StarFunc result for job id O94813

User Input

>input (1529 residues)
MRGVGWQMLSLSLGLVLAILNKVAPQACPAQCSCSGSTVDCHGLALRSVPRNIPRNTERL
DLNGNNITRITKTDFAGLRHLRVLQLMENKISTIERGAFQDLKELERLRLNRNHLQLFPE
LLFLGTAKLYRLDLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVL
TLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPS
HLRGHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPE
TITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQGLRSLNSLVLYGNKI
TELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLYDNKLQTIAKGTFSPLR
AIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSA
KEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRL
NNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHK
MFKGLESLKTLMLRSNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLN
LLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNS
CSPLSRCPTECTCLDTVVRCSNKGLKVLPKGIPRDVTELYLDGNQFTLVPKELSNYKHLT
LIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVV
PEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTT
PSKKFTCQGPVDVNILAKCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHA
CISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNY
TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDC
QDNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRI
NEPICQCLPGYQGEKCEKLVSVNFINKESYLQIPSAKVRPQTNITLQIATDEDSGILLYK
GDKDHIAVELYRGRVRASYDTGSHPASAIYSVETINDGNFHIVELLALDQSLSLSVDGGN
PKIITNLSKQSTLNFDSPLYVGGMPGKSNVASLRQAPGQNGTSFHGCIRNLYINSELQDF
QKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKC
VHGTCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSS
GYTGDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQCCGPLRSKRR
KYSFECTDGSSFVDEVEKVVKCGCTRCVS

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:A0A2R8QDY6	0.438	0.437	0.000	1532	0.605	0.604	A0A2R8QDY6.pdb.gz
2	AFDB:A0A2R8RXU4	0.291	0.292	0.000	1521	0.793	0.797	A0A2R8RXU4.pdb.gz
3	AFDB:B8A498	0.443	0.444	0.000	1524	0.655	0.657	B8A498.pdb.gz
4	AFDB:F1RCV3	0.288	0.290	0.000	1516	0.625	0.630	F1RCV3.pdb.gz	F1RCV3_DANRE Slit homolog 3 (Drosophila) OS=Danio rerio OX=7955 GN=zgc:111911 PE=1 SV=1
5	AFDB:G5EFX6	0.338	0.360	0.000	1410	0.358	0.388	G5EFX6.pdb.gz	SLIT1_CAEEL Slit homolog 1 protein OS=Caenorhabditis elegans OX=6239 GN=slt-1 PE=1 SV=1
6	AFDB:O75093	0.511	0.510	0.000	1534	0.658	0.656	O75093.pdb.gz	SLIT1_HUMAN Slit homolog 1 protein OS=Homo sapiens OX=9606 GN=SLIT1 PE=1 SV=4
7	AFDB:O75094	0.568	0.570	0.000	1523	0.662	0.664	O75094.pdb.gz	SLIT3_HUMAN Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3
8	AFDB:O94813	1.000	1.000	0.000	1529	1.000	1.000	O94813.pdb.gz	SLIT2_HUMAN Slit homolog 2 protein OS=Homo sapiens OX=9606 GN=SLIT2 PE=1 SV=1
9	AFDB:P24014	0.306	0.310	0.000	1504	0.440	0.447	P24014.pdb.gz	SLIT_DROME Protein slit OS=Drosophila melanogaster OX=7227 GN=sli PE=1 SV=2
10	AFDB:Q90XG4	0.204	0.268	0.000	1095	0.471	0.658	Q90XG4.pdb.gz	Q90XG4_CHICK Slit-3 (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
11	PDB:3t6qA	0.106	0.250	3.978E-19	601	0.097	0.248	3t6qA.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
12	PDB:6gffI	0.106	0.268	1.871E-18	551	0.099	0.276	6gffI.pdb.gz
13	PDB:7wv3A	0.109	0.232	4.335E-17	668	0.105	0.241	7wv3A.pdb.gz	TLR3 forms a highly organized cluster when bound to a poly(I:C) RNA ligand.
14	PDB:3b2dA	0.126	0.269	1.468E-16	601	0.080	0.203	3b2dA.pdb.gz	Crystal Structures of Mouse and Human RP105/MD-1 Complexes Reveal Unique Dimer Organization of the Toll-Like Receptor Family.
15	PDB:7tvfD	0.096	0.271	2.831E-16	515	0.071	0.212	7tvfD.pdb.gz	Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome.
16	PDB:7wrqA	0.116	0.304	3.415E-16	566	0.107	0.290	7wrqA.pdb.gz
17	PDB:1xcdA	0.103	0.502	2.328E-14	305	0.061	0.308	1xcdA.pdb.gz
18	PDB:3j0aA	0.106	0.193	3.707E-13	797	0.080	0.154	3j0aA.pdb.gz	Toll-like receptor 5 forms asymmetric dimers in the absence of flagellin.
19	PDB:2ft3F	0.094	0.440	5.395E-13	305	0.060	0.298	2ft3F.pdb.gz
20	PDB:5yq5B	0.101	0.472	1.188E-10	306	0.056	0.281	5yq5B.pdb.gz

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A0R4IU60	1867	1531	0.604	0.604	A0A0R4IU60_DANRE Slit homolog 1b (Drosophila) OS=Danio rerio OX=7955 GN=slit1b PE=4 SV=1
2	D2XV92	2048	1513	0.651	0.658	D2XV92_CHICK SLIT1 (Fragment) OS=Gallus gallus OX=9031 GN=SLIT1 PE=2 SV=1
3	F1RCV3	1981	1516	0.629	0.634	F1RCV3_DANRE Slit homolog 3 (Drosophila) OS=Danio rerio OX=7955 GN=zgc:111911 PE=1 SV=1
4	G5EFX6	930	1410	0.351	0.380	SLIT1_CAEEL Slit homolog 1 protein OS=Caenorhabditis elegans OX=6239 GN=slt-1 PE=1 SV=1
5	O75093	2093	1534	0.654	0.652	SLIT1_HUMAN Slit homolog 1 protein OS=Homo sapiens OX=9606 GN=SLIT1 PE=1 SV=4
6	O75094	2121	1523	0.661	0.663	SLIT3_HUMAN Slit homolog 3 protein OS=Homo sapiens OX=9606 GN=SLIT3 PE=2 SV=3
7	O88279	2085	1531	0.650	0.649	SLIT1_RAT Slit homolog 1 protein OS=Rattus norvegicus OX=10116 GN=Slit1 PE=1 SV=1
8	O88280	2133	1523	0.661	0.664	SLIT3_RAT Slit homolog 3 protein OS=Rattus norvegicus OX=10116 GN=Slit3 PE=2 SV=1
9	O94813	3149	1529	1.000	1.000	SLIT2_HUMAN Slit homolog 2 protein OS=Homo sapiens OX=9606 GN=SLIT2 PE=1 SV=1
10	P24014	1286	1504	0.440	0.447	SLIT_DROME Protein slit OS=Drosophila melanogaster OX=7227 GN=sli PE=1 SV=2
11	Q3S2J2	2048	1524	0.650	0.652	Q3S2J2_DANRE Slit homolog 1 protein precursor OS=Danio rerio OX=7955 GN=slit1a PE=1 SV=1
12	Q3Y6S4	1859	1532	0.604	0.602	Q3Y6S4_DANRE Slit homolog 1b precursor OS=Danio rerio OX=7955 GN=slit1b PE=2 SV=1
13	Q80TR4	2073	1531	0.647	0.646	SLIT1_MOUSE Slit homolog 1 protein OS=Mus musculus OX=10090 GN=Slit1 PE=1 SV=2
14	Q90XG2	1531	783	0.478	0.934	Q90XG2_CHICK Slit-2 (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
15	Q90XG4	1565	1095	0.471	0.658	Q90XG4_CHICK Slit-3 (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
16	Q90Z43	1093	792	0.325	0.628	Q90Z43_CHICK Slit3 protein (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
17	Q90Z44	1847	950	0.574	0.924	Q90Z44_CHICK Slit2 protein (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
18	Q90Z45	997	738	0.309	0.641	Q90Z45_CHICK Slit1 protein (Fragment) OS=Gallus gallus OX=9031 PE=2 SV=1
19	Q9DE36	2544	1512	0.795	0.804	Q9DE36_DANRE Slit homolog 2 protein precursor OS=Danio rerio OX=7955 GN=slit2 PE=1 SV=1
20	Q9R1B9	3046	1521	0.962	0.967	SLIT2_MOUSE Slit homolog 2 protein OS=Mus musculus OX=10090 GN=Slit2 PE=2 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF00008 EGF	4.6e-30	114.9	EGF-like domain
2	PF12947 EGF_3	17	17.0	EGF domain
3	PF12661 hEGF	5.6e-13	60.2	Human growth factor-like EGF
4	PF00054 Laminin_G_1	1.6e-23	94.8	Laminin G domain
5	PF02210 Laminin_G_2	1.9e-20	85.1	Laminin G domain
6	PF01463 LRRCT	6.2e-14	62.4	Leucine rich repeat C-terminal domain
7	PF01462 LRRNT	8.4e-17	71.6	Leucine rich repeat N-terminal domain
8	PF00560 LRR_1	0.075	24.4	Leucine Rich Repeat
9	PF12799 LRR_4	1.1e-32	122.6	Leucine Rich repeats (2 copies)
10	PF13306 LRR_5	7.5e-38	140.8	BspA type Leucine rich repeat region (6 copies)
11	PF13855 LRR_8	8.9e-102	344.2	Leucine rich repeat
12	PF14580 LRR_9	6e-17	73.2	Leucine-rich repeat

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000422591

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000420321	0.999	Roundabout homolog 1
2	9606.ENSP00000417335	0.998	Roundabout homolog 2
3	9606.ENSP00000304945	0.992	Roundabout homolog 4
4	9606.ENSP00000264039	0.989	Glypican-1
5	9606.ENSP00000383118	0.952	Cell division control protein 42 homolog
6	9606.ENSP00000400175	0.942	Transforming protein RhoA
7	9606.ENSP00000230658	0.933	Insulin gene enhancer protein ISL-1
8	9606.ENSP00000380903	0.928	Roundabout homolog 3
9	9606.ENSP00000348461	0.922	Ras-related C3 botulinum toxin substrate 1
10	9606.ENSP00000360811	0.921	LIM/homeobox protein Lhx3
11	9606.ENSP00000263726	0.905	LIM/homeobox protein Lhx4
12	9606.ENSP00000392466	0.901	LIM domain-binding protein 1
13	9606.ENSP00000389140	0.874	Netrin receptor DCC
14	9606.ENSP00000173229	0.846	Netrin-1
15	9606.ENSP00000355809	0.807	Protein enabled homolog
16	9606.ENSP00000427562	0.796	Abelson tyrosine-protein kinase 2
17	9606.ENSP00000347198	0.793	SLIT-ROBO Rho GTPase-activating protein 1
18	9606.ENSP00000366522	0.771	Rho GTPase activating protein 39
19	9606.ENSP00000361423	0.770	Tyrosine-protein kinase ABL1
20	9606.ENSP00000379140	0.768	Stromal cell-derived factor 1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005102	0.997	signaling receptor binding
GO:0097367	0.957	carbohydrate derivative binding
GO:0098772	0.946	molecular function regulator activity
GO:1901681	0.937	sulfur compound binding
GO:0005539	0.885	glycosaminoglycan binding
GO:0008201	0.883	heparin binding
GO:0048495	0.789	Roundabout binding
GO:0043394	0.736	proteoglycan binding
GO:0042802	0.529	identical protein binding
GO:0140677	0.357	molecular function activator activity
GO:0046983	0.329	protein dimerization activity
GO:0042803	0.324	protein homodimerization activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0050896	0.994	response to stimulus
GO:0009987	0.994	cellular process
GO:0007399	0.989	nervous system development
GO:0048523	0.988	negative regulation of cellular process
GO:0009653	0.987	anatomical structure morphogenesis
GO:0051128	0.981	regulation of cellular component organization
GO:0040011	0.979	locomotion
GO:0051239	0.979	regulation of multicellular organismal process
GO:0071840	0.977	cellular component organization or biogenesis
GO:0009605	0.969	response to external stimulus
GO:0050793	0.967	regulation of developmental process
GO:0007417	0.961	central nervous system development
GO:0061387	0.956	regulation of extent of cell growth
GO:0010975	0.952	regulation of neuron projection development
GO:0006935	0.950	chemotaxis
GO:0022603	0.946	regulation of anatomical structure morphogenesis
GO:0051129	0.946	negative regulation of cellular component organization
GO:0032990	0.945	cell part morphogenesis
GO:0048858	0.944	cell projection morphogenesis
GO:0051241	0.941	negative regulation of multicellular organismal process
GO:0030308	0.941	negative regulation of cell growth
GO:0031345	0.940	negative regulation of cell projection organization
GO:0048513	0.939	animal organ development
GO:0050770	0.938	regulation of axonogenesis
GO:0010977	0.934	negative regulation of neuron projection development
GO:0060284	0.930	regulation of cell development
GO:0051960	0.927	regulation of nervous system development
GO:0050767	0.923	regulation of neurogenesis
GO:0030516	0.909	regulation of axon extension
GO:0007411	0.890	axon guidance
GO:0016477	0.887	cell migration
GO:0051093	0.884	negative regulation of developmental process
GO:0050771	0.873	negative regulation of axonogenesis
GO:0007507	0.870	heart development
GO:0048640	0.868	negative regulation of developmental growth
GO:0030517	0.848	negative regulation of axon extension
GO:0048518	0.824	positive regulation of biological process
GO:0060429	0.784	epithelium development
GO:0048583	0.770	regulation of response to stimulus
GO:0040012	0.769	regulation of locomotion
GO:0048729	0.738	tissue morphogenesis
GO:0048522	0.735	positive regulation of cellular process
GO:0003007	0.735	heart morphogenesis
GO:0051716	0.689	cellular response to stimulus
GO:0008038	0.689	neuron recognition
GO:0048645	0.687	animal organ formation
GO:0060914	0.659	heart formation
GO:0060973	0.630	cell migration involved in heart development
GO:0032101	0.594	regulation of response to external stimulus
GO:0001763	0.560	morphogenesis of a branching structure
GO:0007154	0.547	cell communication
GO:0048585	0.547	negative regulation of response to stimulus
GO:0023052	0.538	signaling
GO:0021954	0.533	central nervous system neuron development
GO:0002009	0.523	morphogenesis of an epithelium
GO:0021952	0.516	central nervous system projection neuron axonogenesis
GO:0050919	0.510	negative chemotaxis
GO:0007420	0.503	brain development
GO:0007165	0.472	signal transduction
GO:0019222	0.423	regulation of metabolic process
GO:0009966	0.418	regulation of signal transduction
GO:0030334	0.415	regulation of cell migration
GO:0060255	0.405	regulation of macromolecule metabolic process
GO:0040017	0.317	positive regulation of locomotion
GO:0051130	0.314	positive regulation of cellular component organization
GO:0048584	0.307	positive regulation of response to stimulus
GO:0051171	0.301	regulation of nitrogen compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0071944	0.999	cell periphery
GO:0016020	0.999	membrane
GO:0005576	0.995	extracellular region
GO:0005886	0.991	plasma membrane
GO:0005622	0.927	intracellular anatomical structure
GO:0005615	0.927	extracellular space
GO:0043226	0.906	organelle
GO:0043227	0.869	membrane-bounded organelle
GO:0005737	0.842	cytoplasm
GO:0043231	0.785	intracellular membrane-bounded organelle
GO:0065010	0.605	extracellular membrane-bounded organelle
GO:1903561	0.591	extracellular vesicle
GO:0070062	0.580	extracellular exosome

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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