StarFunc result for job id O94992

User Input

>input (359 residues)
MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPG
PEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQ
PCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDE
KQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDD
FMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSR
MEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O94992	1.000	1.000	1.985E-53	359	1.000	1.000	O94992.pdb.gz	HEXI1_HUMAN Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1
2	AFDB:Q8R409	0.369	0.371	1.059E-42	356	0.852	0.860	Q8R409.pdb.gz	HEXI1_MOUSE Protein HEXIM1 OS=Mus musculus OX=10090 GN=Hexim1 PE=1 SV=1
3	AFDB:Q96MH2	0.258	0.317	1.660E-18	286	0.337	0.423	Q96MH2.pdb.gz	HEXI2_HUMAN Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1
4	AFDB:Q75JH1	0.088	0.066	1.924E-4	522	0.117	0.080	Q75JH1.pdb.gz	Q75JH1_DICDI RRM Nup35-type domain-containing protein OS=Dictyostelium discoideum OX=44689 GN=DDB_G0276109 PE=4 SV=1
5	AFDB:Q9VUX7	0.138	0.133	6.177E-4	377	0.162	0.154	Q9VUX7.pdb.gz	Q9VUX7_DROME GH16214p OS=Drosophila melanogaster OX=7227 GN=Mbs PE=1 SV=1
6	AFDB:Q3LGD4	0.150	0.096	1.070E-3	621	0.148	0.085	Q3LGD4.pdb.gz	RFP4A_DANRE Rab11 family-interacting protein 4A OS=Danio rerio OX=7955 GN=rab11fip4a PE=2 SV=1
7	AFDB:H0Y4T4	0.076	0.099	1.450E-2	263	0.092	0.125	H0Y4T4.pdb.gz	H0Y4T4_HUMAN Centrosomal protein 170 (Fragment) OS=Homo sapiens OX=9606 GN=CEP170 PE=1 SV=1
8	AFDB:P34402	0.137	0.068	1.908E-2	808	0.159	0.071	P34402.pdb.gz	SAS4_CAEEL Spindle assembly abnormal protein 4 OS=Caenorhabditis elegans OX=6239 GN=sas-4 PE=1 SV=2
9	AFDB:M9NDQ8	0.124	0.091	2.511E-2	530	0.156	0.106	M9NDQ8.pdb.gz	M9NDQ8_DROME Nuclear fallout, isoform G OS=Drosophila melanogaster OX=7227 GN=nuf PE=4 SV=1
10	AFDB:Q6DIC6	0.136	0.032	2.880E-2	2087	0.120	0.021	Q6DIC6.pdb.gz	Q6DIC6_MOUSE Tro protein OS=Mus musculus OX=10090 GN=Tro PE=1 SV=1
11	PDB:6iczL	0.079	0.064	1.954	454	0.058	0.046	6iczL.pdb.gz	Structures of the human spliceosomes before and after release of the ligated exon.
12	PDB:6qdvO	0.072	0.061	2.241	441	0.100	0.082	6qdvO.pdb.gz	A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
13	PDB:6id0L	0.079	0.063	2.400	475	0.067	0.051	6id0L.pdb.gz	Structures of the human spliceosomes before and after release of the ligated exon.
14	PDB:7w5a2	0.093	0.245	3.158	123	0.056	0.163	7w5a2.pdb.gz	Mechanism of exon ligation by human spliceosome.
15	PDB:5yzgL	0.134	0.118	4.451	419	0.128	0.110	5yzgL.pdb.gz	Structure of a human catalytic step I spliceosome
16	PDB:7w59R	0.085	0.106	4.767	280	0.097	0.125	7w59R.pdb.gz	Mechanism of exon ligation by human spliceosome.
17	PDB:5lj5O	0.098	0.122	5.468	283	0.086	0.110	5lj5O.pdb.gz	Cryo-EM structure of the spliceosome immediately after branching.
18	PDB:5xtcg	0.059	0.138	6.272	119	0.028	0.084	5xtcg.pdb.gz	Architecture of Human Mitochondrial Respiratory Megacomplex I2III2IV2.
19	PDB:6exnO	0.092	0.102	6.718	320	0.100	0.113	6exnO.pdb.gz	Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection.
20	PDB:7ajtCL	0.089	0.046	6.718	781	0.061	0.028	7ajtCL.pdb.gz	Structure of the Maturing 90S Pre-ribosome in Association with the RNA Exosome.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O94992	0.0	727	359	1.000	1.000	HEXI1_HUMAN Protein HEXIM1 OS=Homo sapiens OX=9606 GN=HEXIM1 PE=1 SV=1
2	Q8R409	0.0	576	356	0.858	0.865	HEXI1_MOUSE Protein HEXIM1 OS=Mus musculus OX=10090 GN=Hexim1 PE=1 SV=1
3	A5D8S8	7.91e-61	200	319	0.312	0.351	HEXI1_DANRE Protein HEXIM1 OS=Danio rerio OX=7955 GN=hexim1 PE=2 SV=1
4	Q96MH2	1.03e-60	198	286	0.304	0.381	HEXI2_HUMAN Protein HEXIM2 OS=Homo sapiens OX=9606 GN=HEXIM2 PE=1 SV=1
5	Q8INF6	6.10e-10	62.4	360	0.159	0.158	Q8INF6_DROME Hexamethylene bisacetamide inducible, isoform B OS=Drosophila melanogaster OX=7227 GN=Hexim PE=3 SV=1
6	L7RKJ8	0.032	38.9	1299	0.117	0.032	L7RKJ8_DANRE C-Jun-amino-terminal kinase-interacting protein 3 OS=Danio rerio OX=7955 GN=mapk8ip3 PE=2 SV=1
7	Q9P2N2	0.51	35.0	729	0.100	0.049	RHG28_HUMAN Rho GTPase-activating protein 28 OS=Homo sapiens OX=9606 GN=ARHGAP28 PE=1 SV=3
8	Q9Z272	1.6	33.1	770	0.056	0.026	GIT1_RAT ARF GTPase-activating protein GIT1 OS=Rattus norvegicus OX=10116 GN=Git1 PE=1 SV=1
9	Q9LSP7	2.1	32.7	309	0.075	0.087	UBC32_ARATH Ubiquitin-conjugating enzyme E2 32 OS=Arabidopsis thaliana OX=3702 GN=UBC32 PE=2 SV=1
10	Q9Y2X7	2.5	32.7	761	0.056	0.026	GIT1_HUMAN ARF GTPase-activating protein GIT1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=2
11	J3QRU8	2.6	32.7	694	0.056	0.029	J3QRU8_HUMAN GIT ArfGAP 1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=1
12	Q68FF6	2.6	32.7	770	0.056	0.026	GIT1_MOUSE ARF GTPase-activating protein GIT1 OS=Mus musculus OX=10090 GN=Git1 PE=1 SV=1
13	A0A0C4DGN6	2.9	32.3	747	0.056	0.027	A0A0C4DGN6_HUMAN GIT ArfGAP 1 OS=Homo sapiens OX=9606 GN=GIT1 PE=1 SV=1
14	Q8NCY6	3.5	32.0	345	0.078	0.081	MSD4_HUMAN Myb/SANT-like DNA-binding domain-containing protein 4 OS=Homo sapiens OX=9606 GN=MSANTD4 PE=1 SV=1
15	Q57XE6	5.5	31.6	1179	0.081	0.025	Q57XE6_TRYB2 Uncharacterized protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb08.26A17.270 PE=4 SV=1
16	Q8SX68	6.2	31.2	609	0.095	0.056	CT2NL_DROME CTTNBP2 N-terminal-like protein OS=Drosophila melanogaster OX=7227 GN=Naus PE=1 SV=1
17	Q9VW51	6.6	31.2	1059	0.078	0.026	ELL_DROME RNA polymerase II elongation factor Ell OS=Drosophila melanogaster OX=7227 GN=Ell PE=1 SV=3
18	Q5B4Z3	8.2	31.2	1346	0.053	0.014	SEPH_EMENI Cytokinesis protein sepH OS=Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) OX=227321 GN=sepH PE=3 SV=2

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF15313 HEXIM	6.3e-56	200.0	Hexamethylene bis-acetamide-inducible protein

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000328773

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000261900	0.999	Cyclin-T1
2	9606.ENSP00000362361	0.999	Cyclin-dependent kinase 9
3	9606.ENSP00000422626	0.996	La-related protein 7
4	9606.ENSP00000308546	0.995	7SK snRNA methylphosphate capping enzyme
5	9606.ENSP00000264157	0.980	Cyclin-T2
6	9606.ENSP00000296930	0.941	Nucleophosmin
7	9606.ENSP00000263377	0.937	Bromodomain-containing protein 4
8	9606.ENSP00000265343	0.910	AF4/FMR2 family member 4
9	9606.ENSP00000302276	0.886	Protein HEXIM2
10	9606.ENSP00000228284	0.830	Squamous cell carcinoma antigen recognized by T-cells 3
11	9606.ENSP00000463058	0.830	RNA-binding protein 8A
12	9606.ENSP00000442699	0.810	HIV Tat-specific factor 1
13	9606.ENSP00000341885	0.728	Ribosomal protein S2
14	9606.ENSP00000356520	0.727	ATP-dependent RNA helicase A
15	9606.ENSP00000378578	0.722	AF4/FMR2 family member 1
16	9606.ENSP00000480158	0.702	DNA-directed RNA polymerase II subunit RPB1
17	9606.ENSP00000231509	0.698	Glucocorticoid receptor
18	9606.ENSP00000376276	0.697	Serine/arginine-rich splicing factor 2
19	9606.ENSP00000346120	0.695	Nucleolar RNA helicase 2
20	9606.ENSP00000325634	0.689	Zinc finger protein 639

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0017069	0.996	snRNA binding
GO:0042802	0.995	identical protein binding
GO:0004861	0.992	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0044877	0.987	protein-containing complex binding
GO:0030234	0.984	enzyme regulator activity
GO:0019210	0.971	kinase inhibitor activity
GO:0019887	0.969	protein kinase regulator activity
GO:0004860	0.964	protein kinase inhibitor activity
GO:0097322	0.963	7SK snRNA binding
GO:0106140	0.937	P-TEFb complex binding

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0050794	0.996	regulation of cellular process
GO:0048523	0.992	negative regulation of cellular process
GO:0080090	0.979	regulation of primary metabolic process
GO:0051171	0.979	regulation of nitrogen compound metabolic process
GO:0031323	0.979	regulation of cellular metabolic process
GO:0060255	0.973	regulation of macromolecule metabolic process
GO:0009892	0.965	negative regulation of metabolic process
GO:0031324	0.962	negative regulation of cellular metabolic process
GO:0051172	0.959	negative regulation of nitrogen compound metabolic process
GO:0019219	0.959	regulation of nucleobase-containing compound metabolic process
GO:0010468	0.958	regulation of gene expression
GO:0051252	0.950	regulation of RNA metabolic process
GO:0010556	0.948	regulation of macromolecule biosynthetic process
GO:0010605	0.948	negative regulation of macromolecule metabolic process
GO:0031326	0.947	regulation of cellular biosynthetic process
GO:0045934	0.941	negative regulation of nucleobase-containing compound metabolic process
GO:0048518	0.940	positive regulation of biological process
GO:1903506	0.936	regulation of nucleic acid-templated transcription
GO:0006355	0.932	regulation of DNA-templated transcription
GO:0048522	0.931	positive regulation of cellular process
GO:1903507	0.921	negative regulation of nucleic acid-templated transcription
GO:0045892	0.909	negative regulation of DNA-templated transcription
GO:0051246	0.813	regulation of protein metabolic process
GO:0006357	0.776	regulation of transcription by RNA polymerase II
GO:0009987	0.737	cellular process
GO:0008152	0.589	metabolic process
GO:0048583	0.575	regulation of response to stimulus
GO:0065009	0.543	regulation of molecular function
GO:0050790	0.477	regulation of catalytic activity
GO:0044237	0.458	cellular metabolic process
GO:0071704	0.410	organic substance metabolic process
GO:0051726	0.391	regulation of cell cycle
GO:0031399	0.368	regulation of protein modification process
GO:0051338	0.355	regulation of transferase activity
GO:0042325	0.347	regulation of phosphorylation
GO:0002376	0.330	immune system process
GO:0080134	0.321	regulation of response to stress
GO:0048584	0.308	positive regulation of response to stimulus
GO:0071840	0.303	cellular component organization or biogenesis

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005654	0.997	nucleoplasm
GO:0032991	0.993	protein-containing complex
GO:0005737	0.953	cytoplasm
GO:0140513	0.934	nuclear protein-containing complex
GO:1990904	0.930	ribonucleoprotein complex
GO:0005829	0.899	cytosol
GO:0043232	0.513	intracellular non-membrane-bounded organelle
GO:0030532	0.472	small nuclear ribonucleoprotein complex
GO:0120259	0.387	7SK snRNP

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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