StarFunc result for job id O95563

User Input

>input (127 residues)
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADM
ARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQE
LKAKAHK

Proteins with similar structure

Top structural analogs (as identified by Foldseek and TM-align)

Rank	Structure template	TM-score1	TM-score2	Foldseek E-value	Length	ID1	ID2	Download	Description
1	AFDB:O95563	1.000	1.000	4.580E-18	127	1.000	1.000	O95563.pdb.gz	MPC2_HUMAN Mitochondrial pyruvate carrier 2 OS=Homo sapiens OX=9606 GN=MPC2 PE=1 SV=1
2	AFDB:Q09896	0.753	0.808	6.734E-9	118	0.386	0.415	Q09896.pdb.gz	MPC2_SCHPO Probable mitochondrial pyruvate carrier 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mpc2 PE=3 SV=1
3	AFDB:O49636	0.730	0.850	9.827E-9	108	0.386	0.454	O49636.pdb.gz	MPC4_ARATH Mitochondrial pyruvate carrier 4 OS=Arabidopsis thaliana OX=3702 GN=MPC4 PE=3 SV=1
4	AFDB:Q8L7H8	0.751	0.869	1.095E-8	109	0.370	0.431	Q8L7H8.pdb.gz	MPC2_ARATH Mitochondrial pyruvate carrier 2 OS=Arabidopsis thaliana OX=3702 GN=MPC2 PE=3 SV=1
5	AFDB:Q8LD38	0.738	0.863	1.434E-8	108	0.370	0.435	Q8LD38.pdb.gz	MPC3_ARATH Mitochondrial pyruvate carrier 3 OS=Arabidopsis thaliana OX=3702 GN=MPC3 PE=2 SV=1
6	AFDB:Q5A328	0.736	0.709	1.057E-7	132	0.386	0.371	Q5A328.pdb.gz	Q5A328_CANAL Mitochondrial pyruvate carrier OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CAALFM_CR08610WA PE=3 SV=1
7	AFDB:P38857	0.676	0.666	2.646E-7	129	0.370	0.364	P38857.pdb.gz	MPC2_YEAST Mitochondrial pyruvate carrier 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MPC2 PE=1 SV=1
8	AFDB:P53311	0.596	0.528	5.947E-7	146	0.394	0.342	P53311.pdb.gz	MPC3_YEAST Mitochondrial pyruvate carrier 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MPC3 PE=1 SV=1
9	AFDB:Q949R9	0.693	0.790	1.848E-6	110	0.252	0.291	Q949R9.pdb.gz	MPC1_ARATH Mitochondrial pyruvate carrier 1 OS=Arabidopsis thaliana OX=3702 GN=MPC1 PE=3 SV=1
10	AFDB:F1Q6Z3	0.663	0.763	1.690E-5	109	0.252	0.294	F1Q6Z3.pdb.gz	F1Q6Z3_DANRE Mitochondrial pyruvate carrier OS=Danio rerio OX=7955 GN=zgc:92707 PE=1 SV=1
11	PDB:4qndA	0.432	0.545	2.338E-1	97	0.118	0.155	4qndA.pdb.gz
12	PDB:7eebM	0.238	0.253	1.246	116	0.110	0.121	7eebM.pdb.gz	Structure of a mammalian sperm cation channel complex.
13	PDB:1yo7A	0.343	0.360	1.547	120	0.110	0.117	1yo7A.pdb.gz	Structure of the ColE1 rop protein at 1.7 A resolution
14	PDB:5sv0A	0.181	0.113	1.547	233	0.150	0.082	5sv0A.pdb.gz
15	PDB:4o93A	0.217	0.267	2.026	94	0.102	0.138	4o93A.pdb.gz
16	PDB:1gncA	0.207	0.170	2.138	175	0.205	0.149	1gncA.pdb.gz
17	PDB:4u4tA	0.308	0.117	2.138	444	0.126	0.036	4u4tA.pdb.gz	Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK
18	PDB:3craA	0.355	0.202	2.257	239	0.094	0.050	3craA.pdb.gz
19	PDB:7zh0A	0.330	0.107	2.382	495	0.110	0.028	7zh0A.pdb.gz
20	PDB:6s7oH	0.243	0.275	2.514	108	0.102	0.120	6s7oH.pdb.gz	Cryo-electron microscopy structures of human oligosaccharyltransferase complexes OST-A and OST-B.

(a)	The query structure is shown in cartoon, while the structural analog is displayed using a backbone trace.
(b)	Ranking of proteins is based on E-value of Foldseek alignment.
(c)	TM-score1 and ID1 are TM-score and sequence identity normalized by query sequence length.
(d)	TM-score2 and ID2 are TM-score and sequence identity normalized by template sequence length.

Proteins with similar sequence

Top sequence homologs in UniProt

Rank	Template	E-value	Bit-score	Length	ID1	ID2	Description
1	O95563	3.20e-91	261	127	1.000	1.000	MPC2_HUMAN Mitochondrial pyruvate carrier 2 OS=Homo sapiens OX=9606 GN=MPC2 PE=1 SV=1
2	Q9D023	3.09e-70	208	127	0.843	0.843	MPC2_MOUSE Mitochondrial pyruvate carrier 2 OS=Mus musculus OX=10090 GN=Mpc2 PE=1 SV=1
3	O49636	1.13e-31	110	108	0.394	0.463	MPC4_ARATH Mitochondrial pyruvate carrier 4 OS=Arabidopsis thaliana OX=3702 GN=MPC4 PE=3 SV=1
4	Q8LD38	1.61e-30	107	108	0.378	0.444	MPC3_ARATH Mitochondrial pyruvate carrier 3 OS=Arabidopsis thaliana OX=3702 GN=MPC3 PE=2 SV=1
5	Q8L7H8	8.05e-30	105	109	0.378	0.440	MPC2_ARATH Mitochondrial pyruvate carrier 2 OS=Arabidopsis thaliana OX=3702 GN=MPC2 PE=3 SV=1
6	Q09896	3.93e-28	101	118	0.394	0.424	MPC2_SCHPO Probable mitochondrial pyruvate carrier 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mpc2 PE=3 SV=1
7	P53311	4.92e-27	99.8	146	0.370	0.322	MPC3_YEAST Mitochondrial pyruvate carrier 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MPC3 PE=1 SV=1
8	Q5A328	1.35e-26	98.2	132	0.386	0.371	Q5A328_CANAL Mitochondrial pyruvate carrier OS=Candida albicans (strain SC5314 / ATCC MYA-2876) OX=237561 GN=CAALFM_CR08610WA PE=3 SV=1
9	P38857	6.04e-24	91.3	129	0.346	0.341	MPC2_YEAST Mitochondrial pyruvate carrier 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MPC2 PE=1 SV=1
10	Q949R9	2.74e-13	63.5	110	0.236	0.273	MPC1_ARATH Mitochondrial pyruvate carrier 1 OS=Arabidopsis thaliana OX=3702 GN=MPC1 PE=3 SV=1
11	F1Q6Z3	1.82e-10	56.2	109	0.213	0.248	F1Q6Z3_DANRE Mitochondrial pyruvate carrier OS=Danio rerio OX=7955 GN=zgc:92707 PE=1 SV=1
12	Q7KSC4	4.06e-07	47.4	107	0.189	0.224	MPC1_DROME Mitochondrial pyruvate carrier 1 OS=Drosophila melanogaster OX=7227 GN=Mpc1 PE=3 SV=1
13	P63030	2.09e-06	45.4	109	0.189	0.220	MPC1_MOUSE Mitochondrial pyruvate carrier 1 OS=Mus musculus OX=10090 GN=Mpc1 PE=1 SV=1
14	Q9Y5U8	4.46e-06	44.7	109	0.150	0.174	MPC1_HUMAN Mitochondrial pyruvate carrier 1 OS=Homo sapiens OX=9606 GN=MPC1 PE=1 SV=1
15	A0A087WVZ0	5.06e-06	44.3	109	0.150	0.174	A0A087WVZ0_HUMAN Mitochondrial pyruvate carrier OS=Homo sapiens OX=9606 GN=MPC1 PE=1 SV=1
16	P53157	5.94e-06	44.7	130	0.157	0.154	MPC1_YEAST Mitochondrial pyruvate carrier 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) OX=559292 GN=MPC1 PE=1 SV=1
17	Q57WG7	2.37e-05	43.1	134	0.228	0.216	Q57WG7_TRYB2 Mitochondrial pyruvate carrier OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb07.28B13.540 PE=3 SV=1
18	O74847	0.018	35.4	141	0.157	0.142	MPC1_SCHPO Probable mitochondrial pyruvate carrier 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) OX=284812 GN=mpc1 PE=3 SV=3
19	Q1A5L2	1.5	30.8	1466	0.087	0.008	Q1A5L2_DANRE Crb2 OS=Danio rerio OX=7955 GN=crb2 PE=1 SV=1
20	Q388P3	2.0	30.4	1046	0.189	0.023	Q388P3_TRYB2 Abnormal spindle-like microcephaly-associated protein ASH domain-containing protein OS=Trypanosoma brucei brucei (strain 927/4 GUTat10.1) OX=185431 GN=Tb10.05.0270 PE=4 SV=1

(a)	Ranking of proteins is based on the E-value of a BLASTp alignment.
(b)	ID1 and ID2 are sequence identities normalized by the query and template sequence lengths, respectively.

Pfam families

Top Pfam family matches

Rank	Pfam family	E-value	Score	Description
1	PF03650 MPC	2.1e-36	135.8	Mitochondrial pyruvate carriers

(a)	Ranking of Pfam families is based on the E-value provided by HMMsearch.

Protein-protein interaction (PPI) partners

Top PPI partners to 61853.ENSNLEP00000018116

Rank	PPI partner	STRING score	Description
1	61853.ENSNLEP00000014044	0.980	Mitochondrial pyruvate carrier
2	61853.ENSNLEP00000022898	0.922	Mitochondrial pyruvate carrier
3	61853.ENSNLEP00000009229	0.897	Cytochrome b-c1 complex subunit Rieske, mitochondrial
4	61853.ENSNLEP00000008162	0.884	Solute carrier family 25 (carnitine/acylcarnitine translocase), member 20
5	61853.ENSNLEP00000006986	0.842	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
6	61853.ENSNLEP00000001838	0.836	NADH:ubiquinone oxidoreductase core subunit S7
7	61853.ENSNLEP00000006643	0.835	NADH:ubiquinone oxidoreductase subunit B9
8	61853.ENSNLEP00000016410	0.806	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial
9	61853.ENSNLEP00000014869	0.797	Ubiquinol-cytochrome c reductase core protein II
10	61853.ENSNLEP00000004835	0.779	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
11	61853.ENSNLEP00000010064	0.762	Uncharacterized protein
12	61853.ENSNLEP00000022999	0.754	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G2
13	61853.ENSNLEP00000017296	0.653	NADH:ubiquinone oxidoreductase core subunit S2
14	61853.ENSNLEP00000017885	0.652	Uncharacterized protein
15	61853.ENSNLEP00000023483	0.652	Cytochrome c oxidase subunit 5A
16	61853.ENSNLEP00000006766	0.649	Solute carrier family 25, member 45
17	61853.ENSNLEP00000005120	0.630	Uncharacterized protein
18	61853.ENSNLEP00000003597	0.625	Pyruvate dehyrogenase phosphatase catalytic subunit 1
19	61853.ENSNLEP00000023415	0.610	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain
20	61853.ENSNLEP00000023814	0.610	Cytochrome b-c1 complex subunit 7

A higher STRING score indicates a greater likelihood of interaction.
The query and PPI partners are shown as grey oval and white rectangles, respectively.
Interactions between query and PPI partners are shown by solid black lines. Interactions among PPI partners are by dashed grey lines.
Values in the rectangles are the STRING scores between query and each corresponding PPI partner

Predicted Gene Ontology (GO) Terms

GO term	C-score	Name
GO:0042802	1.000	identical protein binding
GO:0005215	0.960	transporter activity
GO:0022857	0.952	transmembrane transporter activity
GO:0008514	0.909	organic anion transmembrane transporter activity
GO:0005342	0.902	organic acid transmembrane transporter activity
GO:0046943	0.885	carboxylic acid transmembrane transporter activity
GO:0008028	0.879	monocarboxylic acid transmembrane transporter activity
GO:1901702	0.801	salt transmembrane transporter activity

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Molecular Function (MF) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0009987	0.995	cellular process
GO:0044237	0.976	cellular metabolic process
GO:0055085	0.970	transmembrane transport
GO:0046942	0.970	carboxylic acid transport
GO:1990542	0.956	mitochondrial transmembrane transport
GO:0015718	0.933	monocarboxylic acid transport
GO:0071704	0.925	organic substance metabolic process
GO:0065007	0.921	biological regulation
GO:1905039	0.921	carboxylic acid transmembrane transport
GO:0044238	0.816	primary metabolic process
GO:0006807	0.653	nitrogen compound metabolic process
GO:0044281	0.624	small molecule metabolic process
GO:1901564	0.610	organonitrogen compound metabolic process
GO:0050789	0.545	regulation of biological process
GO:0055086	0.509	nucleobase-containing small molecule metabolic process
GO:0019637	0.477	organophosphate metabolic process
GO:0050794	0.458	regulation of cellular process
GO:1901135	0.440	carbohydrate derivative metabolic process
GO:0006796	0.431	phosphate-containing compound metabolic process
GO:0019752	0.400	carboxylic acid metabolic process
GO:0009117	0.400	nucleotide metabolic process
GO:1901576	0.395	organic substance biosynthetic process
GO:0032787	0.394	monocarboxylic acid metabolic process
GO:0006163	0.394	purine nucleotide metabolic process
GO:0034654	0.378	nucleobase-containing compound biosynthetic process
GO:0009150	0.367	purine ribonucleotide metabolic process
GO:0006090	0.364	pyruvate metabolic process
GO:0009152	0.356	purine ribonucleotide biosynthetic process
GO:1901475	0.355	pyruvate transmembrane transport
GO:0006850	0.325	mitochondrial pyruvate transmembrane transport
GO:0006790	0.318	sulfur compound metabolic process

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Biological Process (BP) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

GO term	C-score	Name
GO:0005739	1.000	mitochondrion
GO:0016020	0.995	membrane
GO:0005634	0.975	nucleus
GO:0031090	0.974	organelle membrane
GO:0005743	0.956	mitochondrial inner membrane
GO:0032991	0.930	protein-containing complex
GO:0070013	0.434	intracellular organelle lumen

C-score is the confidence score of a predicted GO term. Its value ranges from (0,1], where a higher value indicates a higher confidence prediction.
If a child GO term and its parent term have the same C-score, only the child term is shown in this table.

The graph shows the predicted terms for the Cellular Component (CC) GO aspect. GO terms shown in the table are colored by C-score in the graph:

[0.3,0.4)

[0.4,0.5)

[0.5,0.6)

[0.6,0.7)

[0.7,0.8)

[0.8,0.9)

[0.9,1.0]

Predicted reactions (EC numbers and Rhea reactions)

Reaction	C-score	Name

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