StarFunc result for job id O76054

User Input

>input (403 residues)
MSGRVGDLSPRQKEALAKFRENVQDVLPALPNPDDYFLLRWLRARSFDLQKSEAMLRKHV
EFRKQKDIDNIISWQPPEVIQQYLSGGMCGYDLDGCPVWYDIIGPLDAKGLLFSASKQDL
LRTKMRECELLLQECAHQTTKLGRKVETITIIYDCEGLGLKHLWKPAVEAYGEFLCMFEE
NYPETLKRLFVVKAPKLFPVAYNLIKPFLSEDTRKKIMVLGANWKEVLLKHISPDQVPVE
YGGTMTDPDGNPKCKSKINYGGDIPRKYYVRDQVKQQYEHSVQISRGSSHQVEYEILFPG
CVLRWQFMSDGADVGFGIFLKTKMGERQRAGEMTEVLPNQRYNSHLVPEDGTLTCSDPGI
YVLRFDNTYSFIHAKKVNFTVEVLLPDKASEEKMKQLGAGTPK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A024R1I5	0.992	0.992	4.545E-82	403	1.000	1.000	A0A024R1I5.pdb.gz
2	PDB:1olmE	0.973	0.988	2.867E-79	397	0.980	0.995	1olmE.pdb.gz	Supernatant Protein Factor in Complex with Rrr-Alpha-Tocopherylquinone: A Link between Oxidized Vitamin E and Cholesterol Biosynthesis
3	AFDB:Q9UDX3	0.981	0.974	3.296E-69	406	0.702	0.697	Q9UDX3.pdb.gz	S14L4_HUMAN SEC14-like protein 4 OS=Homo sapiens OX=9606 GN=SEC14L4 PE=1 SV=1
4	AFDB:A2BIR0	0.954	0.973	1.260E-68	395	0.655	0.668	A2BIR0.pdb.gz	A2BIR0_DANRE SEC14-like lipid-binding 8 OS=Danio rerio OX=7955 GN=si:ch211-89f7.1 PE=4 SV=2
5	PDB:4uybA	0.965	0.970	1.466E-68	401	0.767	0.771	4uybA.pdb.gz
6	AFDB:Q9UDX4	0.968	0.975	2.535E-68	400	0.764	0.770	Q9UDX4.pdb.gz	S14L3_HUMAN SEC14-like protein 3 OS=Homo sapiens OX=9606 GN=SEC14L3 PE=1 SV=1
7	PDB:4tlgA	0.962	0.978	1.850E-66	396	0.690	0.702	4tlgA.pdb.gz	Crystal structure of SEC14-like protein 4 (SEC14L4)
8	AFDB:O43304	0.734	0.451	2.458E-37	696	0.310	0.180	O43304.pdb.gz	S14L5_HUMAN SEC14-like protein 5 OS=Homo sapiens OX=9606 GN=SEC14L5 PE=1 SV=3
9	AFDB:O17907	0.606	0.636	7.018E-37	383	0.266	0.279	O17907.pdb.gz	CTG1_CAEEL Protein ctg-1 OS=Caenorhabditis elegans OX=6239 GN=ctg-1 PE=2 SV=2
10	AFDB:Q92503	0.705	0.424	4.152E-35	715	0.290	0.164	Q92503.pdb.gz	S14L1_HUMAN SEC14-like protein 1 OS=Homo sapiens OX=9606 GN=SEC14L1 PE=1 SV=2
11	AFDB:Q9VMD6	0.619	0.388	4.401E-33	659	0.268	0.164	Q9VMD6.pdb.gz	RETM_DROME Protein real-time OS=Drosophila melanogaster OX=7227 GN=retm PE=1 SV=2
12	AFDB:Q22824	0.588	0.617	8.116E-32	383	0.216	0.227	Q22824.pdb.gz	Q22824_CAEEL CRAL-TRIO domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=cgr-1 PE=1 SV=3
13	AFDB:Q9SCU1	0.515	0.508	3.803E-26	409	0.216	0.213	Q9SCU1.pdb.gz	PATL6_ARATH Patellin-6 OS=Arabidopsis thaliana OX=3702 GN=PATL6 PE=2 SV=1
14	PDB:6f0eA	0.556	0.735	5.267E-18	300	0.194	0.260	6f0eA.pdb.gz	Target Identification and Mechanism of Action of Picolinamide and Benzamide Chemotypes with Antifungal Properties.
15	PDB:3b7nA	0.560	0.727	7.257E-17	307	0.171	0.225	3b7nA.pdb.gz	Functional anatomy of phospholipid binding and regulation of phosphoinositide homeostasis by proteins of the sec14 superfamily
16	PDB:1oizA	0.371	0.516	1.791E-11	265	0.161	0.245	1oizA.pdb.gz	The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein
17	PDB:7wvtA	0.471	0.518	8.152E-11	364	0.166	0.184	7wvtA.pdb.gz	Structural basis of ligand recognition and transport by Sfh2, a yeast phosphatidylinositol transfer protein of the Sec14 superfamily.
18	PDB:3w68C	0.390	0.575	1.091E-10	252	0.164	0.262	3w68C.pdb.gz	Impaired alpha-TTP-PIPs interaction underlies familial vitamin E deficiency
19	PDB:4cizA	0.425	0.574	1.123E-9	284	0.136	0.194	4cizA.pdb.gz	Human Cellular Retinaldehyde-Binding Protein Has Secondary Thermal 9-Cis-Retinal Isomerase Activity.
20	PDB:4fmmB	0.419	0.508	1.059E-7	325	0.114	0.142	4fmmB.pdb.gz	Dimeric Sfh3 has structural changes in its binding pocket that are associated with a dimer-monomer state transformation induced by substrate binding.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	A2BIR0	0.0	593	395	0.655	0.668	A2BIR0_DANRE SEC14-like lipid-binding 8 OS=Danio rerio OX=7955 GN=si:ch211-89f7.1 PE=4 SV=2
2	B3KRD8	0.0	679	329	0.806	0.988	B3KRD8_HUMAN SEC14 like lipid binding 2 OS=Homo sapiens OX=9606 GN=SEC14L2 PE=1 SV=1
3	O76054	0.0	838	403	1.000	1.000	S14L2_HUMAN SEC14-like protein 2 OS=Homo sapiens OX=9606 GN=SEC14L2 PE=1 SV=1
4	Q99MS0	0.0	798	403	0.938	0.938	S14L2_RAT SEC14-like protein 2 OS=Rattus norvegicus OX=10116 GN=Sec14l2 PE=1 SV=1
5	Q9UDX3	0.0	625	406	0.702	0.697	S14L4_HUMAN SEC14-like protein 4 OS=Homo sapiens OX=9606 GN=SEC14L4 PE=1 SV=1
6	Q9UDX4	0.0	669	400	0.762	0.767	S14L3_HUMAN SEC14-like protein 3 OS=Homo sapiens OX=9606 GN=SEC14L3 PE=1 SV=1
7	C9JZI9	4.63e-150	424	203	0.504	1.000	C9JZI9_HUMAN SEC14 like lipid binding 2 (Fragment) OS=Homo sapiens OX=9606 GN=SEC14L2 PE=1 SV=1
8	O17907	6.87e-59	198	383	0.273	0.287	CTG1_CAEEL Protein ctg-1 OS=Caenorhabditis elegans OX=6239 GN=ctg-1 PE=2 SV=2
9	O43304	1.00e-54	194	696	0.295	0.171	S14L5_HUMAN SEC14-like protein 5 OS=Homo sapiens OX=9606 GN=SEC14L5 PE=1 SV=3
10	Q92503	8.50e-51	183	715	0.251	0.141	S14L1_HUMAN SEC14-like protein 1 OS=Homo sapiens OX=9606 GN=SEC14L1 PE=1 SV=2
11	Q9VMD6	1.38e-41	157	659	0.280	0.171	RETM_DROME Protein real-time OS=Drosophila melanogaster OX=7227 GN=retm PE=1 SV=2
12	Q10137	2.43e-31	122	286	0.208	0.294	SEC14_SCHPO Sec14 cytosolic factor OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=sec14 PE=4 SV=1
13	Q22824	1.14e-28	117	383	0.218	0.230	Q22824_CAEEL CRAL-TRIO domain-containing protein OS=Caenorhabditis elegans OX=6239 GN=cgr-1 PE=1 SV=3
14	Q93ZE9	2.09e-27	115	548	0.191	0.141	SFH3_ARATH Phosphatidylinositol/phosphatidylcholine transfer protein SFH3 OS=Arabidopsis thaliana OX=3702 GN=SFH3 PE=2 SV=1
15	F4JLE5	2.38e-26	113	554	0.189	0.137	SFH1_ARATH Phosphatidylinositol/phosphatidylcholine transfer protein SFH1 OS=Arabidopsis thaliana OX=3702 GN=SFH1 PE=2 SV=1
16	P46250	4.98e-26	108	301	0.186	0.249	SEC14_CANAL SEC14 cytosolic factor OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=SEC14 PE=2 SV=1
17	P24280	5.70e-26	108	304	0.184	0.243	SEC14_YEAST SEC14 cytosolic factor OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=SEC14 PE=1 SV=3
18	F4JVA9	5.07e-25	108	554	0.181	0.132	SFH2_ARATH Phosphatidylinositol/phosphatidylcholine transfer protein SFH2 OS=Arabidopsis thaliana OX=3702 GN=SFH2 PE=3 SV=1
19	F4HZ25	4.56e-24	106	668	0.189	0.114	F4HZ25_ARATH Sec14p-like phosphatidylinositol transfer family protein OS=Arabidopsis thaliana OX=3702 GN=At1g75370 PE=1 SV=1
20	P33324	4.79e-24	103	310	0.196	0.255	YKJ1_YEAST CRAL-TRIO domain-containing protein YKL091C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=YKL091C PE=1 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00650 CRAL_TRIO	3.7e-37	139.0	CRAL/TRIO domain
2	PF13716 CRAL_TRIO_2	0.00029	32.5	Divergent CRAL/TRIO domain
3	PF03765 CRAL_TRIO_N	0.6	21.6	CRAL/TRIO, N-terminal domain
4	PF13897 GOLD_2	9.3e-05	34.4	Golgi-dynamics membrane-trafficking

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000478755

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000321266	0.549	Phosphatidylinositol transfer protein beta isoform
2	9606.ENSP00000265896	0.519	Squalene monooxygenase
3	9606.ENSP00000374213	0.514	E1A-binding protein p400

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005515	0.999	protein binding
GO:0003824	0.998	catalytic activity
GO:0043168	0.795	anion binding
GO:1901363	0.640	heterocyclic compound binding
GO:0097159	0.624	organic cyclic compound binding
GO:0036094	0.617	small molecule binding
GO:0000166	0.592	nucleotide binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050789	0.988	regulation of biological process
GO:0080090	0.968	regulation of primary metabolic process
GO:0009893	0.953	positive regulation of metabolic process
GO:0019216	0.930	regulation of lipid metabolic process
GO:0019218	0.915	regulation of steroid metabolic process
GO:0009987	0.897	cellular process
GO:0046890	0.856	regulation of lipid biosynthetic process
GO:0045834	0.845	positive regulation of lipid metabolic process
GO:0062012	0.844	regulation of small molecule metabolic process
GO:0046889	0.833	positive regulation of lipid biosynthetic process
GO:1902930	0.824	regulation of alcohol biosynthetic process
GO:0090181	0.823	regulation of cholesterol metabolic process
GO:0050810	0.823	regulation of steroid biosynthetic process
GO:0045940	0.822	positive regulation of steroid metabolic process
GO:0062013	0.762	positive regulation of small molecule metabolic process
GO:0010893	0.730	positive regulation of steroid biosynthetic process
GO:0050794	0.591	regulation of cellular process
GO:1902932	0.528	positive regulation of alcohol biosynthetic process
GO:0071704	0.430	organic substance metabolic process
GO:0050896	0.403	response to stimulus
GO:0044238	0.401	primary metabolic process
GO:0048522	0.312	positive regulation of cellular process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0043227	0.998	membrane-bounded organelle
GO:0005737	0.998	cytoplasm
GO:0070013	0.990	intracellular organelle lumen
GO:0005654	0.982	nucleoplasm
GO:0005829	0.972	cytosol
GO:0016020	0.872	membrane
GO:0012505	0.446	endomembrane system

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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