StarFunc result for job id O95477

User Input

>input (2261 residues)
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKA
MPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVARLFSDARRLLLYSQKDT
SMKDMRKVLRTLQQIKKSSSNLKLQDFLVDNETFSGFLYHNLSLPKSTVDKMLRADVILH
KVFLQGYQLHLTSLCNGSKSEEMIQLGDQEVSELCGLPREKLAAAERVLRSNMDILKPIL
RTLNSTSPFPSKELAEATKTLLHSLGTLAQELFSMRSWSDMRQEVMFLTNVNSSSSSTQI
YQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNGTEEDAETFYDNSTTPYCNDLMK
NLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELS
PKIWTFMENSQEMDLVRMLLDSRDNDHFWEQQLDGLDWTAQDIVAFLAKHPEDVQSSNGS
VYTWREAFNETNQAIRTISRFMECVNLNKLEPIATEVWLINKSMELLDERKFWAGIVFTG
ITPGSIELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVV
EQAIIRVLTGTEKKTGVYMQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKGIV
YEKEARLKETMRIMGLDNSILWFSWFISSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFV
FLSVFAVVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFTLKIFAS
LLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTSVSMMLFDTFLYGVMTW
YIEAVFPGQYGIPRPWYFPCTKSYWFGEESDEKSHPGSNQKRISEICMEEEPTHLKLGVS
IQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYIL
GKDIRSEMSTIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVG
LPSSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQ
GRTIILSTHHMDEADVLGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLS
SCRNSSSTVSYLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDI
GHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAE
TSDGTLPARRNRRAFGDKQSCLRPFTEDDAADPNDSDIDPESRETDLLSGMDGKGSYQVK
GWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQ
PWMYNEQYTFVSNDAPEDTGTLELLNALTKDPGFGTRCMEGNPIPDTPCQAGEEEWTTAP
VPQTIMDLFQNGNWTMQNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQNTADILQDL
TGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNTQALPPSQEVNDAIKQMKK
HLKLAKDSSADRFLNSLGRFMTGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQK
GENPSHYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQER
VSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLAL
LLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTDNKLNNIN
DILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEG
VVFFLITVLIQYRFFIRPRPVNAKLSPLNDEDEDVRRERQRILDGGGQNDILEIKELTKI
YRRKRKPAVDRICVGIPPGECFGLLGVNGAGKSSTFKMLTGDTTVTRGDAFLNKNSILSN
IHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEK
YAGNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSVVKEGRSVVLT
SHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQDFFG
LAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNF
AKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Length	ID1	ID2	Download	Description
1	PDB:5xjyA	0.547	0.628	1901	0.798	0.950	5xjyA.pdb.gz
2	PDB:7e7iA	0.648	0.715	2011	0.481	0.541	7e7iA.pdb.gz
3	PDB:7e7qA	0.785	0.901	1958	0.469	0.541	7e7qA.pdb.gz	Structural basis of substrate recognition and translocation by human ABCA4.
4	PDB:7lkzA	0.782	0.916	1920	0.475	0.559	7lkzA.pdb.gz	Molecular structures of the eukaryotic retinal importer ABCA4.
5	PDB:7m1pA	0.636	0.725	1938	0.462	0.539	7m1pA.pdb.gz
6	PDB:7m1qA	0.620	0.715	1911	0.448	0.530	7m1qA.pdb.gz	Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.
7	PDB:7roqA	0.590	0.701	1831	0.805	0.994	7roqA.pdb.gz	Structure of the Human Lipid Exporter ABCA1.
8	PDB:7tbwA	0.800	0.932	1928	0.846	0.992	7tbwA.pdb.gz	Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
9	PDB:7tbyA	0.618	0.754	1788	0.788	0.997	7tbyA.pdb.gz	Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
10	PDB:7w01A	0.542	0.743	1598	0.268	0.380	7w01A.pdb.gz
11	AFDB:A0A0G2K1Q8	0.617	0.810	1704	0.264	0.350	A0A0G2K1Q8.pdb.gz	ABCA3_RAT Phospholipid-transporting ATPase ABCA3 OS=Rattus norvegicus OX=10116 GN=Abca3 PE=1 SV=1
12	AFDB:B8A446	0.783	0.781	2268	0.746	0.744	B8A446.pdb.gz	B8A446_DANRE ATP-binding cassette sub-family A member 1 OS=Danio rerio OX=7955 GN=abca1 PE=4 SV=1
13	AFDB:E9PWH4	0.590	0.788	1668	0.240	0.326	E9PWH4.pdb.gz	E9PWH4_MOUSE ATP-binding cassette, sub-family A (ABC1), member 15 OS=Mus musculus OX=10090 GN=Abca15 PE=1 SV=1
14	AFDB:E9PX95	0.612	0.791	1733	0.238	0.310	E9PX95.pdb.gz	ABCAH_MOUSE ATP-binding cassette sub-family A member 17 OS=Mus musculus OX=10090 GN=Abca17 PE=1 SV=1
15	AFDB:E9Q876	0.705	0.619	2595	0.312	0.272	E9Q876.pdb.gz	ABCAC_MOUSE Glucosylceramide transporter ABCA12 OS=Mus musculus OX=10090 GN=Abca12 PE=1 SV=1
16	AFDB:O35600	0.738	0.724	2310	0.506	0.496	O35600.pdb.gz	ABCA4_MOUSE Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Mus musculus OX=10090 GN=Abca4 PE=1 SV=1
17	AFDB:O95477	1.000	1.000	2261	1.000	1.000	O95477.pdb.gz	ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3
18	AFDB:P78363	0.758	0.754	2273	0.508	0.505	P78363.pdb.gz	ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Homo sapiens OX=9606 GN=ABCA4 PE=1 SV=3
19	AFDB:Q385F7	0.594	0.764	1738	0.203	0.265	Q385F7.pdb.gz	Q385F7_TRYB2 ABC transporter, putative OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb11.02.3950 PE=4 SV=1
20	AFDB:Q7TNJ2	0.749	0.777	2170	0.498	0.519	Q7TNJ2.pdb.gz	ABCA7_RAT ATP-binding cassette sub-family A member 7 OS=Rattus norvegicus OX=10116 GN=Abca7 PE=1 SV=1

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	Bit-score	Length	ID1	ID2	Description
1	A0A087WXK5	1563	2466	0.395	0.363	A0A087WXK5_HUMAN ATP-binding cassette sub-family A member 2 OS=Homo sapiens OX=9606 GN=ABCA2 PE=1 SV=1
2	A0A8I5ZLK5	4324	2263	0.936	0.935	A0A8I5ZLK5_RAT ATP binding cassette subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=1 SV=1
3	A0A8I6ATT1	4221	2190	0.913	0.943	A0A8I6ATT1_RAT ATP binding cassette subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=1 SV=1
4	B2RY11	1207	2595	0.320	0.279	B2RY11_MOUSE Abca12 protein OS=Mus musculus OX=10090 GN=Abca12 PE=2 SV=1
5	B2RY21	1209	2595	0.320	0.279	B2RY21_MOUSE Abca12 protein OS=Mus musculus OX=10090 GN=Abca12 PE=2 SV=1
6	B8A446	3461	2268	0.748	0.746	B8A446_DANRE ATP-binding cassette sub-family A member 1 OS=Danio rerio OX=7955 GN=abca1 PE=4 SV=1
7	E9Q876	1210	2595	0.320	0.279	ABCAC_MOUSE Glucosylceramide transporter ABCA12 OS=Mus musculus OX=10090 GN=Abca12 PE=1 SV=1
8	F1LNL3	4249	2201	0.918	0.943	F1LNL3_RAT ATP binding cassette subfamily A member 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=1 SV=4
9	F1MWM0	2289	2281	0.510	0.505	ABCA4_BOVIN Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Bos taurus OX=9913 GN=ABCA4 PE=1 SV=2
10	K9J4V5	4425	2262	0.953	0.952	K9J4V5_PIG ATP-binding cassette sub-family A member 1 OS=Sus scrofa OX=9823 GN=ABCA1 PE=2 SV=1
11	O35600	2281	2310	0.515	0.504	ABCA4_MOUSE Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Mus musculus OX=10090 GN=Abca4 PE=1 SV=1
12	O95477	4692	2261	1.000	1.000	ABCA1_HUMAN Phospholipid-transporting ATPase ABCA1 OS=Homo sapiens OX=9606 GN=ABCA1 PE=1 SV=3
13	P41233	4399	2261	0.953	0.953	ABCA1_MOUSE Phospholipid-transporting ATPase ABCA1 OS=Mus musculus OX=10090 GN=Abca1 PE=1 SV=4
14	P41234	1497	2434	0.378	0.351	ABCA2_MOUSE ATP-binding cassette sub-family A member 2 OS=Mus musculus OX=10090 GN=Abca2 PE=1 SV=4
15	P78363	2261	2273	0.510	0.507	ABCA4_HUMAN Retinal-specific phospholipid-transporting ATPase ABCA4 OS=Homo sapiens OX=9606 GN=ABCA4 PE=1 SV=3
16	Q5SSE9	1021	5034	0.316	0.142	ABCAD_MOUSE ATP-binding cassette sub-family A member 13 OS=Mus musculus OX=10090 GN=Abca13 PE=1 SV=1
17	Q7TNJ2	2103	2170	0.498	0.519	ABCA7_RAT ATP-binding cassette sub-family A member 7 OS=Rattus norvegicus OX=10116 GN=Abca7 PE=1 SV=1
18	Q80ZB2	4210	2201	0.912	0.937	Q80ZB2_RAT ATP-binding cassette 1 OS=Rattus norvegicus OX=10116 GN=Abca1 PE=2 SV=1
19	Q86UK0	1189	2595	0.305	0.266	ABCAC_HUMAN Glucosylceramide transporter ABCA12 OS=Homo sapiens OX=9606 GN=ABCA12 PE=1 SV=3
20	Q86UQ4	1072	5058	0.317	0.142	ABCAD_HUMAN ATP-binding cassette sub-family A member 13 OS=Homo sapiens OX=9606 GN=ABCA13 PE=2 SV=3

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF13175 AAA_15	2.9e+02	12.4	AAA ATPase domain
2	PF13304 AAA_21	7.8e-15	67.0	AAA domain, putative AbiEii toxin, Type IV TA system
3	PF13476 AAA_23	8.7	18.3	AAA domain
4	PF13555 AAA_29	1.4e+02	13.7	P-loop containing region of AAA domain
5	PF12698 ABC2_membrane_3	2.2e-59	213.0	ABC-2 family transporter protein
6	PF00005 ABC_tran	6.8e-49	177.4	ABC transporter
7	PF13732 DUF4162	0.24	23.5	Domain of unknown function (DUF4162)

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 9606.ENSP00000363868

Rank	PPI partner	STRING score	Description
1	9606.ENSP00000236850	0.999	Apolipoprotein A-I
2	9606.ENSP00000253727	0.989	Oxysterols receptor LXR-beta
3	9606.ENSP00000477707	0.984	Oxysterols receptor LXR-alpha
4	9606.ENSP00000252486	0.983	Apolipoprotein E
5	9606.ENSP00000385523	0.970	Peroxisome proliferator-activated receptor alpha
6	9606.ENSP00000309591	0.952	cAMP-dependent protein kinase catalytic subunit alpha
7	9606.ENSP00000264657	0.939	Signal transducer and activator of transcription 3
8	9606.ENSP00000268712	0.937	Nuclear receptor corepressor 1
9	9606.ENSP00000417138	0.936	Phospholipid transfer protein
10	9606.ENSP00000261693	0.935	Scavenger receptor class B member 1
11	9606.ENSP00000370104	0.929	G protein pathway suppressor 2
12	9606.ENSP00000363817	0.926	Retinoic acid receptor RXR-beta
13	9606.ENSP00000220592	0.925	Protein argonaute-2
14	9606.ENSP00000384018	0.924	Nuclear receptor corepressor 2
15	9606.ENSP00000385216	0.919	Nuclear receptor coactivator 1
16	9606.ENSP00000457466	0.916	Chromodomain-helicase-DNA-binding protein 9
17	9606.ENSP00000363929	0.913	Nuclear receptor coactivator 6
18	9606.ENSP00000217964	0.912	F-box-like/WD repeat-containing protein TBL1X
19	9606.ENSP00000262367	0.910	CREB-binding protein
20	9606.ENSP00000362300	0.910	Protein argonaute-1

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0005548	0.999	phospholipid transporter activity
GO:0044877	0.998	protein-containing complex binding
GO:0005515	0.996	protein binding
GO:0140326	0.996	ATPase-coupled intramembrane lipid transporter activity
GO:0042626	0.996	ATPase-coupled transmembrane transporter activity
GO:0008289	0.993	lipid binding
GO:0097159	0.985	organic cyclic compound binding
GO:1901363	0.982	heterocyclic compound binding
GO:0008035	0.977	high-density lipoprotein particle binding
GO:0120013	0.974	lipid transfer activity
GO:0036094	0.948	small molecule binding
GO:0043167	0.908	ion binding
GO:0038023	0.898	signaling receptor activity
GO:0097367	0.886	carbohydrate derivative binding
GO:0043168	0.882	anion binding
GO:0015248	0.870	sterol transporter activity
GO:0035639	0.869	purine ribonucleoside triphosphate binding
GO:0032559	0.868	adenyl ribonucleotide binding
GO:0038024	0.836	cargo receptor activity
GO:0005524	0.833	ATP binding
GO:0004888	0.820	transmembrane signaling receptor activity
GO:0003824	0.656	catalytic activity
GO:0008525	0.641	phosphatidylcholine transporter activity
GO:0120020	0.621	cholesterol transfer activity
GO:0019899	0.531	enzyme binding
GO:0005102	0.378	signaling receptor binding
GO:0005496	0.364	steroid binding
GO:0046624	0.347	sphingolipid transporter activity
GO:0015485	0.347	cholesterol binding
GO:0140333	0.343	glycerophospholipid flippase activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0008150	1.000	biological_process
GO:0071704	0.992	organic substance metabolic process
GO:0044238	0.992	primary metabolic process
GO:0009987	0.986	cellular process
GO:0015918	0.947	sterol transport
GO:0050896	0.941	response to stimulus
GO:0030301	0.937	cholesterol transport
GO:0050789	0.915	regulation of biological process
GO:0050794	0.820	regulation of cellular process
GO:0015748	0.794	organophosphate ester transport
GO:0015914	0.783	phospholipid transport
GO:0006807	0.750	nitrogen compound metabolic process
GO:0044237	0.730	cellular metabolic process
GO:0051716	0.682	cellular response to stimulus
GO:0043170	0.625	macromolecule metabolic process
GO:1901564	0.617	organonitrogen compound metabolic process
GO:0048518	0.605	positive regulation of biological process
GO:0032501	0.597	multicellular organismal process
GO:0071840	0.560	cellular component organization or biogenesis
GO:0042221	0.530	response to chemical
GO:0016043	0.521	cellular component organization
GO:0010033	0.440	response to organic substance
GO:1901576	0.435	organic substance biosynthetic process
GO:0032879	0.403	regulation of localization
GO:0048522	0.371	positive regulation of cellular process
GO:0006629	0.358	lipid metabolic process
GO:0048519	0.351	negative regulation of biological process
GO:0070887	0.348	cellular response to chemical stimulus
GO:0044249	0.314	cellular biosynthetic process
GO:1901700	0.301	response to oxygen-containing compound
GO:1905952	0.300	regulation of lipid localization

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005886	1.000	plasma membrane
GO:0043226	0.985	organelle
GO:0005737	0.983	cytoplasm
GO:0043231	0.978	intracellular membrane-bounded organelle
GO:0012505	0.930	endomembrane system
GO:0045178	0.601	basal part of cell
GO:0098590	0.506	plasma membrane region
GO:0009986	0.498	cell surface
GO:0031982	0.451	vesicle
GO:0031410	0.430	cytoplasmic vesicle
GO:0031090	0.413	organelle membrane
GO:0005783	0.369	endoplasmic reticulum

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name
EC:7.-.-.-	0.996	Translocases.
EC:7.6.2.1	0.996	P-type phospholipid transporter.
RHEA:39747	0.870	cholesterol(in) = cholesterol(out)

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