StarFunc result for job id O75506

User Input

>input (76 residues)
MAETDPKTVQDLTSVVQTLLQQMQDKFQTMSDQIIGRIDDMSSRIDDLEKNIADLMTQAG
VEELESENKIPATQKS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O75506	1.000	1.000	8.637E-10	76	1.000	1.000	O75506.pdb.gz	HSBP1_HUMAN Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1
2	AFDB:Q8K3X8	0.951	0.951	1.557E-8	76	0.882	0.882	Q8K3X8.pdb.gz	HSBP1_RAT Heat shock factor-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Hsbp1 PE=3 SV=1
3	AFDB:Q6PBV8	0.876	0.876	3.864E-8	76	0.842	0.842	Q6PBV8.pdb.gz	Q6PBV8_DANRE Heat shock factor-binding protein 1 OS=Danio rerio OX=7955 GN=hsbp1 PE=2 SV=1
4	AFDB:Q6NLF5	0.335	0.282	2.364	99	0.132	0.101	Q6NLF5.pdb.gz	Q6NLF5_ARATH At5g18850 OS=Arabidopsis thaliana OX=3702 GN=At5g18850 PE=1 SV=1
5	AFDB:Q9NQ25	0.440	0.131	3.029	335	0.197	0.045	Q9NQ25.pdb.gz	SLAF7_HUMAN SLAM family member 7 OS=Homo sapiens OX=9606 GN=SLAMF7 PE=1 SV=1
6	AFDB:Q94AZ7	0.333	0.127	3.290	232	0.171	0.056	Q94AZ7.pdb.gz	Q94AZ7_ARATH AT5g43680/MQO24_4 OS=Arabidopsis thaliana OX=3702 GN=MTTATB PE=1 SV=1
7	AFDB:Q9Y4E1	0.597	0.044	3.290	1320	0.132	0.008	Q9Y4E1.pdb.gz	WAC2C_HUMAN WASH complex subunit 2C OS=Homo sapiens OX=9606 GN=WASHC2C PE=1 SV=5
8	AFDB:Q59QH4	0.311	0.084	3.573	480	0.197	0.031	Q59QH4.pdb.gz	Q59QH4_CANAL Mannosyltransferase OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=KTR4 PE=3 SV=1
9	AFDB:Q8IBN1	0.624	0.078	3.881	749	0.171	0.017	Q8IBN1.pdb.gz	Q8IBN1_PLAF7 Rhoptry-associated leucine zipper-like protein 1 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_0722200 PE=4 SV=1
10	AFDB:Q9P6S5	0.509	0.157	6.371	307	0.158	0.039	Q9P6S5.pdb.gz	ASK1_SCHPO DASH complex subunit ask1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=ask1 PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O75506	5.20e-49	150	76	1.000	1.000	HSBP1_HUMAN Heat shock factor-binding protein 1 OS=Homo sapiens OX=9606 GN=HSBP1 PE=1 SV=1
2	Q8K3X8	7.30e-43	135	76	0.882	0.882	HSBP1_RAT Heat shock factor-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Hsbp1 PE=3 SV=1
3	Q9CQZ1	1.84e-42	134	76	0.882	0.882	HSBP1_MOUSE Heat shock factor-binding protein 1 OS=Mus musculus OX=10090 GN=Hsbp1 PE=1 SV=1
4	Q6PBV8	5.71e-41	130	76	0.829	0.829	Q6PBV8_DANRE Heat shock factor-binding protein 1 OS=Danio rerio OX=7955 GN=hsbp1 PE=2 SV=1
5	Q9U3B7	2.64e-18	73.2	80	0.487	0.463	Q9U3B7_CAEEL Heat shock factor-binding protein 1 OS=Caenorhabditis elegans OX=6239 GN=hsb-1 PE=1 SV=1
6	Q8GW48	5.38e-16	67.8	86	0.421	0.372	HSBP_ARATH Heat shock factor-binding protein OS=Arabidopsis thaliana OX=3702 GN=HSBP PE=1 SV=1
7	Q556J3	3.86e-10	53.1	102	0.316	0.235	Q556J3_DICDI Heat shock factor-binding protein 1 OS=Dictyostelium discoideum OX=44689 GN=DDB_G0272620 PE=3 SV=1
8	C9JCN9	9.87e-10	51.6	74	0.276	0.284	HSBPL_HUMAN Heat shock factor-binding protein 1-like protein 1 OS=Homo sapiens OX=9606 GN=HSBP1L1 PE=1 SV=2
9	Q8IIF8	4.33e-06	43.1	113	0.211	0.142	Q8IIF8_PLAF7 Heat shock factor-binding protein 1 OS=Plasmodium falciparum (isolate 3D7) OX=36329 GN=PF3D7_1120900 PE=3 SV=1
10	P06757	0.005	35.8	376	0.224	0.045	ADH1_RAT Alcohol dehydrogenase 1 OS=Rattus norvegicus OX=10116 GN=Adh1 PE=1 SV=3
11	O14330	0.008	33.9	75	0.184	0.187	YB7F_SCHPO Uncharacterized protein C16E9.15 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPBC16E9.15 PE=3 SV=1
12	P00329	0.058	32.7	375	0.184	0.037	ADH1_MOUSE Alcohol dehydrogenase 1 OS=Mus musculus OX=10090 GN=Adh1 PE=1 SV=2
13	F1MMT2	0.35	30.8	1964	0.211	0.008	F1MMT2_BOVIN Laminin subunit alpha 2 OS=Bos taurus OX=9913 GN=LAMA2 PE=4 SV=3
14	O42657	0.39	30.4	750	0.250	0.025	YF82_SCHPO GRIP and coiled-coil domain-containing protein C27D7.02c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=SPAC27D7.02c PE=4 SV=1
15	P31493	0.74	29.6	219	0.211	0.073	YOPE_YERPE Outer membrane virulence protein YopE OS=Yersinia pestis OX=632 GN=yopE PE=1 SV=1
16	P38930	1.3	28.9	258	0.250	0.074	CSK2C_YEAST Casein kinase II subunit beta' OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=CKB2 PE=1 SV=1
17	P24043	1.5	28.9	3122	0.171	0.004	LAMA2_HUMAN Laminin subunit alpha-2 OS=Homo sapiens OX=9606 GN=LAMA2 PE=1 SV=4
18	O74395	1.9	28.5	612	0.184	0.023	STR1_SCHPO Siderophore iron transporter 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=str1 PE=1 SV=1
19	D6RHZ6	2.6	28.1	335	0.158	0.036	D6RHZ6_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=2
20	P00325	2.6	28.1	375	0.158	0.032	ADH1B_HUMAN All-trans-retinol dehydrogenase [NAD(+)] ADH1B OS=Homo sapiens OX=9606 GN=ADH1B PE=1 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03915 AIP3	20	15.8	Actin interacting protein 3
2	PF04513 Baculo_PEP_C	26	16.3	Baculovirus polyhedron envelope protein, PEP, C terminus
3	PF10046 BLOC1_2	82	15.0	Biogenesis of lysosome-related organelles complex-1 subunit 2
4	PF07716 bZIP_2	2.8e+02	13.0	Basic region leucine zipper
5	PF16526 CLZ	6.9	18.5	C-terminal leucine zipper domain of cyclic nucleotide-gated channels
6	PF01544 CorA	36	15.1	CorA-like Mg2+ transporter protein
7	PF07889 DUF1664	1.2e+02	14.2	Protein of unknown function (DUF1664)
8	PF10805 DUF2730	2.1e+02	13.5	Protein of unknown function (DUF2730)
9	PF18151 DUF5601	13	17.3	Domain of unknown function (DUF5601)
10	PF19111 DUF5798	27	16.4	Family of unknown function (DUF5798)
11	PF19286 DUF5909	89	15.1	Domain of unknown function (DUF5909)
12	PF06103 DUF948	3e+02	13.1	Bacterial protein of unknown function (DUF948)
13	PF16046 FAM76	63	14.4	FAM76 protein
14	PF04799 Fzo_mitofusin	2.9e+02	12.3	fzo-like conserved region
15	PF06825 HSBP1	2.1e-27	106.0	Heat shock factor binding protein 1
16	PF06008 Laminin_I	15	16.7	Laminin Domain I
17	PF10393 Matrilin_ccoil	3.1e+02	12.6	Trimeric coiled-coil oligomerisation domain of matrilin
18	PF07558 Shugoshin_N	5.7e+02	11.8	Shugoshin N-terminal coiled-coil region

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000392896

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000240079	0.964	WASH complex subunit 3
2	9606.ENSP00000364802	0.926	Heat shock 70 kDa protein 1A
3	9606.ENSP00000335153	0.917	Heat shock protein HSP 90-alpha
4	9606.ENSP00000364805	0.917	Heat shock 70 kDa protein 1-like
5	9606.ENSP00000364801	0.916	Heat shock protein family A member 1B
6	9606.ENSP00000432083	0.913	Heat shock cognate 71 kDa protein
7	9606.ENSP00000360609	0.910	Heat shock protein HSP 90-beta
8	9606.ENSP00000281938	0.908	Heat shock protein beta-8
9	9606.ENSP00000254322	0.905	DnaJ homolog subfamily B member 1
10	9606.ENSP00000433560	0.903	Alpha-crystallin B chain
11	9606.ENSP00000431512	0.872	Heat shock factor protein 1
12	9606.ENSP00000302961	0.772	Heat shock protein family A member 4
13	9606.ENSP00000250495	0.755	NEDD8
14	9606.ENSP00000348886	0.729	Stomatin-like protein 2, mitochondrial
15	9606.ENSP00000455625	0.642	cAMP-regulated phosphoprotein 19
16	9606.ENSP00000385746	0.640	Spermine synthase
17	9606.ENSP00000379691	0.621	Pyridoxal-dependent decarboxylase domain-containing protein 1
18	9606.ENSP00000357440	0.601	Heat shock factor protein 2
19	9606.ENSP00000220822	0.599	Ganglioside-induced differentiation-associated protein 1
20	9606.ENSP00000349957	0.587	Anaphase promoting complex subunit 11

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0003714	1.000	transcription corepressor activity
GO:0042802	0.999	identical protein binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0009987	0.994	cellular process
GO:0065007	0.891	biological regulation
GO:0050794	0.880	regulation of cellular process
GO:0032502	0.716	developmental process
GO:0051179	0.690	localization
GO:0019222	0.658	regulation of metabolic process
GO:0080090	0.503	regulation of primary metabolic process
GO:0060255	0.502	regulation of macromolecule metabolic process
GO:0051171	0.502	regulation of nitrogen compound metabolic process
GO:0031323	0.492	regulation of cellular metabolic process
GO:0048519	0.475	negative regulation of biological process
GO:0009889	0.475	regulation of biosynthetic process
GO:0010468	0.470	regulation of gene expression
GO:0031326	0.470	regulation of cellular biosynthetic process
GO:0010556	0.467	regulation of macromolecule biosynthetic process
GO:0019219	0.464	regulation of nucleobase-containing compound metabolic process
GO:0048856	0.461	anatomical structure development
GO:0032501	0.459	multicellular organismal process
GO:0048523	0.459	negative regulation of cellular process
GO:0051641	0.436	cellular localization
GO:0051172	0.356	negative regulation of nitrogen compound metabolic process
GO:0046907	0.348	intracellular transport
GO:0048518	0.341	positive regulation of biological process
GO:0010605	0.340	negative regulation of macromolecule metabolic process
GO:0007275	0.325	multicellular organism development
GO:0031324	0.301	negative regulation of cellular metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.995	nucleoplasm
GO:0043232	0.863	intracellular non-membrane-bounded organelle
GO:0005737	0.797	cytoplasm
GO:0005856	0.518	cytoskeleton
GO:0005829	0.414	cytosol
GO:0032991	0.399	protein-containing complex

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

[back to server]