTLVGESPPSQAVGKGLLPM
GRGKYKKGFSVNPRCQAQMEERAADRGMPFSISMRHAFVPFPGGSILAADYSQLELRILA
HLSHDRRLIQVLNTGADVFRSIAAEWKMIEPESVGDDLRQQAKQICYGIIYGMGAKSLGE
QMGIKENDAACYIDSFKSRYTGINQFMTETVKNCKRDGFVQTILGRRRYLPGIKDNNPYR
KAHAERQAINTIVQGSAADIVKIATVNIQKQLETFHSTFKSHGHREGMLQSDQTGLSRKR
KLQGMFCPIRGGFFILQLHDELLYEVAEEDVVQVAQIVKNEMESAVKLSVKLKVKVKIGA
SWGELKDFDV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O75417	1.000	1.000	0.000	2590	1.000	1.000	O75417.pdb.gz	DPOLQ_HUMAN DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2
2	AFDB:Q8CGS6	0.345	0.351	0.000	2544	0.727	0.741	Q8CGS6.pdb.gz	DPOLQ_MOUSE DNA polymerase theta OS=Mus musculus OX=10090 GN=Polq PE=1 SV=2
3	AFDB:A5X572	0.210	0.457	5.138E-36	1146	0.099	0.224	A5X572.pdb.gz	A5X572_DANRE DNA polymerase nu OS=Danio rerio OX=7955 GN=POLN PE=2 SV=1
4	PDB:5dcaA	0.209	0.270	1.521E-25	1948	0.069	0.091	5dcaA.pdb.gz
5	PDB:6qw65B	0.220	0.278	4.328E-24	2001	0.065	0.084	6qw65B.pdb.gz	Mechanism of 5' splice site transfer for human spliceosome activation.
6	PDB:3jcmN	0.206	0.307	1.479E-23	1686	0.059	0.091	3jcmN.pdb.gz	The 3.8 angstrom structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis
7	PDB:6d6qM	0.203	0.679	2.716E-21	709	0.054	0.199	6d6qM.pdb.gz	Helicase-Dependent RNA Decay Illuminated by a Cryo-EM Structure of a Human Nuclear RNA Exosome-MTR4 Complex.
8	PDB:6ro1A	0.185	0.491	8.896E-21	919	0.054	0.151	6ro1A.pdb.gz	The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs.
9	PDB:6iegA	0.179	0.481	1.100E-20	872	0.058	0.172	6iegA.pdb.gz	NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
10	PDB:2xgjB	0.189	0.585	3.602E-20	777	0.056	0.187	2xgjB.pdb.gz	Structural Analysis Reveals the Characteristic Features of Mtr4, a Dexh Helicase Involved in Nuclear RNA Processing and Surveillance.
11	PDB:4xgtA	0.178	0.451	5.824E-18	961	0.061	0.163	4xgtA.pdb.gz
12	PDB:7z4yB	0.177	0.456	2.077E-17	930	0.057	0.159	7z4yB.pdb.gz
13	PDB:7qdyA	0.174	0.362	1.963E-16	1169	0.061	0.135	7qdyA.pdb.gz	The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
14	AFDB:Q8IYD8	0.106	0.131	6.267E-8	2048	0.111	0.140	Q8IYD8.pdb.gz	FANCM_HUMAN Fanconi anemia group M protein OS=Homo sapiens OX=9606 GN=FANCM PE=1 SV=2
15	AFDB:Q8T145	0.107	0.149	8.798E-5	1789	0.078	0.113	Q8T145.pdb.gz	Q8T145_DICDI DNA helicase OS=Dictyostelium discoideum OX=44689 GN=DDB_G0274841 PE=3 SV=2
16	AFDB:A2A690	0.056	0.067	2.204E-3	1994	0.081	0.106	A2A690.pdb.gz	TANC2_MOUSE Protein TANC2 OS=Mus musculus OX=10090 GN=Tanc2 PE=1 SV=1
17	AFDB:F4HS99	0.043	0.055	2.299E-3	1797	0.059	0.085	F4HS99.pdb.gz	REC1_ARATH Protein REDUCED CHLOROPLAST COVERAGE 1 OS=Arabidopsis thaliana OX=3702 GN=REC1 PE=1 SV=1
18	AFDB:F4HZK4	0.047	0.057	5.841E-3	1608	0.052	0.084	F4HZK4.pdb.gz	REC3_ARATH Protein REDUCED CHLOROPLAST COVERAGE 3 OS=Arabidopsis thaliana OX=3702 GN=REC3 PE=3 SV=1
19	AFDB:Q0VGY8	0.050	0.058	5.841E-3	1856	0.075	0.105	Q0VGY8.pdb.gz	TANC1_MOUSE Protein TANC1 OS=Mus musculus OX=10090 GN=Tanc1 PE=1 SV=2
20	AFDB:F4JKH6	0.050	0.060	6.358E-3	1819	0.072	0.102	F4JKH6.pdb.gz	REC2_ARATH Protein REDUCED CHLOROPLAST COVERAGE 2 OS=Arabidopsis thaliana OX=3702 GN=REC2 PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O18475	0.0	727	2059	0.147	0.185	DPOLQ_DROME DNA polymerase theta OS=Drosophila melanogaster OX=7227 GN=PolQ PE=1 SV=1
2	O75417	0.0	5376	2590	1.000	1.000	DPOLQ_HUMAN DNA polymerase theta OS=Homo sapiens OX=9606 GN=POLQ PE=1 SV=2
3	Q8CGS6	0.0	3613	2544	0.721	0.734	DPOLQ_MOUSE DNA polymerase theta OS=Mus musculus OX=10090 GN=Polq PE=1 SV=2
4	Q588V7	7.27e-176	600	2154	0.127	0.153	TEB_ARATH Helicase and polymerase-containing protein TEBICHI OS=Arabidopsis thaliana OX=3702 GN=TEB PE=2 SV=1
5	Q8TDG4	1.50e-126	431	1101	0.105	0.248	HELQ_HUMAN Helicase POLQ-like OS=Homo sapiens OX=9606 GN=HELQ PE=1 SV=2
6	Q2VPA6	4.86e-126	429	1069	0.109	0.265	HELQ_MOUSE Helicase POLQ-like OS=Mus musculus OX=10090 GN=Helq PE=1 SV=2
7	A0FLQ6	3.24e-117	414	1661	0.114	0.177	DPOLQ_CAEEL DNA polymerase theta OS=Caenorhabditis elegans OX=6239 GN=polq-1 PE=1 SV=3
8	Q57YX8	1.14e-113	392	1057	0.107	0.261	Q57YX8_TRYB2 DNA polymerase theta (Helicase domain only), putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.28L1.410 PE=4 SV=1
9	H2KY86	1.21e-104	362	923	0.100	0.281	HELQ_CAEEL Helicase POLQ-like OS=Caenorhabditis elegans OX=6239 GN=helq-1 PE=3 SV=1
10	Q9VSE2	5.84e-98	345	1051	0.098	0.242	HELQ_DROME Helicase POLQ-like OS=Drosophila melanogaster OX=7227 GN=mus301 PE=1 SV=1
11	Q7Z5Q5	2.50e-64	240	900	0.069	0.200	DPOLN_HUMAN DNA polymerase nu OS=Homo sapiens OX=9606 GN=POLN PE=1 SV=2
12	A5X572	3.35e-63	240	1146	0.068	0.154	A5X572_DANRE DNA polymerase nu OS=Danio rerio OX=7955 GN=POLN PE=2 SV=1
13	H0YA88	1.31e-61	223	524	0.063	0.309	H0YA88_HUMAN DNA polymerase nu (Fragment) OS=Homo sapiens OX=9606 GN=POLN PE=1 SV=1
14	Q583X2	1.03e-43	177	958	0.064	0.174	Q583X2_TRYB2 DNA-directed DNA polymerase OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb04.2H8.940 PE=4 SV=1
15	P9WNU5	7.57e-42	171	904	0.036	0.104	DPO1_MYCTU DNA polymerase I OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) OX=83332 GN=polA PE=1 SV=1
16	P00582	8.31e-40	164	928	0.040	0.111	DPO1_ECOLI DNA polymerase I OS=Escherichia coli (strain K12) OX=83333 GN=polA PE=1 SV=1
17	Q9SYP1	2.62e-35	151	2171	0.054	0.064	DEXHC_ARATH DExH-box ATP-dependent RNA helicase DExH12 OS=Arabidopsis thaliana OX=3702 GN=BRR2A PE=1 SV=1
18	D3Z4R1	2.86e-34	147	1434	0.047	0.085	HFM1_MOUSE Probable ATP-dependent DNA helicase HFM1 OS=Mus musculus OX=10090 GN=Hfm1 PE=3 SV=2
19	O48534	3.42e-34	147	2172	0.053	0.063	DEXHD_ARATH DExH-box ATP-dependent RNA helicase DExH13 OS=Arabidopsis thaliana OX=3702 GN=BRR2B PE=2 SV=1
20	A0A494C1A5	3.04e-33	144	1375	0.058	0.108	A0A494C1A5_HUMAN U5 small nuclear ribonucleoprotein 200 kDa helicase (Fragment) OS=Homo sapiens OX=9606 GN=SNRNP200 PE=1 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00270 DEAD	1.2e-13	62.8	DEAD/DEAH box helicase
2	PF00476 DNA_pol_A	4.5e-112	386.4	DNA polymerase family A
3	PF14229 DUF4332	12	17.6	Domain of unknown function (DUF4332)
4	PF00271 Helicase_C	1.8e-07	42.9	Helicase conserved C-terminal domain
5	PF14520 HHH_5	4.2e+02	12.9	Helix-hairpin-helix domain
6	PF20470 HTH_61	3.4e-27	106.1	Helix-turn-helix domain

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000264233

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000355506	0.890	Exonuclease 1
2	9606.ENSP00000372088	0.888	DNA repair protein RAD51 homolog 1
3	9606.ENSP00000355759	0.866	Poly [ADP-ribose] polymerase 1
4	9606.ENSP00000382628	0.852	DNA endonuclease RBBP8
5	9606.ENSP00000347232	0.851	Bloom syndrome protein
6	9606.ENSP00000305480	0.843	Flap endonuclease 1
7	9606.ENSP00000287647	0.827	Fanconi anemia group D2 protein
8	9606.ENSP00000411532	0.821	DNA topoisomerase 2-alpha
9	9606.ENSP00000405726	0.806	Cell division control protein 45 homolog
10	9606.ENSP00000356379	0.799	Abnormal spindle-like microcephaly-associated protein
11	9606.ENSP00000302530	0.798	Mitotic checkpoint serine/threonine-protein kinase BUB1
12	9606.ENSP00000242576	0.796	Uracil-DNA glycosylase
13	9606.ENSP00000250416	0.791	Poly [ADP-ribose] polymerase 2
14	9606.ENSP00000251496	0.791	Condensin complex subunit 3
15	9606.ENSP00000351697	0.789	DNA polymerase zeta catalytic subunit
16	9606.ENSP00000418268	0.787	Protein MCM10 homolog
17	9606.ENSP00000484288	0.785	DNA ligase 4
18	9606.ENSP00000247191	0.784	Disks large-associated protein 5
19	9606.ENSP00000358813	0.784	Dual specificity protein kinase TTK
20	9606.ENSP00000355922	0.783	Centromere protein F

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003887	1.000	DNA-directed DNA polymerase activity
GO:0005515	0.999	protein binding
GO:0003677	0.996	DNA binding
GO:0003678	0.996	DNA helicase activity
GO:0003682	0.970	chromatin binding
GO:0042802	0.969	identical protein binding
GO:0017116	0.953	single-stranded DNA helicase activity
GO:0003684	0.937	damaged DNA binding
GO:0016835	0.919	carbon-oxygen lyase activity
GO:0051575	0.652	5'-deoxyribose-5-phosphate lyase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050896	0.996	response to stimulus
GO:0071704	0.996	organic substance metabolic process
GO:0044238	0.996	primary metabolic process
GO:0044237	0.996	cellular metabolic process
GO:0050794	0.995	regulation of cellular process
GO:0006302	0.985	double-strand break repair
GO:0006282	0.979	regulation of DNA repair
GO:0000018	0.976	regulation of DNA recombination
GO:0006303	0.970	double-strand break repair via nonhomologous end joining
GO:0051053	0.964	negative regulation of DNA metabolic process
GO:2000779	0.952	regulation of double-strand break repair
GO:0010569	0.934	regulation of double-strand break repair via homologous recombination
GO:0016043	0.915	cellular component organization
GO:0045910	0.849	negative regulation of DNA recombination
GO:2001021	0.836	negative regulation of response to DNA damage stimulus

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	1.000	nucleoplasm
GO:0005829	0.999	cytosol
GO:0012505	0.995	endomembrane system
GO:0005794	0.991	Golgi apparatus
GO:0043232	0.955	intracellular non-membrane-bounded organelle
GO:0005694	0.848	chromosome
GO:0032991	0.526	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:2.7.7.7	1.000	DNA-directed DNA polymerase.
EC:4.2.-.-	0.919	Carbon-oxygen lyases.

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