StarFunc result for job id O75888

User Input

>input (250 residues)
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRR
EVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHL
VPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQ
VVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSP
HGTFLGFVKL

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O75888	1.000	1.000	4.288E-43	250	1.000	1.000	O75888.pdb.gz	TNF13_HUMAN Tumor necrosis factor ligand superfamily member 13 OS=Homo sapiens OX=9606 GN=TNFSF13 PE=1 SV=1
2	AFDB:Q9D777	0.588	0.610	5.333E-36	241	0.780	0.809	Q9D777.pdb.gz	TNF13_MOUSE Tumor necrosis factor ligand superfamily member 13 OS=Mus musculus OX=10090 GN=Tnfsf13 PE=1 SV=1
3	AFDB:D2DMJ8	0.560	0.699	1.359E-20	199	0.252	0.317	D2DMJ8.pdb.gz	D2DMJ8_DANRE A proliferation-inducing ligand-like protein OS=Danio rerio OX=7955 GN=april PE=2 SV=1
4	AFDB:A9CDZ0	0.523	0.561	9.555E-18	233	0.276	0.296	A9CDZ0.pdb.gz	A9CDZ0_PIG B-cell activating factor OS=Sus scrofa OX=9823 PE=2 SV=1
5	AFDB:A0A0U5J7Q1	0.528	0.465	1.007E-17	285	0.272	0.239	A0A0U5J7Q1.pdb.gz	A0A0U5J7Q1_HUMAN Epididymis secretory sperm binding protein OS=Homo sapiens OX=9606 GN=TNLG7A PE=2 SV=1
6	AFDB:Q9WU72	0.526	0.428	1.459E-17	309	0.292	0.236	Q9WU72.pdb.gz	TN13B_MOUSE Tumor necrosis factor ligand superfamily member 13B OS=Mus musculus OX=10090 GN=Tnfsf13b PE=1 SV=1
7	AFDB:B0LKN7	0.531	0.476	2.609E-17	280	0.308	0.275	B0LKN7.pdb.gz	B0LKN7_BOVIN B-cell activating factor OS=Bos taurus OX=9913 GN=TNFSF13B PE=2 SV=1
8	AFDB:A8WG11	0.493	0.462	1.845E-16	268	0.284	0.265	A8WG11.pdb.gz	A8WG11_DANRE TNF superfamily member 13b-like protein OS=Danio rerio OX=7955 GN=tnfsf13b PE=2 SV=1
9	AFDB:P48023	0.429	0.386	1.290E-11	281	0.212	0.189	P48023.pdb.gz	TNFL6_HUMAN Tumor necrosis factor ligand superfamily member 6 OS=Homo sapiens OX=9606 GN=FASLG PE=1 SV=1
10	AFDB:P41047	0.464	0.419	1.360E-11	279	0.200	0.179	P41047.pdb.gz	TNFL6_MOUSE Tumor necrosis factor ligand superfamily member 6 OS=Mus musculus OX=10090 GN=Faslg PE=1 SV=1
11	PDB:7e57B	0.363	0.693	1.434E-5	123	0.084	0.171	7e57B.pdb.gz	Atypical TNF-TNFR superfamily binding interface in the GITR-GITRL complex for T cell activation.
12	PDB:5h4bA	0.414	0.703	2.565E-5	136	0.048	0.088	5h4bA.pdb.gz
13	PDB:5kc6B	0.367	0.586	8.654E-5	144	0.072	0.125	5kc6B.pdb.gz
14	PDB:4fixA	0.273	0.123	5.943E-3	629	0.084	0.033	4fixA.pdb.gz	Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan.
15	PDB:5eiyB	0.224	0.103	5.943E-3	658	0.080	0.030	5eiyB.pdb.gz	Observing cellulose biosynthesis and membrane translocation in crystallo.
16	PDB:6xwuA	0.164	0.249	7.742E-3	138	0.048	0.087	6xwuA.pdb.gz
17	PDB:5jovA	0.154	0.058	1.246E-2	949	0.064	0.017	5jovA.pdb.gz	Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut.
18	PDB:3cl5A	0.240	0.184	1.385E-2	358	0.064	0.045	3cl5A.pdb.gz	Structure of coronavirus hemagglutinin-esterase offers insight into corona and influenza virus evolution.
19	PDB:6oj0A	0.234	0.293	1.804E-2	178	0.052	0.073	6oj0A.pdb.gz
20	PDB:6xwvD	0.169	0.273	2.612E-2	123	0.044	0.089	6xwvD.pdb.gz	Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O75888	0.0	513	250	1.000	1.000	TNF13_HUMAN Tumor necrosis factor ligand superfamily member 13 OS=Homo sapiens OX=9606 GN=TNFSF13 PE=1 SV=1
2	Q9D777	8.75e-143	401	241	0.780	0.809	TNF13_MOUSE Tumor necrosis factor ligand superfamily member 13 OS=Mus musculus OX=10090 GN=Tnfsf13 PE=1 SV=1
3	D2DMJ8	1.38e-34	124	199	0.220	0.276	D2DMJ8_DANRE A proliferation-inducing ligand-like protein OS=Danio rerio OX=7955 GN=april PE=2 SV=1
4	B0LKN7	8.77e-23	95.9	280	0.220	0.196	B0LKN7_BOVIN B-cell activating factor OS=Bos taurus OX=9913 GN=TNFSF13B PE=2 SV=1
5	A0A0U5J7Q1	3.15e-22	94.7	285	0.272	0.239	A0A0U5J7Q1_HUMAN Epididymis secretory sperm binding protein OS=Homo sapiens OX=9606 GN=TNLG7A PE=2 SV=1
6	Q9Y275	3.15e-22	94.7	285	0.272	0.239	TN13B_HUMAN Tumor necrosis factor ligand superfamily member 13B OS=Homo sapiens OX=9606 GN=TNFSF13B PE=1 SV=1
7	A9CDZ0	9.86e-22	92.0	233	0.228	0.245	A9CDZ0_PIG B-cell activating factor OS=Sus scrofa OX=9823 PE=2 SV=1
8	A8WG11	8.32e-21	90.5	268	0.192	0.179	A8WG11_DANRE TNF superfamily member 13b-like protein OS=Danio rerio OX=7955 GN=tnfsf13b PE=2 SV=1
9	Q9WU72	6.37e-19	85.9	309	0.184	0.149	TN13B_MOUSE Tumor necrosis factor ligand superfamily member 13B OS=Mus musculus OX=10090 GN=Tnfsf13b PE=1 SV=1
10	A0A0C4DGX3	1.52e-07	53.1	259	0.120	0.116	A0A0C4DGX3_HUMAN Ectodysplasin A OS=Homo sapiens OX=9606 GN=EDA PE=1 SV=1
11	B0YIF1	2.59e-07	53.1	359	0.120	0.084	B0YIF1_DANRE Ectodysplasin OS=Danio rerio OX=7955 GN=si:ch73-223d24.5 PE=2 SV=1
12	A0A0U5J797	2.69e-07	53.1	389	0.124	0.080	A0A0U5J797_HUMAN Tumor necrosis factor ligand 7C OS=Homo sapiens OX=9606 GN=TNLG7C PE=2 SV=1
13	Q92838	3.09e-07	52.8	391	0.120	0.077	EDA_HUMAN Ectodysplasin-A OS=Homo sapiens OX=9606 GN=EDA PE=1 SV=2
14	O54693	3.75e-07	52.8	391	0.120	0.077	EDA_MOUSE Ectodysplasin-A OS=Mus musculus OX=10090 GN=Eda PE=1 SV=2
15	Q08CQ3	6.09e-04	42.4	234	0.144	0.154	Q08CQ3_DANRE Lymphotoxin-alpha OS=Danio rerio OX=7955 GN=tnfa PE=2 SV=1
16	Q1L8A5	6.56e-04	42.4	234	0.144	0.154	Q1L8A5_DANRE Lymphotoxin-alpha OS=Danio rerio OX=7955 GN=tnfa PE=1 SV=1
17	P16599	0.009	38.9	235	0.160	0.170	TNFA_RAT Tumor necrosis factor OS=Rattus norvegicus OX=10116 GN=Tnf PE=2 SV=1
18	C1K3N5	0.011	38.5	232	0.152	0.164	C1K3N5_HUMAN Tumor necrosis factor (Fragment) OS=Homo sapiens OX=9606 GN=TNF PE=2 SV=1
19	P01375	0.012	38.5	233	0.152	0.163	TNFA_HUMAN Tumor necrosis factor OS=Homo sapiens OX=9606 GN=TNF PE=1 SV=1
20	A0A0U5J7B5	0.018	38.1	292	0.160	0.137	A0A0U5J7B5_RAT Tumor necrosis factor ligand superfamily member OS=Rattus norvegicus OX=10116 GN=Tnfsf10 PE=2 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF06305 LapA_dom	1.3e+02	13.8	Lipopolysaccharide assembly protein A domain
2	PF00229 TNF	2.9e-09	48.3	TNF(Tumour Necrosis Factor) family

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000343505

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000261652	0.988	Tumor necrosis factor receptor superfamily member 13B
2	9606.ENSP00000053243	0.976	Tumor necrosis factor receptor superfamily member 17
3	9606.ENSP00000454207	0.913	TNF receptor-associated factor 3
4	9606.ENSP00000433623	0.910	TNF receptor-associated factor 6
5	9606.ENSP00000261464	0.906	TNF receptor-associated factor 5
6	9606.ENSP00000247668	0.903	TNF receptor-associated factor 2
7	9606.ENSP00000352400	0.800	Nuclear pore complex protein Nup214
8	9606.ENSP00000361777	0.800	Protein SET
9	9606.ENSP00000384863	0.800	Exportin-1
10	9606.ENSP00000417864	0.800	Acidic leucine-rich nuclear phosphoprotein 32 family member A
11	9606.ENSP00000365048	0.770	Tumor necrosis factor ligand superfamily member 13B
12	9606.ENSP00000291232	0.738	Tumor necrosis factor receptor superfamily member 13C
13	9606.ENSP00000293825	0.706	Tumor necrosis factor ligand superfamily member 12
14	9606.ENSP00000250092	0.634	Macrosialin
15	9606.ENSP00000385269	0.600	ELAV-like protein 1
16	9606.ENSP00000368450	0.593	CD83 antigen
17	9606.ENSP00000336984	0.548	HORMA domain-containing protein 2
18	9606.ENSP00000359073	0.510	Guanine nucleotide exchange factor VAV3
19	9606.ENSP00000412209	0.503	Interleukin-5 receptor subunit alpha

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005102	1.000	signaling receptor binding
GO:0098772	0.449	molecular function regulator activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0045911	0.989	positive regulation of DNA recombination
GO:0002891	0.988	positive regulation of immunoglobulin mediated immune response
GO:0050896	0.987	response to stimulus
GO:0009987	0.982	cellular process
GO:0050865	0.974	regulation of cell activation
GO:0008284	0.959	positive regulation of cell population proliferation
GO:0007165	0.957	signal transduction
GO:0002702	0.955	positive regulation of production of molecular mediator of immune response
GO:0002696	0.953	positive regulation of leukocyte activation
GO:0002637	0.946	regulation of immunoglobulin production
GO:0002639	0.935	positive regulation of immunoglobulin production
GO:0051251	0.933	positive regulation of lymphocyte activation
GO:0050871	0.901	positive regulation of B cell activation
GO:0050793	0.663	regulation of developmental process
GO:0051094	0.579	positive regulation of developmental process
GO:0002376	0.378	immune system process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0110165	0.998	cellular anatomical entity
GO:0005886	0.993	plasma membrane
GO:0005654	0.987	nucleoplasm
GO:0005576	0.955	extracellular region
GO:0005829	0.951	cytosol
GO:0005615	0.804	extracellular space
GO:0031982	0.712	vesicle
GO:1903561	0.622	extracellular vesicle
GO:0070062	0.568	extracellular exosome
GO:0009986	0.545	cell surface

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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